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  • 1
    Electronic Resource
    Electronic Resource
    Centrifugal Force in Paper Chromatography and Electrophoresis (1959)
    s.l. : American Chemical Society
    Analytical chemistry 31 (1959), S. 825-829 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60149a026
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of the effect of cyclic AMP on the content and release of dopamine and 1-methyl-4-phenylpyridinium (MPP+) in PC12 cells (2002)
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 22 (2002), S. 0 
    Details
    ISSN: 1474-8673
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Chemistry and Pharmacology , Medicine
    Notes: 1 The aim of this work was to investigate the effect of acute and chronic exposure of rat pheochromocytoma (PC12) cells to elevated cAMP, using forskolin, dibutyryl-cAMP (db-cAMP) or isobutylmethylxanthine (IBMX), on endogenous dopamine content and release and on [3H]-1-methyl-4-phenylpyridinium ([3H]-MPP+) uptake and release, under basal conditions and under KCl-stimulation. 2 Cultured PC12 cells synthetized and accumulated large amounts of dopamine, but not noradrenaline or adrenaline. The release of dopamine by the cells was markedly increased in response to 50 mm KCl. 3 Acute and chronic treatment of the cells with forskolin (30 μm), but not IBMX (100 μm), slightly increased the spontaneous release of dopamine and significantly decreased the release induced by 50 mm KCl. 4 Chronic treatment of the cells with forskolin (30 μm), but not IBMX (100 μm), markedly decreased the cellular content of dopamine. 5 Cultured PC12 cells removed and accumulated [3H]-MPP+, which, similarly to dopamine, was released by KCl. 6 Acute treatment of the cells with forskolin (30 μm) or db-cAMP (2.5 mm), but not IBMX (100 μm), slightly increased the spontaneous release, but did not affect KCl-induced release of [3H]-MPP+. On the other hand, chronic treatment of the cells with forskolin produced, on [3H]-MPP+, similar effects to those obtained for dopamine. 7 Acute and chronic treatment of the cells with reserpine (50 nm) produced similar results to those obtained with forskolin on either dopamine or [3H]-MPP+ handling. 8 In conclusion, cAMP, similarly to reserpine, increases the spontaneous release and decreases the KCl-induced release of [3H]-MPP+ and dopamine. This suggests that cAMP impairs the vesicular monoamine transporter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1474-8673.2002.00273.x
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  • 3
    Electronic Resource
    Electronic Resource
    Differentiation of Trypanosoma cruzi in Culture (1967)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 14 (1967), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SYNOPSIS. A medium containing sodium and potassium chloride, phosphate buffer, glucose, calf serum, hemoglobin and lactalbumin hydrolysate permits some growth and differentiation of crithidiae into the metacyclic forms of Trypanosoma cruzi. The addition of ox liver infusion greatly enhances the growth promoting properties of this medium while making it very poor as far as differentiation is concerned. With dog heart infusion instead of ox liver, the medium is still good for growth but not much better for differentiation. If, however, the pH of the dog heart infusion medium is lowered from 7.2 to 6.7, it continues to be good for growth and becomes excellent for differentiation.Other factors were studied that stimulate or repress the rate of differentiation, such as preincubation at certain levels of temperature and the size and age of inocula.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1967.tb02024.x
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of Bricanyl® Turbuhaler and Berotec® dry powder inhaler (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 45 (1990), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Terbutaline (Bricanyl®) 0.5 mg t.i.d. administered via Turbuhaler® was compared with fenoterol (Berotec®) 0.2 mg t.i.d. administered via Inhalator Ingelheim® in 36 asthmatic children aged 7–12 years. The study was of an open crossover design with two randomly allocated treatment periods, each lasting 2 weeks. Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were measured at clinic visits before study start and at the end of each treatment period. The patients recorded peak expiratory flow (PEF) before and after inhaler use, morning and evening. They also recorded asthma symptoms and number of extra inhalations. At the end of the study, children and parents were asked for inhaler preference. No differences between the treatments were found concerning the results of the lung function measurements at the clinic or at the PEF measurements at home. No differences were found between the treatments as regards asthma symptoms or number of extra inhalations. Two patients experienced mild side effects during fenoterol treatment, none during terbutaline treatment. Treatment with terbutaline in Turbuhaler was preferred by a majority of children and parents. In conclusion, in this group of asthmatic children, treatment with terbutaline administered via Turbuhaler was as efficacious as treatment with fenoterol administered via Inhalator Ingelheim. There was a clear preference in favour of the Turbuhaler.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1990.tb00515.x
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  • 5
    Electronic Resource
    Electronic Resource
    Hepatitis E in Portuguese haemophiliacs and blood donors (1997)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 3 (1997), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.1997.00098.x
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  • 6
    Electronic Resource
    Electronic Resource
    The clinical phenotype modulation of haemophilia by prothrombotic gene mutations (2003)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 9 (2003), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.2003.00718_2.x
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  • 7
    Electronic Resource
    Electronic Resource
    Budesonide: safety and efficacy aspects of its long-term use in children (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric allergy and immunology 4 (1993), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Fifty-two asthmatic children aged 4 to 13 years (mean 9. 6) were enrolled in this open 12-month study of budesonide, 200 meg bid, administered by tube-spacer inhaler (INHALETE® ASTRA DRACO). The aim of the study was to assess long-term safety, as well as efficacy, of budesonide in children whose asthma was not adequately controlled by their current therapy. Children attended the clinic every three months for assessment of lung function and height. In addition, an adrenal function test and routine clinical chemistry and haematology were performed. Parents completed diary cards once each week, recording the child's PEF, asthma symptoms, β2-agonist consumption and other medication (no prophylactic drugs or other inhaled steroids were allowed and oral steroids were used for emergency treatment only). There were significant increases in all clinic lung function tests (baseline to last visit) and in diary card PEF (first 3 months vs last 3 months). These were accompanied by decreases in asthma symptoms and use of β2-agonists or other medication. There was no indication that growth was affected by study treatment and basal adrenal function (basal cortisol) did not change significantly throughout the study. The adrenal response to Synacthen had actually increased significantly by the end of the study. No serious adverse events were associated with budesonide treatment. In conclusion, regular budesonide therapy was associated with a significant improvement in lung function and symptoms over one year. Budesonide was well-tolerated by the children and appeared to have no adverse influence on either growth or adrenal function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3038.1993.tb00070.x
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  • 8
    Electronic Resource
    Electronic Resource
    Edwardsiella tarda isolated in integrated fish farming (2000)
    Oxford, UK : Blackwell Science Ltd
    Aquaculture research 31 (2000), S. 0 
    Details
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The use of pig manure in fish farming reduces the environmental pollution from this material and gives it an economic application. However, the microbiological implications of such a process are not completely understood. Five hundred and forty tilapia Oreochromis niloticus L. from an integrated fish farm (using pig excrements as food) were collected and evaluated microbiologically for the presence of Edwardsiella tarda. Samples of the external surface (skin, gills and fin), intestines and muscle were analysed. E. tarda was isolated from 93 (17.2%) of the external surface samples, 77 (14.3%) of the muscle samples and 61 (11.2%) of the intestine samples. These rates were compared using the chi-squared test, which showed that the skin samples had higher contamination than the others. Selenite–cystine (SC) broth was better than Rappaport–Vassiliadis (RV) enrichment broth for the microbiological assay. Salmonella–Shigella (SS) agar presented superior performance to that of Hektoen enteric (HE) medium. The combination SC and SS showed the best efficiency for E. tarda detection, isolating the bacterium in 107 (6.6%) out of 1620 samples studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2109.2000.00448.x
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  • 9
    Electronic Resource
    Electronic Resource
    Degradation of crystallins from a psoriatic patient undergoing PUVA therapy
    Amsterdam : Elsevier
    FEBS Letters 268 (1990), S. 72-74 
    Details
    ISSN: 0014-5793
    Keywords: 8-Methoxypsoralen ; Lens fluorescence ; Lens protein ; PUVA cataract ; Photosensitizer ; Tryptophan
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(90)80975-O
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  • 10
    Electronic Resource
    Electronic Resource
    Comparison between uptake2 and rOCT1: effects of catecholamines, metanephrines and corticosterone (1999)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 359 (1999), S. 303-309 
    Details
    ISSN: 1432-1912
    Keywords: Key words Catecholamines ; Corticosterone ; Metanephrines ; MPP+ ; rOCT1 ; Uptake2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Active and specialized transmembrane transport systems are responsible for the functional inactivation of catecholamines. Uptake2, the classical extraneuronal uptake system, and rOCT1, a recently cloned organic cation transporter, share a number of properties. The present study was undertaken to investigate putative differences between these two transporters that might clarify their relative physiological roles. Uptake of [3H]MPP+ ([3H]1-methyl-4-phenylpyridi-nium) by Caki-1 cells (to study uptake2) and by primary cultured rat hepatocytes (to study rOCT1) was kinetically and pharmacologically characterized. In both cell types, [3H]MPP+ was avidly taken up and accumulated. All compounds tested (catecholamines, metanephrines and corticosterone) inhibited [3H]MPP+ uptake, albeit with different potencies. In Caki-1 cells, the ranking order of inhibitory potency was: (–)isoprenaline 〉 (–)adrenaline 〉〉 (–)noradrenaline 〉 dopamine. Metanephrine and normetanephrine were equipotent. Corticosterone had an IC50 of 102 nM. In cultured hepatocytes, the ranking order of inhibitory potency was: (–)isoprenaline 〉 dopamine 〉 (–)adrenaline 〉〉 (–)noradrenaline. Metanephrine was about seven times more potent than normetanephrine. Corticosterone had an IC50 of 72 μM, being about 700-fold less potent in inhibiting rOCT1 than uptake2. The results showed that uptake2 and rOCT1 can be clearly distinguished on a functional basis. On the one hand, uptake2 prefers adrenaline among the endogenous catecholamines, whereas rOCT1 has similar affinity for adrenaline and dopamine. On the other hand, corticosterone and normetanephrine are significantly more potent in inhibiting uptake2 than rOCT1. The results are compatible with a possible physiological role of corticosteroids in the modulation of adrenaline effects in tissues equipped with uptake2, without significant interference with the hepatic and renal excretion of catecholamines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005356
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