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  • 1
    Electronic Resource
    Electronic Resource
    Correlation between heterozygosity and subunit molecular weight (1979)
    [s.l.] : Nature Publishing Group
    Nature 277 (1979), S. 649-651 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] For our test we used data on six of the enzymes used by Koehn and Eanes4 and estimated the MWs on a series of at least seven enzymes in Drosophila melanogaster for which such information was not previously available. We excluded several enzymes from our analysis because of inadequacies in the data. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/277649a0
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  • 2
    Electronic Resource
    Electronic Resource
    Early Evolutionary Origin of the Planktic Foraminifera Inferred from Small Subunit rDNA Sequence Comparisons (1996)
    Springer
    Journal of molecular evolution 43 (1996), S. 672-677 
    Details
    ISSN: 1432-1432
    Keywords: Key words: Planktic foraminifera — Eukaryote evolution — SSU rDNA phylogeny
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Phylogenetic analysis of five partial planktic foraminiferal small subunit (SSU) ribosomal (r) DNA sequences with representatives of a diverse range of eukaryote, archaebacterial, and eubacterial taxa has revealed that the evolutionary origin of the foraminiferal lineage precedes the rapid eukaryote diversification represented by the ``crown'' of the eukaryotic tree and probably represents one of the earliest splits among extant free-living aerobic eukaryotes. The foraminiferal rDNA sequences could be clearly separated from known symbionts, commensals, and food organisms. All five species formed a single monophyletic group distinguished from the ``crown'' group by unique foraminiferal specific insertions as well as considerable nucleotide distance in aligned regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02202115
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  • 3
    Electronic Resource
    Electronic Resource
    Early evolutionary origin of the planktic foraminifera inferred from small subunit rDNA sequence comparisons (1996)
    Springer
    Journal of molecular evolution 43 (1996), S. 672-677 
    Details
    ISSN: 1432-1432
    Keywords: Planktic foraminifera ; Eukaryote evolution ; SSU rDNA phylogeny
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Phylogenetic analysis of five partial planktic foraminiferal small subunit (SSU) ribosomal (r) DNA sequences with representatives of a diverse range of eukaryote, archaebacterial, and eubacterial taxa has revealed that the evolutionary origin of the foraminiferal lineage precedes the rapid eukaryote diversification represented by the “crown” of the eukaryotic tree and probably represents one of the earliest splits among extant free-living aerobic eukaryotes. The foraminiferal rDNA sequences could be clearly separated from known symbionts, commensals, and food organisms. All five species formed a single monophyletic group distinguished from the “crown” group by unique foraminiferal specific insertions as well as considerable nucleotide distance in aligned regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02202115
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    HIV-1: Gambling on the evolution of drug resistance? (1997)
    [s.l.] : Nature Publishing Group
    Nature medicine 3 (1997), S. 268-271 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The increasing appreciation of the massive replication rates of human immunodeficiency virus (HIV) and the virus's high mutation rate gives the impression of a population of genetic variants of almost unlimited size that can adapt to any selective pressure that arises. Although there is much truth ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0397-268
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  • 5
    Electronic Resource
    Electronic Resource
    Sequence data as evidence (1993)
    [s.l.] : Nature Publishing Group
    Nature 364 (1993), S. 766-766 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - The debate1'2 concerning the proposed transmission of HIV to five patients of a dentist suffering from AIDS highlights the difficulties in establishing networks of HIV transmission from the analysis of viral nucleotide sequence data. The details of that particular case ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/364766b0
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  • 6
    Electronic Resource
    Electronic Resource
    Genetic and biochemical studies on glutamate-pyruvate transaminase from Drosophila melanogaster (1980)
    Springer
    Biochemical genetics 18 (1980), S. 303-309 
    Details
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; allozymes ; GPT ; genetic mapping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract We have used electrophoretic variants of glutamate-pyruvate transaminase (GPT, E.C. 2.6.1.2) in Drosophila melanogaster to genetically map the structural gene to position 42.6 on the X chromosome. By pseudodominance tests over several deficiencies we have localized it cytogenetically to the interval 11Fl-2 to 12Al-2. The sedimentation constant (s 20,w) of the native enzyme was determined in sucrose density gradients to be 5.9 and the native molecular weight approximately 87,000. The similarity in physical properties to mammalian enzymes suggests that the enzyme may also be dimeric in D. melanogaster.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484243
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  • 7
    Electronic Resource
    Electronic Resource
    Instability in the ct MR2 strain of Drosophila melanogaster: Role of P element functions and structure of revertants (1989)
    Springer
    Molecular genetics and genomics 218 (1989), S. 208-213 
    Details
    ISSN: 1617-4623
    Keywords: Transposable element ; Genetic instability ; cut locus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Simultaneous multiple transpositions and longterm genetic instability have been described in the ct MR2 strain of Drosophila melanogaster and its derivatives. This strain originated from a cross that was dysgenic in the P-M system. While spontaneous instability declined over 2 years, instability has been reactivated by backcross to the progenitor P element bearing strain MRh12/Cy. We show here using germline transformation that active P factor alone cannot mimic the effect of this cross, suggesting that MRh12/Cy contains some other activator. In addition, we have observed that ct + exceptional progeny arise in the F1 s well as the F2 generations. Molecular analysis of X chromosomes from some ct + progeny indicates that phenotypic reversion of the ct mutation can arise through two unrelated mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00331270
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  • 8
    Electronic Resource
    Electronic Resource
    Complete reversions of a gypsy retrotransposon-induced cut locus mutation in Drosopbila melanogaster involving jockey transposon insertions and flanking gypsy sequence deletions (1990)
    Springer
    Molecular genetics and genomics 220 (1990), S. 181-185 
    Details
    ISSN: 1617-4623
    Keywords: Retrotransposon ; LINE element ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have analysed the structures of three phenotypic revertant alleles of a gypsy retrotransposon-induced mutation at the cut locus of Drosophila melanogaster. All three revertants are associated with the insertion of jockey transposons into a common region of gypsy. Two of these alleles are complete reversions to wild type. One complete revertant (ct +D) is derived from a third allele, a partial revertant (ct MRPD) by a deletion of part of the gypsy sequence flanking the jockey transposon. Sequence differences between the jockey elements in ct MRpD and ct +D suggest that this deletion may have been created by the insertion of a second jockey near to the first, followed by recombinational excision of a composite jockey and the region between the two genetic elements. The other complete revertant also carries a deletion of gypsy DNA flanking the jockey insertion. The deleted regions of both complete revertants and the target region for all the jockey insertions contain a repeated sequence that resembles a transcriptional enhancer. The strength of the cut phenotype in these mutants correlates with the proportion of this region remaining near the gypsy transcriptional start site, suggesting that the jockey insertions relieve the gypsy-induced mutation at cut by interfering with a region which is required for the transcriptional competence of gypsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00260479
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