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  • 1
    Online Resource
    Online Resource
    Identification, Isolation and Characterization of Poly-Hydroxy Butyrate (PHB) Producing Bacteria, and Extraction of the PHB Granule
    EManuscript Technologies ; 2021
    In:  Current Trends in Biotechnology and Pharmacy Vol. 15, No. 5 ( 2021-11-02), p. 540-544
    Details
    In: Current Trends in Biotechnology and Pharmacy, EManuscript Technologies, Vol. 15, No. 5 ( 2021-11-02), p. 540-544
    Type of Medium: Online Resource
    ISSN: 0973-8916 , 2230-7303
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.5530/ctbp.2021.3s
    DOI: 10.5530/ctbp
    DOI: 10.5530/ctbp.2021.3s.51
    Language: Unknown
    Publisher: EManuscript Technologies
    Publication Date: 2021
    detail.hit.zdb_id: 2445798-X
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  • 2
    Online Resource
    Online Resource
    The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores
    Springer Science and Business Media LLC ; 2022
    In:  Communications Biology Vol. 5, No. 1 ( 2022-09-02)
    Details
    In: Communications Biology, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2022-09-02)
    Abstract: The process of identifying suitable genome-wide association (GWA) studies and formatting the data to calculate multiple polygenic risk scores on a single genome can be laborious. Here, we present a centralized polygenic risk score calculator currently containing over 250,000 genetic variant associations from the NHGRI-EBI GWAS Catalog for users to easily calculate sample-specific polygenic risk scores with comparable results to other available tools. Polygenic risk scores are calculated either online through the Polygenic Risk Score Knowledge Base (PRSKB; https://prs.byu.edu ) or via a command-line interface. We report study-specific polygenic risk scores across the UK Biobank, 1000 Genomes, and the Alzheimer’s Disease Neuroimaging Initiative (ADNI), contextualize computed scores, and identify potentially confounding genetic risk factors in ADNI. We introduce a streamlined analysis tool and web interface to calculate and contextualize polygenic risk scores across various studies, which we anticipate will facilitate a wider adaptation of polygenic risk scores in future disease research.
    Type of Medium: Online Resource
    ISSN: 2399-3642
    URL: Article
    DOI: 10.1038/s42003-022-03795-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2919698-X
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  • 3
    Online Resource
    Online Resource
    Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
    Elsevier BV ; 2021
    In:  The Lancet Vol. 397, No. 10274 ( 2021-02), p. 605-612
    Details
    In: The Lancet, Elsevier BV, Vol. 397, No. 10274 ( 2021-02), p. 605-612
    Type of Medium: Online Resource
    ISSN: 0140-6736
    URL: Article
    DOI: 10.1016/S0140-6736(21)00149-5
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2067452-1
    detail.hit.zdb_id: 3306-6
    detail.hit.zdb_id: 1476593-7
    SSG: 5,21
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  • 4
    Online Resource
    Online Resource
    Effect of exercise, relaxation, and ergonomics on physiological stress indicators - An experimental study on teachers
    Indian Association of Biomedical Scientists ; 2022
    In:  Biomedicine Vol. 42, No. 6 ( 2022-12-31), p. 1259-1263
    Details
    In: Biomedicine, Indian Association of Biomedical Scientists, Vol. 42, No. 6 ( 2022-12-31), p. 1259-1263
    Abstract: Introduction and Aim: Stress is a reaction of the body to substantial or unusual demands. It, a complex reaction of the neurologic and endocrinologic system which can initiate the ‘Fight or Flight’ response. This may lead to headache, tense muscles, insomnia. Stress can alter the memory function, immune function, metabolism, and susceptibility to the disease. The effect of stress and relationship in making teachers quite inefficient in their profession is a growing concern. The present study objective is to investigate the effective significance of exercise, relaxation, and ergonomics on physiological stress in teachers.   Materials and Methods: A total of 30 teachers, both male and female were randomly selected. They supported the inclusion and exclusion criteria and were between 30 to 60 years, separated into 2 groups. They were asked to fill necessary information in the stress profile for teachers. The subjects with moderate to high stress were taken for the study and were divided into two groups. Group ‘A’ were given aerobic stepper exercise and relaxation techniques. Group ‘B’ were given aerobic stepper exercise and suggestions given on ergonomic correction for an intervention period of about 8 weeks, 5 days per week 45 minutes per session. Pre- and post-test values were taken on blood pressure and blood glucose level using sphygmomanometer and glucometer.   Results: The pre- and post-test between group A and group B show a highly significant difference. However, group A showed higher significance than group B.     Conclusion: According to the findings, aerobic stepper exercise with relaxation techniques shows highly significant difference and aerobic stepper exercise with ergonomic correction shows significance but aerobic exercise with relaxation technique is highly effective in reducing stress and maintaining blood pressure and glucose level in teachers.
    Type of Medium: Online Resource
    ISSN: 0970-2067
    URL: Issue
    URL: Article
    DOI: 10.51248/.v42i6
    DOI: 10.51248/.v42i6.1393
    Language: Unknown
    Publisher: Indian Association of Biomedical Scientists
    Publication Date: 2022
    detail.hit.zdb_id: 2823181-8
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  • 5
    Online Resource
    Online Resource
    Effectiveness of Pilates exercises on non-specific low back pain to determine pain and disability
    Indian Association of Biomedical Scientists ; 2021
    In:  Biomedicine Vol. 41, No. 4 ( 2021-12-31), p. 825-829
    Details
    In: Biomedicine, Indian Association of Biomedical Scientists, Vol. 41, No. 4 ( 2021-12-31), p. 825-829
    Abstract: Introduction and Aim: Low back discomfort is one of the commonest musculoskeletal problems. The Pilates exercises are an approach to stretching and strengthening techniques and specifically train all the core muscles. The intend of the current study was to verify the influences of the Pilates exercises among pain and disability among patients with Non-specific Low Back Pain (NSLBP).     Materials and Methods: A 100 non-specific low back pain subjects were randomly selected for this experimental study. The study includes of non-specific LBP age group between 25 to 40 years, both male and female patients with pain and disability and this study excludes spinal fractures and Pregnant Women. The estimations were taken utilizing Visual Analogue scale (VAS), Patient Specific Functional Scale (PSFS) and Modified Oswestry Low Back Pain Disability Questionnaire (MODQ). Subjects are allotted in two groups, Group A (Pilates group) receives Pilate’s exercise and Group B (conventional group) receives conventional exercise. Exercises were given for 3 times a week for 12 weeks and a regular follow up was done for every 4 weeks.   Results: Group A (Pilates group) were found to be more effective than Group B (conventional group). It shows a highly significant difference in mean values at P ? 0.001. This implies that Pilates exercise is more beneficial in decreasing pain and functional disability.   Conclusion: On comparing the mean values, Group A (Pilates group) showed significant improvement at the end of the study when compared with Group B (conventional group).
    Type of Medium: Online Resource
    ISSN: 0970-2067
    URL: Issue
    URL: Article
    DOI: 10.51248/.v41i4
    DOI: 10.51248/.v41i4.1361
    Language: Unknown
    Publisher: Indian Association of Biomedical Scientists
    Publication Date: 2021
    detail.hit.zdb_id: 2823181-8
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  • 6
    Online Resource
    Online Resource
    A study to analyse the effect of Mckenzie’s method of exercise to treat upper cross syndrome associated with cervicogenic headache
    Indian Association of Biomedical Scientists ; 2021
    In:  Biomedicine Vol. 41, No. 4 ( 2021-12-31), p. 855-858
    Details
    In: Biomedicine, Indian Association of Biomedical Scientists, Vol. 41, No. 4 ( 2021-12-31), p. 855-858
    Abstract: Introduction: Upper cross syndrome (UCS) occurs when the muscle in the neck, shoulders, and chest become deformed usually as a result of poor posture. The aim of the study is to analyse the effect of McKenzie’s method of exercise to treat upper cross syndrome associated with cervicogenic headache. Materials and Methods: This experimental study was conducted in outpatient department physiotherapy A.C.S. Medical College and Hospital. Fifty subjects were selected for the study of the age group between 20 to 50 years of both male and female sex. Duration of this study was about 3 months. Each patient was trained about three session per week, 30 minutes per session. The session included McKenzie’s method of exercise to improve the shoulder and neck movements and postural corrections of the subjects. The outcome measure done using visual analogue scale (VAS) for cervicogenic headache and upper cross syndrome questionnaire (UCS). Results: The results on comparing upper cross syndrome questionnaire score and Visual Analog Scale score showed that between the pre-test (4.93) and post-test (3.43) mean values with group McKenzie’s exercise showed highly significant difference. Thus, it is appropriate that McKenzie’s method of exercise to treat upper cross syndrome associated with cervicogenic headache is effective.
    Type of Medium: Online Resource
    ISSN: 0970-2067
    URL: Issue
    URL: Article
    DOI: 10.51248/.v41i4
    DOI: 10.51248/.v41i4.499
    Language: Unknown
    Publisher: Indian Association of Biomedical Scientists
    Publication Date: 2021
    detail.hit.zdb_id: 2823181-8
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  • 7
    Online Resource
    Online Resource
    A study to compare the effects of aerobic exercises and yoga on depression and maternal anxiety orienting among primiparous women
    Indian Association of Biomedical Scientists ; 2020
    In:  Biomedicine Vol. 40, No. 3 ( 2020-11-09), p. 395-398
    Details
    In: Biomedicine, Indian Association of Biomedical Scientists, Vol. 40, No. 3 ( 2020-11-09), p. 395-398
    Abstract: Introduction and Aim: Primiparous women undergo stages of depression or anxiety during pregnancy especially the risk of preterm birth, breast-feeding problems and disruption of the mother-infant attachment. It is a most common psychiatric disorder and is associated with a greater risk of low fetal quality, Pregnancy complication and developmental disorder of the child. During pregnancy 10-15% women were affected with depression and the incidence increases in low economic status. It is associated with greater risk of prenatal and perinatal complication. In recent years the physical therapy is associated with psychological health in pregnant women. Physical activity during pregnancy is more beneficial to the maternal fetal unit and it may prevent recurrence of maternal disorders. The objective of this study is to compare the effects of aerobic exercise and yoga on depression and maternal anxiety orienting among primiparous women. Materials and Methods: This experimental study was conducted with 30 subjects at ACS Medical College and Hospital, from January 2018 to March 2018. The outcome measures of CES-D scale were used to assess the severity of depression and anxiety. Group A received Aerobic exercise for 30 minutes initially started with warm up for 10 minutes and followed by 10 minutes stretching and 10 minutes relaxation. Group B received yoga for 20 minutes up to 3 months. The treatment duration was followed from the 16 to 20 weeks of gestation for 3 months. Results: On comparing the mean values of group A and group B on centre for epidemiological studies depression scale score, it showed significant decrease in the post test mean values of group A (24.60)  and group B  (24.40) at P ? 0.001. Hence both the groups were equally effective in decreasing the depression and maternal anxiety among primiparous women. Conclusion: This study concluded that the aerobic and yoga showed significant effect in both groups for reducing the symptoms of depression and anxiety among primiparous women. Keywords: Primiparous women; aerobic exercises; yoga; CES - D scale.
    Type of Medium: Online Resource
    ISSN: 0970-2067
    URL: Article
    DOI: 10.51248/.v40i3.38
    Language: Unknown
    Publisher: Indian Association of Biomedical Scientists
    Publication Date: 2020
    detail.hit.zdb_id: 2823181-8
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  • 8
    Online Resource
    Online Resource
    Effects of Swiss ball exercise and Pilates exercise on core muscle strengthening in college cricketers
    Indian Association of Biomedical Scientists ; 2020
    In:  Biomedicine Vol. 40, No. 3 ( 2020-11-09), p. 377-380
    Details
    In: Biomedicine, Indian Association of Biomedical Scientists, Vol. 40, No. 3 ( 2020-11-09), p. 377-380
    Abstract: Introduction and Aim: Cricket is one of the most popular game in India played by men and women of all ages. Core stability is defined as the ability to control the position and movement of the trunk over the pelvis to allow optimum production, transfer and control of force and movement to the terminal segment. Major muscles involved are pelvic floor muscles, Transverse abdominis, multifidus, internal and external obliques, and rectus abdominis. Core is used to stabilize the thorax and the pelvis during dynamic movement. The study helps to compare the effectiveness of Swiss ball exercise and Pilates exercise on gaining core muscle strength. The aim of the study is to compare the effect of Swiss ball exercise and Pilates exercise on core muscle strengthening in college cricketers. Materials and Methods: The design of the study is comparative type. The study was carried out in faculty of Physiotherapy, Dr.M.G.R. Educational and Research Institute. The study sample of 30 male college cricketers between the age group of 18 to 25 years are included in the study. Individuals with associated neuromuscular conditions, any injuries to lower limbs and any spinal injuries have been excluded in the study. Swiss ball and Pilates mat are the materials used. Sphygmomanometer is the outcome measure.30 male individuals between the age group of 18 to 25 years were divided into two groups, group A and group B. Individuals in the group A (n=15) received the Swiss ball exercise and group B (n=15) received Pilates exercise for 4 session/ week for 6 weeks. Results: On comparing the mean values of group A and group B on double leg lowering test (DLLT), it shows significant decrease in the post test mean values but (group B- Pilates exercise) shows (30.60) which has the lower mean value is more effective than (group A- Swiss ball exercise) (46.80) at P ? 0.001. Hence, null hypothesis is rejected. Conclusion: The study concluded that both the group was effective but while comparing Pilates exercise showed the potential treatment option than swiss ball exercise. Hence, Pilates exercise was effective on core muscle strengthening in college cricketers. Keywords: Swiss ball; Pilates mat; core muscle; sphygmomanometer.
    Type of Medium: Online Resource
    ISSN: 0970-2067
    URL: Article
    DOI: 10.51248/.v40i3.31
    Language: Unknown
    Publisher: Indian Association of Biomedical Scientists
    Publication Date: 2020
    detail.hit.zdb_id: 2823181-8
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  • 9
    Online Resource
    Online Resource
    Comparison of laser therapy and galvanic stimulation on facial appearance and function in Bell’s palsy among south Indian population
    Indian Association of Biomedical Scientists ; 2022
    In:  Biomedicine Vol. 42, No. 6 ( 2022-12-31), p. 1264-1267
    Details
    In: Biomedicine, Indian Association of Biomedical Scientists, Vol. 42, No. 6 ( 2022-12-31), p. 1264-1267
    Abstract: Introduction and Aim: Bell’s palsy is an instantaneous lower motor neurons injury of 7th cranial nerve associated with infection and swelling. It produces unexpected unilateral weakness of facial muscles, progresses rapidly and attains peak symptoms within a week. The most common age of incidence is between 20 to 40 years. Although facial paralysis in Bell’s palsy is self-limited, only 80% of the patients make a full recovery. There are studies stating that both galvanic electrical stimulation and laser therapy speed up the recovery of facial paralysis, but the extent of complete recovery is unknown. Hence, this study is an attempt to understand and compare how laser therapy and galvanic electrical stimulation affect facial appearance and facial muscle functions in Bell's palsy.   Materials and Methods: This study included thirty subjects with acute onset of Bell’s palsy aged between 20-40 years. They were randomly grouped into A and B. Galvanic electrical stimulation and low-level laser therapy were given to group A and group B respectively for 6 weeks (3 sessions/week) along with facial exercises. Facial disability index scale was used to measure facial muscle function and Sunny brook scale was used to measure facial symmetry in pre- and post-treatment periods.   Results: When comparing the pre- and post-mean values of groups A and B on the Sunny Brook facial grading and the facial disability index (physical, social), group B (with low level laser therapy) showed a highly significant difference in mean values at p 0.001.   Conclusion: Low-level laser therapy can be used as an adjective in treating the patients with Bell’s palsy.
    Type of Medium: Online Resource
    ISSN: 0970-2067
    URL: Issue
    URL: Article
    DOI: 10.51248/.v42i6
    DOI: 10.51248/.v42i6.1189
    Language: Unknown
    Publisher: Indian Association of Biomedical Scientists
    Publication Date: 2022
    detail.hit.zdb_id: 2823181-8
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  • 10
    Online Resource
    Online Resource
    ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition
    American Society of Hematology ; 2022
    In:  Blood Vol. 139, No. 2 ( 2022-01-13), p. 256-280
    Details
    In: Blood, American Society of Hematology, Vol. 139, No. 2 ( 2022-01-13), p. 256-280
    Abstract: ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 in 3 infants with multisystemic disease involving the liver and hematopoietic system. This entity has subsequently been documented in case reports and series to occupy a wider clinicopathologic spectrum with recurrent KIF5B-ALK fusions. The full clinicopathologic and molecular spectra of ALK-positive histiocytosis remain, however, poorly characterized. Here, we describe the largest study of ALK-positive histiocytosis to date, with detailed clinicopathologic data of 39 cases, including 37 cases with confirmed ALK rearrangements. The clinical spectrum comprised distinct clinical phenotypic groups: infants with multisystemic disease with liver and hematopoietic involvement, as originally described (Group 1A: 6/39), other patients with multisystemic disease (Group 1B: 10/39), and patients with single-system disease (Group 2: 23/39). Nineteen patients of the entire cohort (49%) had neurologic involvement (7 and 12 from Groups 1B and 2, respectively). Histology included classic xanthogranuloma features in almost one-third of cases, whereas the majority displayed a more densely cellular, monomorphic appearance without lipidized histiocytes but sometimes more spindled or epithelioid morphology. Neoplastic histiocytes were positive for macrophage markers and often conferred strong expression of phosphorylated extracellular signal-regulated kinase, confirming MAPK pathway activation. KIF5B-ALK fusions were detected in 27 patients, whereas CLTC-ALK, TPM3-ALK, TFG-ALK, EML4-ALK, and DCTN1-ALK fusions were identified in single cases. Robust and durable responses were observed in 11/11 patients treated with ALK inhibition, 10 with neurologic involvement. This study presents the existing clinicopathologic and molecular landscape of ALK-positive histiocytosis and provides guidance for the clinical management of this emerging histiocytic entity.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.2021013338
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2022
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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