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  • 1
    Electronic Resource
    Electronic Resource
    Epidemiologic aspects and results of applying the TRISS methodology in a Spanish trauma intensive care unit (TICU) (1995)
    Springer
    Intensive care medicine 21 (1995), S. 729-736 
    Details
    ISSN: 1432-1238
    Keywords: Multiple trauma ; Intensive care ; Mortality ; Trauma severity indices
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective Analysis of epidemiologic aspects in a trauma intensive care unit (TICU) and assessment of predicted outcomes. Design Prospective study. Samples collected over a 2-year period. Setting A Spanish TICU at a tertiary care centre. Patients A group of 404 trauma patients. Interventions TRISS methodology was applied. Main results Mean age was 35.8±17 years. Mortality was 19.6% over a median ISS=17. Blunt trauma was more frequent than penetrating trauma (90.1% versus 9.9%). Car accident was the major aetiological factor (32.4%) and the highest mortality was among struck pedestrians (26.4%). The cranial region showed the highest incidence of lesion (57.9%) and the neurological complications on stage were the commonest reported on the discharge forms (49.7%). Mechanical ventilatory support (MVS) was applied in 53.2% of patients, with a relative mortality of 35.8%. Survivors differed significantly from nonsurvivors in terms of age, Glasgow Coma Scale rating, RTS, ISS, TRISS, stage and number of complications reported. The risk factors found to be associated with mortality were injury to cranial and abdominal/pelvic regions and age over 65. The TRISS total accuracy was 0.88 (sensitivity=0.67; specificity=0.93; area under the ROC curve=0.85±0.03). Forward stepwise logistic regression analysis selected age, ISS and RTS as the best predictors of survival. When our TRISS results were compared with those anticipated on the basis the MTOS, an injury severity mismatch appeared (z=0.02; M=0.78). Conclusions We found a 19.6% mortality in the TICU. Cranial and abdominal/pelvic injury and age over 65 were the main risk factors on admittance. Clinically, we finally agreed with the majority of TRISS outcome predictions. However, we could not statistically validate the apparent clinical goodness of the TRISS methodology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01704740
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  • 2
    Electronic Resource
    Electronic Resource
    Sensitization to a weed pollen in a non-atopic subject during a clinical study. A case report (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 23 (1993), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The case of a non-atopic subject developing occupational sensitization and allergic rhinitis to Mercurialis annua pollen after intense exposure is described. The subject was involved in a clinical study by handling flowering plants daily. Preventive measures should be taken even in non-atopic subjects exposed temporarily to proteins or potentially allergenic material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1993.tb00322.x
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  • 3
    Electronic Resource
    Electronic Resource
    Evaluation of the conjunctival provocation test in allergy diagnosis (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 19 (1989), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Conjunctival provocation tests (CPT) were performed in 65 respiratory allergic patients, 24 of them with a clinical history of allergic conjunctivitis and 41 who had never complained of allergic conjunctivitis, to assess the role of the conjunctiva as a target organ. The usefulness of CPT and RAST to identify symptom-related and symptom-unrelated allergen in 51 patients sensitized to two allergens but only symptomatic to one of them was also studied. Conjunctiva was found to react in a similar way to skin in patients with and without clinical conjunctivitis. CPT was positive for both symptom-related and symptom-unrelated allergens in 33 of the 51 pluri-sensitized patients. Nevertheless, in the 18 patients showing positive CPT to only one allergen, agreement with clinical data was generally found. Thus CPT appears to be a useful test in the evaluation of atopic sensitization in patients reactive to a single allergen, but not in the identification of clinically relevant allergens in individuals who are skin or RAST positive to multiple agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1989.tb02428.x
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  • 4
    Electronic Resource
    Electronic Resource
    Large B-cell lymphoma with Hodgkin's features (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 47 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims : To describe the features of a series of nine cases of diffuse large B-cell lymphoma (DLBCL) showing morphological and immunophenotypic features that are intermediate with Hodgkin's lymphoma (HL).Methods and results : Most cases (6/9) presented as mediastinal tumours affecting young males, while the other three cases arose in extramediastinal locations. Histopathologically, tumours showed diffuse large cell areas in a polymorphous background, with pleomorphic cytology and the common presence of Hodgkin's and Reed–Sternberg cells. Immunophenotypically, tumours shared features of DLBCL and classical HL, with expression of CD30, CD15 (6/9), and a full B-cell profile including CD45RB, CD20, CD79a and OCT2. Epstein–Barr virus–latent membrane protein expression was found in 2/9 cases. The majority of tumours had immunohistochemical features consistent with activation of the NF-κB pathway, including nuclear location of the c-REL/p65 subunit, overexpression of phosphorylated IκBα, and overexpression of NF-κB targets. Finally, 2/9 cases showed 3q27 (BCL6) rearrangement, and 1/9 had p53 gene mutations, both of which are rarely detected in classical HL.Conclusions : These findings suggest that DLBCLs with HL features constitute a distinctive subgroup of aggressive lymphomas whose neoplastic growth and peculiar characteristics could be facilitated by a particular microenvironment found in the mediastinum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02175.x
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  • 5
    Electronic Resource
    Electronic Resource
    Postoperative rash to ceftriaxone [Delayed hy] (2000)
    Copenhagen : Munksgaard International Publishers
    Allergy 55 (2000), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2000.00717.x
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  • 6
    Electronic Resource
    Electronic Resource
    Failure of montelukast to prevent anaphylaxis to diclofenac (1999)
    Copenhagen : Munksgaard International Publishers
    Allergy 54 (1999), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.1999.00148.x
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  • 7
    Electronic Resource
    Electronic Resource
    Usefulness of UniCAP-Tryptase fluoroimmunoassay in the diagnosis of anaphylaxis (1999)
    Copenhagen : Munksgaard International Publishers
    Allergy 54 (1999), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Serum tryptase level measured by RIA is the main in vitro tool to confirm the diagnosis of anaphylaxis. Methods: Serum tryptase levels were determined by UniCAP-Tryptase fluoroimmunoassay (Pharmacia & Upjohn, Uppsala, Sweden), in 30 consecutive patients who presented at the emergency room with a clinical allergic reaction of less than 6-h duration to assess the value of this method in the diagnosis of anaphylaxis. Anaphylaxis was established by clinical criteria and by immunoallergic study. Baseline tryptase levels were determined 1 month later in 21 patients. The receiver operating curve (ROC) was used to establish the best cutoff point of tryptase levels to confirm the diagnosis of anaphylaxis. Results: Seventeen patients were diagnosed with anaphylaxis. In this group, tryptase levels were higher than in the nonanaphylaxis group, composed mostly of patients with urticaria or angioedema (P〈0.001). ROC established the best cutoff of tryptase levels at 8.23 ng/ml with a 94.12% sensitivity and 92.31% specificity, whereas the 13.5 ng/ml cutoff recommended by the manufacturers showed 35.29% sensitivity and 92.31% specificity. The reaction-tryptase/baseline-tryptase ratio was 2.85 in the anaphylaxis group and 1.29 in the nonanaphylaxis group. Conclusions: Serum tryptase levels of 〉8.23 ng/ml by UniCAP-Tryptase fluoroimmunoassay identify anaphylaxis in patients with symptoms of less than 6-h duration. The usefulness of this determination is higher if baseline tryptase levels are available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.1999.00882.x
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  • 8
    Electronic Resource
    Electronic Resource
    Allergy to pomegranate (Punica granatum) (1999)
    Copenhagen : Munksgaard International Publishers
    Allergy 54 (1999), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.1999.00980.x
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  • 9
    Electronic Resource
    Electronic Resource
    A case of coconut allergy (2003)
    Oxford, UK : Munksgaard International Publishers
    Allergy 58 (2003), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2003.00213.x
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  • 10
    Electronic Resource
    Electronic Resource
    Allergy to Diplotaxis erucoides pollen: occupational sensitization and cross-reactivity with other common pollens (2001)
    Copenhagen : Munksgaard International Publishers
    Allergy 56 (2001), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Diplotaxis erucoides is a common weed of the Brassicaceae family widespread in southern and central Europe. Methods: A total of 410 consecutive patients referred for allergy study of rhinoconjunctivitis and/or asthma were skin tested with D. erucoides pollen, 14 proving positive. A purified D. erucoides pollen extract was prepared to perform quantitative skin tests, provocation tests, immunoblotting, and EIA inhibition in the 14 sensitized patients. Results: Three patients, directly involved in viniculture, had rhinoconjunctivitis related to D. erucoides pollen. No D. erucoides-related symptoms were observed in most patients, who were also sensitized to Artemisia pollen. RAST was positive in 12/14 patients and nasal provocation tests in 9/12. The molecular masses of the most prevalent IgE-binding proteins ranged from 26 to 27.5 and from 31 to 34 kDa. D. erucoides pollen inhibited the IgE-binding of other sensitizing pollens in the three viniculture workers, whereas both Artemisia and D. erucoides pollen produced similar heterologous inhibition in the pooled serum of the remaining, nonclinically affected, D. erucoides-sensitized patients. Conclusions: D. erucoides pollen may be an important prevalent aeroallergen, particularly in rural areas. It may act as an occupational allergen in vineyard workers, in whom it seems to be the primary sensitizing agent, playing a secondary cross-reactive role in other sensitized patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2001.00043.x
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