In:
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 41, No. 3 ( 2014-05), p. 368-374
Abstract:
To identify predictors of good outcome in acute basilar artery occlusion (BAO). Background: Acute ischemic stroke (AIS) caused by BAO is often associated with a severe and persistent neurological deficit and a high mortality rate. Methods: The set consisted of 70 consecutive AIS patients (51 males; mean age 64.5±14.5 years) with BAO. The role of the following factors was assessed: baseline characteristics, stroke risk factors, pre-event antithrombotic treatment, neurological deficit at time of treatment, estimated time to therapy procedure initiation, treatment method, recanalization rate, change in neurological deficit, post-treatment imaging findings. 30- and 90-day outcome was assessed using the modified Rankin scale with a good outcome defined as a score of 0–3. Results: The following statistically significant differences were found between patients with good versus poor outcomes: mean age (54.2 vs. 68.9 years; p =0.0001), presence of arterial hypertension (52.4% vs. 83.7%; p =0.015), diabetes mellitus (9.5% vs. 55.1%; p =0.0004) and severe stroke (14.3% vs. 65.3%; p =0.0002), neurological deficit at time of treatment (14.0 vs. 24.0 median of National Institutes of Health Stroke Scale [NIHSS] points; p =0.001), successful recanalization (90.0% vs. 54.2%; p =0.005), change in neurological deficit (12.0 vs. 1.0 median difference of NIHSS points; p =0.005). Stepwise binary logistic regression analysis identified age (OR=0.932, 95% CI=0.882–0.984; p =0.012), presence of diabetes mellitus (OR=0.105, 95% CI=0.018–0.618; p =0.013) and severe stroke (OR=0.071, 95% CI=0.013–0.383; p =0.002) as significant independent negative predictors of good outcome. Conclusions: In the present study, higher age, presence of diabetes mellitus and severe stroke were identified as significant independent negative predictors of good outcome.
Type of Medium:
Online Resource
ISSN:
0317-1671
,
2057-0155
DOI:
10.1017/S0317167100017327
Language:
English
Publisher:
Cambridge University Press (CUP)
Publication Date:
2014
detail.hit.zdb_id:
2577275-2
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