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  • 1
    ISSN: 1573-4919
    Keywords: Crystals ; X-ray ; Calcineurin A ; Calcineurin B ; Protein Phosphatase ; PP2B
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Calcineurin is a serine/threonine protein phosphatase which catalyzes the hydrolysis of both phosphoseryl/phosphothreonyl and phosphotyrosyl proteins as well as low molecular weight compounds such as p-nitrophenyl phosphate. It is a hetero-dimeric protein consisting of a 60 kDa A chain and 19 kDa B chain. Calcineurin A is organized into functionally distinct domains such as a catalytic domain, a calcineurin B binding domain, a calmodulin-binding domain, and an inhibitory domain. Calcineurin B has four EF-hand calcium binding domains with a secondary structure that is homologous to calmodulin but its metal binding properties are more similar to troponin-C. The N-terminal myristoyl group of calcineurin B might play a role in the interaction between subunits A and B during phosphorylation/dephosphorylation processes. Crystals of size 0.125×0.07×0.03 mm and 0.7×0.03×0.02 mm have been obtained for calcineurin and the A subunit respectively. Crystals of calcineurin show strong diffraction to 5.3 Å and weak diffraction to 3.0 Å on rotating anode operated at 50 kV and 100 mA. Further work is in progress to improve the X-ray diffraction quality of these crystals and to obtain well diffracting crystals of calcineurin B.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Population and environment 21 (1999), S. 45-58 
    ISSN: 1573-7810
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Sociology
    Notes: Abstract Human population size and growth have been recognized as important factors affecting biodiversity, but the impacts of population structural changes on biodiversity are not clear. In this paper, we made the first attempt to link human population structural changes with implications for biodiveristy, using Wolong Nature Reserve (southwestern China) for the endangered giant panda as a case study. From 1982 to 1996, the labor force (20–59 years of age) in the reserve jumped by 59.76 percent, although the total population size increased by only 14.65 percent. During the same time period, the sex ratio (males:females) of small children (0–4 years of age) changed from 0.98:1 to 1.20:1, and the percentage of children receiving education beyond the elementary school level increased from 14.04 to 27.47. The increase in labor force and the number of male-biased children could have more negative impacts on the panda habitat, whereas improving school education could help more young people move out of the reserve by going to college and finding jobs elsewhere and thus reduce destruction to the panda habitat.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Population and environment 21 (1999), S. 45-58 
    ISSN: 1573-7810
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Sociology
    Notes: Abstract Human population size and growth have been recognized as important factors affecting biodiversity, but the impacts of population structural changes on biodiversity are not clear. In this paper, we made the first attempt to link human population structural changes with implications for biodiversity, using Wolong Nature Reserve (south-western China) for the endangered giant panda as a case study. From 1982 to 1996, the labor force (20–59 years of age) in the reserve jumped by 59.76 percent, although the total population size increased by only 14.65 percent. During the same time period, the sex ratio (males:females) of small children (0–4 years of age) changed from 0.98∶1 to 1.20∶1, and the percentage of children receiving education beyond the elementary school level increased from 14.04 to 27.47. The increase in labor force and the number of male-biased children could have more negative impacts on the panda habitat, whereas improving school education could help more young people move out of the reserve by going to college and finding jobs elsewhere and thus reduce destruction to the panda habitat.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
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