In:
PLOS Global Public Health, Public Library of Science (PLoS), Vol. 3, No. 2 ( 2023-2-8), p. e0001125-
Kurzfassung:
Paradoxically, patients with advanced stomach cancer who are Helicobacter pylori -positive (HP + ) have a higher survival rate than those who are HP - . This finding suggests that HP infection has beneficial effects for cancer treatment. The present study examines whether HP + individuals have a lower likelihood of death from cancer than those who are HP - . Prospective cohort data ( n = 4,982 subjects enrolled in the DAIKO study between 2008–2010) were used to assess whether anti-HP antibody status was associated with cancer incidence. The median age in the primary registry was 53 years-old (range 35–69 years-old). Over the 8-year observation period there were 234 (4.7%) cancer cases in the cohort and 88 (1.8%) all-cause deaths. Urine anti-HP antibody data was available for all but one participant (n = 4,981; 99.98%). The number of HP + and HP - individuals was 1,825 (37%) and 3,156 (63%), respectively. Anti-HP antibody distribution per birth year revealed that earlier birth year was associated with higher HP + rates. With a birth year-matched cohort ( n = 3,376), all-cancer incidence was significantly higher in HP + individuals than those who were HP - (p = 0.00328), whereas there was no significant difference in the cancer death rate between HP + and HP - individuals (p = 0.888). Cox regression analysis for prognostic factors revealed that the hazards ratio of HP + was 1.59-fold (95%CI 1.17–2.26) higher than HP - in all-cancer incidence. Potential systemic effects of HP + status may contribute to reduced likelihood of death for patients after an initial diagnosis of cancer.
Materialart:
Online-Ressource
ISSN:
2767-3375
DOI:
10.1371/journal.pgph.0001125
DOI:
10.1371/journal.pgph.0001125.g001
DOI:
10.1371/journal.pgph.0001125.g002
DOI:
10.1371/journal.pgph.0001125.g003
DOI:
10.1371/journal.pgph.0001125.g004
DOI:
10.1371/journal.pgph.0001125.t001
DOI:
10.1371/journal.pgph.0001125.t002
DOI:
10.1371/journal.pgph.0001125.s001
DOI:
10.1371/journal.pgph.0001125.s002
DOI:
10.1371/journal.pgph.0001125.s003
DOI:
10.1371/journal.pgph.0001125.s004
DOI:
10.1371/journal.pgph.0001125.s005
DOI:
10.1371/journal.pgph.0001125.s006
DOI:
10.1371/journal.pgph.0001125.s007
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2023
ZDB Id:
3101394-6
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