In:
Learning & Memory, Cold Spring Harbor Laboratory, Vol. 17, No. 1 ( 2010-01), p. 18-22
Abstract:
Cannabinoid CB1 receptor is abundantly expressed throughout the CNS and is implicated in numerous physiological and behavioral functions, including appetite and feeding. In the present study, wild-type and CB1 heterozygous and homozygous knockout mice were tested on an instrumental outcome-selective devaluation task to assess changes in acquired instrumental response levels for a distinct food reward following selective satiation. Deletion of CB1 receptor, as well as reduction in CB1 expression (HET), produced deficits in outcome-selective instrumental devaluation. These results identify a critical role for CB1 receptor in the ability of animals to represent, update, and/or use sensory-specific outcome representations to alter appetitive behaviors.
Type of Medium:
Online Resource
ISSN:
1072-0502
,
1549-5485
Language:
English
Publisher:
Cold Spring Harbor Laboratory
Publication Date:
2010
detail.hit.zdb_id:
2022057-1
SSG:
12
SSG:
5,2
Permalink