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  • 1
    Electronic Resource
    Electronic Resource
    Management of refractory plaque psoriasis (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 27 (2002), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The treatment of limited extent plaque psoriasis in the majority of cases is a routine procedure for dermatologists and only a small number of patients need a change of the chosen regimen. However, in patients with widespread plaque psoriasis treatment can be hampered for various reasons; in particular, the use of a systemic regimen or UV light and all their combination modalities may be restricted by individual factors such as concomitant diseases, personal risk factors and previous treatments. In another group of psoriasis patients with high disease activity and frequent relapses after each treatment course effective intervention can be difficult. In mild forms of plaque psoriasis a combination of different topical agents, mainly with sequential use, are given. For several of these combinations like such as D3 and its analogues, and topical corticosteroids clinical studies have shown synergistic mechanisms. A next step of treatment is the introduction of occlusive treatment. In moderate plaque psoriasis topical agents are usually combined with W-light (LTVB or PUVA). Salt-water bathing plus UVB is an alternative modality. For severe forms of plaque psoriasis systemic compounds are combined with topical agents. The systemic retinoid acitretin may also be combined with PLIVA. In very severe cases the combination of systemic compounds such as cyclosporin and methotrexate may be adequate. Initial treatment with new biological compounds such as monoclonal antibodies targeting multifunctional cytokines such as tumour necrosis factor α, or which interfere with T-cell activation (interleukin-2 receptor antibodies) seems to be highly effective in active or triggered severe plaque psoriasis. A better definition of the type of psoriasis in the individual patient, as well as the recognition of risk and trigger factors, will help in choosing ‘tailored’ therapy. Records of previous treatment results further help to define an individual pattern of plaque psoriasis which may enable the dermatologist to predict treatment outcome with a good reliability. Combination of different regimens, rotation between them and sequential use of systemic registered compounds may help to prevent refractory diseases states. The limited use of new biological compounds may further help to treat patients with a history of unresponsive plaque psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2230.2002.10434.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Advances in systemic therapy for psoriasis (2001)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 26 (2001), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Severe cases of psoriasis and psoriasis arthritis require systemic treatment. Although a number of established drugs are in clinical use, there is a need for new compounds with an improved risk-benefit ratio with a major emphasis on long-term safety. Furthermore, patients with moderate psoriasis ask for systemic drugs to make therapy easier and to avoid excessive local treatments.This article aims to give a brief overview about new drugs or groups of compounds together with an evaluation of their present status in the treatment of psoriasis and their future role with particular respect to efficacy, tolerability, safety and usability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2230.2001.00835.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Significant reduction of human monocyte chemotactic response to monocyte-chemotactic protein 1 in patients with primary and metastatic malignant melanoma (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 6 (1997), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract The recruitment of leukocytes from the peripheral blood is a key event for the development and composition of the inflammatory infiltrate in solid tumors and tumor metastases like malignant melanoma. Tumor-infiltrating lymphocytes (TIL) and tumor-associated macro-phages (TAM) are thought to play a crucial rôle in tumor immunosurveillance. In malignant melanoma expression and secretion of monocyte-chemotactic protein 1 (MCP-1) have been demonstrated. MCP-1 serves as an attractant for monocytes and activated T-cells. In this study we addressed the question whether circulating monocytes show altered chemotaxis to MCP-1. Therefore the chemotactic responsiveness of monocytes towards MCP-1 was investigated in patients with primary and metastatic melanoma and compared to patients with basal cell carcinoma and healthy persons. The results show that monocytes from melanoma patients showed a significantly decreased chemotactic migration towards MCP-1 while chemotaxis to the stimulus N-formyl-methionyl-leucyl-phenylalanine (FMLP) remained normal. Patients with basal cell carcinoma showed normal monocyte chemotaxis to all stimuli tested. In primary melanoma, there was no relation of the number of TAM or TIL to ihe decreased chemotaxis of circulating monocytes to MCP-1. From these data it can be concluded that circulating monocytes from patients with primary and metastatic melanoma show a MCP-1-specific decrease in chemotactic migration. This may be due to deactivation or modulation of the MCP-1-receptor expression on these cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1997.tb00151.x
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  • 4
    Electronic Resource
    Electronic Resource
    Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease (2003)
    [s.l.] : Nature Publishing Group
    Nature medicine 9 (2003), S. 40-46 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Selective skewing of autoreactive interferon-γ (IFN-γ)-producing T helper cells (Th1) toward an interleukin-4 (IL-4)-producing (Th2) phenotype can in experimental animals alleviate autoimmune disease without inducing general immunosuppression. In a prospective dose escalation study, we ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm804
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Bedeutung von T-Lymphozyten für die Pathogenese der Psoriasis – interdisziplinäre Ansichten Bericht über einen Workshop am 22.11.1996 im Schloß Heiligenstedten (1997)
    Springer
    Der Hautarzt 48 (1997), S. 766-769 
    Details
    ISSN: 1432-1173
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050659
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Rheumatoide neutrophile Dermatitis – eine seltene Dermatose bei Patienten mit aktiver rheumatoider Arthritis Eine Kasuistik mit Literaturübersicht (1996)
    Springer
    Der Hautarzt 47 (1996), S. 921-926 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Rheumatoide neutrophile Dermatitis ; Rheumatoide Arthritis ; Neutrophile Dermatosen ; Key words Rheumatoid neutrophilic dermatitis ; Rheumatoid arthritis ; Neutrophilic dermatoses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Rheumatoid neutrophilic dermatitis is a rare dermatologic disorder seen in patients with active rheumatoid arthritis. Clinically firm erythematous 3-5 mm papules are found mainly on the arms, the hips and the proximal thighs. The lesions may be pruritic leading to excoriations and crusts. Histology reveals a dense dermal infiltrate with neutrophilic granulocytes, while leukocytoclasia may be seen, vasculitits is not observed. This overview of rheumatoid neutrophilic dermatitis may help remind the practioner to include this uncommon disorder in the differential diagnosis of rheumatoid arthritis-related dermatoses.
    Notes: Zusammenfassung Die rheumatoide neutrophile Dermatitis ist eine bisher sehr selten beschriebene Dermatose bei Patienten mit aktiver rheumatoider Arthritis. Klinisch zeigen sich 3–5 mm große zumeist erythematöse, indurierte Papeln besonders im Bereich der Arme, der Hüften und der Oberschenkel. Teilweise besteht leichter Juckreiz, der zu krustigen Oberflächen durch Kratzartefakte führen kann. Histologisch imponiert ein dichtes dermales Infiltrat neutrophiler Granulozyten, teilweise mit Leukozytoklasie ohne die Zeichen einer Vaskulitis. Die vorliegende Arbeit soll das Krankheitsbild der rheumatoiden neutrophilen Dermatitis darstellen und helfen, diese bislang noch selten diagnostizierte Dermatose in die Differentialdiagnose mit rheumatoider Arthritis assoziierter kutaner Erkrankungen einzubeziehen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050532
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  • 7
    Electronic Resource
    Electronic Resource
    Protection of human skin against jellyfish (Cyanea capillata) stings (1992)
    Springer
    Marine biology 113 (1992), S. 669-678 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In tropical and subtropical regions of the world, jellyfish stings cause fatalities by means of venom injecting nematocysts. For nematocyst discharge an adequate combination of chemical and mechanical stimulation is required. In order to test whether skin care products can protect against nematocyst discharge, we tested two sunscreens and one lotion applied to pieces of live human skin and exposed them to Cyanea capillata tentacles. (Test specimens were collected in 1990 along the shore of Rømø, Denmark and in the Flensburger Förde.) The fine structure analysis of the cnidom of C. capillata showed a high grade of variation in shape and size. The basic distinctive characteristic for stomocnides and astomocnides, the terminal opening at the tubule tip, could not be found. The identification of spines at the basal tubule of atrichous isorhizas suggested that these should be characterized as basitrichous isorhizas. An association between nematocyst morphology and a special function such as penetration or entanglement was not observed. All nematocyst types penetrated unprotected skin. Parafilm (an inert material) and unprotected skin substrates served as controls. The discharged nematocysts on the skin and Parafilm surfaces were counted using scanning electron microscopy. The percentage of discharged nematocysts on test substance protected skin surfaces ranged from only 7.7 to 38.2%, compared to 100% on the unprotected control skin. In addition to this marked reduction in nematocyst discharge, the relatively few discharged nematocysts on protected skin showed malfunctions, and the injection of venom would have failed because the tubules of the nematocysts did not penetrate the skin. The results indicate a general possibility that human skin may be protected against nematocyst discharge of jellyfish with the application of sunscreen or lotion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00349710
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  • 8
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    Protection of human skin against jellyfish (Cyanea capillata) stings (1992)
    Springer
    In:  Marine Biology, 113 (4). pp. 669-678.
    Details
    Publication Date: 2018-03-20
    Description: In tropical and subtropical regions of the world, jellyfish stings cause fatalities by means of venom injecting nematocysts. For nematocyst discharge an adequate combination of chemical and mechanical stimulation is required. In order to test whether skin care products can protect against nematocyst discharge, we tested two sunscreens and one lotion applied to pieces of live human skin and exposed them to Cyanea capillata tentacles. (Test specimens were collected in 1990 along the shore of Rømø, Denmark and in the Flensburger Förde.) The fine structure analysis of the cnidom of C. capillata showed a high grade of variation in shape and size. The basic distinctive characteristic for stomocnides and astomocnides, the terminal opening at the tubule tip, could not be found. The identification of spines at the basal tubule of atrichous isorhizas suggested that these should be characterized as basitrichous isorhizas. An association between nematocyst morphology and a special function such as penetration or entanglement was not observed. All nematocyst types penetrated unprotected skin. Parafilm (an inert material) and unprotected skin substrates served as controls. The discharged nematocysts on the skin and Parafilm surfaces were counted using scanning electron microscopy. The percentage of discharged nematocysts on test substance protected skin surfaces ranged from only 7.7 to 38.2%, compared to 100% on the unprotected control skin. In addition to this marked reduction in nematocyst discharge, the relatively few discharged nematocysts on protected skin showed malfunctions, and the injection of venom would have failed because the tubules of the nematocysts did not penetrate the skin. The results indicate a general possibility that human skin may be protected against nematocyst discharge of jellyfish with the application of sunscreen or lotion.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1007/BF00349710
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    OceanRep: Article in a Scientific Journal - peer-reviewed
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