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  • 1
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2017
    In:  ZWR - Das Deutsche Zahnärzteblatt Vol. 126, No. 12 ( 2017-12), p. 616-621
    In: ZWR - Das Deutsche Zahnärzteblatt, Georg Thieme Verlag KG, Vol. 126, No. 12 ( 2017-12), p. 616-621
    Type of Medium: Online Resource
    ISSN: 0044-166X , 1439-9148
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2017
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  • 2
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2020
    In:  ZWR - Das Deutsche Zahnärzteblatt Vol. 129, No. 09 ( 2020-09), p. 415-420
    In: ZWR - Das Deutsche Zahnärzteblatt, Georg Thieme Verlag KG, Vol. 129, No. 09 ( 2020-09), p. 415-420
    Type of Medium: Online Resource
    ISSN: 0044-166X , 1439-9148
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2020
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  • 3
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2022
    In:  International Journal of Implant Dentistry Vol. 8, No. 1 ( 2022-11-04)
    In: International Journal of Implant Dentistry, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2022-11-04)
    Abstract: There is currently a lack of guidelines for clinicians regarding titanium hypersensitivity in implant dentistry. Diagnostic tests such as the epicutaneous test or the lymphocyte transformation test showed inconsistent results regarding reliability and validity and thus, evidence-based consensus recommendations regarding diagnostic and therapeutic options may be helpful in clinical decision-making. Therefore, the German S3 guideline on titanium hypersensitivity in implant dentistry was developed. Findings In the objectives, procedure, voting method and venue were defined and the consensus participants were invited. A systematic literature research was performed, and the overall quality of the evidence was rated according to the GRADE working group. Eight recommendations were formulated within the framework of a structured consensus conference under independent moderation and could be voted on with strong consensus ( 〉  95% agreement). The formulated statements and recommendations were developed in small groups according to the guidelines of the Association of the Scientific Medical Societies in Germany (AWMF) and were discussed and agreed upon in the plenum. Conclusions For reasonable decision-making, a patient’s clinical symptoms should be regarded as leading parameters, which are usually expressed by a local inflammatory reaction with subsequent disturbed osseous integration. Allergy tests, such as the epicutaneous test or the lymphocyte transformation test are not helpful in titanium intolerance assessments, since these tests indicate T cell-mediated allergies, which are not observed in titanium intolerance reactions. Other metals and impurities that might be present in superstructures or alloys also need to be considered as the cause of an intolerance reaction and a trigger for contact sensitization. In the case of a suspected titanium particle-related, local immunologically induced inflammatory reaction with subsequent impaired osseous integration, dental ceramic implants can be considered as a therapeutic option. Graphical Abstract
    Type of Medium: Online Resource
    ISSN: 2198-4034
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2842869-9
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  • 4
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2021
    In:  ZWR - Das Deutsche Zahnärzteblatt Vol. 130, No. 09 ( 2021-09), p. 381-381
    In: ZWR - Das Deutsche Zahnärzteblatt, Georg Thieme Verlag KG, Vol. 130, No. 09 ( 2021-09), p. 381-381
    Type of Medium: Online Resource
    ISSN: 0044-166X , 1439-9148
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2021
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  • 5
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2021
    In:  ZWR - Das Deutsche Zahnärzteblatt Vol. 130, No. 09 ( 2021-09), p. 404-412
    In: ZWR - Das Deutsche Zahnärzteblatt, Georg Thieme Verlag KG, Vol. 130, No. 09 ( 2021-09), p. 404-412
    Type of Medium: Online Resource
    ISSN: 0044-166X , 1439-9148
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2021
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  • 6
    In: Oral Diseases, Wiley, Vol. 28, No. 2 ( 2022-03), p. 503-512
    Abstract: To perform a retrospective, descriptive, histopathological study of peri‐implant tissue pathologies associated with titanium dental implants (TDI), and to evaluate the presence of metallic particles in samples from a single diagnostic center. Methods Sixty‐eight cases of TDI‐associated lesions were retrieved from the Surgical Pathology Laboratory archives, School of Dentistry, University of Buenos Aires (UBA) (1990–2018). The study included re‐examining the histopathological features of the biopsy samples, analyzing the inflammatory infiltrate, and examining the samples to detect metallic particles whose chemical composition was determined spectrophotometrically (EDS). Available clinical and radiographic data were also reviewed. Results The retrieved cases ranged from lesions of inflammatory origin to neoplastic lesions. Metallic particles were observed in 36 cases (52.9%), all of which showed inflammation. Particle length ranged from 2 to 85µm. EDS analysis of the particles/deposits observed in the tissues showed the presence of aluminum, titanium, iron, and nickel, among other elements. Conclusions A significant number of TDI‐associated lesions, including cases not reported to date and diagnosed at a single diagnostic center, are shown here. Cases showing particles exhibited an inflammatory response, irrespective of the histopathological diagnosis. The role of metallic particles in the development of TDI‐associated lesion is yet to be established.
    Type of Medium: Online Resource
    ISSN: 1354-523X , 1601-0825
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2008428-6
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  • 7
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2022
    In:  International Journal of Implant Dentistry Vol. 8, No. 1 ( 2022-12)
    In: International Journal of Implant Dentistry, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2022-12)
    Abstract: There are rising concerns about titanium hypersensitivity reaction regarding dental endosseous implants. This review aims to summarize and compare the validity and reliability of the available dermatological and laboratory diagnostic tests regarding titanium hypersensitivity. The following PICO design was used: In Patients with titanium dental implants (P) does epicutaneous testing (ECT) (I), compared to lymphocyte transformation test (LTT) or Memory Lymphocyte Immunostimulation Assay (MELISA) (C) detect hypersensitivity reactions (O)? A literature search was performed including all studies dealing with this topic. Studies regarding orthopedic implants were excluded. Methods Three databases (MEDLINE PubMed, Cochrane Library, SciELO) were screened for suitable studies and an additional manual search was also performed. Literature regarding hypersensitivity reactions in orthopedic implants, hypersensitivity reactions regarding implants not related to dental or maxillofacial surgery, animal studies and in vitro studies were excluded. A quality assessment of all selected full-text articles was performed. Randomized, controlled trials were evaluated with the Cochrane Risk of Bias Tool I. Cohort studies were assessed according to the New Castle–Ottawa Scale and case series according to Moga et al. (Development of a quality appraisal tool for case series studies using a modified Delphi technique. 2012). Results 10 studies were included in the quantitative synthesis and available for the endpoint diagnostics of intolerance reactions to titanium dental implants: 2 clinical studies, 7 cohort studies and 1 case series. The potential for bias (internal validity) for these studies was overall rated as high. Conclusions The study of the available literature regarding ECT and MELISA or LTT in patients with suspected titanium hypersensitivity showed inconsistent results in terms of reliability and validity and thus, those tests should be regarded cautiously. There is strong evidence that titanium hypersensitivity in dental implants is associated with innate immunity: unspecific pro-inflammatory responses due to particle induced hyperreactivity of macrophages or toxicological responses especially towards nanoparticles rather than activation of the adaptive immune system. Therefore, tests detecting allergies do not seem expedient and inflammatory clinical signs should be regarded as leading parameters. Graphical Abstract
    Type of Medium: Online Resource
    ISSN: 2198-4034
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2842869-9
    Location Call Number Limitation Availability
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