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  • 1
    Electronic Resource
    Electronic Resource
    THE RELEASE AND MOLECULAR STATE OF MAMMALIAN BRAIN ACETYLCHOLINESTERASE (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 20 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— By incubating the particulate fraction of caudate nucleus from calf brain in ion-free media, about 90 per cent of the AChE activity was brought into solution. The effects of different salts, EDTA and tetracaine on the release were studied. The mol. wt. of the enzyme was determined by gel filtration. About 90 per cent of the activity in a fresh preparation appeared in a form with mol. wt. 80,000. During storage this form was gradually transformed into forms with higher mol. wts. The effects of changes in the ionic environment on the aggregation were investigated. Purification attempts always resulted in the transformation of the enzyme into high mol. wt. forms. If the release was performed in the presence of DEAE-Sephadex-A25, the enzyme no longer aggregated. The cytosol fraction always contained some AChE activity; the significance of the presence of AChE in this fraction is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb00042.x
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  • 2
    Electronic Resource
    Electronic Resource
    Hantavirus Dobrava infection with pulmonary manifestation (1999)
    Springer
    Medical microbiology and immunology 188 (1999), S. 51-53 
    Details
    ISSN: 1432-1831
    Keywords: Key words Hantavirus ; Dobrava virus ; Pulmonary manifestation ; East Germany
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dobrava virus infection was diagnosed serologically by enzyme-linked immunosorbent and immunofluorescence assays. To determine which hantavirus serotype was involved, sera were analyzed by a focus reduction neutralization test. The clinical data indicated that only pulmonary manifestation was present. Our data support the presence of Dobrava virus infection outside the Balkan region. In conclusion, a previously healthy adult with unexplained pulmonary perfusion failure should be investigated for hantavirus infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004300050104
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  • 3
    Electronic Resource
    Electronic Resource
    Transplacental passage of atenolol in man (1978)
    Springer
    European journal of clinical pharmacology 14 (1978), S. 93-94 
    Details
    ISSN: 1432-1041
    Keywords: Atenolol ; transplacental passage ; pregnancy ; hypertension ; maternal-fetal ratio
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Maternal and umbilical serum concentrations of atenolol, a hydrophilic, cardioselective beta-adrenoceptor antagonist, were studied at delivery in seven cases of pregnancy hypertension. The drug had been administered to each patient for at least one week. Atenolol was detected in both maternal and umbilical serum in six cases, showing that there is transplacental passage of the drug. In the seventh case, who had stopped taking atenolol more than one day before delivery, neither maternal nor umbilical serum contained a measurable quantity of the drug. Atenolol concentration varied 3- to 6-fold between individuals, but there was no systematic difference between maternal and umbilical levels. It seems reasonable to assume that during steady state conditions the blood level of atenolol in mother and fetus is approximately equal, and that fetal accumulation of the drug does not occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607437
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  • 4
    Electronic Resource
    Electronic Resource
    Hemorrhagic fever with renal syndrome: a study of sequelae following Nephropathia epidemica (1994)
    Springer
    Archives of virology 137 (1994), S. 241-247 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sequelae following Nephropathia epidemica (NE) were investigated in 792 individuals living in an endemic area of Sweden. Volunteers were tested for presence of Puumala (PUU) virus specific IgG antibodies in serum, as well as several parameters linked with renal dysfunction and cardiovascular disease (systolic and diastolic blood pressure, ECG, BMI, total cholesterol and serum creatinine). No differences were seen in any of the variables tested between PUU virus antibody positive (n=110) and negative individuals (n=682). In addition, the blood pressure was measured in 62 serologically confirmed patients diagnosed with clinical NE 2–6 years previously. One patient with moderate hypertension was found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309472
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  • 5
    Electronic Resource
    Electronic Resource
    Bank vole monoclonal antibodies against Puumala virus envelope glycoproteins: identification of epitopes involved in neutralization (1992)
    Springer
    Archives of virology 126 (1992), S. 93-105 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bank vole (Clethrionomys glareolus) monoclonal antibodies (MAbs) against the two envelope glycoproteins (G 1 and G 2) of the Puumala (PUU) virus were generated and characterized. Analyses of the MAbs' antigen and epitope specificities showed non-overlapping reactivities of one anti-G 1 and two anti-G 2 MAbs. A significant neutralizing activity was shown by the anti-G 1 and one of the anti-G 2 MAbs, suggesting the existence of at least one neutralizing domain on each of the two glycoproteins. The two neutralizing MAbs reacted with eight PUU-related (serotype 3) virus strains, but did not react with Hantaan, Seoul, or Prospect Hill viruses in an immunofluorescence assay, indicating reactivity with epitopes unique for PUU virus. The non-neutralizing anti-G 2 MAb also reacted with Seoul virus, revealing the presence of a conserved G 2-epitope common for PUU and Seoul viruses, not involved in neutralization. Competitive binding of the MAbs and sera from nephropathia epidemica patients indicated that the defined neutralizing and non-neutralizing epitopes of the glycoproteins were immunodominant also in humans. In another experiment, magnetic beads coated with two MAbs were bound with the virus glycoproteins and used for selective enrichment of cells secreting anti-glycoprotein antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309687
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  • 6
    Electronic Resource
    Electronic Resource
    Anti-idiotypic antibodies against Puumala virus glycoprotein-specific monoclonal antibodies inhibit virus infection in cell cultures (1993)
    Springer
    Archives of virology 132 (1993), S. 255-265 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rabbit anti-idiotypic antibodies (anti-ids) were generated against three bank vole and one human monoclonal antibody (MAb) specific for the two envelope glycoproteins of Puumala virus (G 1 and G 2). The anti-ids were purified by sequential immunoaffinity chromatography. Each anti-id inhibited the antigen binding of its respective MAb in a competitive ELISA. This inhibition, and the absence of cross-reactivity among the anti-ids for heterologous MAbs, showed that they all were specific for unique determinants on the antigen binding site of the homologous MAb. The anti-ids reacted with non-infected Vero E 6 cells when examined by immunofluorescence and ELISA, indicating the presence of antibodies that mimic epitopes on the virus. Preincubation of Vero E 6 cells with two of the anti-ids produced against neutralizing MAbs inhibited Puumala virus infection, suggesting that these two anti-ids blocked a cellular component involved in virus infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309537
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  • 7
    Electronic Resource
    Electronic Resource
    Antigenic relationships of hantavirus strains analysed by monoclonal antibodies (1995)
    Springer
    Archives of virology 140 (1995), S. 1763-1773 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antigenic relationships among 71 hantavirus strains, isolated from rodent species or humans in several geographic regions, were examined by immunofluorescence assay (IFA) using human patient sera and a panel of 22 monoclonal antibodies prepared against Hantaan, Seoul, and Puumala viruses. The study included virus strains, mainly from the former USSR, for which little or no serological data were available. Fifty-nine of the 71 isolates could be placed into five antigenic groups of hantaviruses, Hantaan (HTN), Puumala (PUU), Seoul (SEO), Prospect Hill (PH), Dobrava/Belgrade (DOB). Twelve isolates were found antigenically closely related to, but distinct from, HTN (2 strains), PUU (4 strains) and PH (6 strains), respectively. The antigenic characteristics of these 12 isolates suggested two supplementary antigenic subgroups of HTN, one of PUU, and two of PH. The two antigenic subgroups of HTN included strains isolated in the Far-East of Russia. The PUU subgroup included strains isolated in European Russia as well as strains isolated in Far-Eastern Russia. The PH group comprised two subgroups, both represented by strains isolated fromM. fortis in Far-Eastern Russia. The results showed that the PUU and PH antigenic groups are more complex than previously known and that PH-like virus strains isolated in Russia are antigenically more closely related to PUU virus when compared to prototype PH virus isolated in the USA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01384340
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  • 8
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    Virus underpins T2D? [Biological Sciences] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-07-24
    Description: Thurner et al. (1) identifies spikes in diabetes incidence using year-of-birth data from Austria over the last century. They intriguingly associate these peaks with intervals of nationwide famine with the disease onset apparently occurring decades later. The information provided by Thurner et al. is a valuable supplement to previous studies...
    Keywords: Letters
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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