In:
Magnetic Resonance in Medicine, Wiley, Vol. 87, No. 1 ( 2022-01), p. 57-69
Kurzfassung:
Hyperpolarized [1‐ 13 C]pyruvate MRS can measure cardiac metaboli sm in vivo. We investigated whether [1‐ 13 C]pyruvate MRS could predict left ventricular remodeling following myocardial infarction (MI), long‐term left ventricular effects of heart failure medication, and could identify responders to treatment. Methods Thirty‐five rats were scanned with hyperpolarized [1‐ 13 C]pyruvate MRS 3 days after MI or sham surgery. The animals were re‐examined after 30 days of therapy with β‐blockers and ACE‐inhibitors (active group, n = 12), placebo treatment (placebo group, n = 13) or no treatment (sham group, n = 10). Furthermore, heart tissue mitochondrial respiratory capacity was assessed by high‐resolution respirometry. Metabolic results were compared between groups, over time and correlated to functional MR data at each time point. Results At 30 ± 0.5 days post MI, left ventricular ejection fraction (LVEF) differed between groups (sham, 77% ± 1%; placebo, 52% ± 3%; active, 63% ± 2%, P 〈 .001). Cardiac metabolism, measured by both hyperpolarized [1‐ 13 C]pyruvate MRS and respirometry, neither differed between groups nor between baseline and follow‐up. Three days post MI, low bicarbonate + CO 2 /pyruvate ratio was associated with low LVEF. At follow‐up, in the active group, a poor recovery of LVEF was associated with high bicarbonate + CO 2 /pyruvate ratio, as measured by hyperpolarized MRS. Conclusion In a rat model of moderate heart failure, medical treatment improved function, but did not on average influence [1‐ 13 C]pyruvate flux as measured by MRS; however, responders to heart failure medication had reduced capacity for carbohydrate metabolism.
Materialart:
Online-Ressource
ISSN:
0740-3194
,
1522-2594
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2022
ZDB Id:
1493786-4
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