GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Changing mechanisms of the atmospheric moisture budget in the Mediterranean region from the last glacial maximum to future projections (2023)
    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Details
    Publication Date: 2023-08-29
    Description: Model simulations of the last glacial maximum (LGM) and RCP8.5 projections suggest that factors responsible for past and future changes in the Mediterranean region are different. The wet LGM conditions were determined mainly by low evaporation, with some increase of precipitation in the western areas, while dry rcp8.5 conditions will be driven by a reduction of precipitation over the whole region. These changes were caused by atmospheric dynamics (changes of mean atmospheric circulation ) in LGM and it will be caused by the atmospheric thermodynamics (reduction of mean moisture content ) in the future rcp8.5. In both cases, the Mediterranean region appears to be more sensitive to climate change than the rest of areas within the same latitudinal range, particularly considering the hydrological cycle, whose characteristics in winter exhibit large changes between these two different climates. These conclusions emerge from the substantial consensus among six PMIP3 and CMIP5 models, simulating LGM, pre-Industrial and rcp8.5 climate conditions.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    GFZ OAI
  • 2
    Electronic Resource
    Electronic Resource
    INDUCTION OF IgA EXPRESSION BY B-CELLS RESPONSIVE TO THYMUS-INDEPENDENT ANTIGENS (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 409 (1983), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1983.tb26958.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Antigenic analysis of the saccharide moiety of the lipooligosaccharide of Bordetella pertussis (1993)
    Springer
    Springer seminars in immunopathology 15 (1993), S. 205-215 
    Details
    ISSN: 1432-2196
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusions In summary, the LOS of B. pertussis lacks the long-chain polysaccharide O antigen, and is resolved electrophoretically into two distinct bands designated LOS A and LOS B. Mice administered with anti-LOS A mAbs can be protected from fatal B. pertussis infection. These observations may indicate potential for oligosaccharides as a component of new acellular pertussis vaccines. Studies performed thus far also suggest that idiotypic profiles influence the protective value of antibodies and that several antibody-mediated effector functions may participate in the protection. Further research investigating the factors inducing protective immunity is needed for a better definition of new vaccine formulations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201101
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    facet.materialart.
    Unknown
    Interface '79 - Humanities and Technology: Southern Technical Institute, Marietta, Georgia, October 25-26, 1979 (1981)
    Detroit, Mich. : Periodicals Archive Online (PAO)
    Technology and Culture. 22:1 (1981:Jan.) 149 
    Details
    ISSN: 0040-165X
    Topics: Technology
    Notes: CONFERENCE REPORTS
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5129-1981-022-01-000008
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol (1999)
    Springer
    Psychopharmacology 141 (1999), S. 339-350 
    Details
    ISSN: 1432-2072
    Keywords: Key words Hyperbaric exposure ; Helium-oxygen gas mixture ; γ-Aminobutryic acid (GABA) ; N-Methyl-d-aspartate (NMDA) ; 4 ; 5 ; 6 ; 7-Tetrahydroisoxazolo-pyridin-3-ol (THIP) ; 3α-Hydroxy-5β-pregnan-20-one (3α ; 5β-P) ; Loss of righting reflex (LORR) ; Anticonvulsant effect ; GABA-activated chloride ion uptake ; Central nervous system ; Benzodiazepines ; Barbiturates ; Neuroactive steroid ; C57BL/6 mice ; Ethanol antagonist ; GABAA receptor complex ; Ligand-gated ion channels ; Allosteric coupling hypothesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The present study uses increased atmospheric pressure as an ethanol antagonist to test the hypothesis that allosteric coupling pathways in the GABAA receptor complex represent initial sites of action for ethanol. This was accomplished using behavioral and in vitro measures to determine the effects of pressure on ethanol and other GABAergic drugs in C57BL/6 and LS mice. Behaviorally, exposure to 12 times normal atmospheric pressure (ATA) of a helium-oxygen gas mixture (heliox) antagonized loss of righting reflex (LORR) induced by the allosteric modulators ethanol and pentobarbital, but did not antagonize LORR induced by the direct GABA agonist 4,5,6,7-tetrahydroisoxazolo-pyridin-3-ol (THIP). Similarly, exposure to 12 ATA heliox antagonized the anticonvulsant effects verses isoniazid of ethanol, diazepam and pentobarbital. Biochemically, exposure to 12 ATA heliox antagonized potentiation of GABA-activated 36Cl– uptake by ethanol, flunitrazepam and pentobarbital in LS mouse brain preparations, but did not alter GABA-activated 36Cl– uptake per se. In contrast to its antagonist effect versus other allosteric modulators, pressure did not antagonize these behavioral or in vitro effects induced by the neuroactive steroid, 3α-hydroxy-5β-pregnan-20-one (3α,5β-P). These findings add to evidence that pressure directly and selectively antagonizes drug effects mediated through allosteric coupling pathways. The results fit predictions, and thus support the hypothesis that allosteric coupling pathways in GABAA receptors represent initial sites of action for ethanol. Collectively, the results suggest that there may be common physicochemical and underlying structural characteristics that define ethanol sensitive regions of receptor proteins and/or their associated membranes that can be identified by pressure within (e.g., GABAA) and possibly across (e.g., GABAA, NMDA, 5HT3) receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050843
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Research report: Susto and pesticide poisoning among Florida farmworkers (1993)
    Springer
    Culture, medicine and psychiatry 17 (1993), S. 321-327 
    Details
    ISSN: 0165-005X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Ethnic Sciences , Medicine
    Notes: Abstract This paper discusses research designed to investigate farmworker interpretation of a serious incident of pesticide poisoning, specifically, whether this incident was considered to precipitate the Mexican folk illness “susto.” The study revealed that a total of 23% of the population interviewed felt that they definitelyor possibly had developed susto as a result of the pesticide exposure. These patients complained of more residual symptoms from the pesticide exposure than did those who had been affected by the poisoning but who did not feel they suffered from susto. The findings have implications for medical providers working with these populations. A self diagnosis of “susto” may indicate that a patient is indeed sicker than other indicators suggest, and point to a need for increased follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01380007
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    facet.materialart.
    Unknown
    Analysis of single-nucleotide polymorphisms (SNPs) in human CYP3A4 and CYP3A5 genes: potential implications for the metabolism of HIV drugs (2014)
    BioMed Central
    Details
    Publication Date: 2014-07-03
    Description: Background: Drug metabolism via the cytochrome P450 (CYP450) system has emerged as an important determinant in the occurrence of several drug interactions (adverse drug reactions, reduced pharmacological effect, drug toxicities). In particular, CYP3A4 and CYP3A5 (interacting with more than 60% of licensed drugs) exhibit the most individual variations of gene expression, mostly caused by single nucleotide polymorphisms (SNPs) within the regulatory region of the CYP3A4 and CYP3A5 genes which might affect the level of enzyme production.In this study, we sought to improve the performance of sensitive screening for CYP3A polymorphism detection in twenty HIV-1 infected patients undergoing lopinavir/ritonavir (LPV/r) monotherapy. Methods: The study was performed by an effective, easy and inexpensive home-made Polymerase Chain Reaction Direct Sequencing approach for analyzing CYP3A4 and CYP3A5 genes which can detect both reported and unreported genetic variants potentially associated with altered or decreased functions of CYP3A4 and CYP3A5 proteins. Proportions and tests of association were used. Results: Among the genetic variants considered, CYP3A4*1B (expression of altered function) was only found in 3 patients (15%) and CYP3A5*3 (expression of splicing defect) in 3 other patients (15%). CYP3A5*3 did not appear to be associated with decreased efficacy of LPV/r in any patient, since none of the patients carrying this variant showed virological rebound during LPV/r treatment or low levels of TDM. In contrast, low-level virological rebound was observed in one patient and a low TDM level was found in another; both were carrying CYP3A4*1B. Conclusions: Our method exhibited an overall efficiency of 100% (DNA amplification and sequencing in our group of patients). This may contribute to producing innovative results for better understanding the inter-genotypic variability in gene coding for CYP3A, and investigating SNPs as biological markers of individual response to drugs requiring metabolism via the cytochrome P450 system.
    Electronic ISSN: 1471-2350
    Topics: Biology , Medicine
    Published by BioMed Central
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Neurosteroids as regenerative agents in the brain: therapeutic implications (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-03-21
    Description: Nature Reviews Endocrinology 9, 241 (2013). doi:10.1038/nrendo.2013.31 Author: Roberta D. Brinton Regenerative therapeutics hold the promise of self-renewal and repair. Ageing and age-associated neurodegenerative diseases are marked by a decline in self-renewal and repair, but a capacity for regeneration is retained. The challenge faced by researchers developing molecular therapeutics to promote self-renewal in the nervous system
    Topics: Medicine
    Published by Nature Publishing Group (NPG)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    On the maximum principle for elliptic operators in weighted spaces (2014)
    Springer
    Details
    Publication Date: 2014-05-07
    Description: We establish a maximum principle for subsolutions of second order elliptic equations. In particular, we consider some linear operators with leading coefficients locally VMO, while the other coefficients and the boundary conditions involve a suitable weight function.MSC: 35J25, 35R05, 35B50.
    Print ISSN: 1687-2762
    Electronic ISSN: 1687-2770
    Topics: Mathematics
    Published by Springer
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Perimenopause as a neurological transition state (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-06-18
    Description: Nature Reviews Endocrinology 11, 393 (2015). doi:10.1038/nrendo.2015.82 Authors: Roberta D. Brinton, Jia Yao, Fei Yin, Wendy J. Mack & Enrique Cadenas Perimenopause is a midlife transition state experienced by women that occurs in the context of a fully functioning neurological system and results in reproductive senescence. Although primarily viewed as a reproductive transition, the symptoms of perimenopause are largely neurological in nature. Neurological symptoms that emerge
    Topics: Medicine
    Published by Nature Publishing Group (NPG)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...