ISSN:
1420-9071
Keywords:
Silver ion
;
calcium channel
;
inward current
;
SH group
;
contraction
;
skeletal muscle deterioration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Exposure of voltage-clamped frog skeletal muscle fibres to silver caused a maintained inward current which could be carried by Ca2+, Mg2+ or Na+. Inorganic Ca2+ channel blockers and dithiothreitol (SH reducing agent) diminished this current, but a Na+ channel blocker did not. Thus, silver activates the Ca2+ channel by acting on SH groups in a Ca2+ channel protein.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01923550
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