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  • 1
    Online-Ressource
    Online-Ressource
    Night sleep in patients with vegetative state
    Wiley ; 2017
    In:  Journal of Sleep Research Vol. 26, No. 5 ( 2017-10), p. 629-640
    Details
    In: Journal of Sleep Research, Wiley, Vol. 26, No. 5 ( 2017-10), p. 629-640
    Kurzfassung: Polysomnographic recording of night sleep was carried out in 15 patients with the diagnosis vegetative state (syn. unresponsive wakefulness syndrome). Sleep scoring was performed by three raters, and confirmed by means of a spectral power analysis of the electroencephalogram, electrooculogram and electromyogram. All patients but one exhibited at least some signs of sleep. In particular, sleep stage N1 was found in 13 patients, N2 in 14 patients, N3 in nine patients, and rapid eye movement sleep in 10 patients. Three patients exhibited all phenomena characteristic for normal sleep, including spindles and rapid eye movements. However, in all but one patient, sleep patterns were severely disturbed as compared with normative data. All patients had frequent and long periods of wakefulness during the night. In some apparent rapid eye movement sleep episodes, no eye movements were recorded. Sleep spindles were detected in five patients only, and their density was very low. We conclude that the majority of vegetative state patients retain some important circadian changes. Further studies are necessary to disentangle multiple factors potentially affecting sleep pattern of vegetative state patients.
    Materialart: Online-Ressource
    ISSN: 0962-1105 , 1365-2869
    URL: Issue
    URL: Article
    DOI: 10.1111/jsr.2017.26.issue-5
    DOI: 10.1111/jsr.12524
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2017
    ZDB Id: 2007459-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
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    Regularien und gesetzliche Bestimmungen bei klinischen Studien mit Medizinprodukten
    Georg Thieme Verlag KG ; 2020
    In:  neuroreha Vol. 12, No. 01 ( 2020-03), p. 23-28
    Details
    In: neuroreha, Georg Thieme Verlag KG, Vol. 12, No. 01 ( 2020-03), p. 23-28
    Kurzfassung: Studien sind das Kernelement einer evidenzbasierten Medizin. Ihr Ziel ist es, dem einzelnen Patienten die für ihn bestmögliche Behandlung zukommen zu lassen. Welche Grundlagen und Bestimmungen es dafür gibt, erläutert dieser Bericht aus der Forschungspraxis.
    Materialart: Online-Ressource
    ISSN: 1611-6496 , 1611-7654
    URL: Article
    DOI: 10.1055/a-1089-8728
    Sprache: Deutsch
    Verlag: Georg Thieme Verlag KG
    Publikationsdatum: 2020
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
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    Is glutamine deficiency the link between inflammation, malnutrition, and fatigue in cancer patients?
    Elsevier BV ; 2015
    In:  Clinical Nutrition Vol. 34, No. 6 ( 2015-12), p. 1258-1265
    Details
    In: Clinical Nutrition, Elsevier BV, Vol. 34, No. 6 ( 2015-12), p. 1258-1265
    Materialart: Online-Ressource
    ISSN: 0261-5614
    URL: Article
    DOI: 10.1016/j.clnu.2014.12.021
    Sprache: Englisch
    Verlag: Elsevier BV
    Publikationsdatum: 2015
    ZDB Id: 2009052-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
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    Quality of life up to 10 years after traumatic brain injury: a cross-sectional analysis
    Springer Science and Business Media LLC ; 2020
    In:  Health and Quality of Life Outcomes Vol. 18, No. 1 ( 2020-12)
    Details
    In: Health and Quality of Life Outcomes, Springer Science and Business Media LLC, Vol. 18, No. 1 ( 2020-12)
    Kurzfassung: Traumatic brain injury (TBI) is the leading cause of death and disability among children and young adults in industrialized countries, but strikingly little is known how patients cope with the long-term consequences of TBI. Thus, the aim of the current study was to elucidate health-related quality of life (HRQoL) and outcome predictors in chronic TBI adults. Methods In this cross-sectional study, 439 former patients were invited to report HRQoL up to 10 years after mild, moderate or severe TBI using the QOLIBRI (Quality of Life after Brain Injury) questionnaire. The QOLIBRI total score has a maximum score of 100. A score below 60 indicates an unfavorable outcome with an increased risk of an affective and/or anxiety disorder. Results were correlated with demographics and basic characteristics received from medical records (TBI severity, etiology, age at TBI, age at survey, time elapsed since TBI, and sex) using regression models. Differences were considered significant at p   〈   0.05. Results From the 439 invited patients, 135 out of 150 in principle eligible patients (90%) completed the questionnaire; 76% were male, and most patients experienced severe TBI due to a traffic-related accident (49%) or a fall (44%). The mean QOLIBRI total score was 65.5 (± 22.6), indicating good HRQoL. Factors for higher level of satisfaction ( p  = 0.03; adjusted R 2  = 0.1) were autonomy in daily life ( p  = 0.03; adjusted R 2  = 0.09) and cognition ( p  = 0.05; adjusted R 2  = 0.05). HRQoL was weakly correlated with initial TBI severity ( p  = 0.04; adjusted R 2  = 0.02). 36% of patients reported unfavorable HRQoL with increased risk of one (20%) or two (16%) psychiatric disorders. Conclusions The majority of chronic TBI patients reported good HRQoL and the initial TBI severity is a slight contributor but not a strong predictor of HRQoL. Autonomy and cognition are decisive factors for satisfied outcome and should be clearly addressed in neurorehabilitation. One third of patients, however, suffer from unsatisfactory outcome with psychiatric sequelae. Thus, an early neuropsychiatric assessment after TBI is necessary and need to be installed in future TBI guidelines.
    Materialart: Online-Ressource
    ISSN: 1477-7525
    URL: Article
    DOI: 10.1186/s12955-020-01391-3
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2020
    ZDB Id: 2098765-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    Determining design requirements for active aging: Personas, experience maps, and stakeholders
    International Society for Gerontechnology (ISG) ; 2017
    In:  Gerontechnology Vol. 16, No. 3 ( 2017-11-7), p. 139-150
    Details
    In: Gerontechnology, International Society for Gerontechnology (ISG), Vol. 16, No. 3 ( 2017-11-7), p. 139-150
    Materialart: Online-Ressource
    ISSN: 1569-1101 , 1569-111X
    URL: Article
    DOI: 10.4017/gt.2017.16.3.003.00
    Sprache: Unbekannt
    Verlag: International Society for Gerontechnology (ISG)
    Publikationsdatum: 2017
    ZDB Id: 2509019-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
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    Advanced Sensing and Human Activity Recognition in Early Intervention and Rehabilitation of Elderly People
    Springer Science and Business Media LLC ; 2020
    In:  Journal of Population Ageing Vol. 13, No. 2 ( 2020-06), p. 139-165
    Details
    In: Journal of Population Ageing, Springer Science and Business Media LLC, Vol. 13, No. 2 ( 2020-06), p. 139-165
    Kurzfassung: Ageing is associated with a decline in physical activity and a decrease in the ability to perform activities of daily living, affecting physical and mental health. Elderly people or patients could be supported by a human activity recognition (HAR) system that monitors their activity patterns and intervenes in case of change in behavior or a critical event has occurred. A HAR system could enable these people to have a more independent life. In our approach, we apply machine learning methods from the field of human activity recognition (HAR) to detect human activities. These algorithmic methods need a large database with structured datasets that contain human activities. Compared to existing data recording procedures for creating HAR datasets, we present a novel approach, since our target group comprises of elderly and diseased people, who do not possess the same physical condition as young and healthy persons. Since our targeted HAR system aims at supporting elderly and diseased people, we focus on daily activities, especially those to which clinical relevance in attributed, like hygiene activities, nutritional activities or lying positions. Therefore, we propose a methodology for capturing data with elderly and diseased people within a hospital under realistic conditions using wearable and ambient sensors. We describe how this approach is first tested with healthy people in a laboratory environment and then transferred to elderly people and patients in a hospital environment. We also describe the implementation of an activity recognition chain (ARC) that is commonly used to analyse human activity data by means of machine learning methods and aims to detect activity patterns. Finally, the results obtained so far are presented and discussed as well as remaining problems that should be addressed in future research.
    Materialart: Online-Ressource
    ISSN: 1874-7884 , 1874-7876
    URL: Article
    DOI: 10.1007/s12062-020-09260-z
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2020
    ZDB Id: 2493750-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
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    Decompressive Craniectomy Is Associated With Good Quality of Life Up to 10 Years After Rehabilitation From Traumatic Brain Injury
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  Critical Care Medicine Vol. 48, No. 8 ( 2020-08), p. 1157-1164
    Details
    In: Critical Care Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 48, No. 8 ( 2020-08), p. 1157-1164
    Kurzfassung: Traumatic brain injury is the number one cause of death in children and young adults and has become increasingly prevalent in the elderly. Decompressive craniectomy prevents intracranial hypertension but does not clearly improve physical outcome 6 months after traumatic brain injury. However, it has not been analyzed if decompressive craniectomy affects traumatic brain injury patients’ quality of life in the long term. Design: Therefore, we conducted a cross-sectional study assessing health-related quality of life in traumatic brain injury patients with or without decompressive craniectomy up to 10 years after injury. Setting: Former critical care patients. Patients: Chronic traumatic brain injury patients having not ( n = 37) or having received ( n = 98) decompressive craniectomy during the acute treatment. Measurements and Main Results: Decompressive craniectomy was necessary in all initial traumatic brain injury severity groups. Eight percent more decompressive craniectomy patients reported good health-related quality of life with a Quality of Life after Brain Injury total score greater than or equal to 60 compared with the no decompressive craniectomy patients up to 10 years after traumatic brain injury ( p = 0.004). Initially, mild classified traumatic brain injury patients had a median Quality of Life after Brain Injury total score of 83 (decompressive craniectomy) versus 62 (no decompressive craniectomy) ( p = 0.028). Health-related quality of life regarding physical status was better in decompressive craniectomy patients ( p = 0.025). Decompressive craniectomy showed a trend toward better health-related quality of life in the 61–85-year-old reflected by median Quality of Life after Brain Injury total scores of 62 (no decompressive craniectomy) versus 79 (decompressive craniectomy) ( p = 0.06). Conclusions: Our results suggest that decompressive craniectomy is associated with good health-related quality of life up to 10 years after traumatic brain injury. Thus, decompressive craniectomy may have an underestimated therapeutic potential after traumatic brain injury.
    Materialart: Online-Ressource
    ISSN: 0090-3493
    URL: Article
    DOI: 10.1097/CCM.0000000000004387
    Sprache: Englisch
    Verlag: Ovid Technologies (Wolters Kluwer Health)
    Publikationsdatum: 2020
    ZDB Id: 2034247-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span
    Springer Science and Business Media LLC ; 2021
    In:  GeroScience Vol. 43, No. 1 ( 2021-02), p. 263-278
    Details
    In: GeroScience, Springer Science and Business Media LLC, Vol. 43, No. 1 ( 2021-02), p. 263-278
    Kurzfassung: Traumatic brain injury (TBI) is the leading cause of disability in the working population and becomes increasingly prevalent in the elderly. Thus, TBI is a major global health burden. However, age- and sex-related long-term outcome regarding patient’s health-related quality of life (HRQoL) is yet not clarified. In this cross-sectional study, we present age- and sex-related demographics and HRQoL up to 10 years after TBI using the Quality of Life after Brain Injury (QOLIBRI) instrument. The QOLIBRI total score ranges from zero to 100 indicating good (≥ 60), moderate (40–59) or unfavorable ( 〈  40) HRQoL. Two-thirds of the entire chronic TBI cohort (102 males; 33 females) aged 18–85 years reported good HRQoL up to 10 years after TBI. TBI etiology differed between sexes with females suffering more often from traffic- than fall-related TBI ( p  = 0.01) with increasing prevalence during aging ( p  =  〈  0.001). HRQoL (good/moderate/unfavorable) differed between sexes ( p   〈  0.0001) with 17% more females reporting moderate outcome ( p  = 0.01). Specifically, older females (54–76-years at TBI) were affected, while males constantly reported good HRQoL ( p  = 0.017). Cognition ( p  = 0.014), self-perception ( p  = 0.009), and emotions ( p  = 0.016) rather than physical problems ( p  = 0.1) constrained older females’ HRQoL after TBI. Experiencing TBI during aging does not influence HRQoL outcome in males but females suggesting that female brains cope less well with a traumatic injury during aging. Therefore, older females need long-term follow-ups after TBI to detect neuropsychiatric sequels that restrict their quality of life. Further investigations are necessary to uncover the mechanisms of this so far unknown phenomenon.
    Materialart: Online-Ressource
    ISSN: 2509-2715 , 2509-2723
    URL: Article
    DOI: 10.1007/s11357-020-00273-2
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2021
    ZDB Id: 2886418-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
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    Low Prevalence of Isolated Growth Hormone Deficiency in Patients After Brain Injury: Results From a Phase II Pilot Study
    Frontiers Media SA ; 2018
    In:  Frontiers in Endocrinology Vol. 9 ( 2018-12-17)
    Details
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 9 ( 2018-12-17)
    Materialart: Online-Ressource
    ISSN: 1664-2392
    URL: Article
    DOI: 10.3389/fendo.2018.00723
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2018
    ZDB Id: 2592084-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
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    REACH: Solutions for Technology-Based Prevention and Empowerment for Older People and their Caregivers
    Springer Science and Business Media LLC ; 2020
    In:  Journal of Population Ageing Vol. 13, No. 2 ( 2020-06), p. 131-137
    Details
    In: Journal of Population Ageing, Springer Science and Business Media LLC, Vol. 13, No. 2 ( 2020-06), p. 131-137
    Kurzfassung: REACH stands for “Responsive Engagement of the Elderly Promoting Activity and Customized Healthcare”. Sustained physical activity matters greatly to the health and well-being of older people and significantly improves their chance of maintaining independent living. It can make a difference across the whole care continuum as well as in almost every setting. Therefore, REACH solutions focus on the systematic, target-oriented increase of physical activity of older people, and tackle the whole prevention spectrum (primary, secondary, and tertiary). It seeks to empower older people and their formal and informal caregivers, and works towards viable solutions for both the formal and in-formal care sector. Technology-based personalization of prevention, activation, and care services provided in various living and care settings is at the center of the developed solutions. Ideally toolkit approach would allow for the tailoring of solutions that create value for end-users, care providers and health care payers alike through the combination, integration and adaptation/re-design elements towards the different contexts of different countries, different payment and reimbursement structures. This Special Issue sheds light on such solutions, their conception, their development, and their testing.
    Materialart: Online-Ressource
    ISSN: 1874-7884 , 1874-7876
    URL: Article
    DOI: 10.1007/s12062-020-09268-5
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2020
    ZDB Id: 2493750-2
    Standort Signatur Einschränkungen Verfügbarkeit
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