Publication Date:
2012-06-12
Description:
Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1 EMBO Reports 13, 163 (2012). doi:10.1038/embor.2011.235 Authors: Deresa Lee, Sang-Joon Park, Ki Sa Sung, Jikyoung Park, Sean Bong Lee, Sang-Yoon Park, Hyo Jeong Lee, Jang-Won Ahn, So Jung Choi, Seok-Geun Lee, Sung-Hoon Kim, Duk-Hwan Kim, Jhingook Kim, Yongsok Kim & Cheol Yong Choi The Ras effector NORE1 is frequently silenced in primary adenocarcinomas, although the significance of this silencing for tumorigenesis is unclear. Here we show that NORE1 induces polyubiquitination and proteasomal degradation of oncoprotein HIPK1 by facilitating its interaction with the Mdm2 E3 ubiquitin ligase. Endogenous HIPK1
Keywords:
Novel Ras effector 1RASSF5homeodomain-interacting protein kinase 1oncogene
;
tumorigenesis
Print ISSN:
1469-221X
Electronic ISSN:
1469-3178
Topics:
Biology
,
Medicine
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