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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 534 (1988), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Differences in risk factors for survival and recurrence after liver resection for hepatocellular carcinoma (HCC) in patients with or without cirrhosis are not fully clarified.Aim : To review a single-centre experience of curative liver resections for HCC in order to evaluate clinicopathologic features and the long-term outcome of cirrhotic and noncirrhotic patients.Methods : From 1981 to 2002, 308 curative liver resections for HCC on cirrhosis (Group 1) and 135 for HCC without cirrhosis (Group 2) were performed. The main demographic, clinicopathologic and operative parameters, as well as early results were analysed and compared. Overall and disease-free survival were evaluated. Prognostic factors for survival and for tumour recurrence were studied by univariate and multivariate analysis.Results : Group 1 had worse preoperative liver function and higher frequency of hepatitis C virus infection. In Group 2, HCC showed larger mean tumour diameter (P 〈 0.001), poorer differentiation (P 〈 0.05) and more frequent macrovascular invasion (P 〈 0.05). Although more extended resections were performed in Group 2 (P 〈 0.001), there were no differences in blood transfusions, while post-operative complication rate was higher in Group 1 (P 〈 0.005). After 1992, in-hospital mortality was 2.9% in Group 1 and 1.1% in Group 2 (P = N.S.). The 3- and 5-year overall survival was 63.7% and 42.2% in Group 1, and 67.9% and 51% in Group 2 (P 〈 0.05). The 3- and 5-year disease-free survival was 49.3% and 27.8% in Group 1, and 58% and 45.6% in Group 2 (P 〈 0.005). Serum bilirubin level 〉 1.2 mg/dL, multiple nodules, micro and macrovascular invasion, diaphragm infiltration and blood transfusions independently affected survival in Group 1. Blood replacement was the only negative prognostic factor in Group 2. Independent risk factors for tumour recurrence were satellite nodules and resection performed before 1992 in Group 1, and age 〈 60 in Group 2.Conclusions : Despite a more aggressive behaviour, HCC without cirrhosis led to better overall and disease-free survival compared to HCC with cirrhosis after curative liver resection. Age and intra-operative blood transfusions are the only predictors of outcome in patients without cirrhosis. The impact of the latter on long-term survival in both our groups outlines the importance of surgical technique on the results of hepatectomies.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-2932
    Keywords: 234Th ; particle flux ; Ross Sea ; Antarctica ; organic C ; N ; Si ; Scavenging rates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The distribution of dissolved and particulate 234Th in the upper 200 m of the water column was obtained for three stations in the Ross Sea off Victoria Land and Terra Nova Bay. At site 24a, close to the retreating ice margin, all the sampled depths showed deficiencies in 234Th relative to the equilibrium with 238U. These are related to uptake of 234Th onto sinking particles. Residence times of 234Th in solution and of particulate 234Th were 130-247 days and 8.1-6.6 days, respectively. A high particle flux (1.23-5.03 g m-2 d-1) was calculated at this station. At the other two sites (11c and 15c), 234Th depth profiles are irregular, probably due to the release of dissolved 234Th by decomposing particles at certain depths, or to the contribution from lateral advection. Bulk mass fluxes measured by floating traps at stations 11c and 15c are very low (66-138 mg m-2 d-1). Also fluxes of organic carbon and nitrogen, and biogenic silica are reported for these two sites. The calculated fluxes are discussed with respect to methodologies and to the dynamics of the ice margin retreat.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-2932
    Keywords: 234Th ; particle flux ; Ross Sea ; Antarctica ; organic C, N, Si ; scavenging rates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The distribution of dissolved and particulate234Th in the upper 200 m of the water column was obtained for three stations in the Ross Sea off Victoria Land and Terra Nova Bay. At site 24a, close to the retreating ice margin, all the sampled depths showed deficiencies in234Th relative to the equilibrium with238U. These are related to uptake of234Th onto sinking particles. Residence times of234Th in solution and of particulate234Th were 130–247 days and 8.1–6.6 days, respectively. A high particle flux (1.23–5.03 g m−2 d−1) was calculated at this station. At the other two sites (11c and 15c),234Th depth profiles are irregular, probably due to the release of dissolved234Th by decomposing particles at certain depths, or to the contribution from lateral advection. Bulk mass fluxes measured by floating traps at stations 11c and 15c are very low (66–138 mg m−2 d−1). Also fluxes of organic carbon and nitrogen, and biogenic silica are reported for these two sites. The calculated fluxes are discussed with respect to methodologies and to the dynamics of the ice margin retreat.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2017-06-26
    Description: A sediment core, collected from the western part of the continental slope of the Ross Sea at 2380 m water depth, records events of the last two climatic cycles (250 kyr). A Full-size image (〈1 K)-based chronology was obtained and boundaries of the isotope stages were set assuming that biological productivity was enhanced during periods of less ice cover. Then, Full-size image (〈1 K), organic carbon, biogenic silica and biogenic Ba distributions were compared to the glacial–interglacial stage boundaries and corresponding ages of the Full-size image (〈1 K) record of Martinson et al. [Martinson, D.G., Pisias, N.G., Hays, J.D., Imbrie, J., Moore, T.C., Jr., Shackleton, N.J, 1987. Age dating and the orbital theory of the ice ages: development of a high-resolution 0 to 300,000-year chronostratigraphy. Quaternary Research, 27: 1–29]. Sediment accumulation rates ranged between 1.2 cm kyr−1 in the isotope stage 6 and 3.8 cm kyr−1 during the Holocene. Variations in the concentrations and fluxes of organic carbon, biogenic Ba, biogenic silica and Mn gave information on palaeoclimate changes. Processes of sediment redistribution in the Ross Sea margin were enlightened from a comparison of the measured and expected fluxes of Full-size image (〈1 K). Calculation of the focusing-corrected accumulation rates of biogenic Ba enabled us to evaluate the export palaeoproductivity. Corrected accumulation rates of biogenic components and calculated palaeoproductivities were low, compared to the Antarctic Polar Front in the Atlantic sector, throughout the last two climatic cycles. Glacial–interglacial changes of sea ice cover and ventilation of the Ross Sea were probably major causes of variations in biogenic particle flux and distribution of redox-sensitive elements within the sediment column.
    Type: Article , PeerReviewed
    Format: text
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  • 6
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    Terra Antartica Publ.
    In:  In: The Antarcric Region: Geological Evolution and Processes. , ed. by Ricci, C. A. Terra Antartica Publ., Siena, Italy, pp. 889-896. ISBN 88-900221-0-8
    Publication Date: 2020-03-25
    Type: Book chapter , NonPeerReviewed
    Format: text
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  • 7
    Publication Date: 2017-07-15
    Description: Purpose: The aberrant expression of miR-221 is a hallmark of human cancers, including hepatocellular carcinoma (HCC), and its involvement in drug resistance, together with a proved in vivo efficacy of anti-miR-221 molecules, strengthen its role as an attractive target candidate in the oncologic field. The discovery of biomarkers predicting the response to treatments represents a clinical challenge in the personalized treatment era. This study aimed to investigate the possible role of miR-221 as a circulating biomarker in HCC patients undergoing sorafenib treatment as well as to evaluate its contribution to sorafenib resistance in advanced HCC. Experimental Design: A chemically induced HCC rat model and a xenograft mouse model, together with HCC-derived cell lines were employed to analyze miR-221 modulation by Sorafenib treatment. Data from the functional analysis were validated in tissue samples from surgically resected HCCs. The variation of circulating miR-221 levels in relation to Sorafenib treatment were assayed in the animal models and in two independent cohorts of patients with advanced HCC. Results: MiR-221 over-expression was associated with Sorafenib resistance in two HCC animal models and caspase-3 was identified as its target gene, driving miR-221 anti-apoptotic activity following Sorafenib administration. Lower pre-treatment miR-221 serum levels were found in patients subsequently experiencing response to Sorafenib and an increase of circulating miR-221 at the two months assessment was observed in responder patients. Conclusions: MiR-221 might represent a candidate biomarker of likelihood of response to Sorafenib in HCC patients to be tested in future studies. Caspase-3 modulation by miR-221 participates to Sorafenib resistance. Clin Cancer Res; 23(14); 3953–65. ©2017 AACR .
    Print ISSN: 1078-0432
    Electronic ISSN: 1557-3265
    Topics: Medicine
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  • 8
    Publication Date: 2016-01-22
    Description: Aims In this paper we aimed to analyse the typology and the phenotype of the different vascular modifications in human hepatocellular carcinomas (HCCs) with a new immunomorphological and gene expression approach. We also attempted to correlate these modifications with the histological parameters of tumour aggressiveness and the surrounding liver parenchyma. Methods Ninety-six HCCs (from 80 patients) were retrospectively enrolled, 46 occurring in non-cirrhotic livers, and 50 in livers transplanted for cirrhosis. Histopathological analysis, immunohistochemistry for CD34, Nestin and WT1 and RT-PCR for Nestin, transforming growth factor-β1 (TGFβ1) and insulin-like growth factor 1 (IGF1R) mRNA were performed in all nodules. Results By correlating the CD34 and Nestin immunoreactivity in HCC vasculature with the tumorous architecture, we identified four vascular patterns (named from ‘a’ to ‘d’). Each of them was characterised by different expressions of TGFβ1 and IGF1R mRNA. Pattern a showed CD34-positive/Nestin-negative sinusoids, and was prevalent in microtrabecular lesions. Pattern b showed similar morphology and architecture as pattern a, but with Nestin-positive sinusoids and a significant ‘boost’ in IGF1R and TGFβ1 mRNAs. In patterns c and d a progressive sinusoid loss and a gain of newly formed arterioles were seen. Notably, HCCs with pattern a arose more frequently in cirrhosis (p=0.024), and showed lower incidence of microvascular invasion (p=0.002) and infiltration (p=0.005) compared with HCCs with other patterns. Conclusions Although future studies are surely required, the identification of different vascular profiles in HCCs from cirrhotic and non-cirrhotic livers may help clarify the relationship between HCC progression and aggressiveness.
    Keywords: Immunology (including allergy), Hepatic cancer
    Print ISSN: 0021-9746
    Electronic ISSN: 1472-4146
    Topics: Medicine
    Published by BMJ Publishing Group
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  • 9
    Publication Date: 2017-04-04
    Description: Abstract Several biogeochemical data have been collected in the last 10 years of Italian activity in Antarctica (ABIOCLEAR, ROSSMIZE, BIOSESO-I/II). A comprehensive 1-D biogeochemical model was implemented as a tool to link observations with processes and to investigate the mechanisms that regulate the flux of biogenic material through the water column. The model is ideally located at station B (175^{o}E - 74^{o}S) and was set up to reproduce the seasonal cycle of phytoplankton and organic matter fluxes as forced by the dominant water column physics over the period 1990-2001. Austral spring-summer bloom conditions are assessed by comparing simulated nutrient drawdown, primary production rates, bacterial respiration and biomass with the available observations. The simulated biogenic fluxes of carbon, nitrogen and silica have been compared with the fluxes derived from sediment traps data. The model reproduces quite well the magnitude of the biogenic fluxes, expecially those observed in the bottom sediment trap, but the peaks are delayed in time. Sensitivity experiments have shown that the characterization of detritus, the choice of the sinking velocity and the degradation rates are crucial for the timing and magnitude of the vertical fluxes. An increase of velocity leads to a shift towards observation but also to an overestimation of the deposition flux which can be counteracted by higher bacterial remineralization rates. Model results suggest that observed fluxes could be explained by the size-distribution and quality of the locally-produced biogenic material. It is hypothesized that the bottom sediment trap collects material originated from rapid sinking of particles and also from previous years production periods, likely modulated by advective and aggregation mechanisms which are still not resolved by the model.
    Description: Acknowledgements This research was supported by the Italian projects BIOSESO I and II, funded by the Progetto Nazionale di Ricerca in Antartide initiative. MV was partly funded by the Italian project VECTOR for the adaptation of the BFM to the Ross Sea. P. Ruardij (NIOZ) is acknowledged for the availability of the OpenSesame simulation package.
    Description: Submitted
    Description: 3.7. Dinamica del clima e dell'oceano
    Description: JCR Journal
    Description: open
    Keywords: Numerical model ; BFM ; Antarctica ; Ross Sea ; Biogeochemistry model ; 02. Cryosphere::02.04. Sea ice::02.04.01. Atmosphere/sea ice/ocean interaction ; 03. Hydrosphere::03.04. Chemical and biological::03.04.01. Biogeochemical cycles ; 03. Hydrosphere::03.04. Chemical and biological::03.04.02. Carbon cycling ; 03. Hydrosphere::03.04. Chemical and biological::03.04.04. Ecosystems
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: manuscript
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  • 10
    Publication Date: 2017-04-04
    Description: The Adriatic Basin Forecasting System implemented within the framework of the ADRICOSM Partnership (ADRIatic sea integrated COstal areaS and river basin Management system), nested to the operational general circulation model of the Mediterranean Sea, has recently been upgraded both in terms of system design and model parameterizations. The operational forecast is now daily, producing 9 days forecast, and a new near real time quality control has been introduced. From the modeling point of view the system has been upgraded in resolution (vertically from 21 to 31 sigma levels, and horizontally from approximately 1/22° to approximately 1/45°). Realistic fresh water fluxes have been introduced through the surface boundary condition taking into account evaporation, precipitation and river runoff, and the Smolarckiwicz advection scheme has been changed to the MUSCL scheme. The details of these developments will be presented, together with the model validation in delayed and real time mode
    Description: Submitted
    Description: Sandy Park, Exeter, UK
    Description: 3.11. Oceanografia Operativa
    Description: open
    Keywords: operational oceanography, numerical models, forecasting system ; 03. Hydrosphere::03.01. General::03.01.05. Operational oceanography
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: Conference paper
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