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  • 1
    Electronic Resource
    Electronic Resource
    Isolierte menschliche Magenschleimhautzellen — Untersuchungen physiologischer und pharmakologischer Regulationsmechanismen (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 15-22 
    Details
    ISSN: 1432-1440
    Keywords: Isolated gastric mucosal cells (man) ; 14C-aminopyrine uptake ; Intrinsic factor ; Adenylate cyclase ; Histamine ; Prostaglandins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cells were isolated by use of collagenase, EDTA and pronase form human gastric mucosa obtained at peptic ulcer surgery (n=61) or at Whipple's operations (n=6). Enriched parietal cell fractions were prepared by isopycnic centrifugation with Percoll. H+ production, intracellular instrinsic factor and histamine content were maximal in the low density fraction containing 75% parietal cells and — among other nonparietal cell types — mast cells. H+ production, intrinsic factor secretion and adenylate cyclase-activity responded to histamine stimulation in a concentration dependent manner. Response was blocked by histamine H2 receptor antagonists (rantidine, famotidine). Dibutyryl cAMP and the phosphodiesterase inhibitor IMX were the most powerful stimuli whereas carbachol, hexoprenaline and pentagastrin were less effective. Prostaglandin E2 and 6-keto-PGF2α occurred in the highest concentrations in the low density cell fraction. PG production increased linearly for 15 min and seemed to be influenced by the intracellular calcium level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721576
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of glucagon on adenylate cyclase activity and acid production of isolated human parietal cells (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 746-749 
    Details
    ISSN: 1432-1440
    Keywords: Glucagon ; Adenylate cyclase ; 14C-aminopyrine ; Human parietal cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The direct effect of glucagon on human parietal cell function in vitro was tested by measuring adenylate cyclase (AC) activity and H+ production in homogenates of human gastric mucosa obtained during surgery or at biopsy. Cells isolated from mucosa obtained during surgery showed an increase in AC with histamine and glucagon. In parietal cell enriched fractions (75%) glucagon and histamine stimulated AC much more effectively than in parietal cell depleted fractions (15% and 7%). In contrast, glucagon did not affect basal or histamine stimulated14C amino pyrine uptake. In homogenates of mucosal biopsy specimens 2×10−7 mol/l glucagon enhanced AC activity by 76% (corpus) and 20% (antrum). In the same homogenates 10−4 mol/l histamine caused a stimulation by 161% (corpus) and 38% (antrum). In fundic biopsy specimens glucagon displayed a biphasic concentration response curve with an increase at 10−10 mol/l (46% above basal AC activity) and a maximum at 2×10−7 mol/l (97%). Histamine elicited the maximal response (192%) at 10−3 mol/l. Increasing histamine and glucagon concentrations caused additive stimulation of AC. Ranitidine did not change AC in response to glucagon but abolished the effect of histamine. Data suggest that the glucagon action is mediated by separate (glucagon?) receptors. As H+ production was not affected by glucagon, the coexistence of two AC systems in the human parietal cell is postulated: One that is activated via histamine H2-receptors and which stimulates H+ production; another that is activated by glucagon and is directed towards other, possibly metabolic effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01734342
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  • 3
    Electronic Resource
    Electronic Resource
    Intrinsic factor secretion from isolated gastric mucosal cells of rat and man — two different patterns of secretagogue control (1984)
    Springer
    Inflammation research 14 (1984), S. 522-528 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intrinsic Factor (IF) secretion was studied using isolated gastric mucosal cells from rat and man. In the rat, IF was localized to the chief cells and its secretion responded most efficaciously to carbachol. DbcAMP and hexoprenaline were less powerful, whereas histamine and pentagastrin lacked any effect. In man, IF secretion derived from the parietal cells and was increasingly enhanced by hexoprenaline, pentagastrin, carbachol, histamine and dbcAMP. In both species, IF secretion differs with respect to its cellular origin and the pattern of secretagogue control: IF release from rat chief cells is due to muscarinic receptor excitation, whereas IF release from human parietal cells responds predominantly to histamine-H2-receptor activation and seems to be mediated by the cAMP system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973863
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  • 4
    Electronic Resource
    Electronic Resource
    Über den Einfluß von exogenem Glueagon auf die Magensekretion bei akuter Hypercaleämie (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 1005-1006 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 12 randomized clinic patients the influence of exogenous glucagon on gastric acid secretion in induced acute hypercalcemia was examined. Statistical analysis of the quantitative secretion studies showed a significant inhibition of parietal cell secretion in acute hypercalcemia by exogenous glucagon. Since the effect of acute hypercalcemia is at least partially mediated by liberation of gastrin in the antral mucosa it is suggested that glucagon inhibits liberation of gastrin and/or the effect of gastrin at the parietal cell.
    Notes: Zusammenfassung Bei 12 unausgewählten Klinikpatienten wurde der Einfluß von exogenem Glucagon auf die gastrale HCl-Sekretion bei induzierter akuter Hypercalcämie geprüft. Die statistische Analyse der Ergebnisse der quantitativen Magensekretionsanalysen ergab eine signifikante Hemmung der Belegzell-Sekretion bei akuter Hypercalcämie durch exogenes Glucagon. Da der Effekt akuter Hypercalcämie zumindest teilweise durch Freisetzung von Gastrin in der Antrumschleimhaut vermittelt wird, darf angenommen werden, daß Glucagon die Freisetzung von Gastrin und/oder die Wirkung von Gastrin an der Belegzelle inhibiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484406
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  • 5
    Electronic Resource
    Electronic Resource
    Der Einfluß von Secretin auf die durch Methylxanthine (Theophyllin) stimulierte Säure-, Elektrolyt- und Pepsinogensekretion des menschlichen Magens (1971)
    Springer
    Journal of molecular medicine 49 (1971), S. 1231-1234 
    Details
    ISSN: 1432-1440
    Keywords: Gastric secretion ; intestinal hormones ; secretin ; Magensekretion ; intestinale Hormone ; Secretin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Secretin hemmt die basale und die durch Pentagastrin stimulierte Säuresekretion des menschlichen Magens, die Pepsinogensekretion wird stimuliert. An 15 Probanden wurde der Einfluß von Secretin auf die durch Methylxanthine (Theophyllin) intracellulär stimulierte Säuresekretion und auf die Elektrolyt- und Pepsinogensekretion untersucht. Secretin verminderte signifikant die H+-Ionen Sekretion und die Konzentrationen der H+-, Cl−- und K+-Ionen. Das Volumen, die Natrium- und Pepsinmenge und Konzentration nahmen signifikant weiter zu. Die Cl−- und K+-Sekretion änderte sich nicht signifikant. Ein Eingreifen des Secretins in die Stimulationsreihe first messenger-target tissue- second messenger wird diskutiert.
    Notes: Summary Secretin inhibits basal acid secretion of the stomach as well as the acid secretion stimulated by pentagastrin, on the one hand, and stimulates the secretion of pepsinogen on the other. The influence of secretin on intracellular acid secretion induced by methylxanthine (theophylline) and on electrolyte and pepsinogen secretion was examined in 15 subjects. Secretin significantly decreases the secretion of H+ ions and the concentration of H+, Cl− and K+ ions. Volume, quantities and concentration of sodium and pepsin continued to increase in significant manner. The influence of secretion on the stimulation path first messenger-target tissue-second messenger is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732733
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  • 6
    Electronic Resource
    Electronic Resource
    Zur Frage der Gastrinfreisetzung durch Methylxanthine (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 42-44 
    Details
    ISSN: 1432-1440
    Keywords: Gastric secretion ; gastrin ; methylxanthines ; Magensekretion ; Gastrin ; Methylxanthine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 10 Probanden wurde untersucht, ob Methylxanthine (Theophyllin, Coffein) eine Stimulation der Säuresekretion durch Erhöhung des Serum-Gastrinspiegels hervorrufen. Der Serum-Gastrinspiegel wurde radioimmunologisch vor und nach der intravenösen Infusion von 193,2 mg Theophyllin (Euphyllin) bestimmt. Ein signifikanter Anstieg des Serum-Gastrinspiegels konnte nicht festgestellt werden, obwohl die Säuresekretion bei einer Vergleichsgruppe (n=16) bereits unter der Infusion von 64,5 mg Theophyllin signifikant anstieg.
    Notes: Summary In 10 test subjects it was investigated, whether the mechanism of acid stimulation by methylxanthines (theophylline, caffeine) operates through an elevation of the serum gastrin level. Serum gastrin concentrations were estimated radioimmunologically before and after the i.v. infusion of 193.2 mg theophylline (Euphylline). A significant increase of the serum gastrin level was not observed, although there was a significant rise of the acid output in a control group (n=16) with the i.v. infusion of 64.5 mg theophylline only.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484144
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  • 7
    Electronic Resource
    Electronic Resource
    Der Einfluß von Aldosteron auf die durch Gastrin stimulierte Magensekretion (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 189-191 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The influence of intravenous aldosterone infusions on gastric secretion, submaximally stimulated with pentagatrin infusions, was investigated in 14 male subjects. An acute increase in the blood aldosterone level did not alter the secretion of acid. Only the potassium ion concentration and the quantity of potassium ions secreted per unit time showed a significant decrease. However, this drop is regularly observed in analyses of gastric secretion and therefore cannot be regarded as an aldosterone effect. To what degree chronic aldosterone doses affect gastric secretion in humans requires further investigation.
    Notes: Zusammenfassung Der Einfluß von intravenösen Aldosteron-Infusionen auf die durch Pentagastrin-Infusionen submaximal stimulierte Magensekretion wurde an 14 männlichen Probanden untersucht. Eine akute Erhöhung des Aldosteronspiegels im Blut veränderte die Säuresekretion nicht. Lediglich die Kalium-Ionen-Konzentration und die Menge der in der Zeiteinheit sezernierten Kalium-Ionen nahm signifikant ab. Dieser Abfall ist jedoch regelmäßig bei Magensekretions-analysen zu beobachten und nicht als Aldosteroneffekt zu bewerten. Inwiefern chronische Aldosterongaben die Magensekretion des Menschen beeinflussen, bedarf weiterer Untersuchungen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01584573
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  • 8
    Electronic Resource
    Electronic Resource
    Akute Hypersiderinämie und Magensekretion (1969)
    Springer
    Journal of molecular medicine 47 (1969), S. 1288-1289 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The basal gastric secretion following the infusion of iron (Ferronascin®) was examined in 12 subjects with a low serum iron level. The results show that the secretion of acid is not stimulated by a sudden rise in the serum iron level. Thus it seems improbable that there is a direct relationship between the serum iron level and gastric secretion. The increase or normalization of gastric secretion following the infusion of iron in cases of chronic iron deficiency, which is described in the literature, is probably due to a direct influence on the gastric mucosa.
    Notes: Zusammenfassung Bei 12 Probanden mit erniedrigtem Eisenspiegel wurde das Verhalten der basalen Magensekretion nach Infusion von Eisen (Ferronascin®) untersucht. Die Ergebnisse zeigen, daß die Säuresekretion durch akute Erhöhung des Eisenspiegels im Serum nicht stimuliert wird. Damit ist ein direkter Zusammenhang zwischen Serum-Eisenspiegel und Magensekretion unwahrscheinlich. Die in der Literatur beschriebene Erhöhung bzw. Normalisierung der Magensekretion nach Eisengaben bei chronischem Eisenmangel ist möglicherweise durch direkte Beeinflussung der Magenschleimhaut zu erklären.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01487562
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  • 9
    Electronic Resource
    Electronic Resource
    Der Einfluß akuter Hypercalcämie auf die durch Hypermagnesiämie gehemmte Magensekretion (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 384-385 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Hypermagnesemia decreases human gastric secretion stimulated by calcium. Twelve subjects were investigated in order to determine whether this process is reversible, i. e. to what degree an acute hypercalcemia normalizes or stimulates gastric secretion inhibited by hypermagnesemia. The inhibitory effect of hypermagnesemia on gastric secretion was nullified by calcium. Therefore this is a process of reversible competitive antagonism.
    Notes: Zusammenfassung Hypermagnesiämie vermindert die durch Calcium stimulierte Magensekretion des Menschen. An zwölf Probanden wurde untersucht, ob dieser Vorgang umkehrbar ist, d. h. inwiefern eine akute Hypercalcämie die durch Hypermagnesiämie gehemmte Magensekretion normalisiert bzw. stimuliert. Die hemmende Wirkung der Hypermagnesiämie auf die Magensekretion wurde durch Calcium aufgehoben. Demnach liegt ein reversibler kompetitiver Antagonismus vor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484875
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  • 10
    Electronic Resource
    Electronic Resource
    Der Einfluß akuter Hypermagnesiämie auf die durch Methylxanthine (Theophyllin) stimulierte Säure-, Elektrolyt- und Pepsinogensekretion des menschlichen Magens (1971)
    Springer
    Journal of molecular medicine 49 (1971), S. 24-27 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Akute Hypermagnesiämie hemmt die basale als auch die durch Calcium, Pentagastrin und Gastrin stimulierte Säuresekretion des menschlichen Magens. An 12 Probanden wurde bei 14 quantitativen Magensekretionsanalysen der Einfluß akuter Hypermagnesiämie auf die durch Methylxanthine (Theophyllin) intracellulär stimulierte Säuresekretion und auf die Elektrolyt- und Pepsinogensekretion untersucht. Magnesium hemmt die Sekretion von H+, Cl−, K+- und Na+-Ionen und von Pepsinogen. Die Konzentration der Cl−-und Na+-Ionen und des Pepsins blieben statistisch unverändert. Die Konzentration der H+-Ionen nahm dagegen in der fünften 15 min-Portion signifikant zu und die der K+-Ionen in der achten 15 min-Portion signifikant ab. Die möglichen Angriffspunkte des Magnesiums in der Stimulationsreihe: first messenger — target tissue — second messenger werden diskutiert.
    Notes: Summary Acute hypermagnesemia inhibits human gastric acid secretion stimulated by calcium, pentagastrin and gastrin. 14 quantitative gastric secretion analyses were performed in 12 subjects to study the influence of acute hypermagnesemia on gastric acid secretion intracellularly stimulated by methylxanthines (theophylline). The influence on the stimulated electrolyte and pepsinogen secretion was also studied. Hypermagnesemia inhibits H+, Cl−, K+, Na+ and pepsinogen secretion. Cl−, Na+ and pepsin concentrations remained unaltered. There was a significant increase in H+ in the fifth 15 min portion, and a significant decrease in K+ concentrations in the eight 15 min portion, respectively. The possible hypotheses for the mechanism of action of hypermagnesemia in the stimulation series are discussed: first messenger—target tissue second messenger.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01494062
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