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  • 1
    Online Resource
    Online Resource
    New York :Nova Science Publishers, Incorporated,
    Keywords: Particle beams. ; Particle accelerators. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (366 pages)
    Edition: 1st ed.
    ISBN: 9781536142907
    Series Statement: Physics Research and Technology Series
    DDC: 539.73
    Language: English
    Note: Intro -- Contents -- List of Appendices -- Preface -- Chapter 1 -- Introduction -- 1.1. Background -- 1.2. Research Issues -- 1.3. Synopsis -- 1.4. Overview of SNS Accelerator Complex -- References -- Chapter 2 -- Fundamentals of Accelerator Magnets -- 2.1. Magnetostatic Fields -- 2.2. Two-Dimensional Fields -- 2.3. Particle Motion -- 2.4. Dipole Magnets -- 2.5. Quadrupole Magnets -- 2.6. Magnet Measurements -- References -- Appendix 2.1. A Command Input File for 2D Harmonic Calculations in the Patch Rotation Method -- Chapter 3 -- Magnet Modeling -- 3.1. Overview of Simulation Codes -- 3.2. Opera/Tosca -- 3.3. A Modeling Example -- References -- Chapter 4 -- Three-Dimensional Field Multipole Expansion -- 4.1. Review of Theory -- 4.2. Expansion Techniques -- 4.3. On-Axis Gradients -- 4.4. A 5th-Order Representation -- 4.5. Higher-Order Effects -- References -- Appendix 4.1. A Command Input File to Calculate the Surface Fields and to Perform Fourier Decomposition for the 3D Multipole Expansion in OPERA3D Post-Processor -- Chapter 5 -- Particle Optics in a Magnetic Quadrupole -- 5.1. Simulation Model of 30Q58 and Field Distributions -- 5.2. Particle Trajectories and Transfer Matrices -- 5.3. Three-Dimensional Mulipole Expansion and Linear Focusing Function -- 5.4. Form Factor Theory on Magnetic Fringe Fields -- 5.5. Linear Transfer Matrices from the Trajectory Equations -- 5.6. Lens Parameters and Hard Edge Models -- 5.7. Third-Order Aberrations -- 5.8. Particle Optics in 30Q44 -- References -- Appendix 5.1. Computation of Particle Optics of a Magnetic Quadrupole -- Chapter 6 -- Magnetic Interference between Two Magnets -- 6.1. Change in Linear Focusing Function -- 6.2. Magnetic Interference as a First-Order Perturbation -- 6.3. Hard Edge Models for a Perturbed Quad -- References -- Chapter 7 -- Particle Optics in a Quad Doublet Assembly. , 7.1. Two-Dimensional Field Parameters -- 7.2. Magnetic Fringe and Interference -- 7.3. Linear Transfer Matrices and Hard Edge Models -- 7.4. Third-Order Aberrations -- 7.5. Verification of Particle Trajectories -- References -- Chapter 8 -- Beam Matching in a Quadrupole Transport Channel -- 8.1. MEBT Line in SNS Linac -- 8.2. Fringe Effect in a Single MEBT Quad -- 8.3. Magnetic Interference between Two MEBT Quads -- 8.4. Error Propagation and Accumulation in MEBT Lattice -- 8.5. A General Solution to Beam Matching -- References -- Appendix 8.1. A Mathematica Notebook File to Compute Beam Matching in the SNS MEBT Lattice -- Chapter 9 -- Field Expansion in Magnetc Dipoles with Midplane Symmetry -- 9.1. Introduction -- 9.2. Field Expansion into Taylor's Series -- 9.2.1. Review of Theory -- 9.2.2. An Expansion Example -- 9.3. 3D Multipole Field Expansion -- 9.3.1. Expansion Formalism -- 9.3.2. Numerical Verification -- 9.4. Summary -- References -- Appendix 9.1. A Command Input File for Taylor's Expansion in Magnetic Dipoles -- Appendix 9.2. A Command Input File for Surface Field Calculation in Magnetic Dipoles with a Planar, Curved Reference Trajectory -- Chapter 10 -- Particle Optics in Main Bending Dipoles of SNS Accumulator Ring -- 10.1. Introduction -- 10.2. 3D Computer Simulation and Field Distribution -- 10.2.1. 3D Simulation Model -- 10.2.2. Magnetic Field Representation -- 10.2.3. Curvature and Derivative Calculations -- 10.3. First-Order Particle Optics -- 10.3.1. Linear Transfer Matrices from the Trajectory Equations -- 10.3.2. Equivalent Hard-Edge Lens Parameters -- 10.4. Second-Order Aberrations -- 10.5. Emittance Growth due to Non-Linear Fields -- 10.6. Summary -- References -- Appendix 10.1. A Mathematica Notebook File to Compute 1st-Order and 2nd-Order Particle Optics in 17D120 -- Chapter 11. , Field Distribution and Particle Optics in SNS Ring Injection Momentum Dump Line -- 11.1. Introduction -- 11.2. 3D Simulation Model -- 11.3. Magnetic Field Distributions -- 11.4. Particle Trajectories and Optics -- 11.5. Particle Distributions on Dump Window -- 11.6. Summary -- References -- Chapter 12 -- Particle Tracking of SNS Ring Injection -- 12.1. SNS Ring Injection and Waste Beam Losses -- 12.2. Injection Constraints -- 12.2.1. Closed Orbit Bump and Good Injection -- 12.2.2. Motion and Collection of Convoy Electrons -- 12.2.3. Transport of Waste Beams through IDSM -- 12.3. Three-Dimensional Modeling of Injection Waste Beam Dump Line -- 12.3.1. Simulation Models -- 12.3.2. Magnets and Fields on Beam Line -- 12.3.3. Initial Conditions of Test Particles -- 12.4. Three-Dimensional Particle Trajectories through IDSM -- 12.5. Particle Optics Through Quadrupole Magnet to Dump -- 12.6. Remedies -- 12.6.1. H(-Proton Particle Losses in the Y-Direction in IDSM -- 12.6.2. H0-Proton Particle Losses in the X-Direction in IDSM -- 12.6.3. Modification of a Spare IDSM -- 12.6.4. Waste Beam Losses Downstream after Quadrupole Magnet -- 12.7. Experimental Verifications -- References -- Appendix 12.1. Tracking Convoy Electrons -- Chapter 13 -- SNS Ring Extraction Beam Profile Distortion -- 13.1. Beam Profile Distortion Due to Strong Skew Quad Term in ELS -- 13.2. Three-Dimensional Simulation Model -- 13.3. General Performance of ELS -- 13.4. Computation of Skew Quad Term -- 13.4.1. Patch Rotation Method -- 13.4.2. Surface Field Analysis -- 13.4.3. Dipole Fields on Grids -- 13.4.4. Comparison with Measurements -- 13.5. Origin of the Large Skew Quad Term -- 13.5.1. Effect of Longitudinal Shims on Skew Quad Term -- 13.5.2. Effect of Magnet Ends on Skew Quad Term -- 13.6. Minimization of Integrated Skew Quad Term -- 13.7. Extracted Beam Profile through ELS. , 13.8. Linear Transfer Matrices -- 13.9. ELS Interference with Adjacent Quad -- 13.9.1. Effect of the ELS on 30Q44 -- 13.9.2. Effects of 30Q44 on the ELS -- 13.10. Summary -- References -- Appendix 13.1. Computation of Beam Profile Distortion on SNS Target -- Index -- Blank Page.
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  • 2
    Online Resource
    Online Resource
    New York, NY :Springer,
    Keywords: Phosphoproteins. ; Cellular control mechanisms. ; Phosphoprotein phosphatases. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (314 pages)
    Edition: 1st ed.
    ISBN: 9781461526001
    Series Statement: Developments in Molecular and Cellular Biochemistry Series ; v.11
    DDC: 574.876
    Language: English
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  • 3
    Online Resource
    Online Resource
    Hauppauge :Nova Science Publishers, Incorporated,
    Keywords: Neutrons -- Scattering. ; Spallation (Nuclear physics). ; Proton accelerators. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (210 pages)
    Edition: 1st ed.
    ISBN: 9781614702016
    DDC: 539.7/3
    Language: English
    Note: Intro -- MAGNETIC FRINGE FIELDS AND INTERFERENCE IN HIGH INTENSITY ACCELERATORS -- MAGNETIC FRINGE FIELDS AND INTERFERENCE IN HIGH INTENSITY ACCELERATORS -- CONTENTS -- PREFACE -- Chapter 1 INTRODUCTION -- 1.1. BACKGROUND -- 1.2. RESEARCH ISSUES -- 1.3. SYNOPSIS -- REFERENCES -- Chapter 2 FUNDAMENTALS OF ACCELERATOR MAGNETS -- 2.1. MAGNETOSTATIC FIELDS -- 2.2. TWO-DIMENSIONAL FIELDS -- 2.3. PARTICLE MOTION -- 2.4. DIPOLE MAGNETS -- 2.5. QUADRUPOLE MAGNETS -- 2.6. MAGNET MEASUREMENTS -- REFERENCES -- Chapter 3 MAGNET MODELING -- 3.1. OVERVIEW OF SIMULATION CODES -- 3.2. OPERA/TOSCA -- 3.3. A MODELING EXAMPLE -- REFERENCES -- Chapter 4 THREE-DIMENSIONAL FIELD MULTIPOLE EXPANSION -- 4.1. REVIEW OF THEORY -- 4.2. EXPANSION TECHNIQUES -- 4.3. ON-AXIS GRADIENTS -- 4.4. A 5TH-ORDER REPRESENTATION -- 4.5. HIGHER-ORDER EFFECTS -- REFERENCES -- Chapter 5 PARTICLE OPTICS IN A SINGLE QUAD -- 5.1. SIMULATION MODEL OF 30Q58 AND FIELD DISTRIBUTIONS -- 5.2 PARTICLE TRAJECTORIES AND TRANSFER MATRICES -- 5.3.THREE-DIMENSIONAL MULIPOLE EXPANSION AND LINEARFOCUSING FUNCTION -- 5.4. FORM FACTOR THEORY ON MAGNETIC FRINGE FIELDS -- 5.5. LINEAR TRANSFER MATRICES FROM THE TRAJECTORY EQUATIONS -- 5.6. LENS PARAMETERS AND HARD EDGE MODELS -- 5.7. THIRD-ORDER ABERRATIONS -- 5.8. PARTICLE OPTICS IN 30Q44 -- REFERENCES -- Chapter 6 MAGNETIC INTERFERENCE BETWEEN TWO MAGNETS -- 6.1. CHANGE IN LINEAR FOCUSING FUNCTION -- 6.2. MAGNETIC INTERFERENCE AS A FIRST-ORDER PERTURBATION -- 6.3. HARD EDGE MODELS FOR A PERTURBED QUAD -- REFERENCES -- Chapter 7 PARTICLE OPTICS IN A QUAD DOUBLET ASSEMBLY -- 7.1. TWO-DIMENSIONAL FIELD PARAMETERS -- 7.2. MAGNETIC FRINGE AND INTERFERENCE -- 7.3. LINEAR TRANSFER MATRICES AND HARD EDGE MODELS -- 7.4. THIRD-ORDER ABERRATIONS -- 7.5. VERIFICATION OF PARTICLE TRAJECTORIES -- REFERENCES. , Chapter 8 PARTICLE TRACKING IN BEAM LINES -- 8.1. SNS RING INJECTION AND WASTE BEAM LOSSES -- 8.2. INJECTION CONSTRAINTS -- 8.2.1. Closed Orbit Bump and Good Injection -- 8.2.2. Transport of Waste Beams Through IDSM -- 8.3. THREE-DIMENSIONAL MODELING OF INJECTION WASTE BEAM DUMP LINE -- 8.3.1. Simulation Models -- 8.3.2. Magnets and Fields on Beam Line -- 8.3.3. Initial Conditions of Test Particles -- 8.4. THREE-DIMENSIONAL PARTICLE TRAJECTORIES THROUGH IDSM -- 8.5. PARTICLE OPTICS THROUGH QUADRUPOLE MAGNET TO DUMP -- 8.6. REMEDIES -- 8.6.1. H−-Proton Particle Losses in the Y-Direction in IDSM -- 8.6.2. H0-Proton Particle Losses in the X-Direction in IDSM -- 8.6.3. Modification of a Spare IDSM -- 8.6.4. Waste Beam Losses Downstream after Quadrupole Magnet -- 8.7. EXPERIMENTAL VERIFICATIONS -- REFERENCES -- Chapter 9 SNS RING EXTRACTION LAMBERTSON SEPTUM MAGNET -- 9.1. BEAM PROFILE DISTORTION DUE TO STRONG SKEW QUAD TERM IN ELS -- 9.2. THREE-DIMENSIONAL SIMULATION MODEL -- 9.3. GENERAL PERFORMANCE OF ELS -- 9.4. COMPUTATION OF SKEW QUAD TERM -- 9.4.1. Patch Rotation Method -- 9.4.2. Surface Field Analysis -- 9.4.3. Dipole Fields on Grids -- 9.4.4. Comparison with Measurements -- 9.5 ORIGIN OF THE LARGE SKEW QUAD TERM -- 9.5.1. Effect of Longitudinal Shims on Skew Quad Term -- 9.5.2. Effect of Magnet Ends on Skew Quad Term -- 9.6. MINIMIZATION OF INTEGRATED SKEW QUAD TERM -- 9.7. EXTRACTED BEAM PROFILE THROUGH ELS -- 9.8. LINEAR TRANSFER MATRICES -- 9.9. ELS INTERFERENCE WITH ADJACENT QUAD -- 9.9.1. Effect of the ELS on 30Q44 -- 9.9.2. Effects of 30Q44 on the ELS -- 9.10. SUMMARY -- REFERENCES -- INDEX -- Blank Page.
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  • 4
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 62 (1993), S. 2845-2847 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In this letter, the spatial correlation model has been used for interpreting the line shapes of the first-order longitudinal-optical phonon Raman spectra of ZnSe/GaAs epitaxial layers. The good agreement between theoretical line shapes and the experiment measurements was illustrated for the samples grown by the molecular beam epitaxy (MBE), hot wall epitaxy (HWE), and hot wall beam epitaxy (HWBE).
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 62 (2005), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The nature of antigens and functional state of dendritic cells (DC) are important in antigen presentation. The ability of DC for the induction of T-cell responses is promoted by maturation. It has been confirmed that mannose receptors mediate highly efficient endocytosis and presentation of mannosylated proteins. In the present study, L2 domain of ErbB2 ectodomain was expressed in Escherichia coli, purified and mannosylated. The maturation and functional capacity of DC induced by mannosylated L2 (mL2) protein were investigated. The results showed that L2 protein could induce DC maturation, which was accompanied by elevated expression of MHC and co-stimulatory molecules. The effect of mL2 protein on DC maturation was more remarkable than that of non-mL2 proteins. Uptake of mL2 antigens by DC was more efficient. Furthermore, the T cells can be stimulated to proliferate in vitro and secrete Th1 and Th2 cytokines. Higher levels of both IFN-γ and IL-10 were detected from the T cells stimulated by mL2-pulsed DC, suggesting a concurrent activation of CD4+ and CD8+ T cells. The results demonstrated that L2 domain of ErbB2 receptor is an immunodominant molecule. The mL2 domain of ErbB2 can induce an enhanced maturation and functional capacity of DC. It may become an effective strategy to induce anti-ErbB2 response.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 46 (1990), S. 1633-1635 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Analytica Chimica Acta 293 (1994), S. 43-48 
    ISSN: 0003-2670
    Keywords: Attomole detection limits ; Blood ; Lead ; Microliter analysis ; Nanoelectrodes ; Potentionmetry ; Sensors ; Stripping analysis ; Stripping voltammetry
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Analytica Chimica Acta 292 (1994), S. 91-97 
    ISSN: 0003-2670
    Keywords: Adsorptive stripping voltammetry ; N-Benzoyl-N-phenylhydroxylamine ; Propyl gallate ; Uranium
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    facet.materialart.
    Unknown
    PANGAEA
    In:  Supplement to: Mu, J; Jin, F; Wang, J Y; Zheng, N; Cong, Y (2015): Effects of CO2-driven ocean acidification on early life stages of marine medaka (Oryzias melastigma). Biogeosciences, 12(12), 3861-3868, https://doi.org/10.5194/bg-12-3861-2015
    Publication Date: 2024-03-15
    Description: The potential effects of elevated CO2 level and reduced carbonate saturation state in marine environment on fishes and other non-calcified organisms are still poorly known. In present study, we investigated the effects of ocean acidification on embryogenesis and organogenesis of newly hatched larvae of marine medaka (Oryzias melastigma) after 21 d exposure of eggs to different artificially acidified seawater (pH 7.6 and 7.2, respectively), and compared with those in control group (pH 8.2). Results showed that CO2-driven seawater acidification (pH 7.6 and 7.2) had no detectable effect on hatching time, hatching rate, and heart rate of embryos. However, the deformity rate of larvae in pH 7.2 treatment was significantly higher than that in control treatment. The left and right sagitta areas did not differ significantly from each other in each treatment. However, the mean sagitta area of larvae in pH 7.6 treatment was significantly smaller than that in the control (p = 0.024). These results suggest that although marine medaka might be more tolerant of elevated CO2 than some other fishes, the effect of elevated CO2 level on the calcification of otolith is likely to be the most susceptibly physiological process of pH regulation in early life stage of marine medaka.
    Keywords: Alkalinity, total; Animalia; Aragonite saturation state; Aragonite saturation state, standard deviation; Behaviour; Bicarbonate ion; Bicarbonate ion, standard deviation; Bottles or small containers/Aquaria (〈20 L); Calcite saturation state; Calculated using CO2SYS; Calculated using seacarb after Nisumaa et al. (2010); Carbon, inorganic, dissolved; Carbon, inorganic, dissolved, standard deviation; Carbonate ion; Carbonate ion, standard deviation; Carbonate system computation flag; Carbon dioxide; Carbon dioxide, standard deviation; Chordata; Coulometric titration; Development; Figure; Fugacity of carbon dioxide (water) at sea surface temperature (wet air); Growth/Morphology; Hatching rate; Hatching rate, standard deviation; Hatching time; Hatching time, standard deviation; Heart rate; Heart rate, standard deviation; Laboratory experiment; Laboratory strains; Larval deformity rate; Larval deformity rate, standard deviation; Mortality/Survival; Nekton; Not applicable; OA-ICC; Ocean Acidification International Coordination Centre; Oryzias melastigma; Otolith area; Otolith area, standard deviation; Oxygen; Oxygen, standard deviation; Partial pressure of carbon dioxide, standard deviation; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); Pelagos; pH; pH, standard deviation; Potentiometric; Reproduction; Salinity; Salinity, standard deviation; Single species; Species; Survival; Survival rate, standard deviation; Temperature, water; Temperature, water, standard deviation; Treatment
    Type: Dataset
    Format: text/tab-separated-values, 345 data points
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  • 10
    facet.materialart.
    Unknown
    Abnet, C. C., Wang, Z., Song, X., Hu, N., Zhou, F.-Y., Freedman, N. D., Li, X.-M., Yu, K., Shu, X.-O., Yuan, J.-M., Zheng, W., Dawsey, S. M., Liao, L. M., Lee, M. P., Ding, T., Qiao, Y.-L., Gao, Y.-T., Koh, W.-P., Xiang, Y.-B., Tang, Z.-Z., Fan, J.-H., Chung, C. C., Wang, C., Wheeler, W., Yeager, M., Yuenger, J., Hutchinson, A., Jacobs, K. B., Giffen, C. A., Burdett, L., Fraumeni, J. F., Tucker, M. A., Chow, W.-H., Zhao, X.-K., Li, J.-M., Li, A.-L., Sun, L.-D., Wei, W., Li, J.-L., Zhang, P., Li, H.-L., Cui, W.-Y., Wang, W.-P., Liu, Z.-C., Yang, X., Fu, W.-J., Cui, J.-L., Lin, H.-L., Zhu, W.-L., Liu, M., Chen, X., Chen, J., Guo, L., Han, J.-J., Zhou, S.-L., Huang, J., Wu, Y., Yuan, C., Huang, J., Ji, A.-F., Kul, J.-W., Fan, Z.-M., Wang, J.-P., Zhang, D.-Y., Zhang, L.-Q., Zhang, W., Chen, Y.-F., Ren, J.-L., Li, X.-M., Dong, J.-C., Xing, G.-L., Guo, Z.-G., Yang, J.-X., Mao, Y.-M., Yuan, Y., Guo, E.-T., Zhang, W., Hou, Z.-C., Liu, J., Li, Y., Tang, S., Chang, J., Peng, X.-Q., Han, M., Yin, W.-L., Liu, Y.-L., Hu, Y.-L., Liu, Y., Yang, L.-Q., Zhu, F.-G., Yang, X.-F., Feng, X.-S., Wang, Z., Li, Y., Gao, S.-G., Liu, H.-L., Yuan, L., Jin, Y., Zhang, Y.-R., Sheyhidin, I., Li, F., Chen, B.-P., Ren, S.-W., Liu, B., Li, D., Zhang, G.-F., Yue, W.-B., Feng, C.-W., Qige, Q., Zhao, J.-T., Yang, W.-J., Lei, G.-Y., Chen, L.-Q., Li, E.-M., Xu, L.-Y., Wu, Z.-Y., Bao, Z.-Q., Chen, J.-L., Li, X.-C., Zhuang, X., Zhou, Y.-F., Zuo, X.-B., Dong, Z.-M., Wang, L.-W., Fan, X.-P., Wang, J., Zhou, Q., Ma, G.-S., Zhang, Q.-X., Liu, H., Jian, X.-Y., Lian, S.-Y., Wang, J.-S., Chang, F.-B., Lu, C.-D., Miao, J.-J., Chen, Z.-G., Wang, R., Guo, M., Fan, Z.-L., Tao, P., Liu, T.-J., Wei, J.-C., Kong, Q.-P., Fan, L., Wang, X.-Z., Gao, F.-S., Wang, T.-Y., Xie, D., Wang, L., Chen, S.-Q., Yang, W.-C., Hong, J.-Y., Wang, L., Qiu, S.-L., Goldstein, A. M., Yuan, Z.-Q., Chanock, S. J., Zhang, X.-J., Taylor, P. R., Wang, L.-D.
    Oxford University Press
    Publication Date: 2012-04-12
    Description: Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P -values in two previously published genome-wide scans that included a total of 2961 ESCC cases and 3400 controls. The meta-analysis revealed five SNPs at 2q33 with P 〈 5 x 10 –8 , and the strongest signal was rs13016963, with a combined odds ratio (95% confidence interval) of 1.29 (1.19–1.40) and P = 7.63 x 10 –10 . An imputation analysis of 4304 SNPs at 2q33 suggested a single association signal, and the strongest imputed SNP associations were similar to those from the genotyped SNPs. We conducted an ancestral recombination graph analysis with 53 SNPs to identify one or more haplotypes that harbor the variants directly responsible for the detected association signal. This showed that the five SNPs exist in a single haplotype along with 45 imputed SNPs in strong linkage disequilibrium, and the strongest candidate was rs10201587, one of the genotyped SNPs. Our meta-analysis found genome-wide significant SNPs at 2q33 that map to the CASP8 / ALS2CR12/TRAK2 gene region. Variants in CASP8 have been extensively studied across a spectrum of cancers with mixed results. The locus we identified appears to be distinct from the widely studied rs3834129 and rs1045485 SNPs in CASP8 . Future studies of esophageal and other cancers should focus on comprehensive sequencing of this 2q33 locus and functional analysis of rs13016963 and rs10201587 and other strongly correlated variants.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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