In:
Revista de Chimie, Revista de Chimie SRL, Vol. 69, No. 7 ( 2018-8-15), p. 1876-1880
Abstract:
In order to increase the biological activity, some novel molecules, esters, hydrazides, hydrazones of N-(2-bromo-phenyl)-2-hydroxy-benzamide, were obtained in good yields (86-93%), working at 150 �C, 500 W, 7-11 min, under microwave irradiation. All synthesized compounds were characterized using modern physico-chemical methods (FTIR, 1H-NMR, 13C-NMR and elemental analysis). Eight dilutions in dimethyl sulfoxide of these derivatives were tested against two phyto-pathogenic fungi, Fusarium oxysporum, Sclerotinia sclerotiorum and one common yeast, Saccharomyces cerevisiae. The antifungal activity was assessed using disc diffusion method, both negative, pure DMSO, and positive control, nystatin, were used. S. cerevisiae was slightly more sensitive than filamentous fungi, the strongest inhibition, MIC=0.3125g/L, was observed for N-(2-bromo-phenyl)-2-hydroxy-benzamide and N-(2-bromo-phenyl)-2-(4-dimethylamino-benzylidene-hydrazinocarbonylmethoxy)-benzamide. The most active compounds against F. oxysporum and S. sclerotiorum were N-(2-bromo-phenyl)-2-hydroxy-benzamide (MIC= 0.625g/L), N-(2-bromo-phenyl)-2-hydrazinocarbonylmethoxy-benzamide (MIC=1.25g/L) and N-(2-bromo-phenyl)-2-(4-dimethylamino-benzylidene-hydrazinocarbonyl-methoxy)-benzamide (MIC=0.625g/L), N-(2-bromo-phenyl)-2-hydrazinocarbonyl-methoxy-benzamide (MIC=1.25g/L), respectively.
Type of Medium:
Online Resource
ISSN:
0034-7752
,
2668-8212
DOI:
10.37358/RC.18.7.6435
Language:
English
Publisher:
Revista de Chimie SRL
Publication Date:
2018
detail.hit.zdb_id:
2488208-2
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