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Digitale Medien

Dynamics of fish diseases in the lower Elbe River (1984)

Möller, H.

Springer

Helgoland marine research 37 (1984), S. 389-413

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ISSN: 1438-3888

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract As part of a survey on population dynamics and ecology of fishesin the Elbe River, seasonal and regional fluctuations of external fish diseases were studied from the open North Sea to Hamburg in 1981–1982. Clinical signs of 11 different diseases, several of them not being recorded before, were noted in 22 fish species. Averaged over all samples, the total disease prevalence was below 1 % in 16 species. Highest prevalences were found in smelt (12.7 %), eel (9.2 %), and flounder (5.5 %). The frequency of most diseases increased in larger (older) fish. High prevalences of skeletal abnormalities in cod could be related to abnormal migration habits of diseased fish. Spawning papillomatosis, skin ulceration, and fin rot in smelt occurred predominantly during the spawning season. Most diseases observed occurred at relatively high prevalences in the central Elbe estuary between Cuxhaven and Brunsbüttel. This is most obvious for lymphocystis, fin rot, skin ulceration, and bleaching syndrome in flounder, but such a tendency also seems to occur in cauliflower disease of eel, as well as spawning papillomatosis and pharyngeal granuloma in smelt. This area is less heavily polluted and less frequently affected by oxygen deficiency than the area upstream of Glückstadt, where diseases in general occurred at lower frequencies. Therefore, it is concluded that neither pollution nor lack of oxygen are the main triggers for the outbreak of diseases in Elbe fish. It is supposed that large tidal fluctuations of salinity are a major stress factor for fish in the estuary between Cuxhaven and Brunsbüttel. Flounder from this area usually are in a relatively bad nutritional state. Their condition factor increases significantly towards Hamburg, while their disease prevalence decreases in the same direction.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01989319

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Digitale Medien

Pseudopituitary dwarfism due to resistance to somatomedin: A new syndrome (1984)

Bierich, J. R. ; Moeller, H. ; Ranke, M. B. ; [weitere]

Springer

European journal of pediatrics 142 (1984), S. 186-188

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ISSN: 1432-1076

Schlagwort(e): Pituitary dwarfism ; Pseudopituitary dwarfism ; Growth hormone ; Somatomedin ; Receptor defects

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The case of an infant is described who at birth was already small and postnatally grew extremely slowly. At age 3 the girl's height was 65 cm, weight 5.6 kg, bone age 21 months. Basal plasma GH was 36–66 ng/ml, basal SM activity was rather high, being around 2.0 U/ml. RIA- and RRA-SM were also increased. Prolonged GH administration did not raise plasma SM. There was a tendency for hypoglycemic episodes in the presence of low insulin levels. Receptor studies with skin fibroblasts showed a diminution of the specific binding of SM-C by 50%. Apparently only the specific IGF-receptor is defective whereas the insulin receptor responds to the increased SM with hypoglycemia. The observation that the high plasma SM did not suppress the enhanced GH-secretion suggests that perhaps the hypothalamic IGF-receptor was also defective.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00442446

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Digitale Medien

Lack of clinically important interaction between erythromycin and theophylline (1984)

Hildebrandt, R. ; Gundert-Remy, U. ; Möller, H. ; [weitere]

Springer

European journal of clinical pharmacology 26 (1984), S. 485-489

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ISSN: 1432-1041

Schlagwort(e): theophylline ; erythromycin ; interaction ; metabolism ; pharmacokinetics

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary In 11 healthy volunteers the kinetics of theophylline and the plasma levels and the urinary excretion of its metabolites were studied before and after treatment with erythromycin for 10 days. Theophylline was administered as an intravenous bolus injection (280 mg) followed by a constant intravenous infusion (23.8±4.1 mg/h) for 6 hours. The total clearance of theophylline at steady-state (63.4±9.9 vs 63.8±14.4 ml/min, before vs after erythromycin treatment) and the elimination half-life after cessation of the infusion (6.7±2.6 vs 7.5±1.8 h, before vs after treatment) did not change during the treatment with erythromycin. No difference in the formation of metabolites before and after treatment with erythromycin was detected; the findings in urine were 40.4±5.0 vs 42.1±5.4% 1,3-dimethyluric acid, 29.6±4.6 vs 30.1±5.9% 1-methyluric acid and 13.4±3.5 vs 12.5±2.2% 3-methylxanthine before and after erythromycin treatment, respectively. It is concluded that a clinically relevant interaction between erythromycin and theophylline does not occur.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00542146

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Digitale Medien

Strauss-Carpenter-Skala: Überprüfung ihres prognostischen wertes für das 5-jahres-„outcome” schizophrener patienten (1984)

Möller, H. J. ; Scharl, W. ; Zerssen, D.

Springer

European archives of psychiatry and clinical neuroscience 234 (1984), S. 112-117

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ISSN: 1433-8491

Schlagwort(e): Prognostic of schizophrenic diseases ; prognostic scale of Strauss and Carpenter ; Prognostik schizophrener Erkrankungen ; Prognose-Skala von Strauss und Carpenter

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Beschreibung / Inhaltsverzeichnis: Zusammenfassung Da die Prognostik schizophrener Erkrankungen auf der Basis von Einzelmerkmalen insuffizient ist, bietet sich die Zusammenfassung von prognostisch relevanten Merkmalen zu Prognose-Skalen als Verfahren an, die prognostischen Möglichkeiten zu verbessern. Die Skala von Strauss und Carpenter, über deren prädictive Validität im angloamerikanischen Schrifttum berichtet wurde, wurde im Rahmen einer Fünf-Jahres-Katamnese an Patienten mit schizophrenen und verwandten endogenen Psychosen hinsichtlich ihrer prognostischen Bedeutung überprüft. Dabei zeigte sich eine enge Korrelation des Summenscores zu allen „outcome”-Kriterien. Obwohl viele Einzelmerkmale eine hohe prognostische Relevanz erreichten, war der Summenscore überlegen.

Notizen: Summary An adequate prognosis of schizophrenic psychoses cannot be made on the basis of single variables. Therefore prognostic scales combining prognostically relevant items should be tried. The prognostic value of the scale of Strauss and Carpenter, the predictive accuracy of which has been described in the Anglo-American literature, was tested in a 5-year follow-up study on patients with schizophrenic or similar psychoses. A high correlation was found between the total score and all outcome criteria. Although many single items reached a high prognostic relevance, the total score of the scale was superior.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00381217

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Digitale Medien

Einschneidende lebensereignisse im vorfeld von akuten psychischen erkrankungen (1984)

Möller, H. J. ; Grießhammer, C. ; Hacker, H.

Springer

European archives of psychiatry and clinical neuroscience 234 (1984), S. 118-124

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ISSN: 1433-8491

Schlagwort(e): Life-events ; Neurosis ; Schizophrenia ; Depression ; Stress ; Lebensereignisse ; Neurosen ; Schizophrenie ; Depression ; Stress

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Beschreibung / Inhaltsverzeichnis: Zusammenfassung An einer Stichprobe von 112 psychisch kranken Patienten wurde im Vergleich mit 70 körperlich Kranken analysiert, wie hdufig psychische Erkrankungen im Zusammenhang mit belastenden Lebensereignissen stehen. Es zeigten sich erhebliche Unterschiede der Life-event-Belastung zwischen den psychisch Kranken and der Kontrollgruppe sowie zwischen den einzelnen diagnostischen Gruppen. Die Life-event-Belastung war am ausgeprdgtesten bei den neurotisch Kranken. Auch bei den endogenen Psychosen, insbesondere bei den Schizophrenien, fand sich eine vermehrte Life-event-Belastung. Verschiedene Methoden (objektive Belastungswerte nach Paykel, vom Patienten angegebene Negativscores, Synthese aus objektiven and subjektiven Bewertungen) führten bei den Gruppenvergleichen zu vergleichbaren Resultaten. Vom Patienten als positiv bewertete Life-events standen nicht in Zusammenhang mit psychischen Erkrankungen.

Notizen: Summary A sample of 112 psychiatric inpatients were examined in comparison to 70 somatic inpatients with respect to the question, how frequent psychiatric diseases were in correlation with stressful life-events. There were significant discrepancies concerning life-event stress between the diagnostic subgroups. The life-event stress was most important in the neurotic patients, also patients suffering from endogenous psychoses, especially schizophrenics, showed an increased life-event stress. Different methods (objective stress scores suggested by Paykel, self-rating scores concerning negative experiences, and a synthesis between these two methods) led to similar results. Experiences, rated positive by the patients, showed no correlation with psychiatric diseases.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00381218

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