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  • 1
    Digitale Medien
    Digitale Medien
    The effects of orthodontic tooth movement on the glycosaminoglycan components of gingival crevicular fluid (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 20 (1993), S. 0 
    Details
    ISSN: 1600-051X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract In this study, gingival crevicular fluid (GCF) was collected from around a canine tooth, in children, before and during orthodontic tooth movement. The aim was to identify and quantify the glycosaminoglycan (GAG) components of GCF and relate them to tooth movement, gingival inflammation, plaque accumulation, pocket probing depth and GCF volume recorded at the site of sampling. GAG in GCF samples, collected for a 15-min period into microcapillary tubes, were separated electrophoretically, stained with Alcian blue and quantified using a laser densitometer. 2 GAG components of hyaluronic acid (HA) and chondroitin sulphate (CS) were identified. The increase in GCF volume during orthodontic tooth movement was only partly due to increased gingival inflammation, GAG levels varied with different types of orthodontic tooth movement. In GCF, levels of CS, in particular, may reflect the changes in the deeper periodontal tissues which could be monitored during orthodontic tooth movements.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-051X.1993.tb00375.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Recombinant human inteleukin-1 inhibits plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 174 (1991), S. 251-257 
    Details
    ISSN: 0006-291X
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/0006-291X(91)90513-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Photoperiodic control of growth and segment proliferation by Nereis (Neanthes) virens in relation to state of maturity and season (1999)
    Springer
    Marine biology 134 (1999), S. 191-199 
    Details
    ISSN: 1432-1793
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The effects of two fixed photoperiodic regimes on the rate of somatic growth and segment proliferation in the semelparous polychaete Nereis (Neanthes) virens Sars has been investigated. The two photoperiods (16 h light:8 h dark and 8 h light:16 h dark, hereafter LD 16:8 and LD 8:16) were close to the extremes experienced naturally by N. (N.) virens in the course of a year. The experiments were carried out during the ambient winter and all worms (including four-setiger larvae raised out of season) showed elevated feeding, growth and enhanced segment-proliferation rates when reared under LD 16:8, compared to worms reared under LD 8:16. The rate of replacement of lost segments after caudal ablation was also higher under LD 16:8. The number of segments present when the segment proliferation rate had fallen to zero was higher in individuals grown from birth under LD 16:8 compared to those grown under LD 8:16. Feeding activity showed a degree of spontaneous recovery under LD 8:16 from January onwards, but remained lower than under LD 16:8. This difference continued into the following spring, and was not attributable to differences in sexual maturity. We conclude that the rate of feeding in N. (N.) virens and other indicators of somatic growth rate such as rates of caudal regeneration and segment proliferation are directly influenced by the photoperiod, but that the seasonal cycle of growth also includes a circa-annual component modifying the response to static photoperiods according to the time of year.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002270050537
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Are monozygotic twins similar due to genetic factors alone? (1982)
    [s.l.] : Nature Publishing Group
    Nature 295 (1982), S. 172-172 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] THE number of errors and inconsistencies in the paper by Gartner et al.1 raises doubts about the validity of their conclusions. In Table 1, the mean and standard deviation of 51-day-old monozygotic (MZ) males are incorrect and differ from the mean and standard deviation for the same data given in ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/295172b0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Sexual Satellites, Moonlight and the Nuptial Dances of Worms: the Influence of the Moon on the Reproduction of Marine Animals (1999)
    Springer
    Earth, moon and planets 85-86 (1999), S. 67-84 
    Details
    ISSN: 1573-0794
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie , Physik
    Notizen: Abstract The evidence that the moon has a profound effect on the timing of reproductive activities of marine animals is compelling. Some moon phase related spawning events are revealed by the constant phase relationship between the timing of “once per year” spawning events and the lunar phase as in the highly synchronised breeding of the palolo worm Palola viridis and the Japanese crinoid Comanthus japonicus In other cases there is a repeated lunar cycle of reproductive activity and again the marine worms provide many good examples. The breeding of the palolo worm involves the highly synchronised release of what are in effect detached sexual satellites and the timing of this has annual (solar year), lunar, daily and tidal rhythm components. In a similar way, the onset of sexual maturation and participation in the nuptial dance of Platynereis dumerilli has strong lunar components. Sexual reproduction is the culmination of a process of sexual maturation that takes many months for completion and the mechanisms by which moon phase relationships are imposed on this process must have been selected for by mechanisms relating to reproductive success. The polychaetes provide excellent models for investigation of both the selective advantage and the physiological processes involved in reproductive synchrony. We have recently shown that the spawning of the lugworm Arenicola marina has lunar components and we conclude that an interaction between solar and lunar signals is widespread in the timing of reproduction in marine animals. Carl Hauenschild was the first to demonstrate the existence of a free-running circa-lunar rhythm in marine animals using captive populations of Platynereis dumerilli His experiments also provided clear evidence for the influence of moonlight (light at night) as the zeitgeber for this rhythm. This implies a high level of sensitivity to light, and the operation of appropriate endogenous biological rhythms. Using Nereis virens we have demonstrated a high level of sensitivity to low intensity solar light signals in relation to rhythmic processes with the properties similar to the circadian and photoperiodic mechanisms of terrestrial organisms. The spawning of N. virens is also believed to have lunar components reflecting the complex influences of the sun and the moon in the marine domain, where influences of the moon and sun are more equal. We suggest that evolution of biological rhythmicity that can be entrained to either lunar or solar systems arose in the marine domain. Recent advances in understanding the molecular components of the circadian clock system suggest that a search for a common molecular mechanism for both lunar and solar related biological rhythms in marine organisms might be very fruitful.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1017039110161
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  • 6
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    Active ADAMTS-5 Is an Oligomer [Glycobiology and Extracellular Matrices] (2016)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Details
    Publikationsdatum: 2016-02-13
    Beschreibung: The metalloproteinase ADAMTS-5 (A disintegrin and metalloproteinase with thrombospondin motifs) degrades aggrecan, a proteoglycan essential for cartilage structure and function. ADAMTS-5 is the major aggrecanase in mouse cartilage, and is also likely to be the major aggrecanase in humans. ADAMTS-5 is a multidomain enzyme, but the function of the C-terminal ancillary domains is poorly understood. We show that mutant ADAMTS-5 lacking the catalytic domain, but with a full suite of ancillary domains inhibits wild type ADAMTS activity, in vitro and in vivo, in a dominant-negative manner. The data suggest that mutant ADAMTS-5 binds to wild type ADAMTS-5; thus we tested the hypothesis that ADAMTS-5 associates to form oligomers. Co-elution, competition, and in situ PLA experiments using full-length and truncated recombinant ADAMTS-5 confirmed that ADAMTS-5 molecules interact, and showed that the catalytic and disintegrin-like domains support these intermolecular interactions. Cross-linking experiments revealed that recombinant ADAMTS-5 formed large, reduction-sensitive oligomers with a nominal molecular mass of ∼400 kDa. The oligomers were unimolecular and proteolytically active. ADAMTS-5 truncates comprising the disintegrin and/or catalytic domains were able to competitively block full-length ADAMTS-5-mediated aggrecan cleavage, measured by production of the G1-EGE373 neoepitope. These results show that ADAMTS-5 oligomerization is required for full aggrecanase activity, and they provide evidence that blocking oligomerization inhibits ADAMTS-5 activity. The data identify the surface provided by the catalytic and disintegrin-like domains of ADAMTS-5 as a legitimate target for the design of aggrecanase inhibitors.
    Print ISSN: 0021-9258
    Digitale ISSN: 1083-351X
    Thema: Biologie , Chemie und Pharmazie
    Publiziert von The American Society for Biochemistry and Molecular Biology (ASBMB)
    Standort Signatur Einschränkungen Verfügbarkeit
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