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  • 1
    Online Resource
    Online Resource
    Research on the Characteristics and Effects of Climate Extremes on Multi-spatial-temporal Scales in the Mongolian Plateau (2024)
    Cham : Springer Nature Switzerland | Cham : Imprint: Springer
    Details Availability
    Keywords: Climatology. ; Bioclimatology. ; Ecology ; Landscape ecology.
    Description / Table of Contents: Chapter 1 Introduction -- Chapter 2 Research Area Overview and Research Methodology -- Chapter 3 Analysis of Extreme Temperature Event Change Characteristics and Influencing Factors -- Chapter 4 Analysis of Extreme Precipitation Event Change Characteristics and Influencing Factors -- Chapter 5 Study on Extreme Climate Event Impacts on Vegetation on the Mongolian Plateau -- Chapter 6 Evaluation and Projection of Extreme Climate Events on the Mongolian Plateau -- Chapter 7 Conclusion and Outlook.
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource(XIV, 163 p. 55 illus., 27 illus. in color.)
    Edition: 1st ed. 2024.
    ISBN: 9783031544934
    Series Statement: Climate Change Management
    URL: https://doi.org/10.1007/978-3-031-54493-4
    DOI: 10.1007/978-3-031-54493-4
    Language: English
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    Loureirin B, an essential component of Sanguis Draxonis, inhibits Kv1.3 channel and suppresses cytokine release from Jurkat T cells (2014)
    BioMed Central
    Details
    Publication Date: 2014-12-13
    Description: Sanguis draxonis (SD), also known as "Dragon's Blood", is a traditional herb medicine that has been used to treat a variety of complications with unknown mechanisms. Recent studies show that SD displays immunosuppressive activities and improves symptoms of type I diabetes in animal models. However, the mechanisms underlying SD's immunosuppressive actions are not completely understood. The voltage-gated Kv1.3 channel plays a critical role in the pathogenesis of autoimmune diseases by regulating the functions of both T cells and B cells. Here we investigated the effect of SD and one of its active components loureirin B (LrB) on Kv1.3. Both SD and LrB inhibited Kv1.3-mediated currents, produced a membrane depolarization, and reduced Ca2+ influx in Jurkat T cells. In addition, application of LrB inhibited phytohemagglutinin (PHA)-induced IL-2 release from activated Jurkat T cells. Furthermore, point mutations in the selective filter region significantly reduced the inhibitory effect of LrB on Kv1.3. The results of these experiments provide evidence that LrB is a channel blocker of Kv1.3 by interacting with amino acid residues in its selective filter region. Direct inhibition of Kv1.3 in T cells by SD and LrB might be the cellular and molecular basis of SD-mediated immunosuppression.
    Electronic ISSN: 2045-3701
    Topics: Biology
    Published by BioMed Central
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