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  • 1
    Online Resource
    Online Resource
    Radioactive waste confinement : clays in natural and engineered barriers (2017)
    London : The Geological Society
    Details Availability
    Keywords: Radioactive waste disposal in the ground ; Radioactive waste repositories ; Clay soils ; Clay soils ; Radioactive waste disposal in the ground ; Radioactive waste repositories ; Konferenzschrift ; Endlagerung ; Abdichtung ; Ton
    Description / Table of Contents: Radioactive waste confinement: clays in natural and engineered barriers - introduction -- Regional aquifer hydrogeochemistry in the confined aquifer system below the Boom Clay (NE Belgium): data analysis and modelling -- An assessment of Palaeogene and Neogene clay deposits in Denmark as possible host rocks for final disposal of low- and intermediate-level radioactive waste -- Approaches to evaluate and underpin the technical feasibility of the Belgian disposal concept -- DOPAS full-scale experiments: approaches to compliance assessment -- DOPAS EPSP experiment -- Laboratory experiments on bentonite pellet saturation -- Quantitative characterization of the excavation damaged zone fracture network in the Meuse/Haute-Marne Underground Research Laboratory: in situ experiment and numerical interpretation of helium injection test -- Characterizing the mechanical behaviour of the Tournemire argillite -- Convergence analysis of an unsupported micro-tunnel at the Meuse/Haute-Marne Underground Research Laboratory -- A pragmatic approach to abstract the excavation damaged zone around tunnels of a geological radioactive waste repository: application to the HG-A experiment in Mont Terri -- The influence of different supports on the properties of the excavation damaged zone along the FE tunnel in the Mont Terri Underground Rock Laboratory -- Characterization of transport and water retention properties of damaged Callovo-Oxfordian claystone -- Vertical distribution of helium and ⁴⁰Ar/³⁶Ar in porewaters of the Eastern Paris Basin (Bure/Haute-Marne): constraints on transport processes through the sedimentary sequence -- Study of ⁸⁵Sr transport through a column filled with crushed granite in the presence of bentonite colloids -- An improved model for through-diffusion experiments: application to strontium and tritiated water (HTO) diffusion in Boom Clay and compacted illite -- Multispecies random walk simulations in radial symmetry: model concept, benchmark, and application to HTO, ²²Na and ³⁶Cl diffusion in clay -- Combining high-resolution two-phase with simplified single-phase simulations in order to optimize the performance of PA/SA simulations for a deep geological repository for radioactive waste -- Coupled THM modelling of engineered barriers for the final disposal of spent nuclear fuel isolation -- Gaining insight into corrosion processes from numerical simulations of an integrated iron-claystone experiment -- Bentonite re-saturation: different conceptual models - similar mathematical descriptions -- Alteration of MX-80 bentonite backfill material by high-pH cementitious fluids under lithostatic conditions - an experimental approach using core infiltration techniques -- Chemical erosion of the bentonite buffer: do we observe it in nature? -- Modelling of water and gas flow through an excavation damaged zone in the Callovo-Oxfordian argillites in the framework of a single porosity model -- The gas permeability, breakthrough behaviour and re-sealing ability of Czech Ca-Mg bentonite -- Measuring diffusion coefficients of dissolved He and Ar in three potential clay host formations: Boom Clay, Callovo-Oxfordian Clay and Opalinus Clay.
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (vi, 370 Seiten) , Illustrationen
    Series Statement: Geological Society special publication no. 443
    URL: https://sp.lyellcollection.org/content/443/1
    URL: https://geoscienceworld.org/books/book/2025
    URL: https://doi.org/10.1144/SP443
    DOI: 10.1144/SP443
    DDC: 621.4838
    Language: English
    Note: Includes bibliographical references and index
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  • 2
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    Impact of rapid genetic counselling and testing on the decision to undergo immediate or delayed prophylactic mastectomy in newly diagnosed breast cancer patients: findings from a randomised controlled trial (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-02-20
    Description: Impact of rapid genetic counselling and testing on the decision to undergo immediate or delayed prophylactic mastectomy in newly diagnosed breast cancer patients: findings from a randomised controlled trial British Journal of Cancer 110, 1081 (18 February 2014). doi:10.1038/bjc.2013.805 Authors: M R Wevers, N K Aaronson, S Verhoef, E M A Bleiker, D E E Hahn, M A Kuenen, J van der Sanden-Melis, T Brouwer, F B L Hogervorst, R B van der Luijt, H B Valdimarsdottir, T van Dalen, E B M Theunissen, B van Ooijen, M A de Roos, P J Borgstein, B C Vrouenraets, E Vriens, W H Bouma, H Rijna, J P Vente, A J Witkamp, E J T Rutgers & M G E M Ausems
    Keywords: breast cancerBRCA1BRCA2rapid genetic counselling and testingcontralateral prophylactic mastectomy
    Print ISSN: 0007-0920
    Electronic ISSN: 1532-1827
    Topics: Medicine
    Published by Nature Publishing Group (NPG)
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  • 3
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    Role for SYK in Prostate Cancer (2015)
    The American Association for Cancer Research (AACR)
    Details
    Publication Date: 2015-01-06
    Description: Improved targeted therapies are needed to combat metastatic prostate cancer. Here, we report the identification of the spleen kinase SYK as a mediator of metastatic dissemination in zebrafish and mouse xenograft models of human prostate cancer. Although SYK has not been implicated previously in this disease, we found that its expression is upregulated in human prostate cancers and associated with malignant progression. RNAi-mediated silencing prevented invasive outgrowth in vitro and bone colonization in vivo, effects that were reversed by wild-type but not kinase-dead SYK expression. In the absence of SYK expression, cell surface levels of the progression-associated adhesion receptors integrin α2β1 and CD44 were diminished. RNAi-mediated silencing of α2β1 phenocopied SYK depletion in vitro and in vivo, suggesting an effector role for α2β1 in this setting. Notably, pharmacologic inhibitors of SYK kinase currently in phase I–II trials for other indications interfered similarly with the invasive growth and dissemination of prostate cancer cells. Our findings offer a mechanistic rationale to reposition SYK kinase inhibitors for evaluation in patients with metastatic prostate cancer. Cancer Res; 75(1); 230–40. ©2014 AACR.
    Print ISSN: 0008-5472
    Electronic ISSN: 1538-7445
    Topics: Medicine
    Published by The American Association for Cancer Research (AACR)
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