In:
European Journal of Clinical Investigation, Wiley, Vol. 44, No. 11 ( 2014-11), p. 1053-1064
Abstract:
We examined the degree of postprandial triglyceride ( TG ) response over the day, representing a highly dynamic state, with continuous metabolic adaptations, among normal‐weight, overweight and obese patients, according to their metabolically healthy or abnormal status. Materials and methods A total of 1002 patients from the CORDIOPREV clinical trial ( NCT 00924937) were submitted to an oral fat load test meal with 0·7 g fat/kg body weight (12% saturated fatty acids ( SFA ), 10% polyunsaturated fatty acids ( PUFA ), 43% monounsaturated fatty acids ( MUFA ), 10% protein and 25% carbohydrates). Serial blood test analysing lipid fractions and inflammation markers (high‐sensitivity C‐reactive protein (hs‐ CRP )) were drawn at 0, 1, 2, 3 and 4 h during postprandial state. We explored the dynamic response according to six body size phenotypes: (i) normal weight, metabolically healthy; (ii) normal weight, metabolically abnormal; (iii) overweight, metabolically healthy; (iv) overweight, metabolically abnormal; (v) obese, metabolically healthy; and (vi) obese, metabolically abnormal. Results Metabolically healthy patients displayed lower postprandial response of plasma TG and large triacylglycerol‐rich lipoproteins ( TRL s)‐ TG , compared with those metabolically abnormal, independently whether or not they were obese ( P 〈 0·001 and P 〈 0·001, respectively). Moreover, the area under the curve ( AUC ) of TG and AUC of large TRL s‐ TG were greater in the group of metabolically abnormal compared with the group of metabolically healthy ( P 〈 0·001 and P 〈 0·001, respectively). Interestingly, metabolically abnormal subjects displayed higher postprandial response of plasma hs‐ CRP than did the subgroup of normal, overweight and obese, metabolically healthy patients ( P 〈 0·001). Conclusions Our findings showed that certain types of the metabolic phenotypes of obesity are more favourable modulating phenotypic flexibility after a dynamic fat load test, through TG metabolism and inflammation homoeostasis. To identify, these phenotypes may be the best strategy for personalized treatment of obesity.
Type of Medium:
Online Resource
ISSN:
0014-2972
,
1365-2362
DOI:
10.1111/eci.2014.44.issue-11
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2004971-7
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