In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 40, No. 6 ( 2014-12), p. 1336-1341
Kurzfassung:
1) To assess the myocardial partition coefficient (λ) of gadolinium quantified using T 1 mapping in dilated cardiomyopathy (DCM); and 2) to assess the impact of increased λ on left ventricular (LV) circumferential strain and ejection fraction in DCM. Materials and Methods Seventeen patients with DCM and 11 controls were prospectively included. All patients and controls underwent a 1.5T MRI using: 1) cine to quantify LV volumes and function; 2) tagging to quantify circumferential strain in mid‐LV; 3) T 1 mapping before and 9 minutes after contrast injection to quantify R 1 , Δ R 1 , and λ; and 4) inversion recovery 3D Flash was used to assess late gadolinium enhancement (LGE) 10 minutes after Gd DOTA injection (0.2 mmol/kg). We used Student's t ‐test to compare means, Pearson's test for correlation assessment, and a mixed linear model to integrate the dependency between myocardial segments. Results No difference in median λ was measured between patients with (0.52 [interquartile range = 0.48–0.56]) and without enhancement on LGE (0.51 [0.47‐0.54] ; P = 0.07). Circumferential strain value measured in each segment was correlated with the λ measured in the corresponding segment ( r = 0.55; P 〈 0.0001). Multivariate analysis revealed a significant link between the λ in each segment and circumferential strain (0.002 ± 0.001; P = 0.009) and also with ejection fraction (−0.001 ± 0.0008; P = 0.04). Conclusion In DCM, λ correlates independently with circumferential strain and ejection fraction, suggesting that there is a link between λ and systolic function. J. Magn. Reson. Imaging 2014;40:1336–1341 . © 2013 Wiley Periodicals, Inc .
Materialart:
Online-Ressource
ISSN:
1053-1807
,
1522-2586
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
1497154-9
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