GLORIA

GEOMAR Library Ocean Research Information Access

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    In: Journal of Bone and Joint Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 93, No. 14 ( 2011-7-20), p. 1355-1357
    Type of Medium: Online Resource
    ISSN: 0021-9355 , 1535-1386
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2011
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    In: Journal of Virology, American Society for Microbiology, Vol. 83, No. 6 ( 2009-03-15), p. 2563-2574
    Abstract: Human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma and primary effusion lymphoma. Activation of the cellular transcription factor nuclear factor-kappa B (NF-κB) is essential for latent persistence of HHV-8, survival of HHV-8-infected cells, and disease progression. We used reverse-transfected cell microarrays (RTCM) as an unbiased systems biology approach to systematically analyze the effects of HHV-8 genes on the NF-κB signaling pathway. All HHV-8 genes individually ( n = 86) and, additionally, all K and latent genes in pairwise combinations ( n = 231) were investigated. Statistical analyses of more than 14,000 transfections identified ORF75 as a novel and confirmed K13 as a known HHV-8 activator of NF-κB. K13 and ORF75 showed cooperative NF-κB activation. Small interfering RNA-mediated knockdown of ORF75 expression demonstrated that this gene contributes significantly to NF-κB activation in HHV-8-infected cells. Furthermore, our approach confirmed K10.5 as an NF-κB inhibitor and newly identified K1 as an inhibitor of both K13- and ORF75-mediated NF-κB activation. All results obtained with RTCM were confirmed with classical transfection experiments. Our work describes the first successful application of RTCM for the systematic analysis of pathofunctions of genes of an infectious agent. With this approach, ORF75 and K1 were identified as novel HHV-8 regulatory molecules on the NF-κB signal transduction pathway. The genes identified may be involved in fine-tuning of the balance between latency and lytic replication, since this depends critically on the state of NF-κB activity.
    Type of Medium: Online Resource
    ISSN: 0022-538X , 1098-5514
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2009
    detail.hit.zdb_id: 1495529-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Online Resource
    Online Resource
    Association for Computing Machinery (ACM) ; 2018
    In:  Proceedings of the ACM on Programming Languages Vol. 2, No. POPL ( 2018-01), p. 1-31
    In: Proceedings of the ACM on Programming Languages, Association for Computing Machinery (ACM), Vol. 2, No. POPL ( 2018-01), p. 1-31
    Abstract: Concurrent separation logics have helped to significantly simplify correctness proofs for concurrent data structures. However, a recurring problem in such proofs is that data structure abstractions that work well in the sequential setting are much harder to reason about in a concurrent setting due to complex sharing and overlays. To solve this problem, we propose a novel approach to abstracting regions in the heap by encoding the data structure invariant into a local condition on each individual node. This condition may depend on a quantity associated with the node that is computed as a fixpoint over the entire heap graph. We refer to this quantity as a flow . Flows can encode both structural properties of the heap (e.g. the reachable nodes from the root form a tree) as well as data invariants (e.g. sortedness). We then introduce the notion of a flow interface , which expresses the relies and guarantees that a heap region imposes on its context to maintain the local flow invariant with respect to the global heap. Our main technical result is that this notion leads to a new semantic model of separation logic. In this model, flow interfaces provide a general abstraction mechanism for describing complex data structures. This abstraction mechanism admits proof rules that generalize over a wide variety of data structures. To demonstrate the versatility of our approach, we show how to extend the logic RGSep with flow interfaces. We have used this new logic to prove linearizability and memory safety of nontrivial concurrent data structures. In particular, we obtain parametric linearizability proofs for concurrent dictionary algorithms that abstract from the details of the underlying data structure representation. These proofs cannot be easily expressed using the abstraction mechanisms provided by existing separation logics.
    Type of Medium: Online Resource
    ISSN: 2475-1421
    Language: English
    Publisher: Association for Computing Machinery (ACM)
    Publication Date: 2018
    detail.hit.zdb_id: 2924207-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2014
    In:  ATZ - Automobiltechnische Zeitschrift Vol. 116, No. 5 ( 2014-05), p. 62-67
    In: ATZ - Automobiltechnische Zeitschrift, Springer Science and Business Media LLC, Vol. 116, No. 5 ( 2014-05), p. 62-67
    Type of Medium: Online Resource
    ISSN: 0001-2785 , 2192-8800
    RVK:
    RVK:
    RVK:
    Language: German
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2014
    detail.hit.zdb_id: 124863-7
    detail.hit.zdb_id: 2097891-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2010
    In:  ATZ - Automobiltechnische Zeitschrift Vol. 112, No. 7-8 ( 2010-07), p. 516-523
    In: ATZ - Automobiltechnische Zeitschrift, Springer Science and Business Media LLC, Vol. 112, No. 7-8 ( 2010-07), p. 516-523
    Type of Medium: Online Resource
    ISSN: 0001-2785 , 2192-8800
    RVK:
    RVK:
    RVK:
    Language: German
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2010
    detail.hit.zdb_id: 124863-7
    detail.hit.zdb_id: 2097891-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2014
    In:  ATZ worldwide Vol. 116, No. 5 ( 2014-5), p. 46-51
    In: ATZ worldwide, Springer Science and Business Media LLC, Vol. 116, No. 5 ( 2014-5), p. 46-51
    Type of Medium: Online Resource
    ISSN: 2192-9076
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2014
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2021
    In:  Formal Methods in System Design Vol. 59, No. 1-3 ( 2021-12), p. 136-169
    In: Formal Methods in System Design, Springer Science and Business Media LLC, Vol. 59, No. 1-3 ( 2021-12), p. 136-169
    Abstract: We present algorithms and techniques for the repair of timed system models, given as networks of timed automata (NTA). The repair is based on an analysis of timed diagnostic traces (TDTs) that are computed by real-time model checking tools, such as UPPAAL, when they detect the violation of a timed safety property. We present an encoding of TDTs in linear real arithmetic and use the MaxSMT capabilities of the SMT solver Z3 to suggest a minimal number of possible syntactic repairs of the analyzed model. The suggested repairs include modified values for clock bounds in location invariants and transition guards, adding or removing clock resets, etc. We then present an admissibility criterion, called functional equivalence, which ensures that the proposed repair preserves the functional behavior of the considered NTA. We discuss a proof-of-concept tool called TarTar that we have developed, implementing the repair and admissibility analysis, and give insights into its design and architecture. We evaluate the proposed repair technique on faulty mutations generated from a diverse suite of case studies taken from the literature. We show that TarTar can admissibly repair for 69– $$88\%$$ 88 % of the seeded errors in the considered system models.
    Type of Medium: Online Resource
    ISSN: 0925-9856 , 1572-8102
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 1479899-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 8
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2021
    In:  Synthesis Lectures on Computer Science Vol. 9, No. 1 ( 2021-06-01), p. 1-188
    In: Synthesis Lectures on Computer Science, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2021-06-01), p. 1-188
    Type of Medium: Online Resource
    ISSN: 1932-1228 , 1932-1686
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 9
    Online Resource
    Online Resource
    Association for Computing Machinery (ACM) ; 2010
    In:  ACM SIGPLAN Notices Vol. 45, No. 1 ( 2010-01-02), p. 249-260
    In: ACM SIGPLAN Notices, Association for Computing Machinery (ACM), Vol. 45, No. 1 ( 2010-01-02), p. 249-260
    Abstract: The automated inference of quantified invariants is considered one of the next challenges in software verification. The question of the right precision-efficiency tradeoff for the corresponding program analyses here boils down to the question of the right treatment of disjunction below and above the universal quantifier. In the closely related setting of shape analysis one uses the focus operator in order to adapt the treatment of disjunction (and thus the efficiency-precision tradeoff) to the individual program statement. One promising research direction is to design parameterized versions of the focus operator which allow the user to fine-tune the focus operator not only to the individual program statements but also to the specific verification task. We carry this research direction one step further. We fine-tune the focus operator to each individual step of the analysis (for a specific verification task). This fine-tuning must be done automatically. Our idea is to use counterexamples for this purpose. We realize this idea in a tool that automatically infers quantified invariants for the verification of a variety of heap-manipulating programs.
    Type of Medium: Online Resource
    ISSN: 0362-1340 , 1558-1160
    Language: English
    Publisher: Association for Computing Machinery (ACM)
    Publication Date: 2010
    detail.hit.zdb_id: 2079194-X
    detail.hit.zdb_id: 282422-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 10
    Online Resource
    Online Resource
    Association for Computing Machinery (ACM) ; 2021
    In:  Proceedings of the ACM on Programming Languages Vol. 5, No. POPL ( 2021-01-04), p. 1-31
    In: Proceedings of the ACM on Programming Languages, Association for Computing Machinery (ACM), Vol. 5, No. POPL ( 2021-01-04), p. 1-31
    Abstract: Refinement types enable lightweight verification of functional programs. Algorithms for statically inferring refinement types typically work by reduction to solving systems of constrained Horn clauses extracted from typing derivations. An example is Liquid type inference, which solves the extracted constraints using predicate abstraction. However, the reduction to constraint solving in itself already signifies an abstraction of the program semantics that affects the precision of the overall static analysis. To better understand this issue, we study the type inference problem in its entirety through the lens of abstract interpretation. We propose a new refinement type system that is parametric with the choice of the abstract domain of type refinements as well as the degree to which it tracks context-sensitive control flow information. We then derive an accompanying parametric inference algorithm as an abstract interpretation of a novel data flow semantics of functional programs. We further show that the type system is sound and complete with respect to the constructed abstract semantics. Our theoretical development reveals the key abstraction steps inherent in refinement type inference algorithms. The trade-off between precision and efficiency of these abstraction steps is controlled by the parameters of the type system. Existing refinement type systems and their respective inference algorithms, such as Liquid types, are captured by concrete parameter instantiations. We have implemented our framework in a prototype tool and evaluated it for a range of new parameter instantiations (e.g., using octagons and polyhedra for expressing type refinements). The tool compares favorably against other existing tools. Our evaluation indicates that our approach can be used to systematically construct new refinement type inference algorithms that are both robust and precise.
    Type of Medium: Online Resource
    ISSN: 2475-1421
    Language: English
    Publisher: Association for Computing Machinery (ACM)
    Publication Date: 2021
    detail.hit.zdb_id: 2924207-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...