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  • 1
    Electronic Resource
    Electronic Resource
    Bovine herpesvirus 1 and caprine herpesvirus 1: Viral polypeptides exhibiting shared and unique antigenic determinants (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 93-93 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01975933
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  • 2
    Electronic Resource
    Electronic Resource
    In vitro protein synthesis by cells infected with different types of bovine herpesvirus 1 (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 93-93 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01975932
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Experimental canine distemper encephalomyelitis in neonatal gnotobiotic dogs (1982)
    Springer
    Acta neuropathologica 57 (1982), S. 287-295 
    Details
    ISSN: 1432-0533
    Keywords: Canine ; Canine distemper virus ; Encephalomyelitis ; Choroid plexus ; Neuronal degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructural morphogenesis of neuronal degeneration and necrosis and patterns of associated myelin and axonal degeneration were studied in gnotobiotic dogs neonatally infected with neurovirulent R 252 strain of canine distemper virus (CDV-R 252). Distemper virus-infected neurons underwent a distinct sequence of ultrastructural changes culminating in direct viral-induced necrosis beginning after 21 days post inoculation (DPI). Viral-induced neuronal cytolysis occurs apparently independently of anti-viral immune mechanisms of immunologic destruction. Viral nucleocapsid aggregates in postsynaptic axosomatic and axodendritic complexes and in structurally intact axons provided morphologic evidence for viral-induced functional modulation of synaptic transmission and possible trans-synaptic interneuronal viral spread. There were secondary degenerative axonal and myelin changes, particularly in heavily myelinated tracts. There was no evidence of primary demyelination. Active phagocytosis of degenerating axons and myelin debris in foci of virus-associated necrosis was apparently restricted to CDV-containing macrophages. Demonstration of a productive CDV infection of choroid plexus epithelium 10 DPI and thereafter was identified as an intracranial source of free infectious virus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692185
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  • 4
    Electronic Resource
    Electronic Resource
    Primary demyelination in experimental canine distemper virus induced encephalomyelitis in gnotobiotic dogs (1982)
    Springer
    Acta neuropathologica 58 (1982), S. 1-8 
    Details
    ISSN: 1432-0533
    Keywords: Canine ; Canine distemper virus ; Demyelination ; Encephalomyelitis ; Antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experimental infection of gnotobiotic Beagle dogs at 21 days of age with neurovirulent R252 strain of canine distemper virus (R252-CDV) resulted in a non-suppurative encephalomyelitis. Segmental internodal primary demyelination was found in almost 90% of the dogs from 27 days post inoculation (DPI). Ultrastructurally demyelination was initiated by the insertion of CDV-infected astrocytic processes at nodes of Ranvier with subsequent cleavage of well-preserved myelin from the axolemma. CDV-infected macrophages were consistently involved in myelin phagocytosis. Some remyelination of denuded axons occurred after 35 DPI. Persistent productive infection of the choroid plexus and ependyma in the fourth ventricle was consistently associated with subependymal foci of demyelination. Primary demyelination occurred without detectable CDV-specific virus-neutralizing (CDV-VN) antibody in either serum or cerebrospinal fluid (CSF). There were no immunoglobulin deposits or inflammatory cells within the lesions. These findings indicate that both direct CDV antibody-dependent and CDV antibody-dependent cell-mediated immune mechanisms of cytolysis or myelin destruction are not involved in the genesis of initial primary demyelination. The sequential morphologic and serologic findings in this model of demyelinating encephalomyelitis indicate that direct virus-induced injury has a major role in both the initiation and early progression of primary demyelination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692691
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  • 5
    Electronic Resource
    Electronic Resource
    In vitro growth characteristics of bovine herpesvirus 4 (BHV-4) as revealed by indirect immunofluorescence assay with monoclonal antibodies and polyvalent antisera (1989)
    Springer
    Archives of virology 104 (1989), S. 309-321 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The bovine herpesvirus 4 (BHV-4) isolate LVR-140 growing in MDBK cell cultures was investigated by indirect immunofluorescence (IF), using bovine antisera and 15 monoclonal antibodies (MAb). The cytopathogenic effect was discernible between 20 and 30 hours post inoculation (p.i.) and developed slowly as has been reported for other BHV-4 strains. According to the protein specificity as revealed by radioimmunoprecipitation and the intracellular localisation of reacting antigens as detected by IF, the MAb could be assigned to one of three groups. The initial antigen expression was first detected at 8 hours p.i. and was limited to a proportion of the infected cells only, despite the high multiplicity of infection used; infectious cell-associated progency virus was first recognized at 12 hours p.i.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01315552
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  • 6
    Electronic Resource
    Electronic Resource
    Bovine herpesvirus 1: Molecular and antigenic characteristics of variant viruses isolated from calves with neurological disease (1986)
    Springer
    Archives of virology 87 (1986), S. 205-217 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report presents data showing that several virus isolates recovered in Argentina, mainly from calves with non-purulent meningo-encephalitis, represent a hitherto unrecognized antigenic variant of BHV-1. The following experimental approaches have been adopted to demonstrate both the unique features among and the relatedness with BHV-1 of these isolates: i) crossed serum neutralization test with rabbit immune sera, ii) analysis by SDS-polyacrylamide gel electrophoresis of radio-labeled virus induced polypeptides and glycoproteins, iii) discriminating reactivity of a panel of monoclonal antibodies which recognize known virus types, and iv) restriction endonuclease analysis of viral DNA. Another strain of BHV-1, which exhibits a specific neuropathogenic potential [Hall et al., Austral. Vet. J.42, 229–237 (1966)] shares all major features with the viral strains originating from Argentina. Our results imply that antigenic variants of BHV-1 exist and that they can be accurately and easily identified and differentiated by the available methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01315300
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  • 7
    Electronic Resource
    Electronic Resource
    Reactivity of monoclonal antibodies to proteins of a neurotropic bovine herpesvirus 1 (BHV-1) strain and to proteins of representative BHV-1 strains (1987)
    Springer
    Archives of virology 94 (1987), S. 109-122 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 15 monoclonal antibodies (McAbs) were induced with the neuropathogenic strain N 569 of bovine herpesvirus 1 type 3 (BHV-1.3). Nine of them could be shown by radioimmunoprecipitation assay to react with viral glycoproteins and two of these McAbs were able to neutralize strain N 569. The reactivity of these 15 monoclonals was compared with 11 monoclonal antibodies induced with a BHV-1.1 strain. The available monoclonal antibodies made it possible to characterize BHV-1.3 and to classify BHV-1 into three types, namely BHV-1.1, BHV-1.2 and BHV-1.3. This confirmed the results based upon restriction endonuclease analysis and viral protein patterns obtained earlier. The main antigenic differences of representative virus strains were found on two glycoproteins designated 3 and 12. Caprine herpesvirus 1, included in this study because of its serological relationship to BHV-1, differed fundamentally from BHV-1 on the grounds of McAb reactivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01313729
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  • 8
    Electronic Resource
    Electronic Resource
    European isolates of bovine herpesvirus 1: A comparison of restriction endonuclease sites, polypeptides, and reactivity with monoclonal antibodies (1985)
    Springer
    Archives of virology 85 (1985), S. 57-69 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eleven European isolates of bovine herpesvirus 1 (BHV-1), together with two reference virus strains were compared by restriction endonuclease digestion, by SDS-polyacrylamide gel electrophoresis (SDS-PAGE), and by their reactivity with a panel of monoclonal antibodies (McAb's). Based on the cleavage pattern of viral DNA with the restriction endonuclease Hind III the strains could be assigned to one of two established major virus types. Analysis by SDS-PAGE of viral polypeptides revealed that four protein species either displayed virus type or subtype specific minor variation of migration characteristics. Of 43 McAb's tested all reacted with all type 1 strains, whereas five antibodies failed to recognize some of the type 2 viruses. The existence of type specific variations among virus specified proteins was further evidenced by the recovery of one McAb recognizing type 1 viruses only. The data show that BHV-1 isolates can be assigned to established virus types according to the SDS-PAGE profile of viral proteins or the selective reactivity with type specific McAb's.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01317006
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  • 9
    Electronic Resource
    Electronic Resource
    Persistentin vitro interaction of virulent and attenuated canine distemper virus with bovine cells (1980)
    Springer
    Archives of virology 66 (1980), S. 329-339 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bovine macrophage and non-macrophage cultures were infected with either virulent or attenuated canine distemper virus (CDV). Macrophages were resistant to virulent CDV; however, they supported growth of the attenuated virus. Nonmacrophage cultures supported growth of both virus variants in a persistent, non-lytic manner. Major differences between these two systems ofin vitro viral persistence were seen in the host cell spectrum of progeny virus and the outcome of cocultivation experiments with Vero cells. Results obtained indicate thatin vivo virulence of CDV is not linked to maturation in a macrophage, but rather, propagation in a given cell culture system results in selective growth of virulent or attenuated viral mutants. It is further concluded thatin vivo virulence andin vitro growth potential of CDV are disparate properties of the virion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01320629
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