In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 6 ( 2023-6-23), p. e0287646-
Kurzfassung:
Human mentality develops with age and is altered in psychiatric disorders, though their underlying mechanism is unknown. In this study, we analyzed nanometer-scale three-dimensional structures of brain tissues of the anterior cingulate cortex from eight schizophrenia and eight control cases. The distribution profiles of neurite curvature of the control cases showed a trend depending on their age, resulting in an age-correlated decrease in the standard deviation of neurite curvature (Pearson’s r = -0.80, p = 0.018). In contrast to the control cases, the schizophrenia cases deviate upward from this correlation, exhibiting a 60% higher neurite curvature compared with the controls ( p = 7.8 × 10 −4 ). The neurite curvature also showed a correlation with a hallucination score (Pearson’s r = 0.80, p = 1.8 × 10 −4 ), indicating that neurite structure is relevant to brain function. This report is based on our 3D analysis of human brain tissues over a decade and is unprecedented in terms of the number of cases. We suggest that neurite curvature plays a pivotal role in brain aging and can be used as a hallmark to exploit a novel treatment of schizophrenia.
Materialart:
Online-Ressource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0287646
DOI:
10.1371/journal.pone.0287646.g001
DOI:
10.1371/journal.pone.0287646.g002
DOI:
10.1371/journal.pone.0287646.g003
DOI:
10.1371/journal.pone.0287646.g004
DOI:
10.1371/journal.pone.0287646.g005
DOI:
10.1371/journal.pone.0287646.s001
DOI:
10.1371/journal.pone.0287646.s002
DOI:
10.1371/journal.pone.0287646.s003
DOI:
10.1371/journal.pone.0287646.s004
DOI:
10.1371/journal.pone.0287646.s005
DOI:
10.1371/journal.pone.0287646.s006
DOI:
10.1371/journal.pone.0287646.s007
DOI:
10.1371/journal.pone.0287646.s008
DOI:
10.1371/journal.pone.0287646.s009
DOI:
10.1371/journal.pone.0287646.s010
DOI:
10.1371/journal.pone.0287646.s011
DOI:
10.1371/journal.pone.0287646.r001
DOI:
10.1371/journal.pone.0287646.r002
DOI:
10.1371/journal.pone.0287646.r003
DOI:
10.1371/journal.pone.0287646.r004
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2023
ZDB Id:
2267670-3
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