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  • 1
    Online-Ressource
    Online-Ressource
    Singapore :Springer,
    Schlagwort(e): Hazard mitigation. ; Information technology. ; Information technology-Japan. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (224 pages)
    Ausgabe: 1st ed.
    ISBN: 9789811956461
    Serie: Disaster Risk Reduction Series
    DDC: 303.4830952
    Sprache: Englisch
    Anmerkung: Intro -- Preface -- About This Book -- Contents -- Editors and Contributors -- 1 Science, Technology, and People-Centered Society -- 1.1 Introduction -- 1.2 People-Centric Process for People-Centered DRR -- 1.3 Digital Transformation for Science and Technology for Human Security and Social Inclusion -- 1.4 Human Security and Well-Being on SDG3: Health and Well-Being for All -- 1.5 About the Book -- References -- 2 Science, Technology, Innovation and Sendai Framework for Disaster Risk Reduction -- 2.1 Introduction -- 2.2 Multiple Hazards -- 2.3 Complex Risk Landscape -- 2.4 Science for Finding Causes and Providing Solutions -- 2.5 Community Research with Science Technology -- 2.6 Science Technology for Co-Designing Solutions -- 2.7 Science Technology for Personalized Choices -- 2.8 Postscript -- References -- 3 Systemic Risk and System-Based Approach for Society 5.0 -- 3.1 Introduction -- 3.2 All Hazard Approach -- 3.3 Methods of Disaster Response: Decision Making in the Face of Uncertainty -- 3.4 Stages of Disaster Response -- 3.5 Utilization of Information in Disaster Response -- 3.5.1 Management and Recovery of Critical Infrastructure -- 3.5.2 Post-Disaster Information Utilization -- 3.6 Way Forward -- Reference -- 4 Emerging Issues and Japan's Milestones in Science and Technology for Disaster Risk Reduction -- 4.1 Introduction -- 4.2  Lesson Learned from Disaster Responce and Information Management by DRR3.0 × Society 4.0 in  Japan -- 4.2.1 Systematization of Sharing Data -- 4.2.2 Collection, Design and Data Uncertainty -- 4.2.3 Processing of Information into Usable Information -- 4.2.4 Importance of Monitoring Over Time -- 4.2.5 Systematic Implementation of Information Collection and Organization -- 4.2.6 From Statistical Thinking to the Utilization of Non-Aggregated Data -- 4.2.7 Message Distribution. , 4.2.8 Consensus Building: Decision-Making, Accountability, and Collaboration -- 4.3 Observation to Orient, Decide, and Act: Demand Based Innovation on Emergency -- 4.4 The Role of Local Institute: Co-Creation of Care Science for Disaster Risk Reduction -- 4.5 Way Forward: To Distributed Sheltering and Communication and Care -- References -- 5 Evidence-Based Policymaking of Smart City: The Case of Challenge in Maebashi City, Japan -- 5.1 Introduction -- 5.1.1 What is "EBPM"? -- 5.1.2 Challenges in Promoting EBPM in Japan -- 5.2 Micro Geodata (MGD) to Support EBPM Promotion and Available MGD in Japan -- 5.3 Application Example of MGD: High-Definition Damage Simulation of a Large-Scale Disaster -- 5.4 The Super City Concept and Its Challenges in Maebashi City -- 5.4.1 The Super City Concept of Japan -- 5.4.2 Background of the Super City Concept of Maebashi City -- 5.4.3 Overall Picture and Challenges of the Super City Concept in Maebashi City -- 5.5 Maebashi City's Approach to EBPM Using Municipal MGD: An Example of Estimating the Spatial Distribution of Vacant Houses -- 5.6 Toward the Realization of a Super City Using Maebashi ID -- 5.7 Prospects for EBPM Promotion in Japan -- References -- 6 Personal Life Records for Health Decision-Making in Disaster Situations Society 5.0 and Implications for Resilient Community -- 6.1 Introduction -- 6.2 Issues of Information Sharing During Disasters -- 6.2.1 Personal Information as the Basis for Information Sharing and Cooperation -- 6.2.2 List of People Requiring Support for Evacuation and Disaster Survivor Register -- 6.2.3 Evacuation List -- 6.2.4 How to Associate the Three Lists -- 6.2.5 Case Study: Machi Care Commons -- 6.2.6 Consensual Bias -- 6.3 Proposals for Data Altruism in Europe -- 6.3.1 Data Governance Bill -- 6.3.2 Data Altruism in Health Care -- 6.3.3 How to View Data Altruism. , 6.4 Examination of Specific Cases -- 6.4.1 Personal Information Protection Act 2000 Issues: Information Sharing Issues -- 6.4.2 Safety Issues: Information Disclosure Issues -- 6.5 Consider Data Altruism: A Break from Consensus Parochialism -- 6.5.1 Validity of Data Altruism -- 6.5.2 Move Away from a Consensus Bias -- 6.5.3 How to Develop the Information Infrastructure, Interoperability -- 6.6 Conclusion -- References -- 7 Digital Transformation and Disaster Risk Reduction -- 7.1 Introduction: What is Digital Transformation and How? -- 7.2 Why Digital Transformation for DRR? -- 7.3 Technologies Supporting Digital Transformation -- 7.3.1 Utilization of Geographic Information Systems -- 7.3.2 Data Management and Sharing -- 7.4 Do It Yourself! Participatory Digital Transformation -- 7.4.1 Service Design for PGIS -- 7.4.2 Data Accuracy -- 7.4.3 Prototyping Process: Rapid Prototyping for Disasters -- 7.5 Challenges in Digital Transformation for DRR -- References -- 8 XR and Implications to DRR: Challenges and Prospects -- 8.1 Introduction -- 8.2 Disaster Literacy and Current Education on Disaster Preparedness -- 8.3 Disaster Literacy on Society 5.0 -- 8.4 XR and the Potential for Disaster Management Application -- 8.5 Feasibility Study on School Education -- 8.5.1 AR Flooding Experience App Disaster Scope® Floods -- 8.5.2 AR Smoke Experience App Disaster Scope® Fire& -- Smoke -- 8.5.3 The Utilization of the System -- 8.5.4 Evaluation -- 8.5.5 Considerations and Future Issues -- 8.6 Implementation and Promotion on Community by Local Government -- 8.6.1 Yokohama City: Yokohama Evacuation Navigation System -- 8.6.2 Kobe City Urban Innovation Challenge -- 8.6.3 Kochi: Gaining the Literacy for Emergency and Resilience -- 8.6.4 Metaverse Disaster Training -- 8.7 Way to Forward -- References -- 9 Open Governance and Disaster Risk Reduction -- 9.1 Introduction. , 9.2 Understanding Open Science and Different Components -- 9.3 Growing Relevance of Open Data for DRR and Governance -- 9.4 Open Governance for DRR: Case Study Examples -- 9.4.1 Open Data in Drought Management-Case of Cape Town, South Africa -- 9.4.2 Open Data in Urban Flood Mitigation-Case of Cameron -- 9.4.3 Case of Typhoon Haiyan 2013 in the Philippines -- 9.4.4 Case of Hurricane Sandy 2012 in the United States -- 9.5 Key Challenges in Operationalizing Open Governance -- 9.5.1 Digital Divide in the Disaster Management -- 9.5.2 Technical Difficulties -- 9.5.3 Insufficient Data Application Capacity -- 9.5.4 Limitations of Social Media -- 9.6 Key Lessons and Opportunities -- 9.6.1 Bridging the Digital Divide -- 9.6.2 Government Support for Technical Issues -- 9.6.3 Multi-Partnership Collaboration Toward Emergency Response -- 9.6.4 Capitalizing on the Social-Media Big Data -- 9.7 Conclusions -- References -- 10 Open Governance and Disaster Planning, Recovery, and Response: Lessons from the United States -- 10.1 Introduction -- 10.2 Theory of Open Governance in Disaster Management -- 10.3 Leveraging Digital Technologies to Communicate and Interact with the Public -- 10.4 Leveraging Crowdsourced Data for Improved Decision Making -- 10.5 Three Examples of Open Government Technologies for Managing Disasters in the United States -- 10.5.1 Background on the United States' Emergency Management System -- 10.5.2 Leveraging Digital Technologies to Communicate and Interact with the Public: The Use of NextDoor in Hurricane Recovery -- 10.5.3 Leveraging Crowdsourced Data for Improved Decision Making: Damage Assessment After Hurricane Sandy -- 10.5.4 Leveraging Open Data, Big Data, and Data Analytics for Intra- and Inter-Governmental Collaboration in Disaster Management: The Hazus Risk Estimation Program -- 10.6 Conclusions -- References. , 11 Technology Landscape in Post COVID-19 Era: Example from China -- 11.1 Introduction -- 11.2 Background of China's COVID-19 Response -- 11.2.1 Fighting the Virus in Wuhan City -- 11.2.2 Information Concealment and Initial Response by Local Governments -- 11.2.3 Causes of Infection Explosion in Wuhan City -- 11.3 Initial Response of the Central Government to COVID-19 Response System -- 11.3.1 Central Government's Initial Response -- 11.3.2 COVID-19 Measures of the Central New Pneumonia Control Guidance Subgroup -- 11.3.3 Formation of a National System for COVID-19 Response -- 11.4 Institutionalizing the "Community" Function -- 11.4.1 Institutionalization of Community Management -- 11.4.2 Institutionalization of Community Housing Blockade and Personnel Structure -- 11.5 Institutionalizing Use of Information Technology in COVID-19 response -- 11.5.1 Infection Cluster Discovery Using Big Data -- 11.5.2 Health Code -- 11.6 Dalian's COVID-19 Response -- 11.6.1 Features of Dalian COVID-19 Response -- 11.6.2 COVID-19 Measures and Use of Information Technology in Dalian Community -- 11.6.3 Overcoming Database Problems -- 11.6.4 Surveillance and Drones -- 11.7 Conclusion -- References -- 12 Jugaad Innovation: Concept and Lessons of Social Innovation in India -- 12.1 Introduction -- 12.2 Jugaad: A Review of the Concept -- 12.2.1 Manifestations and Measures of Frugal Innovations -- 12.3 Theory and Framework -- 12.4 Research Methodology -- 12.5 Case Studies -- 12.5.1 Mobile Money as a Jugaad Innovation for the Bottom of the Pyramid -- 12.5.2 Addressing Sustainable Development Goals: Eat Raja -- 12.5.3 Addressing Sustainability and Inclusion: Mitticool -- 12.5.4 Addressing Inclusion: Padman -- 12.5.5 Addressing Women Empowerment: Laxmi Asu Making Machine -- 12.6 Discussion-Future Trajectories from the Lens of Bricolage Theory -- References. , 13 Towards a People-Centered, Technology-Driven Society.
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  • 2
    Online-Ressource
    Online-Ressource
    Singapore : Springer Nature Singapore | Singapore : Imprint: Springer
    Schlagwort(e): Natural disasters. ; Technology—Sociological aspects. ; Political science.
    Beschreibung / Inhaltsverzeichnis: Science technology and People centered society -- Science, Technology, Innovation and Sendai Framework for Disaster Risk Reduction -- Systemic risk and system-based approach for Society 5.0 -- Emerging issues and Japan’s milestones in science and technology in disaster risk reduction -- Evidence Based Policy Making of Smart City: The Case of Challenge in Maebashi City, Japan -- Personal life records for health decision making in disaster situation -- Digital transformation and disaster risk reduction -- xR and implications to DRR: challenges and prospects -- Open governance and disaster risk reduction -- Open Governance and Disaster Planning, Recovery, and Response: Lessons from the USA -- Technology landscape in post COVID-19 era: Example from China -- Jugaad innovation: concept and lessons of social innovation in India -- Towards a People centric technology driven society. .
    Materialart: Online-Ressource
    Seiten: 1 Online-Ressource(XIV, 217 p. 40 illus., 34 illus. in color.)
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811956461
    Serie: Disaster Risk Reduction, Methods, Approaches and Practices
    Sprache: Englisch
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  • 3
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Nitrogen oxides, such as nitric oxide, have been shown to regulate neuronal functions, including neurotransmitter release. We investigated the effect of S-nitroso-l-cysteine (SNC) on noradrenaline (NA) release in the rat hippocampus in vivo and in vitro. SNC stimulated [3H]NA release from prelabeled hippocampal slices in a dose-dependent manner. SNC stimulated endogenous NA release within 30 min to almost five times the basal level in vivo (microdialysis in freely moving rats). In a Na+-containing Tyrode's buffer, SNC-stimulated [3H]NA release was inhibited 30% by the coaddition of l-leucine. In the Na+-free, choline-containing buffer, SNC-stimulated [3H]NA release, which was similar to that in the Na+-containing buffer, was inhibited markedly by l-leucine, l-alanine, l-methionine, l-phenylalanine, and l-tyrosine. The effects of the other amino acids examined were smaller or very limited. The effect of l-leucine was stronger than that of d-leucine. A specific inhibitor of the L-type amino acid transporter, 2-aminobicyclo[2.2.1]-heptane-2-carboxylate (BCH), inhibited the effects of SNC on [3H]NA release in the Na+-free buffer. Uptake of l-[3H]leucine into the slices in the Na+-free buffer was inhibited by SNC, BCH, and l-phenylalanine, but not by l-lysine. The effect of SNC on cyclic GMP accumulation was not inhibited by l-leucine, although SNC stimulated cyclic GMP accumulation at concentrations up to 25 µM, much less than the concentration that stimulates NA release. These findings suggest that SNC is incorporated into rat hippocampus via the L-type-like amino acid transporter, at least in Na+-free conditions, and that SNC stimulates NA release in vivo and in vitro in a cyclic GMP-independent manner.
    Materialart: Digitale Medien
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  • 4
    ISSN: 1460-9568
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Recently, we have reported that glial cell line-derived neurotrophic factor (GDNF), which supports the survival of dopaminergic neurons, prevents delayed neuronal death in the hippocampal CA1 region induced by transient forebrain ischemia. In the present study, we examined the role of GDNF in the expression of tyrosine hydroxylase (TH) mRNA induced by transient forebrain ischemia in rats. The expression of TH mRNA was increased in a time-dependent manner, with a significant increase in 24 h to 7 days, in the hippocampus after induction of transient forebrain ischemia, as determined using the reverse transcription and polymerase chain reaction method. Although it has been suggested that the increase of dopamine β-hydroxylase mRNA expression correlates with the activation of noradrenergic neurons, no increase of dopamine β-hydroxylase mRNA in the hippocampus was observed in our system. Western blot analysis revealed that TH protein, but not dopamine β-hydroxylase protein, was produced in a time-dependent manner in the hippocampus during the ischemia. Interestingly, the induction level of TH mRNA was reduced by intrahippocampal microinjection of GDNF (1.0 μg), and this local GDNF treatment also reduced the increase of TH-like immunohistochemistry-positive terminals in the hippocampus. In contrast, local GDNF treatment of normal rats increased the TH mRNA expression at 6–12 h. These findings suggest that GDNF protects against neuronal degeneration including delayed neuronal death in the hippocampal CA1 region by modulating the expression levels of TH mRNA and protein.
    Materialart: Digitale Medien
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  • 5
    ISSN: 1432-2307
    Schlagwort(e): Key words Clara cells ; CC10 ; Fetus ; Bronchiole ; Apoproteins
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Morphometric analyses of the immunohistochemical expression of the Clara cell secretory 10-kDa protein (CC10) and surfactant apoproteins A and B (SP-A and -B) were carried out on the developing bronchi and bronchioles of human fetuses and neonates. We analysed the ratio of the number of CC10-positive cells per subepithelial length of the bronchial or bronchiolar basement membrane and found that both the bronchial and the bronchiolar population of CC10-positive cells was significantly higher than that of either SP-A or SP-B. In addition, CC10 was found to be distributed mainly in the bronchiole. CC10-positive cells began to be recognized in the late pseudoglandular phase (15 weeks of gestation) and thereafter gradually increased in the canalicular and terminal sac phases, which correspond to the active development period of the acini or peripheral airways. The earliest expression of SP-A was also noted at 15 weeks of gestation, but its positive epithelial cells were present mainly in the larger bronchi. Double immunohistochemical staining for CC10 and SP-A revealed that the CC10-positive cells lining both the bronchi and bronchioles were different from the SP-A-positive cells. This finding suggests that CC10-positive cells are functionally and developmentally heterogeneous in both fetal and neonatal lungs in humans
    Materialart: Digitale Medien
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  • 6
    ISSN: 1432-0851
    Schlagwort(e): Key words: Polysaccharide SPR-901 – Antitumor effect – Oral administration – T cell effector
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. The growth of MethA tumor was significantly inhibited by oral administration of the α-glucan SPR-901 in BALB/c (+/+) mice but not in nude mice. Mice treated orally with SPR-901 exhibited an augmentation of antigen-specific resistance against rechallenge with the tumor cells. The tumor-neutralizing activity of regional lymph node cells from MethA-bearing mice against the tumor was augmented by oral administration of SPR-901. The tumor-neutralizing activity of lymph node cells from SPR-901-treated mice mainly appeared in Lyt2+ cells. Furthermore, lymphokine-activated killer activity of these cells was enhanced by administration of SPR-901. The antitumor effect of SPR-901 was abrogated in mice depleted of either L3T4+ or Lyt2+ cells, and in cyclosporin-A-treated mice. These results suggest that Lyt2+ cells are important effector cells in MethA-bearing mice orally administered SPR-901 and that functional exertion of both Lyt2+ and L3T4+ T cells is necessary for the antitumor effect of orally administered SPR-901 in vivo.
    Materialart: Digitale Medien
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  • 7
    ISSN: 1432-0851
    Schlagwort(e): Polysaccharide SPR-901 ; Antitumor effect ; Oral administration ; T cell effector
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The growth of MethA tumor was significantly inhibited by oral administration of the α-glucan SPR-901 in BALB/c (+/+) mice but not in nude mice. Mice treated orally with SPR-901 exhibited an augmentation of antigen-specific resistance against rechallenge with the tumor cells. The tumor-neutralizing activity of regional lymph node cells from MethA-bearing mice against the tumor was augmented by oral administration of SPR-901. The tumor-neutralizing activity of lymph node cells from SPR-901-treated mice mainly appeared in Lyt2+cells. Furthermore, lymphokine-activated killer activity of these cells was enhanced by administration of SPR-901. The antitumor effect of SPR-901 was abrogated in mice depleted of either L3T4+ or Lyt2+ cells, and in cyclosporin-A-treated mice. These results suggest that Lyt2+ cells are important effector cells in MethA-bearing mice orally adminstered SPR-901 and that functional exertion of both Lyt2+ and L3T4+T cells is necessary for the antitumor effect of orally administered SPR-901 in vivo.
    Materialart: Digitale Medien
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  • 8
    Publikationsdatum: 2012-11-23
    Beschreibung: Near infrared spectroscopy (NIRS) has been successfully used for non-invasive diagnosis of diseases and abnormalities where water spectral patterns are found to play an important role. The present study investigates water absorbance patterns indicative of estrus in the female giant panda. NIR spectra of urine samples were acquired from the same animal on a daily basis over three consecutive putative estrus periods. Characteristic water absorbance patterns based on 12 specific water absorbance bands were discovered, which displayed high urine spectral variation, suggesting that hydrogen-bonded water structures increase with estrus. Regression analysis of urine spectra and spectra of estrone-3-glucuronide standard concentrations at these water bands showed high correlation with estrogen levels. Cluster analysis of urine spectra grouped together estrus samples from different years. These results open a new avenue for using water structure as a molecular mirror for fast estrus detection. Scientific Reports 2 doi: 10.1038/srep00856
    Digitale ISSN: 2045-2322
    Thema: Allgemeine Naturwissenschaft
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