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Digitale Medien

Monitoring of seasonal variability in bronchial hyper-responsiveness and sputum cell counts in non-asthmatic subjects with rhinitis and effect of specific immunotherapy (2003)

Polosa, R. ; Li Gotti, F. ; Mangano, G. ; [weitere]

Oxford, UK : Blackwell Science Ltd

Clinical & experimental allergy 33 (2003), S. 0

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Details

ISSN: 1365-2222

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Bronchial hyper-responsiveness (BHR) is documented in a proportion of non-asthmatic individuals with allergic rhinitis (NAAR) and reflects inflammatory events in the lower airways. Natural exposure to allergens is known to modulate BHR and the level of airway inflammation in asthma, but less consistently in NAAR. Specific immunotherapy (SIT) attenuates symptoms possibly by reducing BHR and airway inflammation. The influence of natural exposure to Parietaria pollen on BHR and sputum cell counts of NAAR was investigated and the effect of Parietaria SIT examined. Thirty NAAR, monosensitized to Parietaria judaica, participated in a randomized, double-blind, placebo-controlled, parallel group study of the effects of a Parietaria pollen vaccine on symptoms/medication score, BHR to inhaled methacholine and adenosine 5′-monophosphate (AMP), and cell counts in the sputum collected out of and during the pollen seasons for 36 months. Seasonal variation in BHR to inhaled methacholine and AMP and changes in sputum cell counts were documented. Changes were consistent for AMP, but not methacholine, and invariably associated with modifications in sputum eosinophils and epithelial cells. The clinical efficacy of Parietaria SIT was associated with a decline in the seasonal deterioration of BHR to AMP, whereas no significant effect was observed on BHR to methacholine or sputum cell differentials. Between-groups comparison of the seasonal changes in PC15 methacholine values and sputum cell differentials calculated as the AUC were not statistically significant, whereas a significant difference in PC15 AMP was demonstrated throughout the study (P=0.029), the median (inter-quartile range) AUC values being 2478.5 (1153.3–3600.0) and 1545.5 (755.3–1797.9) for the SIT- and placebo-treated group, respectively. Bronchial airways of NAAR exhibit features of active inflammation that deteriorate during natural allergen exposure, particularly with regard to BHR to AMP. The clinical efficacy of Parietaria SIT was exclusively associated with attenuation in seasonal worsening of PC15 AMP, suggesting that AMP may be useful in monitoring changes in allergic inflammation of the airways.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1365-2222.2003.01676.x

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Digitale Medien

Salsola: Caratterizzazione morfopalinologica e incidenza di sensibilizzazione allergica in Sicilia (1987)

Palermo, B. ; Crimi, N. ; Palermo, F. ; [weitere]

Springer

Aerobiologia 3 (1987), S. 31-36

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Details

ISSN: 1573-3025

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Beschreibung / Inhaltsverzeichnis: Summary The pollen morphology of the genusSalsola L. (Chenopodiaceae) and the distribution of the plant in Italy was described and frequency of sensitization in a population of allergic patients was studied. Sensitization toSalsola was present in 13,7% of 343 allergic patients. This sensitization was always been observed in association with other pollen except for one case. The importance of this sensitization in the Mediterranean areas was emphasized considering the common frequency ofChenopodiaceae sensitization and the very frequent cross-reactivity within in the same family and betweenChenopodiaceae andAmaranthaceae.

Notizen: Riassunto Nella zona mediterranea i pollini piùfrequentemente responsabili di allergia respiratoria sono:Parietaria, Graminaceae, Compositae, Platanus, Betulaceae. Recentemente è stata osservata una frequente sensibilizzazione anche al polline diCupressaceae, Ambrosia eChenopodiaceae. Alcuni autori riferiscono che nel Nord Africa la concentrazione di polline di Chenopodiaceae è circa 20 volte maggiore rispetto alla zona mediterranea. Scopo del presente lavoro è quello di studiare le caratteristiche morfologiche del polline diSalsola; nonché la distribuzione della pianta in Italia e di valutarne la frequenza di sensibilizzazione in una popolazione di pazienti allergici. Sono stati studiati 436 pazienti di cui 343 positivi al Prick test per i più comuni allergeni della zona (Parietaria, Graminacee, Olea europaea, Compositae, eSalsola kali) e 90 soggetti negativi. Per la caratterizzazione morfopollinica è stata utilizzata le tecnica di Erdtman. E'stato dimostrato come la sensibilizzazione alla.S. kali è presente nel 13,7% dei casi, sempre in associazione con altri tipi di pollini, tranne in un solo caso di sensibilizzazione isolata. Si sottolinea quindi l'importanza che può rivestire nella nostra penisola la sensibilizzazione alla Salsola, resta da verificare l'incidenza di questo polline nei campionamenti atmosferici.