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  • 1
    Online Resource
    Online Resource
    Singapore :Springer Singapore Pte. Limited,
    Keywords: Engineering: Civil. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (1123 pages)
    Edition: 1st ed.
    ISBN: 9789811537530
    Series Statement: Advances in Intelligent Systems and Computing Series ; v.1143
    DDC: 973.933092
    Language: English
    Note: Intro -- Preface -- Contents -- System Detection -- Design of Collaboration Engine for Large-Scale Heterogeneous Clusters -- 1 Introduction -- 2 Problem Description -- 3 Cooperative Computing Engine -- 3.1 Design of Cooperative Computing Engine -- 3.2 Template Cooperative Execution Plan -- 3.3 State Machine Execution Plan -- 4 Experiments and Analysis -- 5 Summary and Prospect -- References -- Research on Multi-stage GPU Collaborative Model -- 1 Introduction -- 2 Problem Description -- 3 Cooperative Computing Model -- 3.1 Overview of Cooperative Computing Model -- 3.2 Formalized Description -- 3.3 Parameter Analysis -- 4 Experimental Analysis -- 4.1 Validity of Cooperative Computing -- 4.2 Parameter Verification of Cooperative Computing -- 5 Summary -- References -- HSO Algorithm for RRAP Problem in Three-State Device Network -- 1 Introduction -- 2 Hypothesis and Model -- 2.1 Hypothesis -- 2.2 Model -- 3 Coding and the Generation of New Solutions -- 3.1 Coding -- 3.2 New Solution Generation Algorithms -- 3.3 Fitness Function -- 4 Three-Stage Iterative PSO Algorithm -- 4.1 Three-Stage Iterative PSO Algorithms -- 4.2 Simulation -- 5 Improved HSO Algorithm -- 5.1 Algorithm -- 5.2 Simulation -- 6 Conclusion -- References -- A Method of Service Function Chain Arrangement for Load Balancing -- 1 Introduction -- 2 System Model and Constraints -- 3 Experiment and Performance Analysis -- 3.1 Experimental Setup -- 3.2 Analysis of Results -- 4 Conclusion -- References -- The Optimal Implementation of Khudra Lightweight Block Cipher -- 1 Introduction -- 2 Introduction of Khudra Algorithm -- 3 Hardware Optimization Method of Khudra -- 3.1 Local Optimization of the Algorithm -- 3.2 Global Optimization of the Algorithm -- 3.3 Simulation Results -- 4 Results and Analysis of Implementation of FPGA -- 5 Conclusions -- References. , Droop Control of Microgrid Based on Genetic Optimization Algorithm -- 1 Introduction -- 2 Microgrid Overview -- 2.1 Microgrid Composition -- 2.2 Basic Principles of Droop Control -- 3 Optimization Algorithm -- 3.1 Genetic Algorithm -- 3.2 Droop Controller Optimization -- 4 Case Analysis -- 5 Conclusion -- References -- Research and Implementation of a Remote Monitoring Platform for Antarctic Greenhouse -- 1 Introduction -- 2 Remote Monitoring Platform Architecture -- 3 Video Surveillance Design -- 3.1 Network Camera Physical Connection Method -- 3.2 Software Connection Method -- 4 Software Design -- 4.1 Database Design -- 4.2 Communication Protocol Design -- 4.3 Database Form Transfer Process -- 4.4 Socket Communication Design -- 5 System Implementation and Application -- 6 Conclusion -- References -- Application Research in DC Charging Pile of Full-Bridge DC-DC Converter Based on Fuzzy Control -- 1 Introduction -- 2 DC-DC Circuit Topology of Phase-Shifted Full-Bridge for DC Charging Post -- 2.1 Control Principle of DC Charging Pile -- 2.2 Phase-Shifted Full-Bridge DC-DC Circuit Topology -- 3 Small-Signal Model of DC-DC Circuit -- 3.1 The Unified Circuit Model of Buck Circuit -- 3.2 Small-Signal Model of Phase-Shifted Full-Bridge DC-DC Circuit -- 4 Design of Fuzzy Self-tuning PI Controller -- 4.1 Circuit Control Strategy -- 4.2 Design of Fuzzy Self-tuning PI Controller -- 5 Simulation Study -- 5.1 Modeling of Phase-Shifted Full-Bridge DC-DC Converter -- 5.2 Simulation Analysis -- 6 Conclusion -- References -- Performance Analysis of Multi-user Chaos Measurement and Control System -- 1 Introduction -- 2 Analysis of the Performance of Chaotic Spread Spectrum System Against Multiple Access Interference -- 2.1 Effect of Different SNR on the BER of the System -- 2.2 Effect of Spread Frequency Sequence Length on System BER Performance. , 2.3 Effect of Number of Users on System Error Rate -- 3 Conclusions -- References -- Effect of Magnetic Field on the Damping Capability of Ni52.5Mn23.7Ga23.8/Polymer Composites -- 1 Introduction -- 2 Experiments and Discussion -- 3 Conclusion -- References -- Knock Knock: A Binary Human-Machine Interactive Channel for Smartphone with Accelerometer -- 1 Introduction -- 2 Definition and Evaluation of Interactive Gestures -- 2.1 Gesture Definition -- 2.2 Feasibility Analysis -- 3 Construction of Binary Human-Machine Interactive Channel -- 3.1 The Construction Processes -- 3.2 Sensor Data Collecting and Filtering -- 3.3 Bit Cutting -- 3.4 Gesture Recognition Based on Machine Learning -- 4 Experiments -- 4.1 Experiment of Bit Cutting -- 4.2 Recognition Results -- 5 Conclusion -- References -- Remote Network Provisioning with Terminals Priority and Cooperative Relaying for Embedded SIM for NB-IoT Reliability -- 1 Introduction -- 2 System Model and Problem Formulation -- 3 Outage Probability Analysis of the System -- 4 Simulation and Results -- 5 Conclusion -- References -- Design of a Fully Programmable 3D Graphics Processor for Mobile Applications -- 1 Introduction -- 2 Proposed Graphics Processor Design -- 2.1 System Architecture -- 2.2 Distributed Primitive Clipping -- 2.3 Hierarchical Tile-Based Rasterization -- 3 Experimental Results -- 4 Conclusion -- References -- Outer Synchronization Between Complex Delayed Networks with Both Uncertain Parameters and Unknown Topological Structure -- 1 Introduction -- 2 The Network Model and Preliminaries -- 3 Synchronization Between the Networks with Non-identical Topology -- 4 Numerical Simulation -- 5 Conclusions -- References -- Discussion on the Application of Digital Twins in the Wear of Parts -- 1 Introduction -- 2 Research Status of Digital Twin Technology. , 3 The 3D Model of Mechanical Operation Being Applied -- 4 Design of Parameters of Real-Time Wear Detection Model for Parts -- 5 Design of Real-Time Wear Detection Model Panel -- 5.1 Data Comparison Panel Being Designed -- 5.2 Setting the Position of Sensitive Probe -- 5.3 Replacement of Control Panel Design -- 5.4 Design of Model Output Panel -- 5.5 Design of Contrast Panel for Parameter Adjustment Effect -- 6 Research Summary -- References -- Research on Key Algorithms of Segmented Spectrum Retrieval System -- 1 Introduction -- 2 Data Sets and Settings -- 3 Segmented Spectral Feature Extraction Algorithm -- 4 Segmented Spectrogram Retrieval Algorithms -- 4.1 Similarity Measure Method -- 4.2 Segmented Spectrogram Retrieval Algorithms -- 4.3 Analysis of Retrieval Performance -- 5 Conclusion -- References -- Research on Fuzzy Control Strategy for Intelligent Anti-rear-end of Automobile -- 1 Introduction -- 2 Fuzzy Controller for Rear-End Collision Avoidance -- 2.1 Structure of Fuzzy Control System -- 2.2 Process of Fuzzy Controlling Strategy -- 2.3 Designation of Fuzzy Controller -- 3 System Design Scheme -- 3.1 System Hardware Design -- 4 The Software Design of System -- 5 The Fuzzy Control Simulation Based on Simulink -- 5.1 The Establishment of Fuzzy Reasoning System -- 5.2 Compilation of Fuzzy FIS Input and Output Membership Function for Anti-rear-end Collision System -- 5.3 Compilation of FIS Fuzzy Rules for Anti-rear-end Collision System -- 6 Conclusion -- References -- Design and Optimization of Wind Power Electric Pitch Permanent Magnet Synchronous Servo Motor -- 1 Introduction -- 2 Electromagnetic Design -- 2.1 Stator and Rotor Structure Design -- 2.2 Permanent Magnet Design -- 2.3 Electromagnetic Calculation Results -- 3 Electromagnetic Simulation and Optimization of Servo Motor -- 3.1 Motor Optimization Based on Genetic Algorithm. , 3.2 Comparison of Results Before and After Optimization -- 4 Test and Analysis of Electric Pitch PMSM -- 4.1 No-load Back EMF Measurement Test -- 4.2 Motor Load Test -- 5 Summary -- References -- Design of Step Servo Slave System Based on EtherCAT -- 1 Introduction -- 2 Introduction to the EtherCAT Protocol -- 3 Step Servo Slave System Design -- 3.1 The Hardware Design -- 3.2 The Software Design -- 4 EtherCAT Slave Information File Profile -- 5 System Function Test -- 6 Conclusion -- References -- Investigation of Wind Turbine Blade Defect Classification Based on Deep Convolutional Neural Network -- 1 Introduction -- 2 Method -- 2.1 Wind Turbine Blade Ultrasonic Detection Data Acquisition -- 2.2 Structure of One-Dimensional Time-Domain CNN -- 2.3 Structure of WPT-CNN -- 3 Results and Discussion -- 4 Conclusion -- References -- Research on Weakening Cogging Torque of Permanent Magnet Synchronous Wind Generator -- 1 Introduction -- 2 Principle Analysis of Cogging Torque -- 3 Finite Element Analysis -- 3.1 Effect of Pole-Slot Matching on Cogging Torque -- 3.2 Effect of Skew Width on Cogging Torque -- 3.3 Effect of Notch Width on Cogging Torque -- 4 Analysis of Generator Performance Impact After Optimization -- 5 Conclusions -- References -- Research on Edge Network Resource Allocation Mechanism for Mobile Blockchain -- 1 Introduction -- 2 System Model -- 2.1 Trust Value Evaluation Model -- 2.2 Resource Allocation Model -- 3 Model Solving -- 3.1 Trust Value Calculation -- 3.2 Double Auction -- 4 Simulation -- 5 Conclusion -- References -- MATSCO: A Novel Minimum Cost Offloading Algorithm for Task Execution in Multiuser Mobile Edge Computing Systems -- 1 Introduction -- 2 Related Work -- 3 System Model -- 3.1 Architecture -- 3.2 Problem Formulation -- 4 Algorithm Design -- 5 Performance Evaluation -- 6 Conclusions -- References. , Medical Data Crawling Algorithm Based on PageRank.
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  • 2
    Online Resource
    Online Resource
    Singapore :Springer Singapore Pte. Limited,
    Keywords: Computer engineering-Congresses. ; Computer networks-Congresses. ; Computer engineering. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (1700 pages)
    Edition: 1st ed.
    ISBN: 9789811665547
    Series Statement: Lecture Notes in Electrical Engineering Series ; v.808
    DDC: 621.39
    Language: English
    Note: Intro -- Preface -- Contents -- IOTS Internet of Things and Smart Systems -- A Double Incentive Trading Mechanism for IoT and Blockchain Based Electricity Trading in Local Energy Market -- 1 Introduction -- 2 Blockchain-Based Local Energy Market -- 3 Methodology -- 3.1 System Architecture -- 3.2 Transaction Mechanism -- 4 Case Study -- 5 Conclusion -- References -- A Survey on Task Offloading in Edge Computing for Smart Grid -- 1 Introduction -- 2 Edge Computing -- 2.1 Definition of Edge Computing -- 2.2 Architecture of Edge Computing -- 3 Task Offloading in Edge Computing -- 3.1 The Classification of Task Offloading -- 3.2 Task Unloading Process -- 3.3 Task Offloading Scenario -- 4 Challenges and Future Works -- 5 Conclusion -- References -- Data Fusion of Power IoT Based on GOWA Operator and D-S Evidence Theory -- 1 Introduction -- 2 Related Works -- 3 DFMD -- 4 Simulation -- 4.1 Datasets -- 4.2 Simulation Results -- 5 Conclusion -- References -- Edge Task Offloading Method for Power Internet of Things Based on Multi-round Combined Auction -- 1 Introduction -- 2 Related Work -- 3 Problem Formulation -- 4 Algorithm Design Based on Auction Model -- 4.1 Tender Submission Stage -- 4.2 Resource Block Pre-allocation Phase -- 4.3 Winner Determination Stage -- 5 Experimental Evaluation -- 6 Conclusion -- References -- VEC-MOTAG: Vehicular Edge Computing Based Moving Target Defense System -- 1 Introduction -- 2 Related Work -- 3 Threat Model and System Overview -- 4 System Design: Vehicular Edge Computing Based MOTAG System -- 4.1 Accessibility Constraint -- 4.2 QoS Constraints -- 4.3 Capacity Constraints -- 5 Evaluation -- 6 Conclusion -- References -- AIA Artificial Intelligence and Applications -- Short-Term Wind Power Forecasting Based on the Deep Learning Approach Optimized by the Improved T-distributed Stochastic Neighbor Embedding. , 1 Introduction -- 2 Proposed Approaches -- 2.1 Wind Power Forecasting Model Architecture Design -- 2.2 Data Preprocessing of the Wind Power Time Series -- 2.3 Metrics Design for Wind Power Forecasting -- 3 Experiments -- 4 Conclusions -- References -- Adaptive Image Steganographic Analysis System Based on Deep Convolutional Neural Network -- 1 Introduction -- 2 Adaptive Image Steganography Analysis Method -- 2.1 Deep Convolutional Neural Network Structure -- 2.2 Steganalysis Method -- 3 Model Training -- 3.1 Experimental Data and Platform -- 3.2 Experimental Results and Analysis -- 4 System Design -- 4.1 System Framework Design -- 4.2 System Function -- 5 Conclusion -- References -- RETRACTED CHAPTER: An Efficient Channel Attention CNN for Facial Expression Recognition -- 1 Introduction -- 2 Related Work -- 3 Method -- 3.1 Face Detection and Correction -- 3.2 Improved Network Framework Based on DenseNet -- 3.3 Loss Function -- 4 Experiment -- 4.1 Experimental Platform -- 4.2 Experimental Results -- 5 Conclusion -- References -- Handwritten Digit Recognition Application Based on Fully Connected Neural Network -- 1 Introduction -- 2 Key Technologies of Fully Connected Neural Network in Handwritten Digit Recognition -- 2.1 Activation Function -- 2.2 Sigmoid Function -- 2.3 Relu Function -- 2.4 Loss Function -- 2.5 The Core Code of the Fully Connected Neural Network in the Application of Handwritten Digit Recognition -- 3 MNIST Data Set -- 3.1 Analysis of Results -- References -- Detection System of Truck Blind Area Based on YOLOv3 -- 1 The Introduction -- 2 YOLOv3 -- 2.1 Introduction to YOLOV3 Algorithm -- 2.2 YOLO3 Network Structure -- 3 System is Introduced -- 3.1 System Architecture Diagram -- 3.2 The System Design -- 4 The System Test -- 4.1 The Test Environment -- 4.2 Test Indicators -- 4.3 The Experimental Process -- 5 Conclusion -- References. , Driver Fatigue Detection Algorithm Based on SMO Algorithm -- 1 Introduction -- 2 Fatigue State Recognition Based on Machine Vision -- 2.1 Face Feature Location -- 2.2 Extraction of Eye Feature Parameters Based on SMO Selection Strategy -- 2.3 Training Test Based on the Opening and Closing Degree of Human Eyes -- 3 Simulation Experiment -- 4 Conclusion -- References -- Image Mosaic Technology Based on Harris Corner Feature -- 1 Introduction -- 2 Theory and Technology -- 2.1 Image Registration -- 2.2 Harris Image Feature Extraction -- 2.3 Calculation of Homography Matrix -- 3 Image Mosaic Process -- 3.1 Feature Point Capture -- 3.2 Adaptive Non-maximum Suppression -- 3.3 Description of Key Points -- 3.4 Matching of Key Points -- 3.5 The Composition of New Images -- 4 Experiment -- 4.1 Image Mosaic of Existing Data Sets -- 4.2 Actual Shot Image -- 5 Concludes -- References -- Image Semantic Segmentation Based on Joint Normalization -- 1 Introduction -- 2 Related Work -- 3 Method -- 3.1 Network Structure -- 3.2 Normalization Method -- 4 Experiment -- 4.1 Dataset -- 4.2 Analysis -- 5 Conclusion -- References -- DeepINN: Identifying Influential Nodes Based on Deep Learning Method -- 1 Introduction -- 2 Related Work -- 2.1 Node Identification Method Based on Node Ranking Method -- 2.2 Network Embedding Method -- 3 DeepINN -- 3.1 Node Similarity Based on Network Embedding -- 3.2 Node Sampling Algorithm Based on Community Structure -- 3.3 Node Screening Strategy Based on Influential Communities -- 4 Experimental Results -- 4.1 Data Preparation -- 4.2 Parameter Settings of the Network Embedding Methods -- 4.3 Results -- 5 Conclusion -- References -- Lightweight Semantic Segmentation Convolutional Neural Network Based on SKNet -- 1 Introduction -- 2 Related Work -- 3 Method -- 3.1 The Network Structure -- 3.2 SKNet -- 4 Experiment. , 4.1 Experimental Environment -- 4.2 Experimental Results and Analysis -- 5 Conclusion -- References -- The Research on Image Detection and Extraction Method Based on Yin and Yang Discrete Points -- 1 Introduction -- 2 Design of the Sampling Method of Yin and Yang Discrete Points -- 2.1 Yin and Yang Discrete Points Sampling -- 2.2 Parameter Tuning of Discrete Point Sampling Method -- 2.3 Analysis of Anti-noise Interference Ability -- 2.4 Constructing Independent Regions of Discrete Graphs -- 3 Research on Shape Detection and Extraction Based on Yin And Yang Discrete Points -- 4 Experimental Results -- 5 Conclusion -- References -- Research on Short-Term Power Load Prediction Based on Deep Learning -- 1 Introduction -- 2 Deep Learning Models -- 3 Prediction Results and Analysis of Power Short-Term Load Models -- 4 Conclusion -- References -- Image Repair Methods Based on Deep Residual Networks -- 1 Related Work -- 2 Body Method -- 2.1 Repair the Module -- 2.2 Mitigation Module -- 2.3 Loss Function -- 3 Analysis of Experimental Results -- 4 Conclusions -- References -- Real-Time Traffic Sign Detection Based on Improved YOLO V3 -- 1 Introduction -- 2 YOLO V3 Target Detection Algorithm -- 3 Data Collection and Data Enhancement -- 3.1 Data Collection -- 3.2 Data Enhancement -- 4 Analysis of Experimental Simulation Results -- 5 Conclusion -- References -- Design of Ground Station for Fire Fighting Robot -- 1 Introduction -- 2 Ground Station Design -- 2.1 Basic Composition of Ground Stations -- 2.2 Operating System Module -- 2.3 Wireless Communication Module -- 2.4 Power Module -- 3 Project Design -- 3.1 Wireless Communication Module Design -- 3.2 Power Module Design -- 3.3 Overall Design Diagram Design -- 4 Conclusion -- References -- Baby Expression Recognition System Design and Implementation Based on Deep Learning -- 1 Introduction -- 2 Related Work. , 2.1 Deep Learning Based on Neural Networks -- 2.2 Expression Detection and Correction -- 2.3 Face Recognition Technology -- 3 System Design -- 3.1 General Interface Design -- 3.2 Objective Comparison -- 3.3 System Module -- 3.4 Software Testing -- 4 Conclusion -- References -- Handwriting Imitation with Generative Adversarial Networks -- 1 Introduction -- 2 Related Work -- 3 Architecture -- 4 Experiment -- 4.1 Data Set -- 4.2 Experiment Result -- 5 Conclusion -- 6 Expectation -- References -- Epidemic Real-Time Monitor Based on Spark Streaming Real-Time Computing Algorithm -- 1 Introduction -- 2 Related Work -- 2.1 Introduction to Spark -- 2.2 Introduction to Spark Streaming -- 2.3 Comparison of the Advantages and Disadvantages of Spark Streaming and Storm -- 3 Method -- 3.1 Algorithm Introduction -- 3.2 Algorithm Implementation -- 4 Experiments -- 4.1 Test Results -- 5 Conclusion -- References -- Design and Implementation of Fruit and Vegetable Vending Machine Based on Deep Vision -- 1 Introduction -- 2 System Hardware Design -- 3 System Programming -- 3.1 System Control Terminal Design -- 3.2 System Recognition Terminal Program Design -- 4 Overall System Debugging -- 5 Summary and Outlook -- References -- Design and Implementation of License Plate Recognition System Based on Android -- 1 Introduction -- 2 The Overall Algorithm Flow of the System -- 3 Image Preprocessing -- 3.1 Image Grayscale Algorithm Selection -- 3.2 Image Binarization Algorithm Selection -- 3.3 Edge Detection Algorithm Selection -- 3.4 Morphological Processing -- 4 License Plate Positioning -- 5 Character Segmentation Test and Analysis -- 6 Application Design -- 7 Summary and Outlook -- References -- Pseudo-block Diagonally Dominant Matrix Based on Bipartite Non-singular Block Eigenvalues -- 1 Introduction. , 2 Quasi-block Diagonally Dominant Matrix Based on Bipartite Non-singular Block Eigenvalues.
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  • 3
    Online Resource
    Online Resource
    Singapore : Springer
    Keywords: Toxicology ; Biochemistry ; Pharmacology/Toxicology ; Pharmacy ; Pharmacology. ; Medicinal chemistry. ; ATP-Binding Cassette Transporters pharmacokinetics ; ATP-Binding Cassette Transporters toxicity ; Solute Carrier Proteins pharmacokinetics ; Solute Carrier Proteins toxicity ; Drug Resistance, Multiple
    Description / Table of Contents: Overview: role of drug transporters in drug disposition and its clinical significance -- ABC family transporters -- SLC family transporters -- Current research method in transporter study -- Transporter-mediated drug–drug interactions and their significance -- Roles of hepatic drug transporters in drug disposition and liver toxicity -- Roles of renal drug transporter in drug disposition and renal toxicity -- Intestinal transporter associated toxicity and absorption -- Contributions of drug transporters to blood-brain barriers -- Contributions of drug transporters to blood-retinal barrier(BRB) -- Contributions of drug transporters to blood-placental barrier -- ABC transporter-mediated multidrug-resistant cancer
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (X, 580 p. 38 illus., 18 illus. in color)
    Edition: 1st ed. 2019
    ISBN: 9789811376474
    Series Statement: Advances in Experimental Medicine and Biology 1141
    Language: English
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  • 4
    Online Resource
    Online Resource
    Berlin : Weierstraß-Inst. für Angewandte Analysis und Stochastik Leibniz-Inst. im Forschungsverbund Berlin e. V.
    Keywords: Forschungsbericht
    Description / Table of Contents: In this paper, we prove uniqueness in determining a sound-soft ball or polyhedral scatterer in the inverse acoustic scattering problem with a single incident point source wave in RN (N = 2, 3). Our proofs rely on the reflection principle for the Helmholtz equation with respect to a Dirichlet hyperplane or sphere, which is essentially a 'point-to-point’ extension formula. The method has been adapted to proving uniqueness in inverse scattering from sound-soft cavities with interior measurement data incited by a single point source. The corresponding uniqueness for sound-hard balls or polyhedral scatterers has also been discussed.
    Type of Medium: Online Resource
    Pages: Online-Ressource (PDF-Datei: 15 S., 246 KB) , graph. Darst.
    Series Statement: Preprint / Weierstraß-Institut für Angewandte Analysis und Stochastik 1952
    Language: English
    Note: Systemvoraussetzungen: Acrobat reader.
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  • 5
    ISSN: 1527-3458
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: β-Amyloid peptides (Aβ) are deposited in an aggregated fibrillar form in both diffuse and senile plaques in the brains of patients with Alzheimer's disease. The neurotoxicity of Aβ in cultured neurons is dependent on its aggregation state, but the factors contributing to aggregation and fibril formation are poorly understood. In the present study, we investigated whether α2-macroglobulin (α2M), a protein present in neuritic plaques and elevated in Alzheimer's disease brain, is a potential regulatory factor for Aβ fibril formation. Previous studies in our laboratory have shown that α2M is an Aβ binding protein. We now report that, in contrast to another plaque-associated protein, α1-antichymotrypsin, α2M coincubated with Aβ significantly reduces aggregation and fibril formation in vitro. Additionally, cultured fetal rat cortical neurons are less vulnerable to the toxic actions of aged Aβ following pretreatment with α2M. We postulate that α2M is able to maintain Aβ in a soluble state, preventing fibril formation and associated neurotoxicity.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1572-9702
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Ticks of nine small mammal species were studied in an area of endemic Lyme disease in Hailin County, Heilongjiang Province, from 1 May to 10 October 1986. The bulk (93%) total small mammal captures wereApodemus speciouss (45%),Clethrionomys rufocanus (31%),A. agrarius (11%) andEutamias sibiricus; (5%): these host species accounted for 97% of the 162 ticks collected.Ixodes persulcatus Schulze were most abundant onE. sibiricus (0.64 larvae and 0.08 nymphs/squirrel), and less abundant onA. agrarius (1.16 larvae/mouse),A. speciosus (0.38 larvae/mouse) andC. rufocanus (0.37 larvae and nymphs/vole). The seasonal abundance pattern of larvalI. persulcatus on four small mammal species appears as a bimodal peak (June and September), but nymphalI. persulcatus has a monomodal peak during spring. The prevalence of immatureI. persulcatus on four small mammal species may play an important role in the epidemiology of Lyme disease in Hailin County.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 18 (1991), S. 177-192 
    ISSN: 0739-4462
    Keywords: acridine orange ; embryogenesis ; Phormia regina ; protein processing ; proton translocation ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: In eggs of the cockroach Blattella germanica, vitellin (Vt) utilization by the embryo is initiated at day 4 postovulation by the proteolytic processing of its three subunits to a specific set of peptides. A report from our laboratory (Nordin et al.: Archives of Insect Biochemistry and Physiology 15:119, 1990) described a yolk proteinase, activated at days 3-4, which processes the Vt. Further investigation of this event has focused on the yolk granules. Granules from eggs 4-6 days postovulation contained a significant subpopulation which accumulated high concentrations of the dye acridine orange (AO), a fluorescent probe of vesicle acidification, while those from eggs 0-3 days postovulation did not. AO accumulation was caused by proton translocation and was not due to dye binding or a Donnan equilibrium. The temporal correlation of granule acidification with Vt processing suggests a role for this event in yolk proteinase activation in B. germanica. This hypothesis was supported by the finding that incubation of yolk from freshly ovulated eggs in vitro at pH of 5 and below resulted in Vt processsing. Yolk granules of the blowfly Phormia regina also became acidified but this occurred in the oocyte prior to egg deposition.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 15 (1990), S. 119-135 
    ISSN: 0739-4462
    Keywords: yolk proteinase ; yolk granules ; translocation heterozygote ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: In the eggs of the cockroach Blattella germanica, vitellin (Vt) utilization is initiated 4 days postovulation by the proteolytic processing of its three subunits. These reactions yield a specific set of peptides that are consumed by the developing embryo. A yolk proteinase activity, believed central to this processing event, has been investigated. First expressed at day 3 postovulation, just prior to Vt's processing, its specific activity with synthetic substrates increased four-fold to 18-fold through day 6. In addition, a mixing experiment showed that these proteinases(s) can also process Vt's large subunits in vitro. A relationship between Vt processing and proteinase specific activity was also noted with two B. germanica translocation heterozygotes, which displayed differences in the extent of Vt processing. One group of eggs (group A) failed to process any Vt subunit. A second group (B) processed the Mr 102,000 subunit but not the Mr 95,000. A third group (C) processed their Vt normally. Proteinase specific activities in the yolk of translocant's eggs at day 6 mirrored the extent of processing, being highest in group C eggs and effectively absent from the yolk of group A eggs. Eggs defective in Vt processing also contained arrested embryos. It is concluded that the yolk proteinase activity described here participates in Vt processing at day 4 postovulation. Microscopic examination of yolk obtained from eggs of wild type females showed that, as processing began in vivo (day 4), the yolk granules also underwent an abrupt decrease in size from diameters of 15-30 μm to 3-10 μm. Yolk granules of those translocant's eggs that were defective in Vt processing did not undergo this size decrease, suggesting that granule reorganization and Vt proteolysis may be linked functionally.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Publication Date: 2022-05-25
    Description: © Macmillan Publishers Limited, 2011. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature Communications 2 (2011): 293, doi:10.1038/ncomms1297.
    Description: The relative importance of north–south migrations of the intertropical convergence zone (ITCZ) versus El Niño-Southern Oscillation and its associated Pacific Walker Circulation (PWC) variability for past hydrological change in the western tropical Pacific is unclear. Here we show that north–south ITCZ migration was not the only mechanism of tropical Pacific hydrologic variability during the last millennium, and that PWC variability profoundly influenced tropical Pacific hydrology. We present hydrological reconstructions from Cattle Pond, Dongdao Island of the South China Sea, where multi-decadal rainfall and downcore grain size variations are correlated to the Southern Oscillation Index during the instrumental era. Our downcore grain size reconstructions indicate that this site received less precipitation during relatively warm periods, AD 1000–1400 and AD 1850–2000, compared with the cool period (AD 1400–1850). Including our new reconstructions in a synthesis of tropical Pacific records results in a spatial pattern of hydrologic variability that implicates the PWC.
    Description: This work was supported by the Natural Science Foundation of China (NSFC) (40730107) and the Major State Basic Research Development Program of China (973 Program) (No.2010CB428902). DWO acknowledges support from the US NSF.
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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