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  • 1
    Publication Date: 2022-10-26
    Description: © The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Foltz, G. R., Brandt, P., Richter, I., Rodriguez-Fonsecao, B., Hernandez, F., Dengler, M., Rodrigues, R. R., Schmidt, J. O., Yu, L., Lefevre, N., Da Cunha, L. C., Mcphaden, M. J., Araujo, M., Karstensen, J., Hahn, J., Martin-Rey, M., Patricola, C. M., Poli, P., Zuidema, P., Hummels, R., Perez, R. C., Hatje, V., Luebbecke, J. F., Palo, I., Lumpkin, R., Bourles, B., Asuquo, F. E., Lehodey, P., Conchon, A., Chang, P., Dandin, P., Schmid, C., Sutton, A., Giordani, H., Xue, Y., Illig, S., Losada, T., Grodsky, S. A., Gasparinss, F., Lees, T., Mohino, E., Nobre, P., Wanninkhof, R., Keenlyside, N., Garcon, V., Sanchez-Gomez, E., Nnamchi, H. C., Drevillon, M., Storto, A., Remy, E., Lazar, A., Speich, S., Goes, M., Dorrington, T., Johns, W. E., Moum, J. N., Robinson, C., Perruches, C., de Souza, R. B., Gaye, A. T., Lopez-Paragess, J., Monerie, P., Castellanos, P., Benson, N. U., Hounkonnou, M. N., Trotte Duha, J., Laxenairess, R., & Reul, N. The tropical Atlantic observing system. Frontiers in Marine Science, 6(206), (2019), doi:10.3389/fmars.2019.00206.
    Description: he tropical Atlantic is home to multiple coupled climate variations covering a wide range of timescales and impacting societally relevant phenomena such as continental rainfall, Atlantic hurricane activity, oceanic biological productivity, and atmospheric circulation in the equatorial Pacific. The tropical Atlantic also connects the southern and northern branches of the Atlantic meridional overturning circulation and receives freshwater input from some of the world’s largest rivers. To address these diverse, unique, and interconnected research challenges, a rich network of ocean observations has developed, building on the backbone of the Prediction and Research Moored Array in the Tropical Atlantic (PIRATA). This network has evolved naturally over time and out of necessity in order to address the most important outstanding scientific questions and to improve predictions of tropical Atlantic severe weather and global climate variability and change. The tropical Atlantic observing system is motivated by goals to understand and better predict phenomena such as tropical Atlantic interannual to decadal variability and climate change; multidecadal variability and its links to the meridional overturning circulation; air-sea fluxes of CO2 and their implications for the fate of anthropogenic CO2; the Amazon River plume and its interactions with biogeochemistry, vertical mixing, and hurricanes; the highly productive eastern boundary and equatorial upwelling systems; and oceanic oxygen minimum zones, their impacts on biogeochemical cycles and marine ecosystems, and their feedbacks to climate. Past success of the tropical Atlantic observing system is the result of an international commitment to sustained observations and scientific cooperation, a willingness to evolve with changing research and monitoring needs, and a desire to share data openly with the scientific community and operational centers. The observing system must continue to evolve in order to meet an expanding set of research priorities and operational challenges. This paper discusses the tropical Atlantic observing system, including emerging scientific questions that demand sustained ocean observations, the potential for further integration of the observing system, and the requirements for sustaining and enhancing the tropical Atlantic observing system.
    Description: MM-R received funding from the MORDICUS grant under contract ANR-13-SENV-0002-01 and the MSCA-IF-EF-ST FESTIVAL (H2020-EU project 797236). GF, MG, RLu, RP, RW, and CS were supported by NOAA/OAR through base funds to AOML and the Ocean Observing and Monitoring Division (OOMD; fund reference 100007298). This is NOAA/PMEL contribution #4918. PB, MDe, JH, RH, and JL are grateful for continuing support from the GEOMAR Helmholtz Centre for Ocean Research Kiel. German participation is further supported by different programs funded by the Deutsche Forschungsgemeinschaft, the Deutsche Bundesministerium für Bildung und Forschung (BMBF), and the European Union. The EU-PREFACE project funded by the EU FP7/2007–2013 programme (Grant No. 603521) contributed to results synthesized here. LCC was supported by the UERJ/Prociencia-2018 research grant. JOS received funding from the Cluster of Excellence Future Ocean (EXC80-DFG), the EU-PREFACE project (Grant No. 603521) and the BMBF-AWA project (Grant No. 01DG12073C).
    Keywords: Tropical Atlantic Ocean ; Observing system ; Weather ; Climate ; Hurricanes ; Biogeochemistry ; Ecosystems ; Coupled model bias
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 2
    Publication Date: 2022-05-26
    Description: © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS ONE 12 (2017): e0184849, doi:10.1371/journal.pone.0184849.
    Description: Diatoms are important components of marine ecosystems and contribute greatly to the world's primary production. Despite their important roles in ecosystems, the molecular basis of how diatoms cope with oxidative stress caused by nutrient fluctuations remains largely unknown. Here, an isobaric tags for relative and absolute quantitation (iTRAQ) proteomic method was coupled with a series of physiological and biochemical techniques to explore oxidative stress- and cell fate decision-related cellular and metabolic responses of the diatom Thalassiosira pseudonana to nitrate (N) and inorganic phosphate (P) stresses. A total of 1151 proteins were detected; 122 and 56 were significantly differentially expressed from control under N- and P-limited conditions, respectively. In N-limited cells, responsive proteins were related to reactive oxygen species (ROS) accumulation, oxidative stress responses and cell death, corresponding to a significant decrease in photosynthetic efficiency, marked intracellular ROS accumulation, and caspase-mediated programmed cell death activation. None of these responses were identified in P-limited cells; however, a significant up-regulation of alkaline phosphatase proteins was observed, which could be the major contributor for P-limited cells to cope with ambient P deficiency. These findings demonstrate that fundamentally different metabolic responses and cellular regulations are employed by the diatom in response to different nutrient stresses and to keep the cells viable.
    Description: This study was funded by the National Natural Science Foundation of China (41576138, 41076080, 41576138) to Dr. Jun-Rong Liang; the Woods Hole Center for Oceans and Human Health, National Science Foundation (OCE-1314642) to Dr. DonaldM Anderson; the National Institute of Environmental Health Sciences (1-P01-ES021923- 01) to Dr. DonaldM Anderson; and the ERC Advanced Award Diatomite and ANR project DiaDomOil to Dr. Chris Bowler.
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 3
    Publication Date: 2022-05-26
    Description: Author Posting. © American Meteorological Society, 2017. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Bulletin of the American Meteorological Society 97 (2016): 2305-2327, doi:10.1175/BAMS-D-15-00274.1.
    Description: Well-known problems trouble coupled general circulation models of the eastern Atlantic and Pacific Ocean basins. Model climates are significantly more symmetric about the equator than is observed. Model sea surface temperatures are biased warm south and southeast of the equator, and the atmosphere is too rainy within a band south of the equator. Near-coastal eastern equatorial SSTs are too warm, producing a zonal SST gradient in the Atlantic opposite in sign to that observed. The U.S. Climate Variability and Predictability Program (CLIVAR) Eastern Tropical Ocean Synthesis Working Group (WG) has pursued an updated assessment of coupled model SST biases, focusing on the surface energy balance components, on regional error sources from clouds, deep convection, winds, and ocean eddies; on the sensitivity to model resolution; and on remote impacts. Motivated by the assessment, the WG makes the following recommendations: 1) encourage identification of the specific parameterizations contributing to the biases in individual models, as these can be model dependent; 2) restrict multimodel intercomparisons to specific processes; 3) encourage development of high-resolution coupled models with a concurrent emphasis on parameterization development of finer-scale ocean and atmosphere features, including low clouds; 4) encourage further availability of all surface flux components from buoys, for longer continuous time periods, in persistently cloudy regions; and 5) focus on the eastern basin coastal oceanic upwelling regions, where further opportunities for observational–modeling synergism exist.
    Description: PZ, BK, and RM acknowledge support from NOAA Grant NA14OAR4310278, and PZ acknowledges support from NSF AGS-1233874. BM acknowledges support from the Regional and Global Climate Modeling Program of the U.S. Department of Energy’s Office of Science, Cooperative Agreement DE-FC02-97ER62402. PC acknowledges support from U.S. NSF Grants OCE-1334707 and AGS-1462127, and NOAA Grant NA11OAR4310154. PC also acknowledges support from China’s National Basic Research Priorities Programme (2013CB956204) and the Natural Science Foundation of China (41222037 and 41221063). TF acknowledges support from NSF Grant OCE-0745508 and NASA Grant NNX14AM71G. PB acknowledges support from the BMBF SACUS (03G0837A) project. TT and PB acknowledge support from the European Union Seventh Framework Programme (FP7 20072013) under Grant Agreement 603521 for the PREFACE Project. ES and ZW acknowledge support from NSF AGS-1338427, NOAA NA14OAR4310160, and NASA NNX14AM19G; and ES is grateful for further support from the National Monsoon Mission, Ministry of Earth Sciences, India.
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 4
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    PANGAEA
    In:  Supplement to: Jia, Yinglai; Chang, Ping; Szunyogh, Istvan; Saravanan, Ramalingam; Bacmeister, Julio T (2019): A Modeling Strategy for the Investigation of the Effect of Mesoscale SST Variability on Atmospheric Dynamics. Geophysical Research Letters, 46(7), 3982-3989, https://doi.org/10.1029/2019GL081960
    Publication Date: 2023-01-13
    Description: An efficient modeling strategy is proposed for the investigation of the effect of SST mesoscale variability on atmospheric dynamics. Two ensembles of numerical simulations are generated with a high-resolution atmospheric global circulation model coupled to a slab ocean model. This dataset contains data from the control and filtered ensembles which ran using the CESM at about 25km horizontal resolution over the globe. CAM5_SOM simulations are used to study the effect of mesoscale SST variability on atmospheric circulations. This dataset contains 25km model simulations from control and filtered ensemble run.
    Keywords: File content; File format; File name; File size; Uniform resource locator/link to file
    Type: Dataset
    Format: text/tab-separated-values, 20 data points
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  • 5
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    AGU (American Geophysical Union) | Wiley
    In:  Journal of Geophysical Research: Oceans, 122 (12). pp. 9795-9813.
    Publication Date: 2020-02-06
    Description: The region encompassing the Kuroshio Extension (KE) in the Northwestern Pacific Ocean (25°N–45°N and 130°E–180°E) is one of the most eddy-energetic regions of the global ocean. The three-dimensional structures and transports of mesoscale eddies in this region are comprehensively investigated by combined use of satellite data and Argo profiles. With the allocation of Argo profiles inside detected eddies, the spatial variations of structures of eddy temperature and salinity anomalies are analyzed. The results show that eddies predominantly have subsurface (near-surface) intensified temperature and salinity anomalies south (north) of the KE jet, which is related to different background stratifications between these regions. A new method based on eddy trajectories and the inferred three-dimensional eddy structures is proposed to estimate heat and salt transports by eddy movements in a Lagrangian framework. Spatial distributions of eddy transports are presented over the vicinity of the KE for the first time. The magnitude of eddy-induced meridional heat (freshwater volume) transport is on the order of 0.01 PW (103 m3/s). The eddy heat transport divergence results in an oceanic heat loss south and heat gain north of the KE, thereby reinforcing and counteracting the oceanic heat loss from air-sea fluxes south and north of the KE jet, respectively. It also suggests a poleward heat transport across the KE jet due to eddy propagation.
    Type: Article , PeerReviewed
    Format: text
    Format: text
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  • 6
    Publication Date: 2019-09-23
    Description: Current climate models systematically underestimate the strength of oceanic fronts associated with strong western boundary currents, such as the Kuroshio and Gulf Stream Extensions, and have difficulty simulating their positions at the mid-latitude ocean’s western boundaries1. Even with an enhanced grid resolution to resolve ocean mesoscale eddies—energetic circulations with horizontal scales of about a hundred kilometres that strongly interact with the fronts and currents—the bias problem can still persist2; to improve climate models we need a better understanding of the dynamics governing these oceanic frontal regimes. Yet prevailing theories about the western boundary fronts are based on ocean internal dynamics without taking into consideration the intense air–sea feedbacks in these oceanic frontal regions. Here, by focusing on the Kuroshio Extension Jet east of Japan as the direct continuation of the Kuroshio, we show that feedback between ocean mesoscale eddies and the atmosphere (OME-A) is fundamental to the dynamics and control of these energetic currents. Suppressing OME-A feedback in eddy-resolving coupled climate model simulations results in a 20–40 per cent weakening in the Kuroshio Extension Jet. This is because OME-A feedback dominates eddy potential energy destruction, which dissipates more than 70 per cent of the eddy potential energy extracted from the Kuroshio Extension Jet. The absence of OME-A feedback inevitably leads to a reduction in eddy potential energy production in order to balance the energy budget, which results in a weakened mean current. The finding has important implications for improving climate models’ representation of major oceanic fronts, which are essential components in the simulation and prediction of extratropical storms and other extreme events3, 4, 5, 6, as well as in the projection of the effect on these events of climate change.
    Type: Article , PeerReviewed
    Format: text
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  • 7
    Publication Date: 2019-02-01
    Description: Well-known problems trouble coupled general circulation models of the eastern Atlantic and Pacific Ocean basins. Model climates are significantly more symmetric about the equator than is observed. Model sea surface temperatures are biased warm south and southeast of the equator, and the atmosphere is too rainy within a band south of the equator. Near-coastal eastern equatorial SSTs are too warm, producing a zonal SST gradient in the Atlantic opposite in sign to that observed. The U.S. Climate Variability and Predictability Program (CLIVAR) Eastern Tropical Ocean Synthesis Working Group (WG) has pursued an updated assessment of coupled model SST biases, focusing on the surface energy balance components, on regional error sources from clouds, deep convection, winds, and ocean eddies; on the sensitivity to model resolution; and on remote impacts. Motivated by the assessment, the WG makes the following recommendations: 1) encourage identification of the specific parameterizations contributing to the biases in individual models, as these can be model dependent; 2) restrict multimodel intercomparisons to specific processes; 3) encourage development of high-resolution coupled models with a concurrent emphasis on parameterization development of finer-scale ocean and atmosphere features, including low clouds; 4) encourage further availability of all surface flux components from buoys, for longer continuous time periods, in persistently cloudy regions; and 5) focus on the eastern basin coastal oceanic upwelling regions, where further opportunities for observational–modeling synergism exist.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
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  • 8
    Publication Date: 2016-07-16
    Description: BACKGROUND Prostate cancer is one of the most prevalent cancers in men worldwide. Aberrant activation of c-Met/signal transducer and activator of transcription-3 (STAT3) signaling is involved in prostate carcinogenesis, underscoring the demand for developing c-Met/STAT3-targeting drugs. Thus, we first utilized virtual screening strategy to identify STAT3-inhibiting marine compound, heteronemin, and then validated the STAT3-inhibiting function of heteronemin in prostate cancer cells. METHODS Human prostate cancer LNCaP, DU145, and PC-3 cell lines were treated with heteronemin for 24 hr, then the cell viability was evaluated by MTT assay. Flow cytometry was performed to analyze the apoptosis in heteronemin-treated cells. Western blot and quantitative real-time PCR were executed to further confirm the c-Met/STAT3 signaling inhibition by heteronemin in DU145 and PC-3 cells. RESULTS In this study, we employed the virtual screening strategy to identify heteronemin, a spongean sesterterpene, as a potential STAT3 inhibitor from Taiwan marine drugs library. Application of heteronemin potently suppressed the viability and anchorage-independent growth of human prostate cancer cells. Besides, heteronemin induced apoptosis in prostate cancer cells by activation of both intrinsic (caspase-9) and extrinsic (caspase-8) apoptotic pathways. By luciferase assay and expression analysis, it was confirmed that heteronemin inhibited the phosphorylation of c-Met/src/STAT3 signaling axis, STAT3-driven luciferase activities and expression of STAT3-regulated genes including Bcl-xL, Bcl-2, and Cyclin D1. Finally, heteronemin effectively antagonized the hepatocyte growth factor (HGF)-stimulated c-Met/STAT3 activation as well as the proliferation and colonies formation in refractory prostate cancer cells. CONCLUSIONS These findings suggest that heteronemin may constitute a novel c-Met/STAT3-targeting agent for prostate cancer. Prostate © 2016 Wiley Periodicals, Inc.
    Print ISSN: 0270-4137
    Electronic ISSN: 1097-0045
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 9
    Publication Date: 2016-07-27
    Description: Integrated multi-omics analyses reveal the biochemical mechanisms and phylogenetic relevance of anaerobic androgen biodegradation in the environment The ISME Journal 10, 1967 (August 2016). doi:10.1038/ismej.2015.255 Authors: Fu-Chun Yang, Yi-Lung Chen, Sen-Lin Tang, Chang-Ping Yu, Po-Hsiang Wang, Wael Ismail, Chia-Hsiang Wang, Jiun-Yan Ding, Cheng-Yu Yang, Chia-Ying Yang & Yin-Ru Chiang
    Print ISSN: 1751-7362
    Electronic ISSN: 1751-7370
    Topics: Biology
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  • 10
    Publication Date: 2015-08-28
    Description: Nature Genetics 47, 1061 (2015). doi:10.1038/ng.3358 Authors: Lu Jiang, Zhao-Hui Gu, Zi-Xun Yan, Xia Zhao, Yin-Yin Xie, Zi-Guan Zhang, Chun-Ming Pan, Yuan Hu, Chang-Ping Cai, Ying Dong, Jin-Yan Huang, Li Wang, Yang Shen, Guoyu Meng, Jian-Feng Zhou, Jian-Da Hu, Jin-Fen Wang, Yuan-Hua Liu, Lin-Hua Yang, Feng Zhang, Jian-Min Wang, Zhao Wang, Zhi-Gang Peng, Fang-Yuan Chen, Zi-Min Sun, Hao Ding, Ju-Mei Shi, Jian Hou, Jin-Song Yan, Jing-Yi Shi, Lan Xu, Yang Li, Jing Lu, Zhong Zheng, Wen Xue, Wei-Li Zhao, Zhu Chen & Sai-Juan Chen Natural killer/T-cell lymphoma (NKTCL) is a malignant proliferation of CD56+ and cytoCD3+ lymphocytes with aggressive clinical course, which is prevalent in Asian and South American populations. The molecular pathogenesis of NKTCL has largely remained elusive. We identified somatic gene mutations in 25 people with NKTCL by whole-exome sequencing and confirmed them in an extended validation group of 80 people by targeted sequencing. Recurrent mutations were most frequently located in the RNA helicase gene DDX3X (21/105 subjects, 20.0%), tumor suppressors (TP53 and MGA), JAK-STAT-pathway molecules (STAT3 and STAT5B) and epigenetic modifiers (MLL2, ARID1A, EP300 and ASXL3). As compared to wild-type protein, DDX3X mutants exhibited decreased RNA-unwinding activity, loss of suppressive effects on cell-cycle progression in NK cells and transcriptional activation of NF-κB and MAPK pathways. Clinically, patients with DDX3X mutations presented a poor prognosis. Our work thus contributes to the understanding of the disease mechanism of NKTCL.
    Print ISSN: 1061-4036
    Electronic ISSN: 1546-1718
    Topics: Biology , Medicine
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