GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Document type
Keywords
Language
  • 1
    Keywords: Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (418 pages)
    Edition: 1st ed.
    ISBN: 9783832583767
    Series Statement: Studien Zum Physik- und Chemielernen Series ; v.353
    Language: German
    Note: Intro -- 1 Einleitung -- 2 Professionelle Handlungskompetenz von Physiklehrkräften -- 2.1 Wirkmodelle auf schulisches Lernen -- 2.1.1 Eine einfache Wirkungskette -- 2.1.2 Angebots-Nutzungs-Modelle -- 2.2 Kompetenz als Handlungsressource -- 2.2.1 Zum Kompetenzbegriff -- 2.2.2 Kompetenz zwischen Disposition und Performanz -- 2.3 Professioneller Handlungskompetenz von Lehrkräften -- 2.3.1 Rahmenmodelle professioneller Handlungskompetenz -- 2.3.2 Das Consensus Model of Teacher Professional Knowledge and Skill including PCK -- 2.3.3 Das Refined Consensus Model of PCK -- 2.4 Professionswissen von Physiklehrkräften -- 2.4.1 Fachwissen Physik -- 2.4.2 Fachdidaktisches Wissen -- 2.4.3 Pädagogisches Wissen -- 3 GrundannahmenundAblaufderUnterrichtsplanung -- 3.1 Ziele der Unterrichtsplanung -- 3.2 Unterrichtsplanung anhand didaktischer Modelle -- 3.2.1 Planung aus bildungstheoretischer Perspektive -- 3.2.2 Planung aus lehr-lerntheoretischer Perspektive -- 3.2.3 Das Modell der didaktischen Rekonstruktion -- 3.2.3.1 Grundlagen des Modells -- 3.2.3.2 Fachliche Klärung und Elementarisierung -- 3.2.3.3 Schülerperspektiven und Schülervorstellungen -- 3.2.3.4 Didaktische Strukturierung -- 3.3 Unterrichtsplanung in der Praxis -- 3.3.1 Ebenen der Unterrichtsplanung -- 3.3.2 Unterrichtsplanung als Prozess -- 3.3.2.1 Einordnung des Planungsprozesses in das alltägliche Handeln -- 3.3.2.2 Ausbildung von Handlungsskripten anhand der Unterrichtsplanung -- 3.3.2.3 Der Planungsprozess im beruflichen Alltag -- 3.3.2.4 Struktur geplanter Unterrichtsstunden -- 3.3.3 Aufbau schriftlicher Produkte der Unterrichtsplanung -- 3.3.4 Planungsprodukte in Ratgebern und Lehrbüchern -- 3.3.5 Planungspraxen von Experten und Novizen -- 4 Modellierung von Planungskompetenz -- 4.1 Rahmenmodell zur Kategorisierung der Erfassung von Wissen und Fähigkeiten. , 4.2 Modelle zur Beschreibung und Erfassung von Planungskompetenz und Planungsqualität -- 4.3 Benennung der betrachteten Konstrukte -- 5 Empirische Ausgangslage und Befunde zum Planungsprozess -- 5.1 Erfassung des Wissens über Unterrichtsplanung und empirische Erkenntnisse -- 5.2 Qualitätsanalysen realer Planungsprodukte zur Messung der Planungsfähigkeit -- 5.3 Einsatz von Performanztest in der Ausbildung von Lehrkräften -- 6 Ziele der Arbeit -- 6.1 Verortung des vorgestellten Vorhabens im Gesamtprojekt Profile-P+ -- 6.2 Ableitung von Forschungsfragen -- 7 Design und Methodik der Gesamtstudie Profile-P+ -- 7.1 Kurzvorstellung der weiteren Testinstrumente -- 7.2 Studiendesign -- 7.3 Beschreibung der Stichprobe -- 7.4 Vorstellung ausgewählter Auswertungsmethoden -- 7.4.1 Koeffizienten zur Urteilerübereinstimmung -- 7.4.2 Cross-Lagged-Panel-Designs -- 8 Entwicklung des Testverfahrens zur Planungsfähigkeit -- 8.1 Entwicklung des Testinstruments -- 8.1.1 Testszenario und bereitgestellte Hilfsmittel -- 8.1.2 Vorstrukturiertes Planungspapier zur Dokumentation der Planung -- 8.2 Operationalisierung der Planungsfähigkeit und Entwicklung des Kodiermanuals -- 8.2.1 Ableitung von Oberkategorien als Item-Entwicklungsmodell -- 8.2.2 Erstellung konkreter Kategorien zur Bewertung der Planungen -- 8.2.2.1 Zusammenführung von Kategorien zu Gruppen -- 9 Untersuchung der Testgüte -- 9.1 Betrachtung von Objektivität und Reliabilität -- 9.2 Weitere Testcharakterisierung -- 9.3 Verständnis von Validität -- 9.4 Validierungsstudien -- 9.4.1 Vergleich des Planungsproduktes aus realen und standardisierten Unterrichtsplanungen -- 9.4.2 Überprüfung der Vorhersage von Expertenurteilen zur Planungsqualität -- 9.4.3 Nutzbarkeit des Kodiermanuals zur Bewertung unstandardisierter Planungen -- 10 Ergebnisse der Hauptstudie zur Entwicklung der Planungsfähigkeit. , 10.1 Standort- und Kohorteneffekten bezüglich der Gesamtstichprobe -- 10.2 Entwicklung der Planungsfähigkeit während des Praxissemesters -- 10.2.1 Veränderungen im Testverhalten -- 10.2.2 Zusammenhänge zu personenbezogenen Daten -- 10.2.2.1 Zusammenhänge zu demographischen Daten -- 10.2.2.2 Zusammenhänge zu den Erfahrungen im Praxissemester -- 10.3 Zusammenhänge zwischen Planungsfähigkeit und Professionswissen -- 10.3.1 Korrelationen zu Bereichen des Professionswissens -- 10.3.2 Cross-Lagged-Panel Analysen -- 11 Diskussion -- 11.1 Zusammenfassung -- 11.2 Grenzen -- 11.3 Ausblick -- Abbildungsverzeichnis -- Tabellenverzeichnis -- Literatur.
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: Forschungsbericht ; Medizinprodukt ; Funktionstextilien ; Lichtleitfaser ; Lasertherapie
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (22 Seiten, 1,61 MB) , Illustrationen, Diagramme
    Language: German
    Note: Förderkennzeichen BMBF 03WKCV04D , Verbundnummer 01173580 , Zuwendungsempfänger und ausführende Stelle dem Förderkatalog entnommen , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Keywords: Forschungsbericht ; Denitrifikation ; Kreislauf
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (37 Seiten, 1,38 MB) , Illustrationen, Diagramme
    Language: German
    Note: Literaturverzeichnis: Blatt 30 , Laufzeit: 12 Monate: Projektbeginn: 26.08.2014, Projektende: 25.08.2015 - [Angaben laut Projektkennblatt der Deutschen Bundesstiftung Umwelt] , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden , Mit deutscher Zusammenfassung
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Keywords: Forschungsbericht ; Wasseraufbereitungsanlage
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (51 Seiten, 2,07 MB) , Illustrationen, Diagramme
    Language: German
    Note: Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Keywords: Hochschulschrift
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (120 Seiten = 6 MB) , Illustrationen, Graphen
    Edition: Online-Ausgabe 2021
    Language: German
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    Keywords: Hochschulschrift
    Type of Medium: Online Resource
    Pages: Online-Ressource (IX, 99 Bl) , Ill., graph. Darst , 30 cm
    Edition: 2011 Online-Ressource [Online-Ausg.]
    DDC: 570
    Language: English
    Note: Enth. 4 Sonderabdr. aus verschiedenen Zeitschr , Kiel, Univ., Diss., 2011 , Online-Ausg.: , [Online-Ausg.]
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 126 (2000), S. 111-116 
    ISSN: 1432-1335
    Keywords: Key words Acute myeloid leukemia ; Multidrug resistance ; MDR modifiers ; Idarubicinol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recent results show that the intracellular uptake pattern of idarubicin (IDA) in multidrug-resistant (MDR) cells is nearly identical to that seen in the drug-sensitive parent cell line, whereas the MDR cells have minimal daunorubicin (DNR) uptake compared with the drug-sensitive parent cells. It is known that the major metabolite of IDA, idarubicinol (IDA-OL), has nearly the same cytotoxicity as IDA, while the cytotoxicity of daunorubicinol (DNR-OL) is about 1/30th of that of DNR. We examined the effect of the MDR modifiers verapamil and dexniguldipine on the efflux of IDA, DNR and their hydroxylated metabolites IDA-OL and DNR-OL in blast populations of acute myeloid leukemia (AML), in the MDR-negative cell line CEM-CCRF and in their MDR-positive counterpart (CEM-VBL). All patients with relapsed or persistent AML had been pretreated with IDA and cytosine arabinoside. The efflux of the anthracyclines was estimated by flow cytometry. A total of 36 patients with AML were investigated; 18 out of 36 AML blast populations showed an efflux of DNR, DNR-OL and IDA-OL. The efflux of DNR, DNR-OL and particularly IDA-OL could be reversed by 10 μM verapamil or 1 μM dexniguldipine. For IDA we found an effusion of 40 ± 11% in all blast populations which could not be significantly inhibited by the modulators. Similar results for IDA were found in the MDR-positive cell line (CEM-VBL 100) and in their MDR-negative counterpart (CEM-CCRF). The incubation of CEM-CCRF cells with DNR, DNR-OL, IDA-OL and especially IDA led to MDR induction as determined by reverse transcription/polymerase chain reaction analysis with MDR-specific primer and by cellular efflux studies. We conclude that the outcome of chemotherapy with idarubicin is influenced by MDR, although IDA is not essentially MDR-dependent itself, but because IDA-OL is actively involved in multidrug resistance. Further investigations should consider the question of whether the combination of IDA and MDR modifiers can enhance the serum level of the active metabolite IDA-OL and can reverse the MDR pattern in cells treated with IDA.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1432-1335
    Keywords: Multidrug resistance ; P-glycoprotein ; Acute myeloid leukemia ; Chemosensitizer ; BIBW22BS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The phenylpteridine derivative BIBW22BS (BIBW22) is a potent modulator of multidrug resistance (MDR). We investigated BIBW22 in comparison to dexniguldipine and verapamil as modifier of MDR in blasts of de novo, relapsed or persistent acute myeloid leukemia (AML) in vitro. All patients with relapsed or persistent AML had been pretreated with idarubicin and cytosine arabinoside. The degree of MDR was determined by efflux kinetics of rhodamine 123 (R123), daunorubicin, and idarubicin measured by flow cytometry (FACS). A total of 51 patients with AML, 25 de novo and 26 relapsed or persistent, were investigated. While only 6 out of 25 de novo AML blast populations showed moderate efflux of R123 and daunorubicin, 17 out of 26 blast populations of relapsed or persistent AML had an efflux between 20% and 44% within 15 min ex vivo. This efflux could be significantly inhibited by 1 μM BIBW22, 1 μM dexniguldipine, or 10 μM verapamil. For idarubicin we found an effusion of 40±9% within 15 min in all blast populations that could not be inhibited by the modulators. Clinically achievable drug concentrations causing only moderate side-effects are in the range of 0.5 μM dexniguldipine and 3 μM verapamil. Up to now, BIBW22 has not been investigated clinically. Thus, the potential toxicity of concentrations of 0.5–1 μM BIBW22, sufficient for an optimal efflux inhibition ex vivo, is not known yet. We conclude from our ex vivo investigations in blast populations of de novo, relapsed or persistent AML that BIBW22 is a potent modulator of MDR.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 9
    facet.materialart.
    Unknown
    Elsevier
    In:  Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, 157 (4). pp. 352-360.
    Publication Date: 2020-08-04
    Description: Pike-perch Sander lucioperca is currently considered as one of the most promising candidates for production in freshwater recirculation aquaculture systems (RAS). Here, due to the lack of studies on nitrite (NO(2)(-)) toxicity in pike-perch, a flow-through exposure at 0, 0.44, 0.88, 1.75, 3.5, 7, 14 and 28 mg/L NO(2)(-)-N was carried out to determine the acute and chronic toxicity over a period of 32 days. In juvenile pike-perch, 120 h LC(50) was 6.1mg/L NO(2)(-)-N and at ≥14 mg/L NO(2)(-)-N all fish had died within 24 h. Chronic exposure revealed a significant build up of NO(2)(-) in the plasma as well as in the muscles at ≥0.44 mg/L NO(2)(-)-N peaking in fish exposed to the highest concentration of 3.5 mg/L NO(2)(-)-N after 32 days. Still, due to high individual variation methemoglobin (MetHb) was only significantly increased (p〈0.01) at 3.5 mg/L NO(2)(-)-N. No adverse effects on red blood cells (RBC) and hematocrit were observed in any of the treatments. In a second experiment, compensation of NO(2)(-) toxicity at increasing chloride concentrations (40 (freshwater), 65, 90, 140, 240, 440 mg/L Cl(-)) was observed at a constant exposure of 10 mg/L NO(2)(-)-N for 42 days. At ≥240 mg/L Cl(-), NO(2)(-) build-up in blood plasma and muscle was completely inhibited. At lower Cl(-) concentrations (≤140 mg/L), NO(2)(-) was significantly increased in plasma, but only insignificantly elevated in muscle due to high individual variation. MetHb was increased significantly difference only at 40 mg/L Cl(-) (freshwater control) compared to the control. Again, high individual variations were observed. As a conclusion, S. lucioperca is moderately sensitive towards NO(2)(-) and acceptable levels in RAS should hence not exceed 1.75 mg/L NO(2)(-)-N to avoid MetHb formation. However, based on the 120 h LC(50) and a factor of 0.01 according to Sprague (1971), a NO(2)(-) concentration of ≤0.061 mg/L NO(2)(-)-N is considered as "safe." Thereby, no NO(2)(-) should accumulate in the plasma or muscle tissue during chronic exposure. For 10 mg/L NO(2)(-)-N, ≥240 mg/L chloride compensates for NO(2)(-) uptake in plasma and muscle.
    Type: Article , PeerReviewed
    Format: text
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2017-12-12
    Description: Ozone is frequently used for water treatment and disinfection in recirculating aquaculture systems. However, due to the fragmentary data on chronic toxicity of ozone produced oxidants (OPO) and its safe concentrations, the daily application of ozone in aquaculture is challenging. To evaluate the chronic effects of sublethal OPO concentrations, juvenile turbot (Psetta maxima, L.) were exposed to OPO concentrations of 0.06, 0.10 and 0.15mg/l for 21 days. Gills were analysed for histopathological alterations and mRNA expression of heat shock protein 70 (hsp70), hsp90 as well as glutathione-S-transferase (gst) were determined in the gills and the liver after 1d, 7d and 21d. Histopathologic findings confirmed adverse effects at 0.10-0.15mg/l, but these (necrosis, lamellar clubbing, hypertrophy, hyperplasia) could only be observed after an extended exposure (mostly 21d), and were considered as irreversible tissue damage. Hsp70 expression in the gills was only significantly increased at the highest OPO concentration (0.15mg/l) on 1d and 7d, and returned to basic levels until day 21. Hsp90 mRNA was already increased at 0.10mg/l after 1 and 7 days of exposure, and again was comparable to the control group on day 21. In contrast, elevated gst mRNA expression was only observed on day 7 at 0.10mg and 0.15mg/l. Although similar trends were observed in the liver for all markers, differences were only significant in exceptional cases due to the high individual variation observed. Thus, mRNA expression in the gills rather than in the liver is recommended as a marker to characterize OPO-induced oxidative stress in turbot. It has to be noted that mRNA expression returned to basic levels on day 21 regardless the actual OPO concentration, suggesting a collapse of adaptive mechanisms as a possible explanation for the observed tissue damage.
    Type: Article , PeerReviewed
    Format: text
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...