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  • 1
    Electronic Resource
    Electronic Resource
    Nasal challenge with serotonin in asymptomatic hay fever patients (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 42 (1987), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To study the nasal response to serotonin, 14 asymptomatic hay fever patients received intranasal serotonin in increasing doses. Itching and the number of sneezes were noted, and the amount of secretion was measured and assayed for substance P. Nasal airway resistance was recorded by active posterior rhinomanometry. Serotonin induced a dose-dependent increase in nasal itching, number of sneezes and secretion. Substance P was found in 41 of 42 secretions. The median concentration was 10.3 pmol/1 (range 0-28.9), and increased parallel to increasing doses of serotonin (P 〈 0.001).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1987.tb00361.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of Topically Applied Atropine, Methysergide and Chlorpheniramine on Nasal Challenge with Serotonin (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 40 (1985), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Serotonin challenge in the nose produces sneezing and rhinorrhoea. To study the mode of action of serotonin in the nose, 14 normal persons, in a double-blind, randomized study, were provoked with serotonin in three concentrations. Fifteen minutes before challenge, they were pretreated in the nose with either a cholinoceptor antagonist (atropine), a serotonin antagonist (methysergide), an H1-histamine antagonist (chlorpheniramine) or isotonic saline. The number of sneezes was noted, and the amount of secretions measured. Serotonin induced dose-related increase in sneezing and hypersecretion (P 〈 0.02). Atropine pretreatment reduced the amount of secretion (P 〈 0.05 and P 〈 0.1), but had no effect on sneering. Methysergide and chlorpheniramine had no effect on the serotonin-induced nasal symptoms. Unilateral challenge with serotonin induced secretions from both sides, suggesting that serotonin-induced nasal symptoms are partly reflex-mediated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1985.tb00892.x
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  • 3
    Electronic Resource
    Electronic Resource
    Nasal Challenge with Serotonin and Histamine in Normal Persons (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 40 (1985), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In order to study the nasal response to serotonin, 14 normal persons, in a double-blind study, were provoked in the nose with serotonin and histamine. Itching and the number of sneezes were noted, the amount of secretion measured, and nasal airway resistance recorded by active posterior rhinomanometry. Serotonin induced significant nasal itching, sneezing and hypersecretion, similar to the effects of histamine. The effect of serotonin on nasal airway resistance, on the other hand, was slight (+ 10%) and insignificant in contrast to that of histamine in equipotent doses (+ 48 %) (P 〈 0.001). In conclusion, we have shown that serotonin provocation can induce a rhinitis response in the human nose. The nasal symptoms suggest an effect on sensory nerves with reflex-induced sneezing and hypersecretion, while there appears to be little direct effect on capacitance vessels. The possible role of serotonin as a mediator of rhinitis remains speculative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1985.tb00246.x
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  • 4
    Electronic Resource
    Electronic Resource
    Intracutaneous and Skin Prick Testing with Serotonin and Histamine (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 41 (1986), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Skin prick and intracutaneous tests were performed with serotonin, histamine and a mixture of both in 32 normal persons, two rhinitis patients and 12 asthmatics. Skin prick tests with serotonin produced a triple response, but the weal reactions were small. Serotonin had no potentiating effect on the histamine reaction. Intracutaneously, serotonin tests also induced a triple response, but with smaller weal reactions than with histamine, and the weal surfaces were wrinkled. Constriction of the large subcutaneous veins was observed locally after serotonin injection. No quantitative or qualitative difference in reaction to serotonin was observed between normal subjects and allergies. The role of serotonin in the immediate allergic reaction in the skin was minimal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1986.tb00300.x
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of nasal allergen challenge on serotonin, substance P and vasoactive intestinal peptide in plasma and nasal secretions (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 43 (1988), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have studied the changes in concentration of serotonin, substance P, and vasoactive intestinal peptide (VIP) in plasma following a nasal allergen provocation in 14 grass pollen-allergic subjects; in five the urinary excretion of serotonin and 5-hydroxy-indolylacetic acid (5-HIAA) was also measured. In addition, the concentration of serotonin and substance P was measured in nasal secretions following nasal challenge with allergen and methacholine. The results showed an allergen-induced increase in free plasma serotonin (P 〈0.01) and no change in platelet serotonin, urinary serotonin and urinary 5–HIAA. The plasma substance P level tended to fall (P 〉 0.1), while plasma VIP increased significantly (P 〈 0.02). In nasal secretions, there were measurable levels of serotonin in all samples and of substance P in all but one. There was no difference between the concentrations of serotonin and substance P in secretions collected after allergen challenge and after methacholine challenge. For both substances, the secretion median value was comparable to that of plasma. Symptom reduction by topical and systemic pretreatment with a serotonin- and VIP-antagonist before nasal allergen provocation is necessary to define the role of these two agents in allergic rhinitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1988.tb00906.x
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  • 6
    Electronic Resource
    Electronic Resource
    Serotonin in nasal secretion (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 43 (1988), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to investigate the serotonin content in nasal secretion. Histamine- and methacholine-induced nasal secretions were collected during a 5-min period after challenge in 33 normal subjects. Serotonin was determined radio-enzymatically and was found in 66% of pure, blown secretions. The median concentration of serotonin in histamine- and methacholine-induced secretions was 6.3 nmol/1 (range 〈 1.6–52.0) and 2.3 nmol/1 (range 1.6-140.0) (NS), respectively. The serotonin concentration in allergen-induced nasal secretions in 7 rhinitis patients was 0.8 to 159 nmol/1, median 10.4 nmol/1 which did not differ from the serotonin levels in the normal subjects. The serotonin concentration in nasal lavage fluids in 5 subjects was low (below the detection limit in 78% of the samples). Further studies of serotonin in patients with nasal hypersecretion are indicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1988.tb00905.x
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  • 7
    Electronic Resource
    Electronic Resource
    Substance P and vasoactive intestinal peptide in serotonin-induced nasal secretions in normal subjects (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 42 (1987), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to examine if nasal secretions contained substance P and/or vasoactive intestinal peptide. Serotonin nasal challenge was performed in 14 normal subjects 15 min after intranasal pretreatment (double-blind) with atropine, methysergide, chlorpheniramine or isotonic saline. Serotonin induced a dose dependent increase in secretion (P 〈 0.05), and only pretreatment with atropine reduced the secretion (P 〈 0.02). Substance P, measured by radioimmunoassay, was found in all of the examined secretions (n= 100) with a median concentration of 13.7 pmol/1 (range 1.7–125.0). Serotonin challenge increased the concentration or content of substance P in a dose-related fashion (P 〈 0.01). The different pretreatments did not affect the concentration of substance P. Vasoactive intestinal peptide was found in low concentration in 37% of the secretions with a median concentration of 0 pmol/1 (range 0–50.0).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1987.tb02373.x
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  • 8
    Electronic Resource
    Electronic Resource
    Activator-associated Ca^2^+-ATPase in erythrocyte membranes from cystic fibrosis patients
    Amsterdam : Elsevier
    Clinica Chimica Acta 104 (1980), S. 187-193 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(80)90195-3
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Two and four mg nicotine chewing gum and group counselling in smoking cessation: An open, randomized, controlled trial with a 22 month follow-up
    Amsterdam : Elsevier
    Addictive Behaviors 13 (1988), S. 17-27 
    Details
    ISSN: 0306-4603
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0306-4603(88)90021-4
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  • 10
    Electronic Resource
    Electronic Resource
    Bronchial Challenge with Serotonin in Asthmatics (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 40 (1985), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Bronochial challenge with serotonin creatinine in phosphate buffer was performed in 20 stable asthmatics. In contrast to some earlier studies we observed no changes in FEV1 or FVC 0 and 2 min after provocation with increasing conecntrations of serotonin (maximal conecntration 20 mg/ml). In the first eight patients the PC20 histamine was 0.125–0.65 mg/ml, performed on a separate day. In three other asthmatics serotonin chloride 20 mg/ml did not affect lung function or produce any subjective symptoms. Serotonin can not be used to evaluate non-specific bronchial hyperreactivity in asthmatics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1985.tb02673.x
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