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  • 1
    Online-Ressource
    Online-Ressource
    Journal Press India ; 2018
    In:  International Journal of Advance Research and Innovation Vol. 6, No. 3 ( 2018), p. 144-146
    In: International Journal of Advance Research and Innovation, Journal Press India, Vol. 6, No. 3 ( 2018), p. 144-146
    Kurzfassung: This paper aims to determine the effect on performance parameter of furnace and microwave compressive molded polymer composite consisting polyvinyl alcohol (PVA) and epoxy matrix reinforced by coconut fiber. The influences of heat on the mechanical properties of the composites were analyzed. The volumetric amounts of fiber and the matrix were kept same for all the samples that are arranged in randomly oriented discontinues form however there is difference in temperature and heating device. The muffle furnace has external heating whereas microwave gives internal heating via radiation. Tensile test, hardness test, charpy impact test and bi-degradability test were carried out to evaluate the characteristics of the material. It was observed that the PVA and Epoxy was blended together and the heat provided eliminated the air voids in the composite, had good dispersion of fiber and interfacial adhesion between them. It showed slight variation on the mechanical characteristics and led to the conclusion that the material is most useful when strength to weight ratio is needed.
    Materialart: Online-Ressource
    ISSN: 2347-3258
    Sprache: Unbekannt
    Verlag: Journal Press India
    Publikationsdatum: 2018
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    In: Communications Medicine, Springer Science and Business Media LLC, Vol. 2, No. 1 ( 2022-06-24)
    Kurzfassung: Over five million joint replacements are performed across the world each year. Cobalt chrome (CoCr) components are used in most of these procedures. Some patients develop delayed-type hypersensitivity (DTH) responses to CoCr implants, resulting in tissue damage and revision surgery. DTH is unpredictable and genetic links have yet to be definitively established. Methods At a single site, we carried out an initial investigation to identify HLA alleles associated with development of DTH following metal-on-metal hip arthroplasty. We then recruited patients from other centres to train and validate an algorithm incorporating patient age, gender, HLA genotype, and blood metal concentrations to predict the development of DTH. Accuracy of the modelling was assessed using performance metrics including time-dependent receiver operator curves. Results Using next-generation sequencing, here we determine the HLA genotypes of 606 patients. 176 of these patients had experienced failure of their prostheses; the remaining 430 remain asymptomatic at a mean follow up of twelve years. We demonstrate that the development of DTH is associated with patient age, gender, the magnitude of metal exposure, and the presence of certain HLA class II alleles. We show that the predictive algorithm developed from this investigation performs to an accuracy suitable for clinical use, with weighted mean survival probability errors of 1.8% and 3.1% for pre-operative and post-operative models respectively. Conclusions The development of DTH following joint replacement appears to be determined by the interaction between implant wear and a patient’s genotype. The algorithm described in this paper may improve implant selection and help direct patient surveillance following surgery. Further consideration should be given towards understanding patient-specific responses to different biomaterials.
    Materialart: Online-Ressource
    ISSN: 2730-664X
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2022
    ZDB Id: 3096949-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    In: Communications Medicine, Springer Science and Business Media LLC, Vol. 2, No. 1 ( 2022-07-15)
    Materialart: Online-Ressource
    ISSN: 2730-664X
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2022
    ZDB Id: 3096949-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    British Editorial Society of Bone & Joint Surgery ; 2021
    In:  The Bone & Joint Journal Vol. 103-B, No. 12 ( 2021-12-01), p. 1791-1801
    In: The Bone & Joint Journal, British Editorial Society of Bone & Joint Surgery, Vol. 103-B, No. 12 ( 2021-12-01), p. 1791-1801
    Kurzfassung: The aim of this study was to investigate whether wear and backside deformation of polyethylene (PE) tibial inserts may influence the cement cover of tibial trays of explanted total knee arthroplasties (TKAs). Methods At our retrieval centre, we measured changes in the wear and deformation of PE inserts using coordinate measuring machines and light microscopy. The amount of cement cover on the backside of tibial trays was quantified as a percentage of the total surface. The study involved data from the explanted fixed-bearing components of four widely used contemporary designs of TKA (Attune, NexGen, Press Fit Condylar (PFC), and Triathlon), revised for any indication, and we compared them with components that used previous generations of PE. Regression modelling was used to identify variables related to the amount of cement cover on the retrieved trays. Results A total of 114 explanted fixed-bearing TKAs were examined. This included 76 used with contemporary PE inserts which were compared with 15 used with older generation PEs. The Attune and NexGen (central locking) trays were found to have significantly less cement cover than Triathlon and PFC trays (peripheral locking group) (p = 0.001). The median planicity values of the PE inserts used with central locking trays were significantly greater than of those with peripheral locking inserts (205 vs 85 microns; p 〈 0.001). Attune and NexGen inserts had a characteristic pattern of backside deformation, with the outer edges of the PE deviating inferiorly, leaving the PE margins as the primary areas of articulation. Conclusion Explanted TKAs with central locking mechanisms were significantly more likely to debond from the cement mantle. The PE inserts of these designs showed characteristic patterns of deformation, which appeared to relate to the manufacturing process and may be exacerbated in vivo. This pattern of deformation was associated with PE wear occurring at the outer edges of the articulation, potentially increasing the frictional torque generated at this interface. Cite this article: Bone Joint J 2021;103-B(12):1791–1801.
    Materialart: Online-Ressource
    ISSN: 2049-4394 , 2049-4408
    Sprache: Englisch
    Verlag: British Editorial Society of Bone & Joint Surgery
    Publikationsdatum: 2021
    ZDB Id: 2697480-0
    Standort Signatur Einschränkungen Verfügbarkeit
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