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  • 1
    Online Resource
    Online Resource
    Neural Regulation of Metabolism (2018)
    Singapore : Springer Singapore
    Details Availability
    Keywords: Cytology ; Cytology ; Neurosciences ; Human physiology ; Biochemistry ; Human physiology ; Biochemistry ; Neurosciences ; Cell biology. ; Metabolism physiology ; Nervous System Physiological Phenomena ; Metabolic Diseases physiopathology ; Electrophysiological Phenomena physiology ; Signal Transduction physiology
    Description / Table of Contents: This book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically. The book first introduces the latest studies on the neural and cellular mechanisms of hypothalamic neurons, hypothalamic glial cells, neural circuitries, cellular signaling pathways, and synaptic plasticity in the control of appetite, body weight, feeding-related behaviors and metabolic disorders. It then summarizes the humoral mechanisms by which critical adipocyte-derived hormones and lipoprotein lipase regulate lipid and glucose metabolism, and examines the role of the hypothalamus-sympathetic nerve, a critical nerve pathway from CNS to peripheral nervous system (PNS), in the regulation of metabolism in multiple tissues/organs. Furthermore, the book discusses the functions of adipose tissue in energy metabolism. Lastly, it explores dietary interventions to treat neural diseases and some of the emerging technologies used to study the neural regulation of metabolism. Presenting cutting-edge developments in the neural regulation of metabolism, the book is a valuable reference resource for graduate students and researchers in the field of neuroscience and metabolism
    Type of Medium: Online Resource
    Pages: Online-Ressource (XI, 233 p. 30 illus., 21 illus. in color, online resource)
    ISBN: 9789811312861
    Series Statement: Advances in Experimental Medicine and Biology 1090
    URL: https://doi.org/10.1007/978-981-13-1286-1
    URL: http://dx.doi.org/10.1007/978-981-13-1286-1
    URL: https://swbplus.bsz-bw.de/bsz104027918xcov.jpg
    DOI: 10.1007/978-981-13-1286-1
    Language: English
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  • 2
    Online Resource
    Online Resource
    Self As Method : Thinking Through China and the World (2022)
    Singapore : Palgrave Macmillan US
    Details Availability
    Keywords: Electronic books
    Type of Medium: Online Resource
    Pages: 1 online resource (262 pages)
    ISBN: 9789811949531
    URL: https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=7102613
    Language: English
    Note: Description based on publisher supplied metadata and other sources
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  • 3
    Electronic Resource
    Electronic Resource
    Birefringent thin-film polarizers for use at normal incidence and with planar technologies (1999)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 74 (1999), S. 1794-1796 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We discuss the design and fabrication of an all-dielectric thin-film polarizer that is compatible with existing planar technologies. This polarizer consists of a stack of quarter-wave biaxial layers. Each quarter-wave layer is formed by reactive electron-beam evaporation, using a bideposition technique that causes a columnar structure to grow perpendicular to the substrate, produces large normal-incidence linear birefringence, and avoids thickness wedging that is inherent in tilted-columnar biaxial layers. p-polarized light that is incident on the polarizer encounters an index-matched stack and is transmitted, whereas s-polarized light is rejected by a coexisting high-reflectance stack. A fabrication figure-of-merit of ten film periods per decade in the extinction ratio has been achieved in practice for a titanium oxide/tantalum oxide polarizer. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.123088
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  • 4
    Electronic Resource
    Electronic Resource
    SIGNALING AND FUNCTION OF INSULIN-LIKE PEPTIDES IN INSECTS (2006)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Entomology 51 (2006), S. 1-24 
    Details
    ISSN: 0066-4170
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Insulin-like peptides (ILPs) exist in insects and are encoded by multigene families that are expressed in the brain and other tissues. Upon secretion, these peptides likely serve as hormones, neurotransmitters, and growth factors, but to date, few direct functions have been demonstrated. In Drosophila melanogaster, molecular genetic studies have revealed elements of a conserved insulin signaling pathway, and as in other animal models, it appears to play a key role in metabolism, growth, reproduction, and aging. This review offers (a) an integrated summary of the efforts to characterize the distribution of ILPs in insects and to define this pathway and its functions in Drosophila and (b) a few considerations for future studies of ILP endocrinology in insects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ento.51.110104.151011
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  • 5
    Electronic Resource
    Electronic Resource
    The enigmatic role of glutamyl aminopeptidase (BP-1/6C3 antigen) in immune system development (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 161 (1998), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: The murine B-lymphocyte differentiation antigen BP-1 /6C3, a homodimeric integral membrane protein composed of M, 140,000 sub-units, has been identified as glutamyl aminopeptidase (EAR EC 3,4. 11.7). This ecto-enzyme cleaves acidic amino acid residues from the amino terminal of polypeptide substrates such as angiotensin II and cholecystoki-nin-8. Although BP-1/6C3/EAP is expressed by cells in many tissues, among hematopoietic cell lineages this ecto-enzyme is restricted to immature B-lineage cells where its expression is upregulated by interleukin-7 and viral transformation, BP-1/6C3/EAP thus serves as a valuable marker of progression along the B-cell differentiation pathway, but a corresponding biological role has not yet been established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-065X.1998.tb01572.x
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  • 6
    Electronic Resource
    Electronic Resource
    Ryanodine-sensitive, thapsigargin-insensitive calcium uptake in rat ventricle homogenates (1998)
    Springer
    Molecular and cellular biochemistry 189 (1998), S. 9-17 
    Details
    ISSN: 1573-4919
    Keywords: sarcoplasmic reticulum ; calcium uptake ; ryanodine ; thapsigargin ; cyclopiazonic acid ; heart
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Thapsigargin is a natural product that specifically inhibits all known SERCA calcium pumps with high affinity. We investigated the effects of thapsigargin on cardiac sarcoplasmic reticulum (SR) by measuring the oxalate-supported calcium uptake rate in the unfractionated homogenate and in the isolated SR fraction. The uptake rate in both the isolated SR and unfractionated homogenate are stimulated about two-fold by preincubation with high concentrations of ryanodine, which closes the SR efflux channel. Thapsigargin stoichiometrically and completely inhibited the calcium uptake rate in the isolated SR, both in the presence and absence of SR channel blockade. In contrast, thapsigargin nearly completely inhibited the homogenate calcium uptake only in the absence of SR channel blockade; in the presence of blockade, about 20% of the uptake activity was insensitive to thapsigargin. This result unmasks a thapsigargin-insensitive, ryanodine-sensitive component of calcium uptake in the heart. This activity is in an oxalate-permeable pool and is inhibited by cyclopiazonic acid, another inhibitor of the SERCA calcium pumps. There was no TG-insensitive activity in the rat EDL muscle homogenate. The absence of thapsigargin-insensitive uptake activity in the isolated SR can be attributed to its inactivation during the isolation of the SR. The oxalate permeability and ryanodine sensitivity suggest that the TG-insensitive calcium uptake activity is closely related to the classical SR. The different thapsigargin sensitivities suggests the existence of two kinds of intracellular calcium pumps in the heart.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006800328118
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  • 7
    Electronic Resource
    Electronic Resource
    New methods of determining the strange attractor by generalized cell mapping approach (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Communications in Applied Numerical Methods 4 (1988), S. 541-548 
    Details
    ISSN: 0748-8025
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The generalized cell mapping method used in solving non-linear dynamical systems is also a powerful means of determining the state volume in which strange attractors reside. Several methods of refining the size of cells are proposed in this paper. With the aid of these methods it is possible to describe the shape of a strange attractor in however much detail is required. Any part of the cell state space can be enlarged by the suggested zoom technique when the finte structure of this strange attractor is going to be studied. By using the limiting probability distribution calculated from the persistent group, the statistical meaning of the attractor is revealed. Results of examples which were computed on an IBM PC computer show the validity and efficiency of the methods.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cnm.1630040411
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  • 8
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    Analyses of the mitochondrial mutations in the Chinese patients with sporadic Creutzfeldt–Jakob disease (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-03-27
    Description: Analyses of the mitochondrial mutations in the Chinese patients with sporadic Creutzfeldt–Jakob disease European Journal of Human Genetics advance online publication, March 26 2014. doi:10.1038/ejhg.2014.52 Authors: Jin Zhang, Zhi-Xia Zhang, Peng-Chen Du, Wei Zhou, Su-Dong Wu, Qi-Ling Wang, Cao Chen, Qi Shi, Chen Chen, Chen Gao, Chan Tian & Xiao-Ping Dong
    Print ISSN: 1018-4813
    Electronic ISSN: 1476-5438
    Topics: Biology , Medicine
    Published by Nature Publishing Group (NPG)
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  • 9
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    Identification of candidate genes for drought tolerance by whole-genome resequencing in maize (2014)
    BioMed Central
    Details
    Publication Date: 2014-04-02
    Description: Background: Drought stress is one of the major limiting factors for maize production. With the availability of maize B73 reference genome and whole-genome resequencing of 15 maize inbreds, common variants (CV) and clustering analyses were applied to identify non-synonymous SNPs (nsSNPs) and corresponding candidate genes for drought tolerance. Results: A total of 524 nsSNPs that were associated with 271 candidate genes involved in plant hormone regulation, carbohydrate and sugar metabolism, signaling molecules regulation, redox reaction and acclimation of photosynthesis to environment were detected by CV and cluster analyses. Most of the nsSNPs identified were clustered in bin 1.07 region that harbored six previously reported QTL with relatively high phenotypic variation explained for drought tolerance. Genes Ontology (GO) analysis of candidate genes revealed that there were 35 GO terms related to biotic stimulus and membrane-bounded organelle, showing significant differences between the candidate genes and the reference B73 background. Changes of expression level in these candidate genes for drought tolerance were detected using RNA sequencing for fertilized ovary, basal leaf meristem tissue and roots collected under drought stressed and well-watered conditions. The results indicated that 70% of candidate genes showed significantly expression changes under two water treatments and our strategies for mining candidate genes are feasible and relatively efficient. Conclusions: Our results successfully revealed candidate nsSNPs and associated genes for drought tolerance by comparative sequence analysis of 16 maize inbred lines. Both methods we applied were proved to be efficient for identifying candidate genes for complex traits through the next-generation sequencing technologies (NGS). These selected genes will not only facilitate understanding of genetic basis of drought stress response, but also accelerate genetic improvement through marker-assisted selection in maize.
    Electronic ISSN: 1471-2229
    Topics: Biology
    Published by BioMed Central
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  • 10
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    Tensorial Kernel Principal Component Analysis for Action Recognition (2013)
    Hindawi
    Details
    Publication Date: 2013-11-20
    Description: We propose the Tensorial Kernel Principal Component Analysis (TKPCA) for dimensionality reduction and feature extraction from tensor objects, which extends the conventional Principal Component Analysis (PCA) in two perspectives: working directly with multidimensional data (tensors) in their native state and generalizing an existing linear technique to its nonlinear version by applying the kernel trick. Our method aims to remedy the shortcomings of multilinear subspace learning (tensorial PCA) developed recently in modelling the nonlinear manifold of tensor objects and brings together the desirable properties of kernel methods and tensor decompositions for significant performance gain when the data are multidimensional and nonlinear dependencies do exist. Our approach begins by formulating TKPCA as an optimization problem. Then, we develop a kernel function based on Grassmann Manifold that can directly take tensorial representation as parameters instead of traditional vectorized representation. Furthermore, a TKPCA-based tensor object recognition is also proposed for application of the action recognition. Experiments with real action datasets show that the proposed method is insensitive to both noise and occlusion and performs well compared with state-of-the-art algorithms.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
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