In:
PLOS Genetics, Public Library of Science (PLoS), Vol. 17, No. 8 ( 2021-8-5), p. e1009686-
Abstract:
Although long noncoding RNAs (lncRNAs) are transcripts that do not encode proteins by definition, some lncRNAs actually contain small open reading frames that are translated. TINCR (terminal differentiation–induced ncRNA) has been recognized as a lncRNA that contributes to keratinocyte differentiation. However, we here show that TINCR encodes a ubiquitin-like protein that is well conserved among species and whose expression was confirmed by the generation of mice harboring a FLAG epitope tag sequence in the endogenous open reading frame as well as by targeted proteomics. Forced expression of this protein promoted cell cycle progression in normal human epidermal keratinocytes, and mice lacking this protein manifested a delay in skin wound healing associated with attenuated cell cycle progression in keratinocytes. We termed this protein TINCR-encoded ubiquitin-like protein (TUBL), and our results reveal a role for TINCR in the regulation of keratinocyte proliferation and skin regeneration that is dependent on TUBL.
Type of Medium:
Online Resource
ISSN:
1553-7404
DOI:
10.1371/journal.pgen.1009686
DOI:
10.1371/journal.pgen.1009686.g001
DOI:
10.1371/journal.pgen.1009686.g002
DOI:
10.1371/journal.pgen.1009686.g003
DOI:
10.1371/journal.pgen.1009686.g004
DOI:
10.1371/journal.pgen.1009686.g005
DOI:
10.1371/journal.pgen.1009686.g006
DOI:
10.1371/journal.pgen.1009686.g007
DOI:
10.1371/journal.pgen.1009686.s001
DOI:
10.1371/journal.pgen.1009686.s002
DOI:
10.1371/journal.pgen.1009686.s003
DOI:
10.1371/journal.pgen.1009686.s004
DOI:
10.1371/journal.pgen.1009686.s005
DOI:
10.1371/journal.pgen.1009686.s006
DOI:
10.1371/journal.pgen.1009686.s007
DOI:
10.1371/journal.pgen.1009686.s008
DOI:
10.1371/journal.pgen.1009686.r001
DOI:
10.1371/journal.pgen.1009686.r002
DOI:
10.1371/journal.pgen.1009686.r003
DOI:
10.1371/journal.pgen.1009686.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2186725-2
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