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  • 1
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    Drag-out effect of piezomagnetic signals due to a borehole: the Mogi source as an example (2007)
    Details
    Publication Date: 2019-11-04
    Description: We show that using borehole measurements in tectonomagnetic experiments allows enhancement of the observed signals. New magnetic dipoles, which vary with stress changes from mechanical sources, are produced on the walls of the borehole. We evaluate such an effect quantitatively. First we formulate a general expression for the borehole effect due to any arbitrary source models. This is valid everywhere above the ground surface as well as within the cylindrical hole. A first-order approximate solution is given by a line of horizontal dipoles and vertical quadrupoles along the central axis of the borehole, which is valid above the ground surface and a slightly away (several tens of cm) from the top of the borehole. Selecting the Mogi model as an example, we numerically evaluated the borehole effect. It turned out that the vertical quadrupoles produce two orders of magnitude more intense magnetic field than the horizontal dipoles. The borehole effect is very local, i.e. detectable only within a few m from its outlet, since it is of the same order or more than the case without a borehole. However, magnetic lines of force cannot reach the ground surface from a deeper portion (〉10 m) of a borehole.
    Description: JCR Journal
    Description: open
    Keywords: piezomagnetic effect ; borehole magnetic measurement ; the Mogi model ; Long Valley ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 2
    Electronic Resource
    Electronic Resource
    Phase separation in deuterated polycarbonate/poly(methylmethacrylate) blend near glass transition temperature (1993)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 99 (1993), S. 2095-2100 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Early stage of spinodal decomposition kinetics of deuterated polycarbonate/poly(methylmethacrylate) blend has been studied by the time resolved small angle neutron scattering measurements. A trapped miscible state was obtained through fast solution casting of film specimens. Time dependence of the structure factor, S(q,t), was measured after the specimen temperature was quickly increased to a final temperature which is above its glass transition temperature, Tg. Thus, the early stage of spinodal decomposition kinetics has been observed starting from the dimension (q−1) comparable to the single chain radius of gyration, Rg, for a binary polymer mixture. The results provide an unequivocal quantitative measure of the virtual structure factor, S(q,∞); the relationship of qm and qc through rate of growth, Cahn-plot analysis, and singularity in S(q,∞); the growth of fluctuation of qRg〈1 and intrachain relaxation of qRg(approximately-greater-than)1; and also a clear proof of the Cahn–Hillard–Cook theory in the early stage of spinodal decomposition of a mean-field system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.465275
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Apparatus for deformation tests of solids in liquid 3He (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 2833-2838 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: An apparatus for deformation of solids in liquid 3He is constructed. Either tensile deformation or compression of a specimen can be performed by exchanging the assemblies in the 3He pot which has a capacity of about 30 cm3. The pulling rod for transmitting load from the tensile testing machine to the specimen runs inside the outlet tube of 3He, being isolated from 4He bath and almost free from mechanical friction. To measure the change in flow stress with the supernormal transition of superconducting metals, a superconducting magnet is mounted outside of the vacuum chamber which separates the 3He pot and the 4He bath. Under an applied load for plastic deformation the system is stably operative down to 0.6 K, while the lowest temperature achieved is 0.5 K. Some results on Ta and NaCl are presented. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1150699
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  • 4
    Electronic Resource
    Electronic Resource
    General session II
Moderated by Yashihiro Takami: Down-Regulation of TFF Expression by TNF-α in Gastric Epithelial Cells (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim:  Trefoil factor family (TFF) peptides are known to facilitate wound healing in gastric mucosa. However, the regulatory mechanisms of gastric TFF expression are not fully understood yet. In this study, we examined the effect of TNF-α on TFF1 and TFF2 expression in gastric epithelial cells.Methods:  MKN45 cells were used. TFF mRNA expression was analyzed by real-time quantitative RT-PCR. Promoter sequences of TFF1 gene (−956 to +36) and TFF2 gene (−912 to +24) were inserted into pGL3 vector and reporter gene assays were performed. NF-κB activity was monitored by using a NF-κB responsive element-driven reporter vector.Results:  (1) TNF-α(0.1–30 ng/ml) down-regulated TFF1 and TFF2 mRNA expression in a dose-dependent manner. (2) Reporter gene assays also confirmed the down-regulation of TFF1 and TFF2 gene transcription by TNF-α. (3) TNF-α activated NF-κB. (4) Overexpression of dominant negative IκBα prevented both TNF-α-induced NF-κB activation and TNF-α-induced down-regulation of TFF expression.Conclusions:  TNF-α down-regulates gastric TFF expression through NF-κB pathway, suggesting that TFF expression is sensitive to inflammatory stimuli.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130116f.x
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  • 5
    Electronic Resource
    Electronic Resource
    034 
Application of Allogeneic Cultured Dermal Substitute to Skin Defects After Excision of Skin Cancer (2004)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 12 (2004), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: This study was aimed to confirm the usefulness of allogeneic cultured dermal substitute (CDS) in the treatment of skin defects after excision of skin cancer. Methods: Eleven elderly patients (mean age of 76.3 year old) with skin cancer were included in this study. Most of the patients had basic disease such as diabetes or ASO. Allogeneic CDS used in the study were produced at Kitasato University. The CDS were applied to skin defects with exposing bone or tendon after oncological surgery, and changed once or twice a week until the open wound became suitable for autologous skin grafting or healed completely. Results: Healthy granulation tissue was formed to cover the exposed bone or tendon in all cases. Only in one case, the treatment with allogeneic CDS was abandoned owing to undesirable infection. In eight cases, appropriate wound beds acceptable for autologous skin graft were prepared. In other two cases, the skin defect became smaller and eventually closed without skin graft. In ten cases with or without skin graft, undesirable scar contracture was not observed over prolonged follow-up. Conclusions: Elderly patients with skin cancer provide reconstructive surgeons with challenging problems when bone or bare tendon is exposed after oncological surgery. Flap transfer might be complicated especially when the patients suffered from a basic disease such as diabetes or ASO. This study has confirmed that the use of allogeneic CDS is a safe and reliable method to achieve wound healing in those high-risk patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2004.abstractaw.x
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  • 6
    Electronic Resource
    Electronic Resource
    Clinical, histopathological and immunological distinction in two cases of IgA pemphigus (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 27 (2002), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Two cases of IgA pemphigus, one of the subcorneal pustular dermatosis (SPD) type and one of the intraepidermal neutrophilic IgA dermatosis (IEN) type, are described. IgA anti-keratinocyte cell surface antibodies reacted only with the uppermost epidermis in the SPD type but with the entire epidermis in the IEN type. A cDNA transfection test for desmocollins (Dsc) revealed that IgA antibodies of the SPD type reacted with Dsc1, but the IEN type did not react with any of the Dsc isoforms (Dsc1–3). ELISA for desmoglein 1 (Dsg1) and Dsg3 showed that neither of the cases had antibodies to Dsg − of either the IgG or IgA subtype. These results confirm that the autoantigen in SPD-type IgA pemphigus is Dsc1, whereas the antigen in most cases of IEN-type IgA pemphigus is unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2230.2002.01061.x
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  • 7
    Electronic Resource
    Electronic Resource
    Psoriasis bullosa acquisita (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 27 (2002), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary We report a 51-year-old man with a 20-year history of chronic plaque psoriasis who developed an autoimmune subepidermal blistering eruption that had clinical features of bullous pemphigoid, erythema multiforme and epidermolysis bullosa acquisita. Investigations revealed a 1 : 400 titre circulating and in vivo bound IgG autoantibody that mapped to the dermal side of 1 m NaCl-split skin and localized to the lower lamina lucida/upper lamina densa on immunogold electron microscopy. Immunoblotting, using dermal extracts, showed serum binding to antigens of ≈ 200- and ≈ 260 kDa. Indirect immunofluorescence microscopy, using the patient's serum on archival skin sections taken from selected individuals with different forms of inherited epidermolysis bullosa as substrate, showed normal basement membrane labelling on all samples apart from recessive dystrophic epidermolysis bullosa skin (with inherent mutations in the type VII collagen gene): in these cases there was a complete absence of immunostaining. Clinically, the patient responded rapidly to combination treatment with intravenous immunoglobulin and oral corticosteroids, dapsone and mycophenolate mofetil. Autoimmune subepidermal blistering has been reported in other patients with psoriasis, although no specific target antigen has ever been determined. Our study provides preliminary evidence that, for this patient at least, the autoantibody may be targeted against a skin component closely associated with type VII collagen (the epidermolysis bullosa acquisita antigen). Therefore, we propose the term ‘psoriasis bullosa acquisita’ for this and possibly other patients with similar skin eruptions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2230.2002.01100.x
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  • 8
    Electronic Resource
    Electronic Resource
    A case of bullous pemphigoid associated with autoantibodies targeting antigenic sites other than the NC16a domain of BP180 (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 30 (2005), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Bullous pemphigoid (BP) is associated with autoantibodies to the 180-kDa BP antigen (BP180), and the antigenic site exists on noncollagenous 16a (NC16a) domain of BP180. We now report a male BP patient whose IgG autoantibodies did not react against the NC16a domain of BP180 by either immunoblotting or ELISA, whereas they did react with BP180 extracted from normal human keratinocytes. Anti-BP180 cicatricial pemphigoid was ruled out due to the lack of conjunctival mucosal involvement and the absence of scarring in the oral cavity. Our findings indicate that there is an antigenic reactive region other than NC16a on the extracellular domain of BP180. There have been few reports describing detailed clinical features of BP caused by autoantibodies targeting antigenic sites other than the NC16a domain. We conclude that it is difficult to differentiate their clinical features from those associated with autoantibodies targeting the NC16a domain of BP180.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.2005.01819.x
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  • 9
    Electronic Resource
    Electronic Resource
    Bullous pemphigoid associated with dermatomyositis successfully controlled with minocycline (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 28 (2003), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2230.2003.01355.x
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  • 10
    Electronic Resource
    Electronic Resource
    A Japanese case of dermatitis herpetiformis with facial and palmar lesions (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 30 (2005), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.2005.01739.x
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