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  • 1
    Electronic Resource
    Electronic Resource
    The source and action of histamine in the isolated guinea-pig gallbladder (1995)
    Springer
    Inflammation research 44 (1995), S. 447-453 
    Details
    ISSN: 1420-908X
    Keywords: Gallbladder ; Histamine ; Mast cells ; Contraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have investigated the effects of histamine on motility of the gallbladder and characterized the receptor types involved. Histamine and the histamine H1-receptor agonist, 2-thiazolylethylamine (2-TEA) contracted the isolated guinea-pig gallbladder strip in a dose dependent manner. The contractile response to histamine was shifted to the right by the H1-receptor antagonist, mepyramine. In pre-contracted gallbladder strips, the H2-receptor agonist dimaprit reduced the tension generated in a dose dependent fashion. The histamine H2-receptor antagonist, ranitidine shifted the histamine concentration effect curve to the left and attenuated the dose dependent relaxations elicited at high concentrations. The histamine H3-receptor agonist, (R)-α-methylhistamine (RMHA) elicited dose dependent contraction of the tissue which was significantly inhibited in the presence of mepyramine. The effects of electrical field stimulation (EFS) on the strips were not significantly altered by the presence of RMHA (10−10−10−7 M) indicating little pre-synaptic H3 activity in this tissue. Histamine immunoreactivity (IR) was detected in gallbladder whole mount preparations of the mucosa and the muscularis/serosa. The histamine IR appeared cell bound in cells of varying morphological characteristics but no IR was detected in nerve fibres or cell bodies (ganglia). Alcian blue staining was consistent with the distribution of histamine IR cells as mast cells. The results indicate that histamine is distributed in the guinea-pig gallbladder and it can regulate contractile activity via activation of H1 and H2 but not H3 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01757702
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Histaminergic modulation of hormonal control in the exocrine guineapig pancreas (1995)
    Springer
    Inflammation research 44 (1995), S. 207-211 
    Details
    ISSN: 1420-908X
    Keywords: Histamine ; Secretin ; Cholecystokinin ; Pancreatic secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of histamine upon secretin- or cholecystokinin (CCK)-evoked exocrine pancreatic secretion were investigated in the anaesthetised guinea pig. Histamine (0.1 µmol/kg/min) induced a slight increase in pancreatic juice flow and total protein release compared to saline controls. Secretin (0.5 pmol/kg/min) and CCK-8 (0.75 pmol/kg/min) evoked marked time course increases in both the rate of pancreatic juice flow and total protein output in the anaesthetised guinea pig. Administration of either secretin or CCK-8 simultaneously with histamine elevated the exocrine pancreatic secretion compared to the smaller response obtained when administered separately. These results indicate that histamine may play an important physiological role in modulating the hormonal control of exocrine guinea pig pancreas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01782260
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Plant hydrolytic enzymes (chitinases and β-1,3-glucanases) in root reactions to pathogenic and symbiotic microorganisms (1996)
    Springer
    Plant and soil 185 (1996), S. 211-221 
    Details
    ISSN: 1573-5036
    Keywords: arbuscular mycorrhizal fungi ; bioprotection ; mycorrhiza-induced isoforms ; plant hydrolytic enzymes ; rhizobial symbiosis ; root pathogens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Within the last decade, a great deal of attention has been devoted to the role of chitinases and β-1,3-glucanases in plant/microbe interactions. While there is strong evidence that these hydrolases are antifungal proteins, there are also recent indications of roles in both plant morphogenesis and plant/microbe signal perception. This paper reviews recent findings pertinent to root/microbe interactions, and discusses the nature and significance of specific hydrolase isoforms in symbioses with arbuscular mycorrhizal (AM) fungi.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02257526
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    Paper (German National Licenses)
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  • 4
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    Characterization of the motor inhibitory role of colonic mucosa under chemical stimulation in mice (2014)
    The American Physiological Society (APS)
    Details
    Publication Date: 2014-04-02
    Description: The main roles of the colonic mucosa are the absorption of water and electrolytes and the barrier function that preserves the integrity of the colonic wall. The mediators and mechanisms to accomplish these functions are under continuous investigation, but little attention has been paid to a possible control of colonic motility by the mucosa that would fine tune the relationship between absorption and motility. The purpose of this study was to establish the role of the mucosa in the control of induced colonic contractility. Young ICR-CD1 mice (3–5 mo old) were studied. Isometric tension transducers were used to record contractility in full-thickness (FT) and mucosa-free (MF) strips from proximal colon. Proximal FT strips showed lower KCl- and bethanechol-induced responses than MF strips. The difference was not due to mechanical artefacts since the contractile response of FT strips to electrical field stimulation was around 50% lower than in MF. The inhibitory effects of the mucosa on FT strips were mimicked by immersion of separate strips of mucosa in the organ bath but not by addition of mucosal extract, suggesting gaseous molecules as mediators of this effect. Incubation of MF strips with synthase inhibitors of nitric oxide, carbon monoxide, and hydrogen sulfide abolished the inhibition caused by addition of the mucosal strip, indicating that mucosal gasotransmitters are the mediators of these effects. This suggests that the control of colonic motility exerted by the mucosa could fine tune the balance between transit and absorption.
    Print ISSN: 0193-1857
    Electronic ISSN: 1522-1547
    Topics: Medicine
    Published by The American Physiological Society (APS)
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