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  • 1
    Online Resource
    Online Resource
    Singapore : Springer Nature Singapore | Singapore : Imprint: Springer
    Keywords: Climatology. ; Soil science. ; Botany. ; Atmospheric science. ; Environmental management. ; Agriculture.
    Description / Table of Contents: Impacts of climate change on soil processes -- Nutrient cycling and climate change -- Soil carbon sequestration in the context of climate change -- Soil health and climate change -- Climate change impact on soil erosion and land degradation -- Response and behavior of paddy soil microbiota towards environmental change variables -- Contemporary use of sensors for soil qualitative and quantitative assessment in the context of climate change -- Evolution of basin-scale soil moisture under changing climate and land use scenarios: A hillslope-based approach -- Prospect of organic agriculture in the present climate change scenario -- Impact of conservation agriculture on soil health and environmental sustainability -- Prospects of modified plant micro-climate in global climate change research -- Climate change and crop resource use efficiency -- Climate change on seeds physiology -- Climate change impacts and adaptation strategies for agronomic crops -- Understanding the effects of changing climate onweeds and their management -- Impacts of abiotic stresses on eco-physiology of crop in changing climate -- Impact of climate change on agriculturally important insects and nematodes -- Plant virus diseases dynamics under modified environments and impacts on host virus-vector landscape -- Breeding rice variety with suitable plant ideotype for next-generation Indian agriculture in the changing climatic conditions -- Crop modelling for climate change studies -- Advanced facilities for climate change research and greenhouse gas mitigation -- Monitoring and impact assessment of climate change: eddy covariance technique -- Greenhouse gas and energy flux measurements with eddy covariance technique under lowland rice ecology -- Climate change scenarios of India with special emphasis on Sundarbans delta and Western Himalayan region -- Drought preparedness under changing climate with special reference to Manipur -- Climate change induced spatiotemporal monsoon variability: assessment of its implications onglobal and regional production systems -- Simple holistic method of quantifying local vs trans-boundary air pollution in NCR-Delhi. .
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource(X, 746 p. 100 illus., 90 illus. in color.)
    Edition: 1st ed. 2024.
    ISBN: 9789819979356
    Series Statement: Advances in Global Change Research 78
    Language: English
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  • 2
    Publication Date: 2018-03-16
    Description: Cell detachment from the extracellular matrix triggers anoikis. Disseminated tumor cells must adapt to survive matrix deprivation, while still retaining the ability to attach at secondary sites and reinitiate cell division. In this study, we elucidate mechanisms that enable reversible matrix attachment by breast cancer cells. Matrix deprival triggered AMPK activity and concomitantly inhibited AKT activity by upregulating the Akt phosphatase PHLPP2. The resultant pAMPKhigh/pAktlow state was critical for cell survival in suspension, as PHLPP2 silencing also increased anoikis while impairing autophagy and metastasis. In contrast, matrix reattachment led to Akt-mediated AMPK inactivation via PP2C-α-mediated restoration of the pAkthigh/pAMPKlow state. Clinical specimens of primary and metastatic breast cancer displayed an Akt-associated gene expression signature, whereas circulating breast tumor cells displayed an elevated AMPK-dependent gene expression signature. Our work establishes a double-negative feedback loop between Akt and AMPK to control the switch between matrix-attached and matrix-detached states needed to coordinate cell growth and survival during metastasis.Significance: These findings reveal a molecular switch that regulates cancer cell survival during metastatic dissemination, with the potential to identify targets to prevent metastasis in breast cancer. Cancer Res; 78(6); 1497–510. ©2018 AACR.
    Print ISSN: 0008-5472
    Electronic ISSN: 1538-7445
    Topics: Medicine
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