In:
European Respiratory Journal, European Respiratory Society (ERS), Vol. 51, No. 1 ( 2018-01), p. 1700397-
Abstract:
Acute exacerbations and worsening of idiopathic pulmonary fibrosis (IPF) have been associated with exposure to ozone (O 3 ), nitrogen dioxide (NO 2 ) and particulate matter, but chronic exposure to air pollution might also affect the incidence of IPF. We investigated the association between chronic exposure to NO 2 , O 3 and particulate matter with an aerodynamic diameter 〈 10 μm (PM 10 ) and IPF incidence in Northern Italy between 2005 and 2010. Daily predictions of PM 10 concentrations were obtained from spatiotemporal models, and NO 2 and O 3 hourly concentrations from fixed monitoring stations. We identified areas with homogenous exposure to each pollutant. We built negative binomial models to assess the association between area-specific IPF incidence rate, estimated through administrative databases, and average overall and seasonal PM 10 , NO 2 , and 8-hour maximum O 3 concentrations. Using unadjusted models, an increment of 10 µg·m −3 in NO 2 concentration was associated with an increase between 7.93% (95% CI 0.36–16.08%) and 8.41% (95% CI −0.23–17.80%) in IPF incidence rate, depending on the season. After adjustment for potential confounders, estimated effects were similar in magnitude, but with larger confidence intervals. Although confirmatory studies are needed, our results trace a potential association between exposure to traffic pollution and the development of IPF.
Type of Medium:
Online Resource
ISSN:
0903-1936
,
1399-3003
DOI:
10.1183/13993003.00397-2017
DOI:
10.1183/13993003.00397-2017.Supp1
DOI:
10.1183/13993003.00397-2017.Supp2
Language:
English
Publisher:
European Respiratory Society (ERS)
Publication Date:
2018
detail.hit.zdb_id:
2834928-3
detail.hit.zdb_id:
1499101-9
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