Note: Cover -- DNA Repair and Replication -- Copyright Page -- CONTENTS -- PREFACE -- Chapter 1. Base Excision Repair -- I. Introduction -- II. Types of Damage Repaired by BER -- III. DNA Glycosylases -- IV. Downstream BER Enzymes -- V. Mammalian BER -- VI. Roles of BER Enzymes in Other Processes -- References -- Chapter 2. Nucleotide Excision Repair in E. Coli and Man -- I. Introduction -- II. Damage Recognition -- III. Mechanism of Excision Repair -- IV. Transcription-Coupled Repair -- V. Repair of Chromatin -- VI. Conclusion -- References -- Chapter 3. Photolyase and Cryptochrome Blue-Light Photoreceptors -- I. Introduction -- II. Phylogenetics -- III. Structure of Photolyase -- IV. Reaction Mechanism of Photolyase -- V. (6-4) Photolyase -- VI. Cryptochrome -- VII. Conclusion -- References -- Chapter 4. Coordination of Repair, Checkpoint, and Cell Death Responses to DNA Damage -- I. Introduction -- II. Overview of Biological Responses to DNA Damage -- III. Molecular Components for the Initiation of DNA Damage Responses -- IV. Apoptotic Effectors in DNA Damage Response -- V. DNA Repair Proteins in Damage Signaling -- VI. Alternative Models for the Temporal Coordination of DNA Damage Responses -- VII. Future Prospects -- References -- Chapter 5. Functions of DNA Polymerases -- I. DNA Polymerase Families -- II. Structures and Compositions of DNA Polymerases -- III. Functions of DNA Polymerases -- IV. Polymerases for DNA Repair -- V. Polymerases for Replicating Undamaged DNA -- VI. Polymerases for Sister Chromatid Cohesion -- VII. Mitochondrial DNA Replication. -- VIII. Polymerases for Replicating Damaged DNA. -- IX. Polymerases and Cell-Cycle Checkpoints -- X. Polymerases for Replication Restart and Homologous Recombination -- XI. Polymerases for DNA Mismatch Repair -- XII. Polymerases in the Development of the Immune System. , XIII. Biological Consequences of Polymerase Dysfunction -- XIV. Closing Comments -- References -- Chapter 6. Cellular Functions of DNA Polymerase and Rev1 Protein -- I. Introduction -- II. Enzymological Studies With Polζ and Rev1p -- III. Genetic Analysis -- IV. Processes Other than General Translesion Replication that Employ Pol and Rev1p -- V. Regulation of Polζ and Rev1p and Interactions with other Proteins -- VI. Conclusions and Speculations -- References -- Chapter 7. DNA Polymerasesη and ι -- I. Historical Perspective -- II. Identification of RAD30 and its Orthologs -- III. Biochemical Properties of Polη and Polι -- IV. Translesion Synthesis by Polη and Polι -- V. Structure of the Catalytic Core of S. cerevisiae Polη -- VI. Regulation and Localization of Polη and Polι -- VII. Mutations in Polcη in XP Variants -- VIII. Polsη and ι and the Polymerase Switch: Interactions with PCNA and Rev1 -- IX. Protection from Cellular Effects of DNA Damage -- X. Roles of Polη and Polι in Somatic Hypermutation -- References -- Chapter 8. Properties and Functions of Escherichia Coli : Pol IV and Pol V -- I. DNA Pol IV, the dinB Gene Product -- II. DNA Polymerase V, the umuDC Gene Product -- References -- Chapter 9. Mammalian Pol κ: Regulation of Its Expression and Lesion Substrates -- I. Structures of the Genes and Proteins -- II. Enzymatic Properties of Polκ -- III. Possible Mechanisms of TLS by Polκ In Vivo -- References -- Chapter 10. DNA Postreplication Repair Modulated by Ubiquitination and Sumoylation -- I. Introduction -- II. DNA Postreplication Repair Prokaryotes -- III. DNA Postreplication Repair in Eukaryotes -- IV. Ubiquitination -- V. Protein Conjugation in PRR -- VI. Postreplication Repair via Covalent Modifications of PCNA -- VII. Functional Conservation of Eukaryotic Postreplication Repair -- VIII. Future Directions -- IX. Conclusions. , References -- Chapter 11. Somatic Hypermutation: A Mutational Panacea -- I. Generation of Antibody Diversity -- II. Somatic Hypermutation -- III. Apobec Protein Family -- IV. Biochemical Perspective -- References -- Author Index -- Subject Index.