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  • 1
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing AG,
    Schlagwort(e): Science-Social aspects. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (205 pages)
    Ausgabe: 1st ed.
    ISBN: 9783030402297
    Serie: Contemporary Trends and Issues in Science Education Series ; v.52
    Sprache: Englisch
    Anmerkung: Intro -- Foreword -- Contents -- List of Figures -- List of Tables -- Contributors -- Chapter 1: Introduction: Socio-scientific Issues as Promoting Responsible Citizenship and the Relevance of Science -- 1.1 Introduction -- 1.2 Socioscientific Issues, Relevance of Science and Responsible Citizenship -- 1.3 The Structure of the Book -- 1.4 Summarizing -- References -- Chapter 2: Teachers and Socioscientific Issues - An Overview of Recent Empirical Research -- 2.1 Introduction -- 2.2 Pre-service Science Teacher' Relations to SSI -- 2.3 Science Teachers' Relations to, and Experiences with, SSI -- 2.4 Conclusions -- References -- Chapter 3: Pre-service Secondary Science Teachers' Beliefs About Teaching Socio-scientific Issues -- 3.1 Background -- 3.2 Theoretical Framework -- 3.2.1 Socio-scientific Issues (SSI) -- 3.2.2 Teachers' Beliefs About SSI -- 3.2.3 Course Design -- 3.3 Methods -- 3.3.1 Data Collection -- 3.3.2 Data Analysis -- 3.4 Results and Discussion -- 3.4.1 Pre-course Teaching Beliefs About SSI -- 3.4.2 Post-course Teachers' Beliefs About SSI -- 3.4.3 Key Learning Moments -- 3.5 Implications for Teaching and Research -- References -- Chapter 4: Socio-Scientific Inquiry-Based Learning: Possibilities and Challenges for Teacher Education -- 4.1 Introduction -- 4.1.1 Raising Authentic Questions - Ask -- 4.1.2 An Inquiry-Based Approach - Find Out -- 4.1.3 Finding a Solution - Act -- 4.1.3.1 Adopting the SSIBL Approach -- 4.1.3.2 SSIBL and National Curricula -- 4.2 Method -- 4.2.1 Pre-service Teacher Cases -- 4.2.1.1 Martina -- 4.2.1.2 Caitlin -- 4.2.1.3 Andrea -- 4.2.2 Summary of Case Studies -- 4.3 Discussion -- 4.4 Implications -- References -- Chapter 5: Critical and Active Public Engagement in Addressing Socioscientific Problems Through Science Teacher Education -- 5.1 Introduction -- 5.2 Status of Socioscientific Issues Education. , 5.3 Research Context and Methods -- 5.3.1 Research Context -- 5.4 Research Methodology and Methods -- 5.5 Summaries of Dispositifs for Mobilization -- 5.5.1 STEPWISE in a Technical College (Sarah El Halwany) -- 5.5.2 STEPWISE in a Suburban Public High School (John Lawrence Bencze) -- 5.5.3 STEPWISE in an International Private High School (Majd Zouda) -- 5.6 CODA -- References -- Chapter 6: Supporting Teachers in the Design and Enactment of Socio-Scientific Issue-Based Teaching in the USA -- 6.1 Introduction -- 6.2 Collaborative Professional Development Model -- 6.2.1 Theoretical Framework -- 6.3 Design Cases -- 6.3.1 Design Case 1: Collaborating with an Exemplary Biology Teacher -- 6.3.2 Design Case 2: Secondary Teachers Co-Designing Curriculum -- 6.3.3 Design Case 3: Implementing SSI Teaching in an Elementary School -- 6.3.4 Conclusions and Next Steps -- References -- Chapter 7: Gamification of SSI's as a Science Pedagogy: Toward a Critical Rationality in Teaching Science -- 7.1 Introduction -- 7.2 Motivation for This Work -- 7.3 Theoretical Framework -- 7.4 Design Case -- 7.5 Methods of Data Production -- 7.6 Findings -- 7.6.1 Episode 1: Immersion into the World of Alternate Reality Gaming -- 7.6.2 Episode 2: Developing an ARG Architecture -- 7.6.3 Episode 3: Planning Framework for an ARG -- 7.7 Discussion -- 7.8 Implications for Teaching and Research -- References -- Chapter 8: Science Teachers as Proponents of Socio-Scientific Inquiry-Based Learning: From Professional Development to Classroom Enactment -- 8.1 Introduction -- 8.2 Theoretical Framework -- 8.2.1 Socio-Scientific Issues and the Role of Students as Active Citizens -- 8.2.2 Socioscientific Inquiry Based Learning -- 8.2.3 Teacher Preparation and Learning to Teach SSIBL -- 8.3 Design of the TPD Model -- 8.4 Overview of the Research Approach -- 8.5 Method. , 8.5.1 Participants and Data Sources -- 8.6 Results -- 8.6.1 Case Study 1: David -- 8.6.2 Case Study 2: Ruth -- 8.7 Conclusions and Discussion -- References -- Chapter 9: Getting Ready to Work with Socio-Scientific Issues in the Classroom: A Study with Argentine Teachers -- 9.1 Introduction -- 9.2 Background -- 9.3 Methods -- 9.3.1 Research Design Overview -- 9.3.2 Part 1: In-Service Professional Development Workshop -- 9.3.2.1 Workshop Contents and Activities -- 9.3.2.2 Final Survey -- 9.3.3 Part 2: Follow-Up: Lesson Planning and Implementation -- 9.3.3.1 Participating Teachers -- 9.3.3.2 Content and Activities of the Follow-Up Program -- 9.3.3.3 Teacher Interviews -- 9.4 Results -- 9.4.1 How Do Teachers Incorporate SSI Approaches to Their Own Practice? -- 9.4.2 Case Study 1: Clara - A Kindergarten Teacher -- 9.4.3 Case Study 2: Julia - A Secondary School Chemistry and Physics Teacher -- 9.4.4 Case Study 3: Sofia - A Secondary School Biology Teacher -- 9.5 Conclusions: What Does It all Mean for Science Teaching? -- References -- Chapter 10: Introducing Model-Based Instruction for SSI Teaching in Primary Pre-service Teacher Education -- 10.1 Motivation -- 10.2 Theoretical Framework -- 10.3 Design Case -- 10.4 Research -- 10.4.1 Research Objectives -- 10.4.2 Data Collection and Analysis -- 10.4.3 Results -- 10.4.3.1 Evolution of PTs' SSI Lessons Plans and PTs' Awareness (RO1) -- 10.4.3.2 The Inclusion of the Scientific Content in SSI Lessons (RO2) -- 10.4.3.3 The Dialogic Role of Pre-service Teachers in SSI Discursive Activities (RO2) -- 10.5 Summary and Conclusions -- 10.6 Implications for Teaching and Research -- References -- Chapter 11: Re-thinking the Integration of Socioscientific Issues in Life Sciences Classrooms Within the Context of Decolonising the Curriculum -- 11.1 Background -- 11.2 Rationale for Integrating SSI into the Curriculum. , 11.3 Critical Pedagogy -- 11.4 Teachers, Learners and the Curriculum -- 11.5 Methodology -- 11.5.1 The Participants -- 11.5.1.1 The Task -- 11.6 Results -- 11.6.1 Results from Teacher A -- 11.6.1.1 Reasons for Selecting Alternative Treatments for Cancer as an SSI -- 11.6.1.2 Preparing to Teach Alternative Treatments for Cancer as an SSI -- 11.6.2 Results from Teacher B -- 11.6.2.1 Reasons for Selecting African Treatments for Cancer as an SSI -- 11.6.2.2 Preparing to Teach about African Treatments for Cancer as an SSI -- 11.6.3 Teacher C -- 11.6.3.1 Reason for Selecting Alien Invasive Plants as an SSI -- 11.6.3.2 Preparing to Teach About Alien Invasive Plants as an SSI -- 11.7 Analysis and Discussion -- 11.7.1 Identifying the SSI -- 11.7.2 Preparing to Teach SSI: Deconstructing the Curriculum -- 11.7.3 Addressing the Social Challenge through SSI-Based Instruction: Reconstruction -- 11.8 Concluding Remarks -- References -- Chapter 12: New Perspectives for Addressing Socioscientific Issues in Teacher Education -- 12.1 Introduction -- 12.2 Teachers' Background and Beliefs -- 12.3 The Embeddedness of SSI-Teaching -- 12.4 The Necessity of Long-Term Professional Development -- 12.5 The Future of Socioscientific Issues in Teacher Education -- References.
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  • 2
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: On the basis of the significantly different distributions of maternal serum alpha-fetoprotein (AFP) levels in 86 pregnancies associated with fetal Down's syndrome and in 2018 unaffected pregnancies, an iso-risk curve for Down's syndrome was constructed. An iso-risk curve shows, for women of all ages, which combinations of maternal age and level of maternal serum AFP result in the same risk of carrying a fetus with Down's syndrome. A 1:400 risk of Down's syndrome, corresponding to the risk of a 35-year-old woman, was chosen as the lowest risk indicating referral for amniocentesis. If all women, irrespective of their age, are offered amniocentesis, when their risk of carrying a Down's syndrome fetus is 1;400 or higher, 53% of the affected fetuses can be detected as compared with 28% of the affected fetuses diagnosed at present in women above 35 years of age.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Journal of the American Chemical Society 88 (1966), S. 446-452 
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    ISSN: 1600-0668
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Architektur, Bauingenieurwesen, Vermessung , Medizin
    Notizen: Background. In the Danish Town Hall Study" it has previously been shown that the sick building syndrome is a widespread phenomenon. This has given rise to speculations as to whether biologically active components in dust or whether absorbed organic gases and vapours in the indoor climate may be partly responsible for the sick building syndrome. Therefore, we wished to study whether qualitative conditions in dust, of a physical, chemical, and biological nature, are related to the prevalence of symptoms of the sick building syndrome. Material and methods. The study included 12 town halls in the Copenhagen area. A total of 870 persons participated, 584 women and 286 men. All the participants filled out a questionnaire regarding health and working conditions, and dust samples were collected with a special vacuum cleaner in the working environment of the participants, after which the contents of inorganic and organic particles as well as of human source fragments the (hair, nails, skin) and various fibres were determined. Results. There was a significant correlation (P〈0.05) between the prevalence of gram-negative bacteria in the indoor climate dust, and general symptoms (fatigue, heavy-headedness, headache, dizziness, concentration problems) (corr.coeff.=0.73), as well as symptoms from the mucous membranes of the upper respiratory tract (corr.coeff.=0.76). Also, there was a significant relation between the prevalence of particles in the dust and the prevalence of symptoms from the mucous membranes (corr.coeff.=0.81). There was a strong and significant correlation between the total amount of volatile organic components (TVOC) and lack of concentration (corr.coeff. =0.85) and feeling heavy-headed (corr.coeff.=0.72). Macromolecular dust (potentially allergenetic material) was significantly correlated to the prevalence of headache and general malaise/dizziness (corr.coeff.=0.66), while the ability of the dust to liberate histamine was significantly related to the prevalence of general malaise, dizziness (corr.coeff.=0.65) and lack of concentration (corr.coeff. =0.58). Further analyses including a number of potential confounders did not change the results of the above analyses. Conclusion. The results of this study support the hypothesis that qualitative properties of dust are important to the sick building syndrome. The study was based on relatively few buildings, but nevertheless strong correlations were found. In perspective, epidemiological intervention studies should be carried out to investigate whether minimizing the amount of both dust and bacteria in the indoor climate affect the prevalence of sick building syndrome.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Hydrobiologia 235-236 (1992), S. 283-293 
    ISSN: 1573-5117
    Schlagwort(e): sediment ; bacteria ; estuary
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Total oxygen uptake, bacterial oxygen uptake, total bacterial biomass and active bacterial biomass were determined at the sediment-water interface at two stations in the brackish Roskilde Fjord between September and December in 1986 before, during and after sedimentation of a phytoplankton bloom. Bacterial oxygen consumption was separated from total oxygen consumption by addition of cycloheximide. The fractional and the absolute bacterial oxygen uptake were greatest at the most eutrophic station, where total oxygen uptake was 870–1740 mg O2 m−2 d−1 and the bacterial oxygen uptake was 232–870 mg O2 m−2 d−1. At the less eutrophic station, total oxygen uptake was 725–1740 mg O2 m−2 d−1. and bacterial oxygen uptake was 200–550 mg O2 m−2 d−1. Active bacterial biomass was separated from total bacterial biomass by addition of the terminal electron acceptor INT-formazan. The active bacterial biomass was 70–120 µg C mg−1 ww of sediment at the most eutrophic station and 50–90 µg C g−1 ww of sediment at the other station. Differences in capacity of bacterial oxygen uptake between the two stations correlated to the active bacterial biomass. The non-temperature dependent bacterial oxygen uptake correlated with the sedimentation rate.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 98 (1965), S. 3385-3400 
    ISSN: 0009-2940
    Schlagwort(e): Chemistry ; Inorganic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Die Bromierung von Bullvalen ergibt ein Dibromid, das durch Eliminierung von HBr zu Brombullvalen führt. Aus letzterem entstehen mit Kaliumalkoholaten in Dimethylsulfoxyd in sehr guten Ausbeuten Alkoxybullvalene.  -  Die monosubstituierten Bullvalene unterliegen prinzipiell denselben Valenzisomerisierungen wie das Bullvalen: Keine zwei Kohlenstoffatome bleiben längere Zeit aneinander gebunden. Hier haben aber nicht alle Valenzisomeren (1.2·106) dieselbe Struktur; sie sind in vier Positionsisomere aufgeteilt. Demzufolge gibt es auch sieben Isomerisierungsgeschwindigkeiten.  -  Das Studium der temperaturabhängigen NMR-Spektren der genannten Bullvalenderivate zeigt, daß die Isomeren mit dem Substituenten in olefinischer Position bevorzugt sind. Man kann aus den Spektren Informationen über die relative Größe der Geschwindigkeitskonstanten erhalten.  -  Das unterschiedliche Verhalten der einzelnen Derivate wird durch den Hybridisierungszustand des substituierten C-Atoms und durch die Konjugationsmöglichkeit des Substituenten mit dem Bullvalylsystem erklärt.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Publikationsdatum: 2013-10-26
    Beschreibung: Background: Type 2 diabetes, obesity and insulin resistance are characterized by hypertriglyceridemia and ectopic accumulation of lipids in liver and skeletal muscle. AGPAT6 encodes a novel glycerol-3 phosphate acyltransferase, GPAT4, which catalyzes the first step in the de novo triglyceride synthesis. AGPAT6-deficient mice show lower weight and resistance to diet- and genetically induced obesity. Here, we examined whether common or low-frequency variants in AGPAT6 associate with type 2 diabetes or related metabolic traits in a Danish population. Methods: Eleven variants selected by a candidate gene approach capturing the common and low-frequency variation of AGPAT6 were genotyped in 12,068 Danes from four study populations of middle-aged individuals. The case--control study involved 4,638 type 2 diabetic and 5,934 glucose-tolerant individuals, while studies of quantitative metabolic traits were performed in 5,645 non-diabetic participants of the Inter99 Study. Results: None of the eleven AGPAT6 variants were robustly associated with type 2 diabetes in the Danish case--control study. Moreover, none of the AGPAT6 variants showed association with measures of obesity (waist circumference and BMI), serum lipid concentrations, fasting or 2-h post-glucose load levels of plasma glucose and serum insulin, or estimated indices of insulin secretion or insulin sensitivity. Conclusions: Common and low-frequency variants in AGPAT6 do not significantly associate with type 2 diabetes susceptibility, or influence related phenotypic traits such as obesity, dyslipidemia or indices of insulin sensitivity or insulin secretion in the population studied.
    Digitale ISSN: 1471-2350
    Thema: Biologie , Medizin
    Publiziert von BioMed Central
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Publikationsdatum: 2016-02-26
    Beschreibung: ABSTRACT Women with hypertensive disorders of pregnancy (HDP) have higher levels of anti-angiogenic growth factors during pregnancy than women with normotensive pregnancies. Since angiogenesis is necessary for solid cancer growth and spread, we hypothesized that women with a history of HDP might have a reduced risk of solid cancers (cancers other than lymphomas, hematologic cancers and non-melanoma skin cancers) later in life. In a register-based cohort study of 1.08 million women giving birth at least once between 1978 and 2011, we used Cox regression to estimate hazard ratios (HRs) comparing solid cancer rates for women with and without a history of HDP. In this cohort, 68,236 women (6.3%) had ≥1 pregnancy complicated by HDP and 42,236 women (3.9%) developed solid tumors during follow-up. A history of HDP was not associated with a clinically meaningful reduction in the overall rate of solid cancer (HR 0.96, 95% confidence interval [CI] 0.92-1.00), regardless of HDP severity or time since HDP, nor was there a general tendency towards reduced solid cancer rates across organ sites. A history of HDP was only significantly associated with decreased rates of breast and lung cancers, and with increased rates of endometrial and urinary tract cancers. Overall, our results do not support the hypothesis that women with a history of HDP have a reduced overall risk of solid cancer due to a persistent post-HDP anti-angiogenic state or an innate tendency toward anti-angiogenesis. Observed associations with specific cancers may instead be due to other pregnancy-related mechanisms or to residual/unmeasured confounding. This article is protected by copyright. All rights reserved.
    Print ISSN: 0020-7136
    Digitale ISSN: 1097-0215
    Thema: Biologie , Medizin
    Publiziert von Wiley-Blackwell
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  • 9
    Publikationsdatum: 2014-07-12
    Beschreibung: Journal of the American Chemical Society DOI: 10.1021/ja504077f
    Print ISSN: 0002-7863
    Digitale ISSN: 1520-5126
    Thema: Chemie und Pharmazie
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Publikationsdatum: 2013-01-24
    Beschreibung: Journal of Medicinal Chemistry DOI: 10.1021/jm301473k
    Thema: Chemie und Pharmazie
    Standort Signatur Einschränkungen Verfügbarkeit
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