Keywords:
Vasopressin.
;
Oxytocin.
;
Electronic books.
Description / Table of Contents:
Vasopressin and oxytocin are the key hormones of the hypothalamo-neurohypophysial system, and are well-known to be critically involved in antidiuresis, labor, and milk ejection. This book highlights the latest research on vasopressin and oxytocin, covering multiple biological aspects. The capacity of both hormones to regulate various aspects of social behaviours including pair-bonding, aggression, maternal love, and sexual behaviour, is a main focus, as are their interactions with a variety of other neuromodulators and transmitters. Moreover, the book illustrates the recent development of vasopressin and oxytocin agonists/antagonists as potential drugs to treat not only disturbances of body fluid homeostasis, but also mental disorders, including social phobia, autism, anxiety, and depression. The promising combination of basic and clinical research, comprising physiology, neuroendocrinology, behavioral biology, pharmacology, imaging and molecular genetics makes this book an essential addition to both experts and scientists new to the field alike. Comprehensive review of OXT and AVP physiology and behaviour Each chapter covers a novel aspect of OXT and AVP research and is written by a leading expert Review articles are ideal for experts and newcomers to the field alike Discusses fascinating behavioural effects of oxytocin and vasopressin Summarizes the recent explosion of neuropeptide research, physiology and behaviour, is in one location.
Type of Medium:
Online Resource
Pages:
1 online resource (657 pages)
Edition:
1st ed.
ISBN:
9780080932477
Series Statement:
Issn Series ; v.Volume 170
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=403654
DDC:
612.492
Language:
English
Note:
Cover -- Advances in vasopressin and oxytocin - from genes to behaviour to disease -- Copyright -- List of Contributors -- Preface -- Acknowledgements -- Contents -- Section I. Vasopressin and Oxytocin in Evolution, Sexual Dichotomy and Stress -- Chapter 1. Nonapeptides and the evolutionary patterning of sociality -- Abstract -- Nonapeptides and the patterning of behaviour -- Deep history of the nonapeptides -- Evolution of central nonapeptide circuits: anatomical and behavioural basics -- Evolutionary plasticity of nonapeptide systems generates social diversity -- Vasotocin and the evolution of avian sociality -- Sociality and septal neuropeptides: what is being modulated? -- Neuromodulatory patterning: overlapping circuits and distinct behavioural states -- Summary -- Abbreviations -- Acknowledgement -- References -- Chapter 2. Sex differences in vasopressin and oxytocin innervation of the brain -- Abstract -- Introduction -- Causes of sex differences in AVP projections -- Effects of circulating hormones in adulthood -- Oestrogen versus androgen effects -- Hormones and sex differences in AVP expression -- Sex chromosomes in sex differences in AVP expression -- Cellular mechanisms underlying differentiation of AVP expression -- The origin of sexually dimorphic AVP innervation -- Sex differences in other AVP systems -- Function of sex differences in AVP expression -- Lessons from spotted hyenas and prairie voles -- Dual function for sex differences in the brain -- Clinical implications -- Abbreviations -- Acknowledgement -- References -- Chapter 3. The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary adrenal axis during chronic stress -- Abstract -- Introduction -- Conclusions -- Acknowledgement -- References -- Section II. Genetics Meets Behaviour.
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Chapter 4. Experimental approaches for the study of oxytocin and vasopressin gene expression in the central nervous system -- Abstract -- Introduction -- Materials and methods -- Results -- Discussion -- Abbreviations -- Acknowledgements -- References -- Chapter 5. Oxytocin knockout mice: a model for studying stress-related and ingestive behaviours -- Abstract -- Introduction -- Methods -- Experiments -- Summary and implications of findings and future directions -- Abbreviations -- References -- Chapter 6. The role of the vasopressin 1b receptor in aggression and other social behaviours -- Abstract -- Introduction -- Avpr 1b and aggression -- Avpr 1b and social memory -- Avpr 1b and social motivation -- Conclusions -- Abbreviations -- Acknowledgement -- References -- Chapter 7. Behavioural studies using temporal and spatial inactivation of the oxytocin receptor -- Abstract -- Introduction -- Oxt and Oxtr knockout mice -- Behavioural analysis using conditional knockout mice -- Phenotypical implication of Oxtr conditional knockout mice -- Future directions -- Abbreviations -- Acknowledgement -- References -- Chapter 8. New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance -- Abstract -- Oxytocin and oxytocin receptor -- Generation of oxytocin deficient (Oxt-/-) mice -- Generation of oxytocin receptor deficient (Oxtr-/-) mice -- Generation of Oxtr-Venus knockin mice to locate ''Oxtr-Neurons'' -- Abbreviations -- Acknowledgements -- References -- Section III. Regulation of Vasopressin and Oxytocin Release -- Chapter 9. Regulation of vasopressin release by co-released neurotransmitters: mechanisms of purinergic and adrenergic synergism -- Abstract -- Introduction -- Mechanism of ATP+PE synergism -- Remaining issues and new hypotheses -- Acknowledgements -- References.
,
Chapter 10. Neuron-glia interactions in the rat supraoptic nucleus -- Abstract -- Introduction -- Diffusion properties in the SON -- Glial contribution to glutamatergic and GABAergic transmission in the SON -- Gliotransmission in the SON and modulation of NMDA receptors -- Conclusions -- Abbreviations -- Acknowledgements -- References -- Chapter 11. Dynamic synapses in the hypothalamic-neurohypophyseal system -- Abstract -- Synaptic physiology of glutamate synapses on MNCs -- Mechanisms responsible for asynchronous release in PVN -- Evoked glutamate release and the regulation of MNC activity -- Conclusions -- Acknowledgements -- References -- Chapter 12. Endogenous modulators of synaptic transmission: cannabinoid regulation in the supraoptic nucleus -- Abstract -- Introduction -- The cannabinoid system in the SON -- Future perspectives -- Abbreviations -- References -- Chapter 13. Oxytocin and appetite -- Abstract -- Introduction -- Oxytocin and oxytocin-like peptides throughout evolution -- Interactions between feeding and sex -- Regulation of feeding in mammals -- Oxytocin and sexual behaviour -- The ventromedial nucleus of the hypothalamus (VMH) -- Peptides and behaviour -- Acknowledgements -- References -- Section IV. Nonapeptide Receptors: Regulation and Signalling -- Chapter 14. Neural mechanisms underlying the milk ejection burst and reflex -- Abstract -- Introduction -- Structural considerations: the SON -- Functional studies of milk ejection bursts and the MER -- Functional studies of milk ejection bursts and the MER -- Cellular mechanisms underlying OXT-induced excitation -- Concluding remarks -- Abbreviations -- Acknowledgements -- References -- Chapter 15. Oxytocin receptor signalling -- Abstract -- General thoughts on oxytocin receptor signalling -- Novel OXTR signalling target: eEF2 -- Novel OXTR-linked signalling pathway: ERK5.
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In vitro contraction assay -- Conclusions -- Abbreviations -- Acknowledgement -- References -- Chapter 16. Neurosteroids are excitatory in supraoptic neurons but inhibitory in the peripheral nervous system: it is all about oxytocin and progesterone receptors -- Abstract -- Introduction -- Neurosteroids: a new class of neuromodulators -- Non-genomic effects of progestins -- GABAA and free cytosolic Ca2+: a developmental pas-de-deux -- Development of the nervous system -- Physiological relevance of the models -- Neuroactive steroid-signalling pathways -- Conclusion -- Abbreviations -- Acknowledgements -- References -- Chapter 17. Oxytocin receptors: ligand binding, signalling and cholesterol dependence -- Abstract -- Oxytocin -- Oxytocin receptors -- Oxytocin receptor research: quo vadis? -- Abbreviations -- Acknowledgements -- References -- Section V. Neuronal Actions of Nonapeptides -- Chapter 18. Opposite effects of oxytocin and vasopressin on the emotional expression of the fear response -- Abstract -- Introduction -- Conclusions and perspectives -- Abbreviations -- Acknowledgements -- References -- Chapter 19. Multi-factorial somato-dendritic regulation of phasic spike discharge in vasopressin neurons -- Abstract -- Phasic spike discharge patterning in vasopressin neurons -- Somato-dendritic neuropeptide release from vasopressin neurons -- Autocrine modulation of phasic spike discharge by somato-dendritic vasopressin release -- Autocrine modulation of phasic spike discharge by co-released neuropeptides -- Autocrine modulation of phasic spike discharge by other factors -- Conclusion -- Abbreviations -- Acknowledgements -- References -- Chapter 20. Neurophysiology of supraoptic neurons in C57/BL mice studied in three acute in vitro preparations -- Abstract -- Introduction -- Methods -- Results -- Discussion -- Abbreviations -- Acknowledgements.
,
References -- Chapter 21. Effects of oxytocin on GABA signalling in the foetal brain during delivery -- Abstract -- GABA in the immature brain -- Perinatal switch in the action of GABA from excitatory to inhibitory -- Involvement of oxytocin in the perinatal GABA switch -- Source of oxytocin in a slice preparation -- Origin of oxytocin in the foetal brain: maternal or foetal? -- Oxytocin and NKCC1 -- Oxytocin as neuroprotector in perinatal hypoxia -- Concluding remarks -- Abbreviations -- Acknowledgements -- References -- Section VI. Regulation of Social Behaviours -- Chapter 22. Central vasopressin and oxytocin release: regulation of complex social behaviours -- Abstract -- Introduction -- Monitoring of local release of AVP and OXT during social behaviour by intracerebral microdialysis -- Behavioural relevance of local neuropeptide release within target brain regions -- Conclusions -- Abbreviations -- Acknowledgements -- References -- Chapter 23. Interactions between dopamine and oxytocin in the control of sexual behaviour -- Abstract -- Introduction -- Hypothalamic nuclei mediating reproductive behaviours -- The role of oxytocin -- The role of dopamine -- Dopamine-oxytocin link -- Signalling pathways -- Conclusion -- Abbreviations -- Acknowledgements -- Reference -- Chapter 24. Steroidal/neuropeptide interactions in hypothalamus and amygdala related to social anxiety -- Abstract -- Introduction -- ERα compared to ERβ -- Social recognition and autism -- E/OT interactions -- A functional genomic network supporting social recognition -- Generalized CNS arousal mechanisms related to fear -- Hyperarousal fostering social anxiety -- Social anxiety fostering autism -- References -- Chapter 25. Functional magnetic resonance imaging and the neurobiology of vasopressin and oxytocin -- Abstract -- Introduction -- Imaging conscious animals.
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Imaging aggressive motivation and the role of vasopressin neurotransmission.
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