Description: This data publication contains the compilation of global heat-flow data by the International Heat Flow Commission (IHFC; http://www.ihfc-iugg.org/) of the International Association of Seismology and Physics of the Earth's Interior (IASPEI). The presented data release 2021 contains data generated between 1939 and 2021 and constitutes an updated and extended version of the 2012 IHFC database release (IHFC 2012; later re-published as PANGAEA release: Global Heat Flow Compilation Group, 2013). The 2021 release contains 74,548 heat-flow data from 1,403 publications. 55% of the reported heat-flow values are from the continental domain (n ~ 40,870), while the remaining 45% are located in the oceanic domain (n ~ 33,678). The data are provided in csv and Excel formats. Compared to earlier compilations, which followed the structure defined by Jessop et al. (1976), the new data release was transformed to the recently redefined structure for reporting and storing heat-flow data in the Global Heat Flow Database (Fuchs et al., 2021). Therefore, the notation and structure of the database was adopted, transforming the database field entries defined after Jessop et al. (1976) to the new field structure. Old code notations are not continued and the dataset was cleaned for entries without reporting any heat-flow value. Although successfully transformed, this release marks an intermediate step as the majority of the newly defined database fields have not been filled yet. Filling these fields, checking the existing entries and assessing the quality of each entry are the aim of the upcoming Global Heat Flow Data Assessment Project, for which this data set provides the basis. Consequently, we kindly ask the user to take notice that the current release still suffers similar problems as previously published compilations in terms of data heterogeneity, documentation and quality.

Description: This data publication contains the compilation of global heat-flow data by the International Heat Flow Commission (IHFC; http://www.ihfc-iugg.org/) of the International Association of Seismology and Physics of the Earth's Interior (IASPEI). The presented data release 2021 contains data generated between 1939 and 2021 and constitutes an updated and extended version of the 2012 IHFC database release (IHFC 2012; later re-published as PANGAEA release: Global Heat Flow Compilation Group, 2013). The 2021 release contains 74,548 heat-flow data from 1,403 publications. 55% of the reported heat-flow values are from the continental domain (n ~ 40,870), while the remaining 45% are located in the oceanic domain (n ~ 33,678). The data are provided in csv and Excel formats. Compared to earlier compilations, which followed the structure defined by Jessop et al. (1976), the new data release was transformed to the recently redefined structure for reporting and storing heat-flow data in the Global Heat Flow Database (Fuchs et al., 2021). Therefore, the notation and structure of the database was adopted, transforming the database field entries defined after Jessop et al. (1976) to the new field structure. Old code notations are not continued and the dataset was cleaned for entries without reporting any heat-flow value. Although successfully transformed, this release marks an intermediate step as the majority of the newly defined database fields have not been filled yet. Filling these fields, checking the existing entries and assessing the quality of each entry are the aim of the upcoming Global Heat Flow Data Assessment Project, for which this data set provides the basis. Consequently, we kindly ask the user to take notice that the current release still suffers similar problems as previously published compilations in terms of data heterogeneity, documentation and quality.

Description: Background: Proton pump is an integral membrane protein that is ubiquitous ATP binding cassette (ABC) involved in many transport processes in all living organisms, among which a specialized form of pump, so called p-type proton pump, exists in the parietal cells of stomach. Though proton pump inhibitors (PPIs) are frequently prescribed to prevent nonsteroidal anti-inflammatory drugs (NSAIDs)-induced gastric damage, the acid suppressive actions do not suffice to explain. Methods: In order to document the effects of pantoprazole, one of PPIs, on the NSAIDs-induced gastric damage, in vitro and in vivo studies were performed. Immunocytochemistry, Western blot analysis, electrophoretic mobility shift assay and RT-PCR were conducted to evaluate the induction of heme oxygenase-1 (HO-1) through Nrf2 activation in normal gastric mucosal RGM-1 cells or in vivo stomach tissues from rats treated with indomethacin and/or pantoprazole. Results: Pantoprazole activated Nrf2 through inactivation of Keap1, after which the expression of HO-1 was significantly increased in a dose-dependent manner in RGM-1 cells. Increased ARE-DNA binding activity was observed maximally at 1 h with 300 muM of pantoprazole. The expression of HO-1 induced by pantoprazole was significantly associated with the increased in vitro tube formation (P 〈 0.05) and angiogenic factors including VEGF, bFGF, and HIF-1alpha. Indomethacin markedly increased the expressions of TNF-alpha, IL-1ss, IL-8, NOX-1, ICAM-1 and VCAM, whereas pantoprazole significantly decreased the expressions of indomethacin-induced these inflammatory mediators in accord with pantoprazole-induced HO-1 (P 〈 0.05) as documented with HO-1 inhibitor. In vivo model of indomethacin-induced gastric damage could validate in vitro-drawn results that pantoprazole remarkably protected against indomethacin-induced gastric damage, in which zinc protoporphyrin (5 mg/kg, ip) significantly abolished the protective efficacy of pantoprazole. Conclusion: These results demonstrate that Nrf2-mediated HO-1 induction of PPIs afforded a significant protective effect against NSAIDs-induced gastric damage beyond acid suppressive actions.

Description: Langmuir DOI: 10.1021/la104136w

Description: Background: Prunus yedoensis Matsum. is used as traditional medicine---'Yaeng-Pi' or 'Hua-Pi'---in Japan and Korea. However, no studies have examined the pharmacological activities of the P. yedoensis bark. Only the antioxidant and antiviral activities of P. yedoensis fruit and the anti-hyperglycaemic effect of P. yedoensis leaf have been investigated. While studying the antihypertensive effects of several medicinal plants, we found that a methanol extract of P. yedoensis bark (MEPY) had distinct vasorelaxant effects on rat aortic rings. Methods: The aortic rings were removed from Sprague--Dawley rats and suspended in organ chambers containing 10 ml Krebs-Henseleit solution. The aortic rings were placed between 2 tungsten stirrups and connected to an isometric force transducer. Changes in tension were recorded via isometric transducers connected to a data acquisition system. Results: MEPY relaxed the contraction induced by phenylephrine both in endothelium-intact and endothelium-denuded aortic rings concentration dependently. However, the vasorelaxant effects of MEPY on endothelium-denuded aortic rings were lower than endothelium-intact aortic rings. The vasorelaxant effects of MEPY on endothelium-intact aortic rings were reduced by pre-treatment with l-NAME, methylene blue, or ODQ. However, pre-treatment with indomethacin, atropine, glibenclamide, tetraethylammonium, or 4-aminopyridine had no affection. In addition, MEPY inhibited the contraction induced by extracellular Ca2+ in endothelium-denuded rat thoracic aorta rings pre-contracted by PE (1 muM) or KCl (60 mM) in Ca2+-free solution. Conclusions: Our results suggest that MEPY exerts its vasorelaxant effects via the activation of NO formation by means of l-Arg and NO-cGMP pathways and via the blockage of extracellular Ca2+ channels.

Description: Nanoparticles are known to form in narrow slip zones in natural and experimental fault zones, but their possible role in dynamic weakening of faults during seismic slip remains almost unexplored. We conducted friction experiments on periclase (MgO) nanoparticles (50 nm in average size) at rates as high as 1.3 m s-1, a typical speed of seismic slip. The nanoparticles were used as the initial gouge to avoid complexities arising from comminution and fluid release. The dynamic friction decreased with increasing slip rate and the steady-state frictional coefficient reduced to as low as 0.1 at a slip rate of 1.3 m s-1. Flash heating is not effective for nanoparticles, and we propose that development of slickensides and dominant operation of nanoparticle rolling cause such a weakening. Nanoparticle lubrication appears to be as effective as melt lubrication and thermal pressurization, and the formation of nanoparticles in slip zones may be an important fault lubrication process.