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  • 1
    Online-Ressource
    Online-Ressource
    San Diego :Elsevier Science & Technology,
    Schlagwort(e): Water-Microbiology. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (448 pages)
    Ausgabe: 1st ed.
    ISBN: 9780323904933
    DDC: 576.192
    Sprache: Englisch
    Anmerkung: Intro -- Safe Water in Healthcare: A Practical and Clinical Guide -- Copyright -- Dedication -- Contents -- Preface -- Acknowledgment -- 1 Importance of leadership and governance -- Overview -- Leadership -- Governance -- In summary -- References -- 2 Design, construction, and commissioning of healthcare water systems -- Introduction to designing safe water systems -- Project water safety plan -- Project governance and accountability -- Project WSG skills and competencies -- Consultation -- Supply water -- Patient risk factors -- Drains -- Supported learning -- Commissioning -- Commissioning plans -- System filling -- Case study: Failures in filling the water system -- Case study: Failures due to partial occupation of a hospital build program -- Handover -- Partial handover -- Examples of checks for commissioning and handover within the project WSP -- References -- 3 Overview and introduction to safe water in healthcare -- Background -- How do bacteria get into buildings' water systems? -- Water supply to healthcare buildings -- Mains water supply -- Case study: Microbial contamination of water supply -- Private water supplies -- Monitoring water supplies -- Maintaining water supply in an emergency -- Bottled water -- Water distribution within healthcare buildings -- Introduction to biofilms -- Case study: Microbial contamination of flexible hoses -- What areas of the water system present microbial risks? -- Learning points -- References -- 4 Cold water systems -- Introduction -- The cold water supply -- Microbial hazards in the supply water -- Water quality within the building -- Why do you need cold water storage? -- Design and construction of cold water storage vessels -- How much cold water should be stored? -- Temperature management of the cold water -- Microbiological risks associated with cold water tanks. , Case study: Cleanliness of storage tanks -- Monitoring of the cold water system -- Case study: Excessive cold water temperatures in new build -- Case study: Filling sections prior to completion -- Maintaining cold water supply in an emergency -- Recommendations for cold water systems -- Learning points -- Risk assessing the cold water system -- Guidance, regulations, and further reading relevant for cold water systems -- References -- 5 Hot water heating systems -- Hot water system -- Temperature requirements for hot water calorifier, flow, and returns? -- Balancing the system -- Case study 1 -- System design and temperature monitoring -- How is hot water produced? -- What is stratification? -- Electrical immersion-type calorifiers -- Combination water heaters -- Microbiological problems with calorifiers and hot water systems? -- Case study 2: What to do when a bolus of potentially contaminated material is injected into your hot water system? -- Transmission routes for calorifiers and hot water systems? -- Monitoring hot water systems -- Recommendation for hot water heaters -- Regulations and guidance for hot water heaters -- Risk assessing the hot water system -- References -- 6 Systemic contamination -- Identifying systemic contamination? -- How does systemic contamination occur? -- What are the impacts of systemic contamination? -- Case study involving Legionella -- Case study involving Cupriavidus pauculus -- Case study involving Pseudomonas aeruginosa -- Monitoring systemic contamination -- Recommendation for systemic contamination -- Issues to consider when risk assessing systemic contamination? -- Guidance for systemic contamination -- References -- 7 Peripheral components -- Introduction -- Why are peripheral components colonized? -- Case study: Outbreak associated with peripheral components that were contaminated with P. aeruginosa. , Strainers to trap harmful debris -- Thermostatic mixer valves -- What is a thermostatic mixer valve and how does it work? -- What are the different types of thermostatic mixer valves? -- Why are TMVs used? -- What are the risks of scalding? -- Where should you not install TMVs? -- How should TMVs be maintained? -- What are the regulations concerning TMVs? -- Microbial problems associated with TMVs -- Solenoids -- What is a solenoid and how does it work? -- Why and where are solenoids used? -- How should solenoids be maintained? -- What are the regulations in the use of solenoids? -- What microbial problems are associated with solenoids? -- Flexible hoses -- What is a flexible hose? -- What are flexible hoses used for? -- What are the microbiological problems with flexible hoses? -- Outbreaks associated with flexible hoses -- What are the alternatives to EPDM? -- What are the regulations concerning flexible hoses? -- What other types of peripheral components are used? -- External influences on the safe use of water in a wash hand station -- Manual separate hot and cold taps -- Manual operated single-lever taps -- Pedestal taps -- Swan neck taps -- Thermostatic mixer tap -- Elbow levers -- Knee or foot-operated water outlets -- Sensor-operated tap -- Different type of outlets fittings -- Aerators -- Flow straighteners -- Recommendations for peripheral components -- Risk assessment considerations for peripheral components -- Regulations for outlet fittings -- References -- 8 Wash hand stations -- How do wash hand stations become contaminated? -- What are the transmission routes and microbial risks? -- Activity space -- Splashing and dispersal from wash hand basins -- What does a safer wash hand station look like? -- Patient wash hand station -- Recommendation for wash hand stations -- Assessing the risks associated with wash hand basins. , Regulations for wash hand stations -- References -- 9 Sinks in ward kitchens or domestic areas -- What is a sink and what is it used for? -- What are the microbial contamination sources of stainless steel sinks? -- What are the transmission routes? -- Outbreaks associated with stainless steel utility sinks -- A hospital-wide CPE outbreak -- Outbreak 1 -- Outbreak 2 -- Guidance on sinks -- Recommendation on sinks -- Risk assessments for sinks -- Questions on sinks -- References -- 10 Showers -- Showers and accessories -- What are the microbiological risks with showers, hoses, and showerheads? -- Shower controller unit -- Shower hoses -- Shower heads -- Ancillary equipment in showers -- Deluge showers -- Shower trolleys -- Patient risk and risk to patients -- Microbial outbreaks associated with showers rooms -- Microbiological monitoring -- Requirements and recommendations for showers -- Risk assessing showers and their equipment -- Guidance -- References -- 11 Assisted baths -- Assisted baths for patient care -- Microbiological problems associated with assisted baths -- Bath accessories and bath toys -- Monitoring of assisted baths -- Recommendations for assisted baths -- Risk assessing assisted baths -- Guidance for assisted baths -- References -- 12 Birthing pools -- Birthing pools -- What are microbiological risks from using birthing pools? -- How do birthing pools become contaminated? -- Case study 1: Black particle appeared in the birthing pool water -- Case study 2: Birthing pool drain may have resulted in an outbreak -- Case study 3: Inflatable pools used in healthcare facilities -- Microbiological case reports associated with birthing pools -- Regulations and recommendations for consideration for birthing pools -- Risk assessment criteria for birthing pools -- Guidance and regulations relevant for birthing pools -- References. , 13 Hydrotherapy pools -- What are hydrotherapy/aquatic physiotherapy pools? -- What is aquatic physiotherapy? -- Design -- Commissioning -- Governance -- General -- Hydrotherapy pools -- Bather loads -- How does a hydrotherapy pool function? -- Backwashing -- Day-to-day management -- An overview of the hazards applicable to hydrotherapy pools -- Patient screening -- Fecal pathogens -- Nonfecal pathogens -- Main challenges for hydrotherapy pools -- Emergency action plans -- Outbreak 1 -- Hydrotherapy tanks/tubs/pools used for burns, etc. -- Outbreak 2 -- Whirlpool baths and assisted baths -- Factors to consider in a risk assessment -- Spas, hot tubs, footbaths, etc. -- Outbreak 3 -- Microbiological monitoring of hydrotherapy pools -- Criteria for risk assessing birthing pools -- Guidance and regulations relevant for birthing pools -- Terminology -- References -- 14 Sources of patient drinking water -- Sources of drinking water -- Chilled drinking water dispensers -- Outbreak scenarios -- Outbreak scenario 1 -- Outbreak scenario 2 -- Monitoring of drinking water sources -- Guidance for chilled drinking water fountains -- Requirements and recommendations for chilled drinking water fountains -- Bottled drinking water dispensers -- Recommendations for bottled water dispensers -- Risk assessing water coolers and other drinking sources for patients -- Guidelines for bottled water dispensers -- References -- 15 Drink vending machines -- Drink vending machines -- Microbiological issues associated with drink vending machines -- Monitoring of vending machines -- Recommendations for vending machines -- Risk assessing vending machines -- Regulations for vending machines -- References -- 16 Expansion vessels -- What are expansion vessels? -- Microbiological sources and problems associated with expansion vessels?. , Microbial contamination of expansion vessels and seeding the system?.
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 65 (1995), S. 0 
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Suppression of protein synthesis in the brain following an ischemic insult has been thought to occur because of inhibition of translation initiation. All eukaryotic mRNAs, with the exception of heat-shock transcripts, require the activity of eukaryotic initiation factor (eIF) 4E for formation of the translation initiation complex, and eIF-4E availability is rate-limiting. The response of brain eIF-4E concentration and phosphorylation following decapitation ischemia was studied in rat brain homogenates after electrophoresis and western blotting with antibodies against eIF-4E and phosphoserine, respectively. There was no change in level of eIF-4E after 5 min of ischemia (p = 0.82 vs. time 0), but it had decreased 32 (p = 0.01) and 57% (p = 0.006) after 10 and 20 min of ischemia, respectively. There was no loss of serine phosphorylation on eIF-4E beyond signal loss observed due to degradation of the protein itself (p = 0.31). In vitro exposure of eIF-4E to activated μ-calpain resulted in a 50% loss in 10 min of eIF-4E on western blots. If active eIF-4E is required for translation of its own mRNA, degradation of this protein during ischemia, possibly by activated μ-calpain, could be a direct mechanism of irreversible neuronal injury, and the rate of proteolysis of eIF-4E could place an upper time limit on the maximal duration of global brain ischemia compatible with neurologic recovery.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Molecular and cellular biochemistry 104 (1991), S. 169-177 
    ISSN: 1573-4919
    Schlagwort(e): myocyte ; hypertrophy ; rRNA ; phorbol ester
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Primary cultures of neonatal cardiac myocytes were used to determine the effects of tumor-promoting phorbol esters on ribosomal RNA (rRNA) synthesis during myocyte growth. Treatment of myocytes with phorbol-12,13-dibutyrate (PDBu) increased protein accumulation by 25% and RNA content by 20%. Rates of rRNA synthesis were measured to assess the mechanism by which rRNA accumulated during myocyte growth. Rates of rRNA synthesis were determined from the incorporation of [3H]uridine into UMP of purified rRNA and the specific radioactivity of the cellular UTP pool. After 24h of PDBu treatment, cellular rates of 18S and 28S rRNA synthesis were accelerated by 67% and 64%, respectively. The increased rate of rRNA synthesis accounted for the net increase in myocyte rRNA content after PDBu treatment.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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