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  • 1
    Online Resource
    Online Resource
    The Turkish Chemical Society ; 2023
    In:  Journal of the Turkish Chemical Society Section A: Chemistry Vol. 10, No. 3 ( 2023-08-30), p. 757-772
    In: Journal of the Turkish Chemical Society Section A: Chemistry, The Turkish Chemical Society, Vol. 10, No. 3 ( 2023-08-30), p. 757-772
    Abstract: Graphene is the name for a monolayer sheet of carbon atoms that are bonded together in a repeating pattern of hexagons. This sheet is only one atom thick. Monolayers of graphene stacked on top of each other. In this article, we have compared the characterization results of graphene and graphene oxide along with synthesis via different methods. A sigma bond connects each atom in a graphene sheet to its three closest neighbours and each atom also contributes one electron to a conduction band that covers the entire graphene sheet. Graphene when oxidized is called graphene oxide (GO) and is mostly used in photoelectric, materialistic, catalyst and energy fields due to its thermal, electrical and mechanical characteristics. It is also used in the field of medical science, drug delivery and biomedical applications. Graphene have been improved due to import of 3D printing technology. In last few years, graphene has taken the attention of most material science researchers due to its various applications. Graphene based polymers and nanocomposites are widely used in sensors, optoelectronics, magneto transport, automotive, biosensors, electronics and aerospace fields.
    Type of Medium: Online Resource
    ISSN: 2149-0120
    Language: Unknown
    Publisher: The Turkish Chemical Society
    Publication Date: 2023
    detail.hit.zdb_id: 2913005-0
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  • 2
    In: Cancers, MDPI AG, Vol. 14, No. 18 ( 2022-09-19), p. 4539-
    Abstract: The ongoing rise in the number of cancer cases raises concerns regarding the efficacy of the various treatment methods that are currently available. Consequently, patients are looking for alternatives to traditional cancer treatments such as surgery, chemotherapy, and radiotherapy as a replacement. Medicinal plants are universally acknowledged as the cornerstone of preventative medicine and therapeutic practices. Annona muricata is a member of the family Annonaceae and is familiar for its medicinal properties. A. muricata has been identified to have promising compounds that could potentially be utilized for the treatment of cancer. The most prevalent phytochemical components identified and isolated from this plant are alkaloids, phenols, and acetogenins. This review focuses on the role of A. muricata extract against various types of cancer, modulation of cellular proliferation and necrosis, and bioactive metabolites responsible for various pharmacological activities along with their ethnomedicinal uses. Additionally, this review highlights the molecular mechanism of the role of A. muricata extract in downregulating anti-apoptotic and several genes involved in the pro-cancer metabolic pathways and decreasing the expression of proteins involved in cell invasion and metastasis while upregulating proapoptotic genes and genes involved in the destruction of cancer cells. Therefore, the active phytochemicals identified in A. muricata have the potential to be employed as a promising anti-cancer agent.
    Type of Medium: Online Resource
    ISSN: 2072-6694
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2527080-1
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  • 3
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 14 ( 2023-6-23)
    Abstract: The recent emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease (COVID-19) has become a global public health crisis, and a crucial need exists for rapid identification and development of novel therapeutic interventions. In this study, a recurrent neural network (RNN) is trained and optimized to produce novel ligands that could serve as potential inhibitors to the SARS-CoV-2 viral protease: 3 chymotrypsin-like protease (3CL pro ). Structure-based virtual screening was performed through molecular docking, ADMET profiling, and predictions of various molecular properties were done to evaluate the toxicity and drug-likeness of the generated novel ligands. The properties of the generated ligands were also compared with current drugs under various phases of clinical trials to assess the efficacy of the novel ligands. Twenty novel ligands were selected that exhibited good drug-likeness properties, with most ligands conforming to Lipinski’s rule of 5, high binding affinity (highest binding affinity: −9.4 kcal/mol), and promising ADMET profile. Additionally, the generated ligands complexed with 3CL pro were found to be stable based on the results of molecular dynamics simulation studies conducted over a 100 ns period. Overall, the findings offer a promising avenue for the rapid identification and development of effective therapeutic interventions to treat COVID-19.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2587354-4
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  • 4
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 10 ( 2023-4-27)
    Abstract: Medical-grade oxygen is the basic need for all medical complications, especially in respiratory-based discomforts. There was a drastic increase in the demand for medical-grade oxygen during the current pandemic. The non-availability of medical-grade oxygen led to several complications, including death. The oxygen concentrator was only the last hope for the patient during COVID-19 pandemic around the globe. The demands also are everlasting during other microbial respiratory infections. The yield of oxygen using conventional molecular zeolites in the traditional oxygen concentrator process is less than the yield noticed when its nano-form is used. Nanotechnology has enlightened hope for the efficient production of oxygen by such oxygen concentrators. Here in the current review work, the authors have highlighted the basic structural features of oxygen concentrators along with the current working principle. Besides, it has been tried to bridge the gap between conventional oxygen concentrators and advanced ones by using nanotechnology. Nanoparticles being usually within 100 nm in size have a high surface area to volume ratio, which makes them suitable adsorbents for oxygen. Here authors have suggested the use of nano zeolite in place of molecular zeolites in the oxygen concentrator for efficient delivery of oxygen by the oxygen concentrators.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2775999-4
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  • 5
    In: Frontiers in Bioengineering and Biotechnology, Frontiers Media SA, Vol. 11 ( 2023-8-3)
    Abstract: Current ethanol production technology has a dire need for efficient conversion of lignocellulosic biomass to fermentable sugars. The conversion requires pretreatment of the biomass, one of the most expensive steps, and thus it is quite necessary to identify the most cost-effective and high-efficiency conversion method. In this study, rice straw (RS) biomass was pretreated using 4% NaOH alkali, soaked for 4 h, and autoclaved for 30 min. The structural and morphological changes were examined using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) analysis in both native and alkali-treated RS. The FTIR analysis revealed that native RS contains a considerable amount of lignin that was removed after the pretreatment process. The XRD pattern of the RS revealed an increasing crystallite size of the pretreated lignocellulosic biomass. The study of SEM clearly showed the distorted structure and surface porosity after the pretreatment process. Enzymatic hydrolysis efficiency was checked by comparing the commercial enzymes and microbial hydrolysis extracted from a fungal isolate. The best-reducing sugar yield obtained was 0.62 g/L, achieved at optimized conditions from the commercial enzymes. Fermentation efficiency was checked using the yeast isolate Saccharomyces cerevisiae in both the native and pretreated substrate, and the highest ethanol concentration (21.45%) was achieved using 20% w/v biomass loading, enzyme loading (2:1:1), and fermentation for a week at 30°C and pH 4.5. This concentration was higher than that of the untreated RS (3.67%). The ethanol thus produced was further checked for analysis by the 1 H and 13 C nuclear magnetic resonance (NMR) methods.
    Type of Medium: Online Resource
    ISSN: 2296-4185
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2719493-0
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  • 6
    In: Cell Biochemistry and Function, Wiley, Vol. 42, No. 3 ( 2024-04)
    Abstract: The administration of antibiotics to combat bacterial infections has become increasingly challenging due to the growing prevalence of antimicrobial resistance displayed by different strains of bacteria. The increase in multidrug‐resistant (MDR) bacterial species is a concerning issue, as the lack of new antibiotics has resulted in higher mortality rates. Phage‐derived endolysins, phage cocktails, and bioengineered phages have proven to be highly effective in combating MDR and extensively drug‐resistant strains due to their potent antimicrobial properties. This review offers a comprehensive look at the importance of phage therapy as a potential substitute for antibiotics in fighting against resistant bacterial strains and also explores its application in different fields and highlights the need to safeguard and enhance treatment effectiveness.
    Type of Medium: Online Resource
    ISSN: 0263-6484 , 1099-0844
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 1496553-7
    SSG: 12
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  • 7
    In: Frontiers in Environmental Science, Frontiers Media SA, Vol. 11 ( 2023-9-15)
    Abstract: Fish are among the best-studied aquatic animals due to their economic and ecological values. Fish meat is the most affordable protein source for the economically weaker section of people. The environment of almost all aquatic ecosystems has a specific influential role on or by fishes. Therefore, studying their stress biology, especially oxidative stress, is vital because it can influence their growth, production, reproduction, etc. To review the above topic, peer-reviewed electronic databases, including Web of Science, science direct, PubMed, Google Scholar, Scopus, and AGRICOLA, were searched with specific keywords associated with fish, oxidative stress, diseases, etc. The influence of abiotic stress, such as the effects of water dissolved oxygen, temperature, salinity, water hardness, alkalinity, pH, pollutants, heavy metals, and anthropogenic activities, was reviewed in the current article to draw a conclusion on the updated relation that exists between fish physiology, disease, and abiotic stressors. Oxidative stress and redox regulatory levels under the above parameters were reviewed as the stress or anti-stress responses differ in various fish models. Undoubtedly, the reviewed abiotic factors modulate fish oxidative health status to a greater extent, and therefore, these factors must be considered on a priority basis to improve the general health and immunity status of fish. The statement above remains valid in both saline and freshwater habitats.
    Type of Medium: Online Resource
    ISSN: 2296-665X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2741535-1
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  • 8
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 14 ( 2023-10-10)
    Abstract: A wide variety of bacteria are present in soil but in rhizospheric area, the majority of microbes helps plant in defending diseases and facilitate nutrient uptake. These microorganisms are supported by plants and they are known as plant growth-promoting rhizobacteria (PGPR). The PGPRs have the potential to replace chemical fertilizers in a way that is more advantageous for the environment. Fluoride (F) is one of the highly escalating, naturally present contaminants that can be hazardous for PGPRs because of its antibacterial capacity. The interactions of F with different bacterial species in groundwater systems are still not well understood. However, the interaction of PGPR with plants in the rhizosphere region reduces the detrimental effects of pollutants and increases plants’ ability to endure abiotic stress. Many studies reveal that PGPRs have developed F defense mechanisms, which include efflux pumps, Intracellular sequestration, enzyme modifications, enhanced DNA repair mechanism, detoxification enzymes, ion transporter/antiporters, F riboswitches, and genetic mutations. These resistance characteristics are frequently discovered by isolating PGPRs from high F-contaminated areas or by exposing cells to fluoride in laboratory conditions. Numerous studies have identified F-resistant microorganisms that possess additional F transporters and duplicates of the well-known targets of F. Plants are prone to F accumulation despite the soil’s low F content, which may negatively affect their growth and development. PGPRs can be used as efficient F bioremediators for the soil environment. Environmental biotechnology focuses on creating genetically modified rhizobacteria that can degrade F contaminants over time. The present review focuses on a thorough systemic analysis of contemporary biotechnological techniques, such as gene editing and manipulation methods, for improving plant-microbe interactions for F remediation and suggests the importance of PGPRs in improving soil health and reducing the detrimental effects of F toxicity. The most recent developments in the realm of microbial assistance in the treatment of F-contaminated environments are also highlighted.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2587354-4
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  • 9
    In: Frontiers in Environmental Science, Frontiers Media SA, Vol. 11 ( 2023-8-4)
    Abstract: Environmental nanotechnology has developed rapidly over the past few decades due to the fast advancement of nanotechnology and nanomaterials (NMs). Due to their nanoscale size, NMs are receiving immense attention in research and development worldwide. Their nano size has led to better catalysis, high reactivity, and high adsorption capacity. In wastewater treatment, nanotechnology has significant potential to improve the performance and efficiency of water decontamination; more effectively, it provides a sustainable way to keep water supplies safe. Numerous studies have found that removing harmful components from wastewater by employing nanoparticles in conjunction with various treatment methods is effective. The purpose of the current investigation is to conduct a review of the envisioned applications of various NMs in the treatment of wastewater. These NMs include carbonaceous NMs, metal-containing nanoparticles, and nanocomposites, all of which will be reviewed and highlighted in depth.
    Type of Medium: Online Resource
    ISSN: 2296-665X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2741535-1
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  • 10
    Online Resource
    Online Resource
    Wiley ; 2017
    In:  ChemPhysChem Vol. 18, No. 24 ( 2017-12-15), p. 3625-3633
    In: ChemPhysChem, Wiley, Vol. 18, No. 24 ( 2017-12-15), p. 3625-3633
    Abstract: Several recent publications have illustrated that electrostatic attraction is not solely responsible for strong hydrogen bonds. Even electropositive and less electronegative atoms such as Te and Se are capable of forming strong H‐bonds. Herein, we provide evidence for intramolecular homopolar dihydrogen bonds [HOMO‐DHBs; X−N(C)−H δ + ⋅⋅⋅ δ + H−N(C)−Y] in porphyrins and related compounds for the first time; these bonds are revealed by careful Cambridge Structural Database (CSD) exploration, quantum theory of atoms in molecules, compliance constant calculations, and natural bond orbital and noncovalent interaction (NCI) analysis. A search of the CSD showed that the inner‐core hydrogen atom distances were less than 2.5 Å (sum of the van der Waals radii of two hydrogen atoms is 2.4 Å) in porphyrinoids, i.e. about 75 % of the cases. This suggested an attractive interaction between hydrogen atoms carrying a positive charge, which was further supported by quantum‐chemical calculations. The HOMO‐DHB energy in some cases was found to be as much as around 20 kJ mol −1 , which is comparable to that of any conventional H‐bond energy such as for the NH 3 dimer. The interplay between hyperconjugative attraction and steric constraint favorably decided the strength of the HOMO‐DHBs. We expect that HOMO‐DHBs could be revealed in many more systems, such as corroles, phlorins, crown ethers, and constrained systems having hydrogen atoms in close contact, and could be an important noncovalent interaction to consider in supramolecular chemistry.
    Type of Medium: Online Resource
    ISSN: 1439-4235 , 1439-7641
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2025223-7
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