Note: Front Cover -- Cytochrome P450 -- Copyright Page -- Table of Contents -- Contributors to Volume 357 -- Preface -- Volume in Series -- Section I: Human Genomics and Genetics -- Chapter 1. Mining Databases for Cytochrome P450 Genes -- Chapter 2. Sequence Alignments, Variabilities, and Vagaries -- Chapter 3. Human CYP Allele Database: Submission Criteria Procedures and Objectives -- Chapter 4. Fine-Scale Mapping of CYP Gene Clusters: An Example from Human CYP4 Family -- Chapter 5. Detection of Single Nucleotide Polymorphisms in CYP2B6 Gene -- Chapter 6. Genotyping Human Cytochrome: P450 1B1 Variants -- Chapter 7. Genotyping Human CYP2A6 Variants -- Section II: Structure and Mechanism -- Chapter 8. Purification and Crystallization of N-Terminally Truncated Forms of Microsomal Cytochrome P450 2C5 -- Chapter 9. Molecular Replacement in P450 Crystal Structure Determinations -- Chapter 10. Optical Biosensor and Scanning Probe Microscopy Studies of Cytochrome P450 Interactions with Redox Partners and Phospholipid Layers -- Chapter 11. Cryoradiolysis for the Study of P450 Reaction Intermediates -- Chapter 12. Analyzing Binding of N-Terminal Truncated, Microsomal Cytochrome P450s to Membranes -- Chapter 13. Sensitizer-Linked Substrates and Ligands: Ruthenium Probes of Cytochrome P450 Structure and Mechanism -- Chapter 14. Combining Pharmacophore and Protein Modeling to Predict CYP450 Inhibitors and Substrates -- Chapter 15. High Pressure: A New Tool to Study P450 Structure and Function -- Section III: Regulation of Expression -- Chapter 16. Use of in Vitro Pregnane X Receptor Assays to Assess CYP3A4 Induction Potential of Drug Candidates -- Chapter 17. Analysis of CYP mRNA Expression by Branched DNA Technology. , Chapter 18. Ligand-Induced Coactivator Recruitment to Peroxisome Proliferator-Activated Receptorα Characterized by Fluorescence Resonance Energy Transfer -- Chapter 19. Fluorescence-Based Ligand-Binding Assays for Peroxisome Proliferator-Activated Receptors -- Chapter 20. Developing Toxicologically Predictive Gene Sets Using cDNA Microarrays and Bayesian Classification -- Chapter 21. Direct Expression of Fluorescent Protein-Tagged Nuclear Receptor CAR in Mouse Liver -- Chapter 22. Application of Fluorescent Differential Display and Peroxisome Proliferator-Activated Receptor (PPAR)α-Null Mice to Analyze PPAR Target Genes -- Chapter 23. Histological and Metabolism Analysis of P450 Expression in the Brain -- Chapter 24. Proteomic Analysis of Rodent Hepatic Responses to Peroxisome Proliferators -- Section IV: Metabolism -- Chapter 25. Kinetic Analysis for Multiple Substrate Interaction at the Active Site of Cytochrome P450 -- Chapter 26. Design and Application of Fluorometric Assays for Human Cytochrome P450 Inhibition -- Chapter 27. Automated Quantitative and Qualitative Analysis of Metabolic Stability:AProcess for Compound Selection during Drug Discovery -- Chapter 28. Characterization of Covalent Adducts to Intact Cytochrome P450s by Mass Spectrometry -- Chapter 29. Mutagenesis Testing Based on Bacterial Expression of Human P450s -- Chapter 30. Use of Long-Term Cultures of Human Hepatocytes to Study Cytochrome P450 Gene Expression -- Chapter 31. Polarized Cell Cultures for Integrated Studies of Drug Metabolism and Transport -- Section V: Invertebrate P450s -- Chapter 32. Use of Methylotropic Yeast Pichia pastoris for Expression of Cytochromes P450 -- Chapter 33. Partial Recoding of P450 and P450 Reductase cDNAs for Improved Expression in Yeast and Plants. , Chapter 34. Selective Covalent Labeling with Radiolabeled Suicide Substrates for Isolating P450s -- Chapter 35. Cloning of cDNAs Encoding P450s in Flavonoid/ Isoflavonoid Pathway from Elicited Leguminous Cell Cultures -- Chapter 36. Selected Cell Cultures and Induction Methods for Cloning and Assaying Cytochromes P450 in Alkaloid Pathways -- Chapter 37. Isolation and Functional Characterization of Cytochrome P450s in Gibberellin Biosynthesis Pathway -- Author Index -- Subject Index.