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  • 1
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    East–west contrast of Northeast Asian summer precipitation during the Holocene (2018)
    Elsevier
    In:  Global and Planetary Change, 170 . pp. 190-200.
    Details
    Publication Date: 2021-02-08
    Description: Highlights: • We compare proxy moisture records in Northeast Asia with the results from a transient simulation. • An east–west antiphasing of summer precipitation in Northeast Asia during the Holocene is found. • The East Asian summer monsoon circulation and mid-latitude westerlies caused the zonal precipitation contrast. Abstract: The East Asian summer monsoon (EASM) is a complex system that brings precipitation to East Asia showing considerable spatiotemporal variations. This study explored the zonal differences of summer precipitation in Northeast Asia at orbital timescales during the Holocene by comparing proxy records with simulation results. At orbital timescales, there was generally an east–west antiphasing of summer precipitation in Northeast Asia during the Holocene. Model–proxy comparison revealed that the driest interval occurred during the late Holocene in western Northeast Asia and during the early to middle Holocene in eastern Northeast Asia. Changes of summer precipitation in western Northeast Asia were mainly influenced by precession-driven EASM circulation. On the one hand, a weaker EASM circulation during the late Holocene weakened water vapor transport from the North Pacific Ocean to Northeast Asia, and on the other hand it was associated with anomalous downward motions in western Northeast Asia. Both factors were in favor of a reduction of summer precipitation in western Northeast Asia during the late Holocene. In contrast, anomalous downward motions prevailed in eastern Northeast Asia during the early to middle Holocene, which were probably related to stronger western Pacific subtropical high and weaker westerlies. The effect of the anomalous downward motions overwhelmed the enhanced water vapor transport, leading to a dry climate in this area from the early to middle Holocene. This study suggests that special care should be taken when discussing the meridional shift of the Holocene climatic optimum in the EASM region due to the zonal precipitation contrast.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1016/j.gloplacha.2018.08.018
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 2
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    Detecting the relationship between moisture changes in arid central Asia and East Asia during the Holocene by model-proxy comparison (2017)
    Elsevier
    In:  Quaternary Science Reviews, 176 . pp. 36-50.
    Details
    Publication Date: 2020-02-06
    Description: Identifying the relationships between moisture changes in arid central Asia and those in East Asia may help us understand the interplay between the westerlies and the Asian summer monsoon. We combined proxy moisture records with the results from a transient simulation forced by changes in orbital parameters to analyse their relationships during the Holocene (9.5–0 ka BP). The proxy records and simulation results generally agree with a relatively dry early Holocene, the wettest period in the middle Holocene, and a dry late Holocene in East Asia. These periods were not solely controlled by precession-driven East Asian summer monsoon variability, but were significantly influenced by precipitation during the other seasons and by evaporation. However, different proxy records show contrasting results for moisture changes in arid central Asia during the Holocene. To study this, we analysed the climatic signals of the competing proxy records by comparing these proxy records with simulation results. We found that speleothem δ18O was significantly influenced by water vapour sources and evaporation rather than by the amount of precipitation. Thus, the model data reveals a persistent wetting trend throughout the Holocene that was out-of-phase with the trend in East Asia. The wetting trend in arid central Asia was caused by precipitation that increased faster than evaporation during the Holocene. The enhanced water vapour input from South Asia and the Middle East was the main cause of the increase in precipitation in arid central Asia, which in turn gave rise to the intensification of evaporation.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
    Format: text
    DOI: 10.1016/j.quascirev.2017.09.012
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 3
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    Asynchronous variation in the East Asian winter monsoon during the Holocene (2015)
    AGU (American Geophysical Union) | Wiley
    In:  Journal of Geophysical Research - Atmospheres, 120 (11). pp. 5357-5370.
    Details
    Publication Date: 2016-12-05
    Description: The East Asian winter monsoon (EAWM) is one of the most active components of the global climate system. Climate anomalies associated with the EAWM differ between extratropical and tropical regions due to the EAWM's meridional extent. Spatial differences in the EAWM variability on centennial and millennial time scales during the Holocene have not been well understood. This study describes Holocene spatiotemporal features of the EAWM based on comparisons of proxy records and climate simulations. The analysis specifically compared four proxy records located throughout China to assess the EAWM's spatial variability during the Holocene. These records indicate a stronger EAWM during the early Holocene than that during the late Holocene. The EAWM also shows a rapid, asynchronous decline from northwestern to southeastern China. The EAWM declined in northwestern China from 10 to 7.5 ka B.P., whereas the decline did not occur in southern China and the eastern Tibetan Plateau until 6–4.5 ka B.P. Coupled equilibrium and transient simulations of climate evolution during the Holocene indicate that the decline of the EAWM from 10 to 7.5 ka B.P. was probably caused by melting of Northern Hemisphere (NH) ice sheets and enhanced Atlantic meridional overturning circulation (AMOC). The decline of the EAWM from 6 to 4.5 ka B.P. over the eastern Tibetan Plateau and southern China is related to an abrupt increase in sea surface temperatures (SSTs) of the tropical western Indian Ocean. We therefore argue that the regional shift in EAWM intensity was probably related to a distinguishing response to high-latitude (NH ice sheets and AMOC) and low-latitude (tropical SSTs) forcings.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1002/2014JD022585
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 4
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    Multifunctional glucose biosensors from Fe3O4 nanoparticles modified chitosan/graphene nanocomposites (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-06-09
    Description: Novel water-dispersible and biocompatible chitosan-functionalized graphene (CG) has been prepared by a one-step ball milling of carboxylic chitosan and graphite. Presence of nitrogen (from chitosan) at the surface of graphene enables the CG to be an outstanding catalyst for the electrochemical biosensors. The resulting CG shows lower ID/IG ratio in the Raman spectrum than other nitrogen-containing graphene prepared using different techniques. Magnetic Fe3O4 nanoparticles (MNP) are further introduced into the as-synthesized CG for multifunctional applications beyond biosensors such as magnetic resonance imaging (MRI). Carboxyl groups from CG is used to directly immobilize glucose oxidase (GOx) via covalent linkage while incorporation of MNP further facilitated enzyme loading and other unique properties. The resulting biosensor exhibits a good glucose detection response with a detection limit of 16 μM, a sensitivity of 5.658 mA/cm2/M, and a linear detection range up to 26 mM glucose. Formation of the multifunctional MNP/CG nanocomposites provides additional advantages for applications in more clinical areas such as in vivo biosensors and MRI agents. Scientific Reports 5 doi: 10.1038/srep11129
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 5
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    MicroRNA-378-5p suppresses cell proliferation and induces apoptosis in colorectal cancer cells by targeting BRAF (2015)
    BioMed Central
    Details
    Publication Date: 2015-04-18
    Description: MicroRNAs (miRNAs) are a group of small non-coding RNA molecules that potentially play a critical role in tumorigenesis. Increasing evidences indicate that miR-378-5p is dysregulated in numerous human cancers including colorectal cancer (CRC) which hypothesizes that miR-378-5p may play an important role in tumorigenesis. However, its role in CRC carcinogenesis remains poorly defined because of lacking target genes information. In the present study, it was demonstrated that the expression of miR-378-5p was down-regulated in CRC tissues and cell lines as determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Furthermore, overexpression of miR-378-5p suppressed cell proliferation, as indicated by CCK-8 assay. Flow cytometric analysis demonstrated that overexpression of miR-378-5p induced cell cycle arrest and promoted apoptosis in CRC cells. A luciferase reporter assay indicated that BRAF was a direct target of miR-378-5p. Western blot and qRT-PCR analysis indicated that BRAF was significantly down-regulated by miR-378-5p in CRC cells. Moreover, miR-378-5p was negatively associated with BRAF in CRC tissues compared to adjacent non-tumor tissues. These results demonstrate that down-regulation of miR-378-5p promotes CRC cells growth by targeting BRAF and restoration of their levels is a potentially promising therapeutic in CRC.
    Electronic ISSN: 1475-2867
    Topics: Medicine
    Published by BioMed Central
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  • 6
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    Raf kinase inhibitor protein negatively regulates FcϵRI-mediated mast cell activation and allergic response [Immunology and Inflammation] (2018)
    National Academy of Sciences
    Details
    Publication Date: 2018-10-17
    Description: The signaling cascades triggered by the cross-linkage of immunoglobulin E (IgE) with its high-affinity receptor (FcεRI) on mast cells contribute to multiple allergic disorders, such as asthma, rhinitis, and atopic dermatitis. Restraint of intracellular signals for mast cell activation is essential to restore homeostasis. In this study, we found that...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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